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ViewRay Announces Pricing of Public Offering of Common Stock

On December 4, 2019 ViewRay, Inc. (Nasdaq: VRAY), maker of the MRIdian, which combines MRI and external-beam radiation therapy to simultaneously image and treat cancer patients, reported the pricing of an underwritten public offering of 41,550,000 shares of common stock at a price to the public of $3.13 per share, for gross proceeds of approximately $130.1 million, before deducting underwriting discounts and commissions and estimated offering expenses payable by ViewRay (Press release, ViewRay, DEC 4, 2019, View Source [SID1234551946]). All of the shares to be sold in the offering will be offered by ViewRay. In addition, ViewRay has granted the underwriters of the offering a 30-day option to purchase up to an additional 6,232,500 shares of common stock at the public offering price, less underwriting discounts and commissions.

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ViewRay intends to use the net proceeds from the offering for working capital and general corporate purposes, including capital expenditures, research and development expenses, investments, commercial expenses, clinical data generation costs and infrastructure expenses.

The offering is expected to close on or about December 6, 2019, subject to satisfaction of customary closing conditions.

Nordic Nanovector: New preclinical Data Offer Insights Into Enhancing Betalutin®-Based Therapies in NHL

On December 4, 2019 Nordic Nanovector ASA (OSE: NANO) reported that new data from preclinical studies investigating the effect of Betalutin (177Lu-lilotomab satetraxetan) on non-Hodgkin’s lymphoma (NHL) cell lines will be presented in a poster at the 61st American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting & Exposition (7-10 December 2019 in Orlando, FL, USA) (Press release, Nordic Nanovector, DEC 4, 2019, View Source [SID1234551945]).

The ongoing research programme aims to investigate resistance mechanisms that enable NHL cells to survive Betalutin treatment and to identify molecules that, when used in combination with Betalutin, could overcome that resistance. The findings of this research could direct future programmes designed to expand the use of Betalutin-based therapies in NHL patients.

The research being presented at ASH (Free ASH Whitepaper) builds on data previously presented (at the European Haematology Association annual meeting in June 2018) describing how a screen of more than 50 different NHL cell lines identified some cell lines that were resistant to Betalutin. Two resistant cell lines were aggressive diffuse large B-cell lymphoma (DLBCL) cell lines (the double-hit/double-expressor ABC-DLBCL cell lines RIVA and U2932).

The new poster reports how these two aggressive DLBCL cell lines have been used in a new screen where Betalutin has been combined with 384 different anti-cancer drugs to identify the Betalutin/drug combinations that could potentially contribute to reverting resistance.

Jostein Dahle, Chief Scientific Officer of Nordic Nanovector, said: "Our ongoing research programmes and collaborations continue to help us understand how NHL cells react to Betalutin treatment. Understanding the mechanisms of resistance to Betalutin, and how to overcome them, is crucial for being able to deliver optimal treatment to patients with difficult to treat tumours. In the case of Betalutin-based treatment, which to date has demonstrated an encouraging clinical profile, such combination strategies could further enhance its potential to become an important option for NHL patients."

Abstract 2574

Abstract title: The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37 Targeted Radioimmunotherapy in Activated B Cell like Diffuse Large B Cell Lymphoma Cell Lines

Authors: G.E. Rødland et al.

Session Name: 605. Molecular Pharmacology, Drug Resistance-Lymphoid and Other Diseases: Poster II

Date: Sunday, 8 December 2019
Presentation Time: 6:00 PM – 8:00 PM Eastern time
Location: Orange County Convention Center, Hall B

The abstract is available at View Source and the poster will be published on the Nordic Nanovector website to coincide with the session.

About ASH (Free ASH Whitepaper)

The ASH (Free ASH Whitepaper) annual meeting is the premier event for scientific exchange in the field of haematology, attracting more than 20,000 attendees from all over the world. Typically, more than 5,000 scientific abstracts are submitted each year, and more than 3,000 abstracts are accepted for oral and poster presentations through an extensive peer review process. View Source

Dong-A ST and Beactica Therapeutics Achieve Key Milestone in Their Collaboration to Develop New Cancer Treatments

On December 4, 2019 Dong-A ST Co., Ltd. (170900: Korea SE), a Korean pharmaceutical company, and Beactica Therapeutics AB, a Swedish drug discovery company, reported that a lead compound meeting certain pre-defined criteria has been selected in their collaborative research programme aimed at developing first-in-class protein-protein interaction inhibitors for a target of therapeutic importance in cancer and other diseases (Press release, Dong-A, DEC 4, 2019, View Source [SID1234551944]).

