Bristol-Myers Squibb Company Announces Final Results of Exchange Offers for Celgene Corporation Notes

On November 21, 2019 Bristol-Myers Squibb Company (NYSE:BMY) ("Bristol-Myers Squibb") reported the final results of the offers to exchange (the "Exchange Offers") notes (the "Celgene Notes") issued by Celgene Corporation (NASDAQ:CELG) ("Celgene") for up to $19,850,000,000 aggregate principal amount of new notes to be issued by Bristol-Myers Squibb Company (the "Bristol-Myers Squibb Notes") and cash and the related consent solicitations (the "Consent Solicitations") made by Bristol-Myers Squibb on behalf of Celgene to adopt certain proposed amendments (the "Amendments") to the indentures governing the Celgene Notes (Press release, Bristol-Myers Squibb, NOV 21, 2019, View Source [SID1234551560]). The Exchange Offers and Consent Solicitations expired at 5:00 p.m., New York City time, on November 20, 2019 (the "Expiration Date").

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As of the Expiration Date, an aggregate of $18.5 billion principal amount of Celgene Notes had been validly tendered and not validly withdrawn as set forth in the table below:

Eligible holders of Celgene Notes who validly tendered and did not validly withdraw such notes at or prior to the Expiration Date are eligible to receive $1,000 principal amount of the Bristol-Myers Squibb Notes of the applicable series for each $1,000 principal amount of Celgene Notes pursuant to the terms set forth in the confidential offering memorandum and consent solicitation statement dated April 17, 2019 and the related letter of transmittal, each as amended by the press releases dated May 1, 2019, May 24, 2019, June 28, 2019, September 23, 2019, October 8, 2019, October 18, 2019, October 30, 2019, November 1, 2019, November 5, 2019, November 7, 2019, November 12, 2019 and November 15, 2019 (as so amended, the "offering memorandum and consent solicitation statement" and the "letter of transmittal", respectively). Eligible holders of Celgene Notes who validly tendered and did not validly withdraw such notes at or prior to 5:00 p.m., New York City time, on May 1, 2019 ("Early Participation Date") are eligible to receive on the settlement date an early participation payment of $1.00 in cash (the "Early Participation Payment"), even if on such settlement date such noteholder is no longer the noteholder of record of such Celgene Notes.

As previously disclosed, on the Early Participation Date, requisite consents were received and supplemental indentures were executed, eliminating substantially all restrictive covenants and certain events of default and other provisions in each of the indentures governing the Celgene Notes. Such supplemental indentures will only become operative upon the settlement date of the Exchange Offers.

The Exchange Offers and Consent Solicitations were made pursuant to the terms and subject to the conditions set forth in the confidential offering memorandum and consent solicitation statement and the related letter of transmittal, and were conditioned upon, among other things, the closing of Bristol-Myers Squibb’s acquisition of Celgene (the "Merger"), which was completed on November 20, 2019. As of the Expiration Date, all conditions to the Exchange Offers and Consent Solicitations were satisfied. The settlement date of the Exchange Offers and Consent Solicitations is expected to occur on November 22, 2019.

Each Bristol-Myers Squibb Note issued in the Exchange Offers for a validly tendered Celgene Note will have an interest rate and maturity date that is identical to the interest rate and maturity date of the tendered Celgene Note, as well as identical interest payment dates and optional redemption terms. No accrued and unpaid interest is payable upon acceptance of any Celgene Notes in the Exchange Offers and Consent Solicitations. However, the first interest payment on the Bristol-Myers Squibb Notes will include the accrued and unpaid interest from the applicable Celgene Notes tendered in exchange therefor so that a tendering eligible holder will receive the same interest payment it would have received had its Celgene Notes not been tendered in the Exchange Offers and Consent Solicitations. The Bristol-Myers Squibb Notes will be unsecured and unsubordinated obligations of Bristol-Myers Squibb and will rank equally with all of Bristol-Myers Squibb’s other unsecured and unsubordinated indebtedness from time to time outstanding.

