Unum Therapeutics Strengthens and Expands Leadership Team

On June 13, 2019 Unum Therapeutics Inc. (NASDAQ: UMRX), a clinical-stage biopharmaceutical company focused on the development of cellular immunotherapies to treat cancer based on its novel T cell technology platforms, reported new additions to its leadership team. Matthew Osborne will be joining as Chief Financial Officer, effective June 24, 2019 (Press release, Unum Therapeutics, JUN 13, 2019, View Source [SID1234537075]). Jessica Sachs, M.D., will become Chief Medical Officer, effective July 15, 2019, replacing Michael Vasconcelles, M.D., who is transitioning to a clinical advisory role and departing the company . Mert Aktar has been appointed to the newly created role of Head of Business and Corporate Development. Each new executive has a proven track record of excellence and adds decades of experience to the Unum leadership team.

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"We are excited to welcome Matt, Jessica, and Mert to the leadership team at Unum. They each bring deep experience to their respective functions, and their contributions will be important to our work building our pipeline of engineered T cell therapies across a broad range of cancers," said Chuck Wilson, President and Chief Executive Officer of Unum. "I would also like to thank Mike Vasconcelles for his enormous contributions at Unum over the last several years, and I look forward to continuing to work with him as he transitions into an advisory role."

"I’ve supported many companies throughout my career helping to bring innovative and transformative new therapies to patients, and am excited about Unum’s cutting-edge T cell therapy platforms, ACTR and BOXR, with potential best-in-class product profiles in lymphoma and myeloma, and expanding these platforms in solid tumors," said Mr. Osborne. "I look forward to joining the talented leadership team at Unum and working together to make a difference in the lives of patients with cancer."

Mr. Osborne joins Unum with over 20 years of biotechnology capital markets and corporate industry experience from past roles as an equity research analyst on Wall Street and as a highly-respected corporate communications and investor relations professional in the biotechnology industry. Most recently, he was vice president of corporate affairs, communications and investor relations at Voyager Therapeutics, and he also served as global head of investor relations at Shire plc (now Takeda) during its acquisitions of Baxalta Inc. and Dyax Corp., vice president of corporate communications and investor relations at Synageva BioPharma from its public inception through its acquisition by Alexion Pharmaceuticals, and investor relations at Vertex Pharmaceuticals as part of an Institutional Investor highly-ranked investor relations team. On Wall Street as a biotechnology sell-side analyst, he covered small-to-large cap biotechnology companies at Lazard Capital Markets and Leerink Swann (now SVB Leerink) analyzing the development of several blockbuster drugs across multiple therapeutic areas. Mr. Osborne received a B.S. in Biology from Syracuse University and M.B.A. from the D’Amore-McKim School of Business at Northeastern University.

Dr. Sachs has over 16 years of experience in oncology and pediatrics, including a decade in industry. She has been serving as Vice President of Clinical Sciences at Unum since 2017, where she has been responsible for the clinical development strategy and medical and translational oversight of the Unum portfolio. Prior to joining Unum, Dr. Sachs spent several years at Takeda/Millennium where she led multiple clinical programs in oncology and transplantation, and at Genzyme Corporation, where she was responsible for post-marketing safety surveillance and risk management activities for a variety of oncology products. Dr. Sachs has been a faculty member of the Harvard Medical School since 2007 and is an Assistant in Pediatrics in the Division of Pediatric Hematology/Oncology at the Massachusetts General Hospital. She completed her fellowship in pediatric hematology and oncology at the Dana Farber Cancer Institute and Children’s Hospital Boston. She received her M.D. from Washington University in St. Louis and her B.S. from Duke University.

Mr. Aktar has 19 years of multinational experience in pharmaceuticals and biotechnology, including leadership roles in business development and technical operations. He joins Unum from Shire plc (now Takeda) where he most recently served as global head of hematology and immunology business development. While at Shire, Mr. Aktar led a team responsible for identification, evaluation and execution of global business development opportunities and facilitated the company’s acquisitions of Baxalta Inc. and Dyax Corp. Prior to Shire, Mr. Aktar held positions of increasing responsibility at Biogen, ensuring clinical and commercial supply of biologics across diverse therapeutic areas. Mr. Aktar received a B.S. in Chemical Engineering from Worcester Polytechnic Institute, M.S. in Engineering Management from Tufts University, and M.B.A. from the Massachusetts Institute of Technology Sloan School of Management.

