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Henlius CEO Dr. Jason Zhu to Deliver a Keynote Presentation at JPM 2026

On December 23, 2025 Henlius reported that the 44th J.P. Morgan Healthcare Conference will take place from January 12 to 15, 2026, in San Francisco, USA. Dr. Jason Zhu, Executive Director and Chief Executive Officer of Henlius (2696.HK), has been invited to attend and will deliver a keynote presentation on January 15 (PST).

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Recognized as one of the world’s largest and most influential healthcare investment and industry conferences, the J.P. Morgan Healthcare Conference is widely regarded as a bellwether for global pharmaceutical and healthcare innovation and capital trends. The event brings together industry leaders, fast-growing emerging companies, technology innovators, and global investors, with more than 8,000 participants expected to convene in San Francisco to explore cutting-edge developments and partnership opportunities.

At the conference, Dr. Zhu will outline the core competencies Henlius has built throughout its internationalisation journey, share updates on the company’s innovative pipeline and next-generation technology platforms—including antibody-drug conjugates (ADCs) and multispecific T-cell engagers (TCEs)—and present Henlius’ strategic outlook for the next five years. Leveraging an integrated platform spanning R&D, manufacturing, regulatory affairs, and commercialisation, Henlius has evolved from an early-stage biotech into a scaled, globally operating biopharmaceutical company with an established international footprint. Henlius has established dedicated clinical development, operations, and regulatory teams in key markets including the United States and Japan, enabling independent clinical trial execution and direct engagement with global regulatory authorities to accelerate localized development and market access. In addition, the company’s commercial manufacturing facilities have obtained GMP certifications in China, the EU, and the United States, with a global supply network that now spans six continents. Through the coordinated advancement of differentiated innovation assets and diversified technology platforms, Henlius continues to deepen its global market presence while building long-term strategic partnerships with leading multinational pharmaceutical companies, forming a sustainable and scalable global development model.

Looking ahead, Henlius will remain focused on addressing unmet patient needs worldwide. By working closely with global capital markets and industry partners, the company aims to further strengthen its global innovation and operational capabilities and to build a globally competitive, patient-centric biopharma, delivering high-quality and affordable biologic medicines to patients around the world.

(Press release, Shanghai Henlius Biotech, DEC 23, 2025, View Source [SID1234661620])

BeOne Medicines to Present at the 44th Annual J.P. Morgan Healthcare Conference

On December 23, 2025 BeOne Medicines Ltd. (NASDAQ: ONC; HKEX: 06160; SSE: 688235), a global oncology company, reported it will participate in the 44th Annual J.P. Morgan Healthcare Conference on Tuesday, January 13, 2026, with a presentation at 7:30 am PST.

Live webcasts of these events can be accessed from the investors section of the Company’s website at View Source, View Source, View Source Archived replays will be available on the Company’s website.

(Press release, BeOne Medicines, DEC 23, 2025, View Source [SID1234661619])

Janux Therapeutics Provides Program Update on Ongoing Phase 1 JANX008 Study

On December 23, 2025 Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies based on its proprietary Tumor Activated T Cell Engager (TRACTr), Tumor Activated Immunomodulator (TRACIr), and Adaptive Immune Response Modulator (ARM) platforms, reported a program update on its ongoing Phase 1 study evaluating JANX008, its EGFR-targeted TRACTr, in multiple solid tumor indications.

JANX008 is being evaluated in an ongoing Phase 1 study (NCT05783622) designed to assess safety, pharmacokinetics/pharmacodynamics, and evidence of clinical activity. The Phase 1a dose-escalation portion of the study has been completed, and the program has initiated expansion cohorts to enable further evaluation and support continued dose optimization across selected solid tumor settings.

Janux expects to provide additional updates on JANX008 as the study progresses and data continue to mature.

(Press release, Janux Therapeutics, DEC 23, 2025, View Source [SID1234661618])

Vyriad Secures Final $25M Series B Tranche to Advance In Vivo CAR T Candidate into Clinic

On December 23, 2025 Vyriad, Inc., a clinical-stage biotechnology company developing targeted genetic therapies for cancer and other serious diseases, reported the closing of the $25M final tranche to its Series B financing, bringing the total Series B round to $85M. This additional funding supports the imminent first-in-human testing of VV169, Vyriad’s in vivo CAR-T candidate, in patients with relapsed or treatment-refractory multiple myeloma.

The Series B, including this latest tranche, was led by Mr. Harry Stine of Stine Seed Farms, Inc., the world’s largest private seed company and a technology leader in plant genetics. Several significant family offices also participated.

"Our mission is to transform the future of medicine with targeted genetic therapies," said Vyriad co-founder and CEO, Dr. Stephen Russell. "We are excited to launch the first-in-human Phase 1 clinical trial of VV169 and bring this therapy to patients. Our work builds on years of research and optimization around cell-specific targeting, G-protein engineering, and immune evasion — the core capabilities needed to enable effective CAR T therapies. We’re looking forward to validating our delivery technology platform and our in vivo CAR T therapeutic candidates in the clinic."

