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Flatiron Health Announces Research to be Presented at European Society for Medical Oncology Congress 2019

On September 26, 2019 Flatiron Health reported 13 abstracts accepted for presentation at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2019, which will be held September 27 – October 1, 2019, in Barcelona, Spain (Press release, Flatiron Health, SEP 26, 2019, View Source [SID1234539827]). The research, spanning multiple tumor types and areas of study, utilized Flatiron’s high-quality, real-world oncology datasets. Collectively, these research presentations highlight the various applications of real-world evidence, enabling deep clinical insights to better understand the use of biomarkers, comparative effectiveness of therapies and outcomes in routine clinical care.

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Presentations include collaborator research by the U.S. Food & Drug Administration’s Oncology Center of Excellence, Huntsman Cancer Institute, Yale Cancer Center, Bayer, Bristol-Myers Squibb, Celgene, Merck, Pfizer, Roche/Genentech and Foundation Medicine.

The presentation schedule and links to abstracts can be found below.

Poster Discussion
Prevalence and prognostic effect of high tumor mutation burden (TMB-H) across multiple less common solid cancers using a real-world dataset
● First Author: Daniel Backenroth (Flatiron Health)
● Date/Time: September 29 — 08:45 – 09:45
● Presentation: #1877PD

Poster Sessions
Second-line (2L) real-world treatment (tx) patterns and outcomes in patients (pts) with advanced/metastatic non-small cell lung cancer (NSCLC) treated with first-line (1L) immuno-oncology (IO) monotherapy (mono tx)
● First Author: Denis Talbot (University of Oxford)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #1497P

Real-world effectiveness of nivolumab monotherapy after prior systemic therapy in advanced non-small cell lung cancer (NSCLC) in the United States
● First Author: David D. Stenehjem (University of Minnesota)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #1498P

Treatment patterns and outcomes for patients (pts) with anaplastic lymphoma kinase-positive (ALK+) advanced non-small cell lung cancer (NSCLC) in US clinical practice
● First Author: Matthew G. Krebs (The Christie NHS Foundation Trust)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #1546P

Brain metastases, treatment patterns and outcomes in ROS1-positive NSCLC patients from US oncology community centers
● First Author: Matthew G. Krebs (The Christie NHS Foundation Trust)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #1551P

Biomarker status as a mediator of age-related overall survival (OS) in advanced non-small cell lung cancer (aNSCLC)
● First Author: Aaron B. Cohen (Flatiron Health)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #1558P

Comparison of real-world response rate (rwRR) to RECIST-based response rate in patients with advanced non-small cell lung cancer (aNSCLC)
● First Author: Xinran Ma (Flatiron Health)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #1581P

Palbociclib plus an aromatase inhibitor as first-line therapy for metastatic breast cancer in US clinical practices: Real-world progression-free survival analysis
● First Author: Mylin Torres (Winship Cancer Institute, Emory University School of Medicine)
● Date/Time: September 28 — 12:00 – 13:00
● Presentation: #327P

Comparative effectiveness of palbociclib plus letrozole vs letrozole for metastatic breast cancer in US real-world clinical practices
● First Author: Rachel M. Layman (Pfizer)
● Date/Time: September 30 — 12:00 – 13:00
● Presentation: #329P

Use of trastuzumab emtansine (T-DM1; K) after pertuzumab + trastuzumab (PH) in patients with HER2-positive metastatic breast cancer (mBC): Challenges in assessing effectiveness of treatment sequencing in the real world (RW)
● First Author: Thibaut Sanglier (Roche)
● Date/Time: September 30 — 12:00 – 13:00
● Presentation: #356P

Co-occurrence of NTRK fusions with other genomic biomarkers in cancer patients
● First Author: Xiaolong Jiao (Bayer)
● Date/Time: September 30 — 12:00 – 13:00
● Presentation: #102P

Association of programmed cell death 1 (PD-1) inhibitor therapy with overall survival (OS) in stage IV melanoma treated with targeted therapies
● First Author: Aracelis Z. Torres (Flatiron Health)
● Date/Time: September 30 — 12:00 – 13:00
● Presentation: #1290P

Comparative-effectiveness of pembrolizumab vs nivolumab for patients with metastatic melanoma
● First Author: Justin Moser (Huntsman Cancer Institute)
● Date/Time: September 30 — 12:00 – 13:00
● Presentation: #1346P

AVEO Oncology to Present at the 2019 Cantor Fitzgerald Global Healthcare Conference

On September 26, 2019 AVEO Oncology (NASDAQ:AVEO) reported that Michael Bailey, president and chief executive officer, will present at the 2019 Cantor Fitzgerald Global Healthcare Conference in New York on Friday, October 4, 2019 at 10:05 a.m. Eastern Time (Press release, AVEO, SEP 26, 2019, View Source [SID1234539826]).

