1stOncology™: Cancer Intelligence Service – Page 12302 – 1stOncology is recognized as a Top 10 Global Pharma Analytic Provider

New European Partnerships to Accelerate Cancer Research

On February 28, 2020 Cancer Research UK and its European partners, Fondazione AIRC and Asociación Española Contra el Cáncer (AECC), reported that it will invest £27.4 million into seven new international projects to accelerate lifesaving cancer research, announced today (Friday) (Press release, Cancer Research UK, FEB 28, 2020, View Source [SID1234554923]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

Schedule Your 30 min Free Demo!

"If current trends continue, the world will see a 60% increase in cancer cases over the next two decades. Cancer is a global problem and no one country can tackle it alone." – Dr Iain Foulkes, Cancer Research UK
The Cancer Research UK Accelerator Awards programme, which provides five years of funding for international projects, reflects a longstanding link between the UK and Europe, working together to drive progress for people affected by cancer.

The successful teams will develop new research tools, resources and infrastructure to improve scientists’ understanding of cancer, including rare and hard-to-treat cancers, helping to find better ways to treat them. Projects include investigating how to best combine radiotherapy with the latest immunotherapies, and refocussing research efforts on mesothelioma, an asbestos related cancer, cases of which continue to rise globally.*

Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: "If current trends continue, the world will see a 60% increase in cancer cases over the next two decades. Cancer is a global problem and no one country can tackle it alone.

"Now the UK has left the European Union, the need to retain collaborative cancer research between the EU and the UK has never been greater. This partnership will also strengthen UK cancer research by the sharing of expertise, new technologies and research talent."

Professor Paul French, a physicist based at Imperial College London, will lead one of the projects to improve the way we develop and test anti-cancer drugs in the lab.

Traditionally, drug discovery research has used thin ‘2D’ layers of cells that can be easily controlled and imaged on conventional microscopes. However, such simplified disease models don’t adequately represent the complex 3D cancer environment within the body.

Professor French said: "The complexity of cancer is beyond our current understanding and existing therapies. By developing technology to investigate more sophisticated 3D cancer models, which allow us to explore how drugs work on tumour cells interacting with their local environment, we could find new ways to overcome challenges like drug resistance."

Professor Kevin Blyth, a clinician scientist based at the University of Glasgow, will lead another of the projects, focussed on finding better treatments for mesothelioma, a hard-to-treat asbestos related cancer that most commonly starts in the layers of tissue that cover each lung.

Professor Blyth said: "It’s been difficult to build a network of scientists, with enough cases of the disease to build a thorough understanding of how to best treat mesothelioma. And this has left people with the disease very few treatment options.

"In the future it’s likely that the global incidence of mesothelioma will continue to increase, as there are many countries that still don’t regulate the use of asbestos. So, it’s important to build a research community now and improve our understanding to help those affected by this cancer."

The Accelerator Awards bring together world-class researchers who would not previously have been able to work together, without the unique structure of this grant scheme. Each collaboration aims to deepen the research community’s understanding of cancer and bring people with cancer closer to new treatments, making use of the expertise and diverse technologies of different partner organisations.

Ignacio Muñoz Pidal, president of the AECC, said: "The AECC believes international collaboration is essential to accelerate cancer research. The Accelerator Awards allow European researchers to not only receive five years of funding, but also enables them access to an international collaborative platform where they can share knowledge and data."

Professor Federico Caligaris Cappio, scientific director of Fondazione AIRC, said: "Rare tumours are individually of little interest to drug developers and are difficult to study because patients are few. For this reason, the knowledge we have of many of these cancers is fairly basic.

"For research to be as effective as possible, it is necessary to bring together expertise from several countries. This is one of the strengths of the Accelerator Awards that sees Fondazione AIRC, Cancer Research UK and AECC come together. Supporting research projects that are aimed at accelerating skills and seeking new and more effective therapeutic solutions."

The next round of the Accelerator Awards will open on 2 March for international research groups.