Medicenna To Host Key Opinion Leader Call Focused on MDNA55 Recurrent Glioblastoma Program and Preliminary Top-Line Results

On June 13, 2019 Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (TSX: MDNA,OTCQB: MDNAF), a clinical stage Immuno-Oncology company, reported that it will host a Key Opinion Leader call and webcast for the investment community on Tuesday, June 18, 2019 at 1 PM, EDT (Press release, Medicenna Therapeutics, JUN 13, 2019, View Source [SID1234537071]).

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The event will be focused on Medicenna’s MDNA55 recurrent glioblastoma (rGBM) program which recently completed enrolment and will discuss preliminary top-line tumor response results to be presented at the Inaugural Immuno-Oncology Pharma Congress held on June 18, 2019 during World Pharma Week in Boston, MA.

Featured Speakers:

John H. Sampson, MD, PhD, Robert H. and Gloria Wilkins Distinguished Professor and Chair of Neurosurgery at Duke University in Durham, NC
Dr. Sampson leads an active research laboratory investigating new modalities of brain tumor infusion using Convection Enhanced Delivery (CED) and immunotherapy and is internationally recognized in the field of neurosurgery, neuro-oncology and immunotherapy. In addition, he has special training in the design and conduct of clinical trials. Dr. Sampson earned his medical degree from the University of Manitoba in Winnipeg, Canada and a PhD in neuro- immunology and brain tumor immunotherapy at Duke University. He completed his MBA at the Fuqua School of Business. He has authored more than 240 peer-reviewed publications in this field and has been continuously funded by the NIH since 2000.

Martin Bexon, MD, Head of Clinical Development at Medicenna
Dr. Bexon, has extensive experience in early and late stage clinical development including medical affairs particularly in oncology and hematology. While at CSL Behring he led multiple global clinical studies and as Global Medical Director, he led their medical affairs function. At Hoffman-La Roche Dr. Bexon designed and implemented multiple global clinical trials enrolling more than 10,000 subjects. He has also led teams filing numerous regulatory submissions on both sides of the Atlantic and Japan. Prior to joining pharma, he practiced in the clinic as a pediatrician.

Conference call and webcast details:
Date: June 18, 2019
Time: 1:00 pm EDT

To access the conference audio:
Local dial in: 416-764-8609
North American Toll Free: 1-888-390-0605
Conference ID No.: 65571448

To access the webcast and slide presentation:

View Source

Following the event, the archived webcast and Medicenna presentation will be available on the Company’s website at www.medicenna.com. The webcast will be archived for 30 days after the event.

IMV Inc. to Present at Two Upcoming Investor Conferences

On June 13, 2019 IMV Inc. (Nasdaq: IMV; TSX: IMV), a clinical stage immuno-oncology company, reported that IMV Chief Executive Officer Frederic Ors will present at the following investor conferences in June (Press release, IMV, JUN 13, 2019, View Source [SID1234537070]):

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Raymond James Life Sciences and MedTech Conference

Date: Wednesday, June 19, 2019
Time: 4:10 p.m. ET
Format: Presentation and webcast
Location: Lotte New York Palace, New York, NY
The Oppenheimer Summit for Emerging Biotechnology

Date: Wednesday, June 26, 2019 to Friday, June 28, 2019
Format: Attendance and one-on-one presentations
Location: Gurney’s Star Island Resort and Marina, Montauk, NY
A copy of each the investor presentations will be available in the events and presentations section of IMV’s website. Also, a live webcast of IMV’s presentation at the Raymond James Life Sciences and MedTech Conference will be available and archived for 90 days on the events and presentations webpage.

Servier announces European Commission decision to convert conditional approval into standard marketing authorization in patients with aggressive non-Hodgkin B-cell lymphoma for PIXUVRI® (pixantrone)

On June 13, 2019 Servier reported that the European Commission (EC) has approved the conversion of the conditional approval of PIXUVRI (pixantrone) into a standard marketing authorization as a single agent for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma (Press release, Servier, JUN 13, 2019, https://www.businesswire.com/news/home/20190613005025/en/Servier-announces-European-Commission-decision-convert-conditional [SID1234537069]).