"The closing of this final tranche reflects the confidence investors have in the Vyriad team, which continues to be laser-focused on improving patient care based on its best-in-class technology," said Ed Kania, managing partner at Farfield Partners and chairman of the Vyriad board of directors. "The capabilities of this team have already been demonstrated through our partnered programs with Regeneron and Novartis, and it is increasingly clear that the company’s delivery platform has differentiated capabilities in targeted reprogramming of immune cells directly in the body — an advancement that could significantly broaden access to CAR T therapies. We are optimistic about the potential of our wholly owned in vivo CAR T therapy, which will enter the clinic in 2026."

Vyriad’s lentiviral platform leverages engineered G proteins to enable precise, direct in vivo CAR delivery without compromising transduction efficiency. By combining high specificity and blood stability with reduced immunogenicity, this approach eliminates complex ex vivo manufacturing. The result is a scalable solution that significantly expands patient access to CAR T therapies. VV169 is one of the first in vivo CAR T candidates leveraging this platform, combining an engineered CAR transgene with the optimized lentiviral delivery vector LV-169. It is being developed as a single intravenous administration targeting B-cell maturation antigen (BCMA) proteins on malignant cells in multiple myeloma. At the ASH (Free ASH Whitepaper) 2025 Annual Meeting, Vyriad presented preclinical data that showed VV169 completely eliminated disseminated multiple myeloma in all humanized mouse models, even at the lowest dose level.

(Press release, Vyriad, DEC 23, 2025, View Source [SID1234661617])

Senhwa Biosciences Highlights AI-Validated Oncology Platform and Strategic Clinical Collaborations Targeting Next-Generation Immuno-Oncology products at Its 2025 Annual Investor Conference

On December 23, 2025 Senhwa Biosciences, Inc. (TPEx: 6492), a clinical stage companies focusing on development of first-in-class therapeutics for oncology, rare diseases, and infectious diseases, reported continued progress across its AI-enabled drug development platform at its 2025 annual investor conference, reinforcing its strategic position as the global immuno-oncology landscape enters a period of generational transition.

Global blockbuster immune-oncology products now face major patent expirations before 2030 pharmaceutical companies are either actively developing or acquiring next-generation assets that are highly combinable, scalable across multiple tumor types with potential of becoming treatment standard in different types of cancers. Senhwa is addressing this demand through an integrated strategy that combines artificial intelligence validation, precision clinical development, and global pharmaceutical partnerships.

Recently, Google DeepMind applied its latest C2S-Scale biological AI model to analyze more than 4,000 drug candidates and identified Senhwa’s lead compound Silmitasertib (CX-4945) as the most potential compound to revigorate immune system to combat with cancer. The study, supported by Google’s computing infrastructure, DeepMind’s proprietary AI models, and preclinical validation conducted by Yale University, demonstrated that CX-4945 significantly enhances tumor antigen presentation—an essential mechanism for improving immune recognition of cancer cells.

This independent third-party validation highlights the potential of CX-4945 as an immune-sensitizing agent and represents a notable milestone in the application of AI to oncology drug discovery. By addressing the long-standing challenge of immunologically "cold" tumors, which had limited response to immunotherapy, CX-4945 has a unique position in the rapidly expanding field of cold-to-hot tumor conversion.

In parallel, Senhwa continues to advance its clinical pipeline through strategic international collaboration. The company recently announced a clinical collaboration with BeOne Medicines to evaluate Senhwa’s lead candidate, Pidnarulex (CX-5461), in combination with BeOne’s commercially approved, best-in-class PD-1 inhibitor tislelizumab. The initial focus of the collaboration includes pancreatic cancer and advanced solid tumors, including immunotherapy-resistant melanoma.

CX-5461 is a first-in-class small molecule with a differentiated dual mechanism of action that stabilizes DNA G-quadruplex (G4) structures while inhibiting RNA polymerase I (Pol I). This dual activity induces replication stress in tumor cells and activates the innate immune cGAS–STING pathway, effectively converting immune-cold tumors into immune-active environments. Robust preclinical data supports the application of CX-5461 in enhancing the efficacy of existing immunotherapies and becoming the ideal candidate for combination therapy with immune-oncology products.

Senhwa believes this pathway-level, multi-target strategic approach positions CX-5461 as a potential next-generation treatment back bone in cancers where immunotherapy is used, rather than positioning the compound as a single-asset or indication-specific solution. This strategic positioning has attracted interest from global pharmaceutical companies seeking high value added platform assets, as reflected by ongoing and prior collaborations involving leading multinational partners.

Looking ahead, Senhwa expects multiple value-driving catalysts over the next one to three years, including clinical data readouts for CX-5461 and CX-4945, expansion of global partnerships, potential licensing collaborations, and increased visibility at major international medical conferences such as ASCO (Free ASCO Whitepaper), AACR (Free AACR Whitepaper), and ESMO (Free ESMO Whitepaper).

"Senhwa has transitioned beyond early-stage discovery and development into a company building a scalable, AI-validated oncology platform," said the Company. "At a pivotal moment for immuno-oncology, we are focused on advancing differentiated science with the potential to create long-term value for patients, partners, and shareholders."

(Press release, Senhwa Biosciences, DEC 23, 2025, View Source [SID1234661616])