Newly founded PokeAcell signs licensing agreement with Technical University of Denmark (DTU) enabling development of a novel personalized cell therapy for cancer

On February 27, 2020 PokeAcell, a newly founded immunotherapy company, has secured exclusive licensing rights to a proprietary technology, for personalized T cell therapy (Press release, PokeAcell, FEB 27, 2020, View Source [SID1234596101]). The new technology can activate and grow cancer-specific T cells present in patient’s own blood and the cells can then be given back to the patient as fully personalized treatment. The T cell therapy hold the potential of curative treatment in Metastatic Melanoma and Merkel Cell carcinoma – two of the most severe skin cancers today and with potential in several other indications.

"We are founding PokeAcell with the mission to provide curative treatment to solid tumor patients with no available treatment today. We are pleased to sign this exclusive licensing agreement with DTU on the ImmPACT activation technology and further strengthen the development of personalized T cell therapy," says Anne Reker Cordt, CEO and co-founder PokeAcell

PokeAcell is a spin out of DTU Health Technologies based on the distinct expertise of Prof. Sine R. Hadrup, PhD., who will receive the prestigious Elite Research Prize from the Ministry of Higher Education and Science at a ceremony later today.

Prof. Sine R. Hadrup – inventor and co-founder of PokeAcell, says: "T cells are the natural soldiers of the immune system and hold immense potential in the treatment of cancer. The ImmPACT technology create a personalized cell product with very beneficial properties and is now one step closer to helping patients in need of better treatment".

PokeAcell is founded by an experienced team of science and business leaders and have established a strong advisory Board, which includes profiles such as John Haurum, biotech executive and board member and Inge Marie Svane, Prof, MD Herlev CCIT.

"In patients with metastatic cancers it can be very difficult for the immune system to overcome the influence of the cancer. T cell therapy has shown good results in clinical trials and PokeAcell’s T cell technology has a very interesting potential for extending T cell therapy to more patients with Metastatic Melanoma. I look forward to the results of the first clinical evaluation," says Inge Marie Svane, Prof, MD Herlev CCIT.

PokeAcells is a Copenhagen based privately owned immunotherapy company. PokeAcell’s personalized T cell product is in pre-clinical evaluation and is in preparation for an investigator lead phase I in Metastatic Melanoma at Herlev CCIT.

Next-generation Targeted Cytokine Therapy to be Explored on Advancements Series

On February 27, 2020, Deka Biosciences reported that an upcoming episode of Advancements with Ted Danson, scheduled to broadcast 2Q/2020, will explore innovative treatment solutions for maladies, such as Inflammatory Bowel Disease (IBD), specifically Crohn’s Disease (Crohn’s), and Oncology (Press release, Deka Biosciences, FEB 27, 2020, View Source [SID1234580080]). Check local listings for more info.

This segment will focus on a novel platform developed by Deka Biosciences, Inc. (Deka Biosciences), that will enable the delivery of next generation cytokine or combination of cytokines to a specific tissue of interest. Viewers will learn how this cutting-edge technology, termed Diakines, has led to the development of two potential therapeutic molecules involving an affinity modified Interleukin 10 cytokine.

The show will also explore how Deka Biosciences is using Diakines to harness the spectrum of therapeutically useful and clinically validated IL10 and other cytokine specific biologies. Spectators will see how these Diakines can maximize patient benefits through improved PK/PD function combined with a MOA directed patient selection strategy.

"The biopharma industry has known for a while that cytokines play an integral role in immunology and disease management, and that delivery of cytokine therapeutics into diseased tissues will dramatically enhance therapeutic benefit," said Dr. John Mumm, co-founder & CEO of Deka Biosciences. He continued to say, "Deka Biosciences has harnessed the wealth of clinical knowledge around cytokines and IL-10 in particular, to develop a novel delivery platform to enrich cytokine variants in effected tissues, coupled with methods to determine how to select the patients with the greatest likelihood of response to ensure that the right patients get the right medicines."

In addition, the show will also inform about Deka Biosciences’ Precision Medicine strategy, which enables Deka to identify the right patients to treat with these new medicines.

"Deka’s platform has the potential to enable discoveries of next generation therapies," said Richard Lubin, senior producer for DMG Productions and the Advancements series. "We are eager to explore how Deka is set to influence future treatment options for IBD, Crohn’s."