Documents relating to the Exchange Offers and Consent Solicitations were only distributed to eligible holders of Celgene Notes who completed and returned an eligibility form confirming that they are either a "qualified institutional buyer" under Rule 144A or not a "U.S. person" and outside the United States under Regulation S for purposes of applicable securities laws. The complete terms and conditions of the Exchange Offers and Consent Solicitations are described in the confidential offering memorandum and consent solicitation statement and the related letter of transmittal.

This press release does not constitute an offer to sell or purchase, or a solicitation of an offer to sell or purchase, or the solicitation of tenders or consents with respect to, any security. No offer, solicitation, purchase or sale will be made in any jurisdiction in which such an offer, solicitation or sale would be unlawful. The Exchange Offers and Consent Solicitations were made solely pursuant to the confidential offering memorandum and consent solicitation statement and the related letter of transmittal and only to such persons and in such jurisdictions as are permitted under applicable law.

The Bristol-Myers Squibb Notes offered in the Exchange Offers have not been registered under the Securities Act of 1933, as amended, or any state securities laws. Therefore, the Bristol-Myers Squibb Notes may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act of 1933, as amended, and any applicable state securities laws.

Vivoryon Therapeutics AG to Publish Third Quarter 2019 Results on November 28, 2019

On November 21, 2019 Vivoryon Therapeutics AG (Euronext Amsterdam: VVY),reported that it will publish its third quarter financial results and a business update for the period ended September 30, 2019 on Thursday, November 28, 2019, in the form of an interim management report (Press release, Vivoryon Therapeutics, NOV 21, 2019, View Source [SID1234551556]).

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Dragonfly Therapeutics Announces Collaboration with AbbVie in Autoimmune Diseases and Oncology

On November 21, 2019 Dragonfly Therapeutics ("Dragonfly"), a biotech company developing novel immunotherapies that use the natural immune system to treat disease, and AbbVie (NYSE: ABBV ), a research-driven, global biopharmaceutical company, reported their collaboration to explore multiple targets with a focus on advancing a range of novel Dragonfly-based immunotherapies based on autoimmune and oncological antibodies to natural killer cells Indications were developed (Press release, Dragonfly Therapeutics, NOV 21, 2019, View Source [SID1234551543]).

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The collaboration gives AbbVie the option to license exclusive intellectual property rights worldwide to develop and market products targeted to specific targets. These targets were developed using Dragonfly’s TriNKET technology platform.

"AbbVie is committed to providing patients with better treatment options by investing in breakthrough technologies and platforms," ​​said Tom Hudson , MD, senior vice president of research and development and chief scientific officer at AbbVie. "The Dragonfly team has made impressive progress in advancing their platform, and they’ve demonstrated the potential in their technology to treat a whole range of diseases."

"AbbVie is a global leader in the treatment of chronic, immune-mediated diseases and is setting new standards in caring for people living with cancer," said Dragonfly Co-Founder and Chief Executive Officer Bill Haney , "We look forward to working with the AbbVie team to develop new treatments for patients. "

AbbVie will make an upfront payment to Dragonfly and, if successful, interim payments on major landmarks and royalties.

Announcement of Series A2 financing

On November 20, 2019 Thyas reported that it has raised JPY 240 million in Series A2 financing on November 20, with participation from Kyoto University Innovation Capital Co., Ltd., Chushin Venture Capital Co., Ltd., and Future Venture Capital Co., Ltd. (Press release, Thyas , NOV 20, 2019, View Source [SID1234629210]).

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The funds will be used for accelerating the research and development including preclinical studies of iPS cell-derived T cell therapy for the treatment of solid cancers.

ONC201 and ONC206 Activity in Neuro-Oncology to be Presented at SNO Conference

On November 20, 2019 Oncoceutics, Inc. reported that new data will be presented on the efficacy and mechanism of action of imipridones ONC201 and ONC206 at the 24nd Annual Scientific Meeting of the Society of Neuro-Oncology, to be held November 20th-24th in Phoenix, Arizona (Press release, Oncoceutics, NOV 20, 2019, View Source [SID1234558320]).