A live webcast of the presentation can be accessed by visiting the investors section of the Company’s website at www.aveooncology.com. A replay of the webcast will be archived for 30 days following the presentation date.

Early and Effective Nutritional Therapy in GI Cancer Patients: An Opportunity to Improve Patient Outcomes & Quality of Life

On September 26, 2019 Baxter International Inc. (NYSE: BAX), a global leader in clinical nutrition reported that it will present at the ESMO (Free ESMO Whitepaper) congress to be held in Barcelona from 27 September to 1 October, organizing the symposium "Early and effective nutritional therapy in GI cancer patients: an opportunity to improve outcome (Press release, Baxter International, SEP 26, 2019, View Source [SID1234539825])."

Approximately 50% of oncology patients in Europe are affected by malnutrition. While the rate of malnutrition is even higher for patients with gastrointestinal (GI) cancers real-world evidence suggests that only 23% of GI cancer patients have malnutrition diagnosed, due to the lack of appropriate nutritional screening.1 Approximately one quarter of all cancer patients die due to consequences of malnutrition, but cancer-related malnutrition goes undiagnosed in many patients.2

Seven out of ten patients experience feeding problems during cancer treatment, chemotherapy and radiotherapy, leaving them at serious risk of malnutrition and its associated problems.3

Early initiation of clinical nutrition therapy after cancer diagnosis allows to achieve the best possible patient outcomes, improvement of cancer care and optimisation of healthcare resources use.4,5 Parenteral nutrition is a life-sustaining therapy when oral and enteral nutrition are not possible.

1 Tlemsani C et al. (2018) Malnutrition in cancer patients: is a late diagnosis a missed opportunity to improve care? Ann Oncol 29: viii603-40.
2 Hu W-H et al. (2015). Nutr J 14: 91. Lee H et al. (2013) Clin Nutr Res 2: 12-8.
3 ECPC Nutrition Booklet, 2018.
4 Tlemsani C et al. (2018) Malnutrition in cancer patients: is a late diagnosis a missed opportunity to improve care? Ann Oncol 29: viii603-4
5 Goldwasser, F et al. Challenges and Opportunities in Clinical Nutrition in Oncology: Available Evidence, Real-World Practices and the Way Forward, 2018.

DURECT to Present at the 2019 Cantor Fitzgerald Global Health Care Conference

On September 26, 2019 DURECT Corporation (Nasdaq: DRRX) reported that James E. Brown, Chief Executive Officer will be presenting at the Cantor Fitzgerald Global Health Care Conference, at the InterContinental New York Barclay Hotel on Friday, October 4, 2019 at 10:40 a.m. EDT (Press release, DURECT, SEP 26, 2019, https://investors.durect.com/news-releases/news-release-details/durect-present-2019-cantor-fitzgerald-global-health-care [SID1234539823]). Institutional investors and analysts that are attending the conference may request a one-on-one meeting through the conference coordinators.

A live audio webcast of the presentation will be available by accessing View Source

The live audio webcast of the presentation will also be available by accessing DURECT’s homepage at www.durect.com and clicking on the "Investors" tab. If you are unable to participate during the live webcast, the call will be archived on DURECT’s website in the "Event Calendar" of the "Investors" section.

Verastem Oncology to Present at the Cantor 2019 Global Healthcare Conference

On September 26, 2019 Verastem, Inc. (Nasdaq: VSTM) (Verastem Oncology or the Company), focused on developing and commercializing medicines seeking to improve the survival and quality of life of cancer patients, reported that the Company will present at the Cantor 2019 Global Healthcare Conference on Thursday, October 3, 2019 at 8:20 a.m. EDT in New York, NY (Press release, Verastem, SEP 26, 2019, View Source [SID1234539822]).

A live webcast of the presentation will be available on the investors section of the Company’s website at www.verastem.com. An archived presentation will be available for 90 days.