DURECT to Present at the Stifel 2019 Health Care Conference

On November 15, 2019 DURECT Corporation (Nasdaq: DRRX) reported that James E. Brown, President and CEO, will be presenting at the Stifel 2019 Health Care Conference, at the Lotte New York Palace Hotel on Tuesday, November 19, 2019 at 3:35 p.m. EST (Press release, DURECT, NOV 15, 2019, View Source [SID1234551389]). Institutional investors and analysts that are attending the conference may request a one-on-one meeting through the conference coordinators.

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A live audio webcast of the presentation will be available by accessing View Source

The live audio webcast of the presentation will also be available by accessing DURECT’s homepage at www.durect.com and clicking on the "Investors" tab. If you are unable to participate during the live webcast, the call will be archived on DURECT’s website in the "Event Calendar" of the "Investors" section.

Eiger to Present at Jefferies 2019 London Healthcare Conference

On November 15, 2019 Eiger BioPharmaceuticals, Inc. (Nasdaq: EIGR), focused on the development and commercialization of targeted therapies for serious rare and ultra-rare diseases, reported that Eiger management will present a corporate update at the Jefferies 2019 London Healthcare Conference on November 20, 2019 from 4:00-4:35 PM GMT in London (Press release, Eiger Biopharmaceuticals, NOV 15, 2019, View Source [SID1234551388]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live webcast of the presentation will be available on the Eiger BioPharmaceuticals website at www.eigerbio.com under the "Investors" tab. A replay of the webcast will be available approximately one hour following the completion of the live event.

Eiger will also host one-on-one meetings with investors.

Centene Corporation Announces Offering of Senior Notes

On November 15, 2019 Centene Corporation (NYSE: CNC) ("Centene" or the "Company") reported that it has commenced an offering to sell $7,000,000,000 of senior notes. The $7,000,000,000 of senior notes will include an add-on to its 5.375% senior notes due 2026 (the "2026 Notes"), new senior notes due 2027 (the "2027 Notes") and new senior notes due 2029 (together with the 2027 Notes, the "New Notes" and, together with the 2026 Notes, the "Notes"), subject to market and other conditions (Press release, Centene , NOV 15, 2019, View Source [SID1234551387]). The 2026 Notes will constitute a further issuance of the $1,800,000,000 aggregate principal amount of 5.375% senior notes due 2026 that were issued on May 23, 2018 and will have the same terms as such notes, other than the issue date, the issue price and the first interest payment date.

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Centene intends to use the net proceeds of the New Notes to finance the cash consideration payable in connection with Centene’s previously announced acquisition of WellCare Health Plans, Inc. ("WellCare") and to pay related fees and expenses. Centene expects to use the net proceeds of the 2026 Notes for general corporate purposes, including the repayment of revolver borrowings. Centene currently expects the acquisition to be completed by the first half of 2020. The acquisition is, however, subject to customary closing conditions, and Centene cannot guarantee that the acquisition will be completed at or about such time, or at all. The closing of this offering is not conditioned on the closing of the acquisition. If the acquisition is not consummated, the Company will be required to redeem the New Notes at a redemption price equal to 100% of the principal amount of the New Notes, plus accrued and unpaid interest, if any, to but excluding the redemption date. The 2026 Notes will not be subject to a special mandatory redemption.

The Notes will be offered to persons reasonably believed to be qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the "Securities Act"), and to non-United States persons outside the United States in compliance with Regulation S under the Securities Act. The Notes have not been registered under the Securities Act and may not be offered or sold in the United States without registration or an applicable exemption from the registration requirements.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of the securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration, qualification or exemption under the securities laws of any such jurisdiction.

Bruker Corporation to Present at Investor Conferences

On November 15, 2019 Bruker Corporation (Nasdaq: BRKR) reported it will present at the following conferences (Press release, Bruker, NOV 15, 2019, View Source [SID1234551386]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Stifel 2019 Healthcare Conference, New York, NY
Tuesday, November 19, 2019, at 1:15 p.m. Eastern Time
Gerald Herman, Chief Financial Officer

Jefferies 2019 London Healthcare Conference, London, UK
Thursday, November 21, 2019, at 8:00 a.m. GMT
Gerald Herman, Chief Financial Officer

A live audio webcast of the Stifel 2019 Healthcare Conference presentation will be available in the Investor Relations section of the Company’s website at View Source A replay will be posted on the Bruker Investor Relations website after the event and will be available for 30 days following the presentation.

Phase 1/2 Clinical Trial Progress for IDE196 to be Presented at Society for Melanoma Research Congress

On November 15, 2019 IDEAYA Biosciences, Inc. (Nasdaq:IDYA), an oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics to treat cancer, reported that it will present data from an ongoing Phase 1/2 clinical trial entitled "A Phase 1/2 Study in Patients with Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions" (ClinicalTrials.gov Identifier: NCT03947385) (Press release, Ideaya Biosciences, NOV 15, 2019, View Source [SID1234551385]). This clinical trial is evaluating the tolerability and preliminary clinical activity of IDE196 for the treatment of MUM and other solid tumors harboring GNAQ or GNA11 (GNAQ/11) mutations activating the PKC signaling pathway.

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An update on the Phase 1 Dose-Escalation portion of the ongoing Phase 1/2 clinical trial will be provided, including:

Dosing schema for dose escalation cohorts
Patient enrollment by dose cohort
Patient baseline characteristics
Summary of adverse events
Duration of treatment through data cut-off (October 28, 2019)
Data will be presented at the 16th International Congress for the Society for Melanoma Research (SMR Congress) at the Grand America Hotel in Salt Lake City, Utah, November 20-23, 2019.

Dr. Matteo Carlino, Medical Oncologist, Westmead Hospital and University of Australia, Westmead, Australia, will provide a poster presentation at the SMR Congress on November 20, 2019, entitled: "A phase 1/2 study of IDE196 in patients with metastatic uveal melanoma or solid tumors harboring GNAQ/11 mutations or PRKC fusions."

Dr. Meredith McKean, MD, MPH, Investigator, Melanoma Research Program at Sarah Cannon Research Institute, Nashville, TN, will provide an oral presentation, at a related meeting hosted by the Melanoma Research Foundation’s CURE Ocular Melanoma (OM) initiative in conjunction with the SMR Congress, on November 20, 2019.