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These data will highlight exciting findings that have emerged over the past year, including:

Updated clinical results for ONC201 in pediatric and adult H3 K27M-mutant gliomas
Extension of ONC201 activity to other brain tumors
Synergy antitumor activity of ONC201 in combination with other treatments
Activity of ONC206 in medulloblastoma
IND-enabling studies with ONC206
Distinctions in the activity of ONC201 and ONC206
Inhibition of mitochondrial function by ONC201
The capability of the imipridone family to bind to distinct molecular targets
Oncoceutics and academic investigators will present a range of results with imipridones that will include mechanistic and efficacy findings from preclinical models that detail their unique therapeutic potential in neuro-oncology. In addition, updated safety, pharmacokinetic, pharmacodynamic, and efficacy results from clinical trials with ONC201 in high-grade glioma patients will be reported. These results are largely derived from the ongoing clinical program that is dedicated to exploring ONC201 a molecularly-defined patient population (H3 K27M-mutant glioma). The rationale for the upcoming first-in-human clinical trial of ONC206 in adult recurrent CNS tumors will also be highlighted.

Summaries and presentation information are provided below:

Date/Time Location Abstract Title Presenter

Wednesday 11/20
9:40 – 9:50 PM JW Marriott Selective targeting of dopamine receptor dysregulation in high grade gliomas with ONC201 Varun Prabhu, PhD, Oncoceutics

Thursday 11/21
5:00 – 7:00 PM Investigator Meeting

Friday 11/22
7:30 – 9:30 PM Ballroom Lawn Imipridone Structure Activity Relationship Uncovers ONC206 as the Next Bitopic DRD2 Antagonist for Oncology with Differentiated Receptor Pharmacology Varun Prabhu, PhD, Oncoceutics
7:30 – 9:30 PM Ballroom Lawn Single agent ONC201 in previously treated, progressive adult H3 K27M-mutant glioma Isabel Arrillaga-Romany, MD, PhD, MGH
7:30 – 9:30 PM Ballroom Lawn Role of ONC206 in regulating medulloblastoma tumor progression Anshu Malhotra, PhD, Emory University
7:38 – 7:42 PM Wildflower B Receptor pharmacology of ONC201: The first bitopic DRD2 antagonist for clinical neuro-oncology Josh Allen, PhD, Oncoceutics

Saturday 11/23
7:15 – 8:30 AM Grand Canyon 8-13 H3K27M glioma and ONC201 (SNO-EANO Joint session) Isabel Arrillaga-Romany, MD, PhD, MGH
3:45 – 3:55 PM Grand Canyon 1-6 Clinical efficacy of ONC201 in thalamic H3 K27M-mutant glioma Carl Koschmann, MD, Michigan Medicine
4:40 – 4:45 PM Grand Canyon 1-6 Phase I clinical trial of ONC201 in pediatric H3 K27M-mutant glioma or newly diagnosed DIPG Sharon Gardner, MD, NYU Langone Health
5:00 – 7:00 PM Ballroom Lawn Preclinical combination of ONC201 with radiotherapy or Temozolomide in GBM, DIPG and ATRT cell lines results in dopamine receptor antagonism, ATF4 induction and cell death Lanlan Zhou, MD, PhD, Brown University
5:00 – 7:00 PM Ballroom Lawn Metabolic rewiring by ONC201/TIC10 and 2-Deoxyglucose has synergistic anti-glioblastoma activity Josh Allen, PhD, Oncoceutics
5:00 – 7:00 PM Ballroom Lawn PDTM-25 Study of ONC201 in pre-clinical models of DIPG Wafik Zaky, MD, MD Anderson
5:00 – 7:00 PM Ballroom Lawn IND-enabling Characterization of ONC206 as the Next Bitopic DRD2 antagonist for Neuro-oncology Varun Prabhu, PhD, Oncoceutics