Incyte Partners with Artist and Patient J.G. Jones to Raise Awareness for Myeloproliferative Neoplasms (MPNs)

On February 27, 2020 In honor of Rare Disease Day on February 29th, Incyte (NASDAQ:INCY) is reported the launch of Rare Reflections: MPNs Unmasked, a disease awareness initiative focused on raising awareness of and educating about myeloproliferative neoplasms (MPNs), a group of rare, chronic blood cancers (Press release, Incyte, FEB 27, 2020, View Source [SID1234555965]).

As part of ongoing efforts to raise awareness of MPNs, Incyte has partnered with J.G. Jones, a renowned comic book artist who was diagnosed with an MPN over a decade ago, to capture the experiences of those impacted by MPNs. Rare Reflections features a series of portraits by Jones who uses graphic art to tell the powerful and personal stories of real patients with MPNs and those impacted by MPNs.

The illustrations can be viewed at www.VoicesofMPN.com/RareReflections, along with more information about Jones’ disease journey and the stories of others living with MPNs.

"Art has the amazing ability to capture the emotions of its subjects beyond the surface, and I am honored to partner with Incyte on Rare Reflections to raise awareness of MPNs by doing the work I love," said Jones. "I know first-hand how living with an MPN can affect many aspects of a person’s life – physically and emotionally – and I hope, through increased awareness and education, to empower others living with an MPN to take control of their journey."

"Rare Disease Day offers a time for patients, caregivers, advocates and healthcare providers to join together to shine a light on the estimated 200,000 individuals in the United States living with an MPN," said Hervé Hoppenot, Chief Executive Officer, Incyte. "Incyte is pleased to partner with a respected illustrator such as J.G. Jones to bring to life the real stories of those living with an MPN and to highlight the unique experiences of people across the MPN community."

In honor of Rare Disease Day, Incyte is also supporting several efforts intended to raise awareness of MPNs and help patients with MPNs find tools and resources to help address the daily challenges they may face:

Ask an MPN Expert Facebook Live: Tune into Voices of MPN’s "Ask an MPN Expert" Facebook Live, where Incyte Oncology Clinical Nurse Educators (OCNEs) will provide educational information about MPNs and answer your MPN-related questions. The Facebook Live Chat will begin tonight, February 27, at 7:00 p.m. ET. Join the conversation here.
Nominate your MPN Hero: Honor the individual or organization in your life who has contributed to the MPN community by going above and beyond to make a real difference. In honor of Rare Disease Day, the nomination period for the 2020 MPN Heroes program opens tomorrow, February 28, and nominations are being accepted through September 12, 2020. To learn more about the program or to submit a nomination, visit www.MPNHeroes.com.
Stay connected and informed about all of the MPN awareness activities by "Liking" the "Voices of MPN" Facebook page, following "Voices of MPN" on Pinterest and following "Voices of MPN" on Twitter.

About Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPNs) are a closely related group of blood cancers in which the bone marrow functions abnormally. The bone marrow is where the body’s blood cells are made. MPNs are progressive blood cancers that can strike anyone at any age, but they are more common in older adults. Estimates of the prevalence of MPNs vary, but analysis of claims data suggests there may be as many as 200,000 people in the U.S. living with MF, PV or ET.1

Radiation/immunotherapy combination shows promise for recurrent/metastatic HNSCC

On February 27, 2020 The American Society for Radiation Oncology reported that a new phase II trial finds that a combination of radiation therapy and immunotherapy led to encouraging survival outcomes and acceptable toxicity for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) (Press release, ASTRO, FEB 27, 2020, View Source [SID1234555007]). The combination of radiation and pembrolizumab may offer a new treatment option for patients who are ineligible for cisplatin chemotherapy, part of standard treatment for the disease. Findings will be presented at the 2020 Multidisciplinary Head and Neck Cancers Symposium, taking place February 27-29 in Scottsdale, Arizona.

