On September 2, 2026 SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) ("SELLAS’’ or the "Company"), a late-stage clinical biopharmaceutical company focused on the development of novel therapies for a broad range of cancer indications, reported that three abstracts evaluating SLS009 (tambiciclib), a potent, selective CDK9 inhibitor, in preclinical models of pancreatic ductal adenocarcinoma (PDAC) have been accepted for poster presentation at the AACR (Free AACR Whitepaper) Conference on Pancreatic Cancer: New Frontiers in Biology and Therapeutic Development. The conference will be held September 25–28, 2026, at the Hilton San Diego Bayfront in San Diego, CA.
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"Pancreatic cancer remains one of the most difficult solid tumors to treat, with a significant need for new therapeutic approaches," said Angelos Stergiou, MD, ScD h.c., President and Chief Executive Officer of SELLAS. "The acceptance of three abstracts evaluating SLS009 across patient-derived organoid models reflects the breadth of our preclinical work in PDAC. We look forward to sharing these findings with the pancreatic cancer research community and discussing their potential implications for the further development of SLS009 in solid tumors."
Jeremy D. Kratz, MD, Assistant Professor of Medicine & Principal Investigator, University of Wisconsin-Madison commented: "These studies are designed to deepen our understanding of the mechanistic and translational rationale for CDK9 inhibition in pancreatic cancer. The presentations will explore the potential for SLS009 to create synthetic lethal interactions through rational combinations with BET- and KRAS-directed approaches, as well as its potential to exploit MYC-associated vulnerabilities. We look forward to sharing this work with the scientific community later this month."
Poster presentation details:
Title: Elucidating MYC allelic imbalance and therapeutic response in pancreatic ductal adenocarcinoma via patient-derived organoids
Authors: Sawyer AG, Flannagan LE, Esguerra PN, Hossan MS, Kratz JD
Poster Number: A036
Title: Synthetic Lethality Through Combined BET and CDK9 Inhibition in MYC-Amplified Pancreatic Ductal Adenocarcinoma
Authors: Esguerra PN, Cadarso M, Livingwell S, Hossan MD, Wong O, Kratz JD
Poster Number: B127
Title: Targeting dual CDK9 and KRASG12D selective inhibition as a novel combination therapy in pancreatic ductal adenocarcinoma
Authors: Cadarso M, Esguerra P, Flannagan L, Hossan MS, Kratz JD
Poster Number: B043
(Press release, Sellas Life Sciences, SEP 2, 2026, View Source [SID1234670542])