The milestone transition provides Dong-A ST with exclusive global rights for further development and commercialization of products based on, or derived from, the lead compound. In return, Beactica receives an undisclosed milestone payment and is eligible to further payments for certain preclinical, clinical and regulatory milestones as well as royalties on commercial sales of the products resulting from the partnership. Beactica is also entitled to a revenue share from any related future licensing activities by Dong-A ST. Full financial details remain undisclosed.

"The collaboration between Dong-A and Beactica was initiated to develop next generation anti-cancer therapeutics and we greatly appreciate the phenomenal contribution Beactica has made in identifying novel modulators for a highly sought-after target," said Dr Taeyoung Yoon, Senior Vice President and Head of Research of Dong-A ST. "We are committed to advance this innovative programme with the ultimate aim to make a clinical impact where it is urgently needed."

"We are delighted to achieve this milestone under our collaboration with Dong-A, further validating the strength of our approach and drug discovery platform, as well as our success in collaborating globally with leading pharmaceutical companies," said Dr Per Källblad, CEO of Beactica. "Dong-A’s commitment to advance this programme towards the clinic is encouraging."

The collaboration between Dong-A ST and Beactica Therapeutics was initiated in October 2016 and expanded in December 2018.

MaxCyte and KSQ Therapeutics Announce Development and Commercialization Agreement to Enable the Advancement of KSQ’s Adoptive Cell Therapy Programs

On December 4, 2019 MaxCyte, the global cell-based therapies and life sciences company, and KSQ Therapeutics, a biotechnology company using its proprietary CRISPRomics discovery platform to achieve higher probabilities of success in drug development, reported that the companies have entered into a new development and commercialization agreement (Press release, MaxCyte, DEC 4, 2019, View Source;adoptive-cell-therapy-programs-300968617.html [SID1234551943]). Under the agreement, KSQ gains rights to use MaxCyte’s Flow Electroporation technology and ExPERT instruments for the advancement of KSQ’s engineered tumor-infiltrating lymphocyte (eTIL) programs, which the company is developing for the treatment of PD-1 refractory solid tumors.

Under the terms of the agreement, KSQ obtains non-exclusive clinical and commercial use rights to MaxCyte’s cell engineering platform to develop multiple adoptive cell therapies. In return, MaxCyte is eligible to receive certain milestone payments in addition to other licensing fees.

"Adoptive cell therapies hold significant potential to improve outcomes for patients that are otherwise unresponsive to current treatments," said David Meeker, M.D., Chief Executive Officer of KSQ. "MaxCyte’s technology will play an important role in enabling the further development of our eTIL programs as we work to bring best-in-class, cell-based medicines forward for difficult to treat solid tumors."

MaxCyte’s ExPERT instrument family represents the next generation of leading, clinically validated, electroporation technology for complex and scalable cellular engineering. By delivering high transfection efficiency with enhanced functionality, the ExPERT platform delivers the high-end performance essential to enable the next wave of biological and cellular therapeutics.

"We are delighted to have signed this agreement with KSQ Therapeutics, a company that’s forging an exciting path in the field of adoptive cell therapies with the potential to deliver significant benefits to patients. This is the fifth commercial license we have signed this year, demonstrating that MaxCyte is the partner of choice for leading technology companies, like KSQ, that are at the cutting edge of cell therapy and gene editing," said Doug Doerfler, President & CEO of MaxCyte, Inc.

Citius Pharmaceuticals to Present at the 12th Annual LD Micro Main Event

On December 4, 2019 Citius Pharmaceuticals, Inc. ("Citius" or the "Company") (NASDAQ: CTXR), a specialty pharmaceutical company focused on adjunctive cancer care and critical care drug products, reported that the Company will present at the 12th Annual LD Micro Main Event on Wednesday December 11, 2019 at 11:40 AM PT (Press release, Citius Pharmaceuticals, DEC 4, 2019, View Source [SID1234551942]). The conference is being held at the Luxe Sunset Boulevard Hotel in Bel Air, California on December 10-12, 2019.

Presentation Date: Wednesday, December 11, 2019

Presentation Time: 11:40 AM PT – Track 3

Location: Luxe Sunset Boulevard Hotel – Bel Air, CA

Mr. Leonard Mazur, Chairman of Citius, will deliver an overview of the Company, answer questions from investors, and be available for one-on-one meetings. To arrange a meeting with the Company, please contact Mr. Andrew Scott: [email protected].