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"There are limited treatment options for multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma," said Prof Pier Luigi Zinzani from the University of Bologna Institute of Hematology and Medical Oncology in Bologna, Italy. "PIXUVRI has demonstrated efficacy in late stage disease and the EC approval confirms PIXUVRI as a treatment option for these patients."

The EC approval is based on data from the global clinical development of PIXUVRI.

The pivotal study, PIX301 was an open-label, randomized, Phase III study comparing PIXUVRI monotherapy with physician’s choice of treatment in 140 patients with relapsed or refractory aggressive non-Hodgkin lymphoma, 50% of whom had been previously treated with rituximab. PIXUVRI was shown to be beneficial in these patients: 20% of patients responded completely to PIXUVRI compared with 5.7% of patients receiving other agents (p=0.021).1,2

To satisfy requirements of the conditional authorization, a further Phase III clinical study, PIX306, was completed to provide additional efficacy data to confirm the benefit of PIXUVRI in patients that had received prior treatment regimens containing rituximab. In the study PIX306, all patients were previously treated with rituximab. While the superiority of PIXUVRI with rituximab compared to gemcitabine with rituximab was not met, both progression-free survival and overall survival results in patients with ≥ 2 prior treatment lines were similar, when indirectly compared to the PIXUVRI treated population in the pivotal study PIX301.2,3

"At Servier, we work diligently to develop and deliver medicines that address critical unmet medical needs in diseases such as multiply relapsed or refractory aggressive non-Hodgkin lymphoma," said Patrick Therasse, Head of Servier Research and Development Oncology. "PIXUVRI has been benefitting patients since its conditional approval in 2012 but today’s decision brings reassurance to patients and clinicians that this medicine remains a relevant treatment option in this indication."

The most common side effects with PIXUVRI are neutropenia, leukopenia, lymphopenia, anemia, thrombocytopenia, nausea, vomiting, skin discolouration, alopecia, chromaturia and asthenia.1

#ENDS#

About non-Hodgkin lymphoma (NHL)

NHL is a blood cancer that affects the lymphatic system, which is defined as a network of vessels and glands that run throughout the body.4 The lymphatic system is a key component of the immune system, as it plays a role in destroying old or abnormal cells and fighting bacteria and other infections.5

NHL can occur in different parts of the body from the lymph nodes in the neck to the liver or spleen, but also in other organs such as the stomach, small bowel, bones, brain, testicles or skin.6 Around 168,000 new cases of NHL are diagnosed in the United States and Europe every year.

About PIXUVRI (pixantrone)

PIXUVRI is indicated in the European Union as monotherapy for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma.7 PIXUVRI is a cytotoxic medicine that works by interfering with the DNA within cells and preventing them from making more copies of DNA. This means that the cancer cells cannot divide and eventually die.8

PIXUVRI is mentioned in the ESMO (Free ESMO Whitepaper) guidelines as an anthracycline-like drug with reduced cardiotoxicity, which demonstrated some efficacy in heavily treated patients.9

More detail is available in the summary of the European public assessment report (EPAR) on the EMA website at www.ema.europa.eu.

Servier commercializes PIXUVRI under a license from CTI BioPharma.

Intrexon’s Subsidiary Precigen to Present at the JMP Securities Life Sciences Conference

On June 13, 2019 Intrexon Corporation (NASDAQ: XON), a leader in the engineering and industrialization of biology to improve the quality of life and health of the planet, and its wholly-owned Intrexon Health subsidiary Precigen, Inc., a biopharmaceutical company specializing in the development of innovative gene and cellular therapies to improve the lives of patients, reported their presentation at the JMP Securities Life Sciences Conference in New York. Helen Sabzevari, PhD, President of Precigen, will highlight Intrexon Health and Precigen in the presentation on Thursday, June 20, 2019 at 12:30 pm Eastern Time (Press release, Intrexon, JUN 13, 2019, View Source [SID1234537068]).

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A live webcast of the presentation will be available on the Investors section of Intrexon’s website under ‘Events’ at investors.dna.com/events and on Precigen’s website under ‘Presentations’ at www.precigen.com/media/#id-presentations. The presentation will be archived on the Intrexon and Precigen websites for 30 days following the event.