The single-arm trial was designed specifically for patients who normally would receive platinum chemotherapy together with radiation but may not be able to tolerate its side effects, most often due to preexisting hearing problems that place patients at risk of permanent hearing loss. Preexisting kidney damage and nerve damage also tend to be aggravated by cisplatin and place patients at risk for permanent side effects.

"That is a common dilemma in the exam room because cisplatin, while effective, tends to be particularly toxic for patients and can lead to permanent side effects for some," explained lead author Jared Weiss, MD, an associate professor of medicine at the University of North Carolina Lineberger Comprehensive Cancer Center. "I will have patients I want to treat with platinum chemotherapy, but I also want to align treatment with their values. Is the patient willing to accept a risk of deafness or exacerbated ringing in their ears? These are not acceptable consequences for most people."

The single-arm trial included 29 patients with locally advanced HNSCC. All patients would have ideally received cisplatin with their radiation but were ineligible for platinum chemotherapy. Patients were treated with three cycles of pembrolizumab and concurrent radiation therapy over six weeks, followed by three additional cycles of the immunotherapy drug.

With a median follow-up of 21 months, the rates of one-year progression-free and overall survival were 76% [95% CI 56-88] and 86% [67-95], respectively. Estimated two-year PFS was 71% [49-84] and estimated two-year OS was 75% [51-88]. For patients with p16+ oropharynx cancer, the one-year PFS and OS rates were 88% and 94%, respectively; for the other patients, the rates were 58% and 75%, respectively.

Most toxicities were mild (grade 1-2) with the exception of grade 3-4 lymphopenia, which affected 59% of patients. "This toxicity profile is better than what patients generally experience with cisplatin and radiation," explained Dr. Weiss. "It was more consistent with what we see from radiation therapy alone, with the exception of a high rate of lymphopenia that warrants additional study."

While engaging PD-1/PD-L1 blockade following chemoradiotherapy has improved survival in lung cancer, this trial is one of the first to show its potential efficacy for head and neck cancers. "There are convincing arguments that radiation sensitizes patients to immunotherapy and can enhance its effects. And the opposite direction also seems to be true – radiation therapy needs a functional immune system to work, and our hope was that pembrolizumab might be a radiation sensitizer for these patients," said Dr. Weiss.

Additionally, unlike chemoradiation therapy, the combination of radiation and pembrolizumab pairs two active modalities that can be curative by themselves. "If you look back to the historic studies, radiation alone often cures patients with this disease.Some of the first patients treated with pembrolizumab for recurrent/metastatic cancer are still alive many years out, with no evidence of disease," said Dr. Weiss. "And so, our concept was that, in addition to whatever synergy the immunotherapy might provide with radiation, we also conceived of it in a more straightforward way as a ‘second shot on goal’ toward cure."

Dr. Weiss cautioned that findings need confirmation in a randomized trial before the combination is recommended to patients.

Dr. Weiss will present "Progression-free survival, overall survival and immunophenotyping outcomes for patients with stage III-IV head and neck cancer and cisplatin contraindication treated with definitive radiotherapy plus pembrolizumab" tomorrow during the symposium’s Oral Abstract Session. The study was funded by Merck. Email [email protected] for a copy of the abstract or presentation slides from the meeting.

Attribution to the 2020 Multidisciplinary Head and Neck Cancers Symposium requested in all coverage. This release includes updated information not available in the abstract.

2020 Head and Neck Cancers Symposium News Planning Team
Robert L. Ferris, MD, PhD; Maie St. John, MD, PhD; Francis P. Worden, MD; Charu Aggarwal, MD, MPH; Sue Yom, MD, PhD; Brian O’Sullivan, MD, FASTRO; disclosures available online.

ABOUT THE SYMPOSIUM
The 2020 Multidisciplinary Head and Neck Cancers Symposium is a two-and-a-half-day meeting that convenes radiation oncologists, medical oncologists, surgeons and all members of the treatment team for a practical and comprehensive examination of treatment advances for patients with head and neck cancers. Scientific, interactive and case-based educational sessions will cover the latest research on multidisciplinary therapies, clinical applications and new treatment strategies, supportive care and toxicity mitigation. The meeting is cosponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper), the American Head and Neck Society (AHNS) and the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper).