Entry into a Material Definitive Agreement.

On November 21, 2019, AbbVie Inc. ("AbbVie") reported that sale of $30 billion aggregate principal amount of its senior unsecured notes, consisting of (i) $750,000,000 aggregate principal amount of senior floating rate notes due May 2021 (the "May 2021 Floating Rate Notes"), (ii) $750,000,000 aggregate principal amount of senior floating rate notes due November 2021 (the "November 2021 Floating Rate Notes"), (iii) $750,000,000 aggregate principal amount of senior floating rate notes due 2022 (the "2022 Floating Rate Notes"), (iv) $1,750,000,000 aggregate principal amount of 2.150% senior notes due 2021 (the "2021 Notes"), (v) $3,000,000,000 aggregate principal amount of 2.300% senior notes due 2022 (the "2022 Notes"), (vi) $3,750,000,000 aggregate principal amount of 2.600% senior notes due 2024 (the "2024 Notes"), (vii) $4,000,000,000 aggregate principal amount of 2.950% senior notes due 2026 (the "2026 Notes"), (viii) $5,500,000,000 aggregate principal amount of 3.200% senior notes due 2029 (the "2029 Notes"), (ix) $4,000,000,000 aggregate principal amount of 4.050% senior notes due 2039 (the "2039 Notes") and (x) $5,750,000,000 aggregate principal amount of 4.250% senior notes due 2049 (the "2049 Notes" and, together with the May 2021 Floating Rate Notes, the November 2021 Floating Rate Notes, the 2022 Floating Rate Notes, the 2021 Notes, the 2022 Notes, the 2024 Notes, the 2026 Notes, the 2029 Notes and the 2039 Notes, the "Notes").

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The offering of the Notes (the "Offering") was made pursuant to a confidential offering memorandum, dated November 12, 2019.

The Notes are governed by an indenture, dated November 8, 2012 (the "Base Indenture"), by and between AbbVie and U.S. Bank National Association, as trustee (the "Trustee"), as supplemented by Supplemental Indenture No. 7, dated November 21, 2019 (the "Supplemental Indenture"), by and between AbbVie and the Trustee. The Notes are unsecured, senior obligations of AbbVie and will rank equally in right of payment with all of AbbVie’s existing and future unsecured, senior indebtedness, liabilities and other obligations.

The May 2021 Floating Rate Notes will bear interest at a floating rate, reset quarterly, equal to the Benchmark (as defined in the Supplemental Indenture), which will initially be three-month London Inter-Bank Offered Rate ("LIBOR") plus 0.350% per annum, and will mature on May 21, 2021. The November 2021 Floating Rate Notes will bear interest at a floating rate, reset quarterly, equal to the Benchmark, which will initially be three-month LIBOR plus 0.460% per annum, and will mature on November 19, 2021. The 2022 Floating Rate Notes will bear interest at a floating rate, reset quarterly, equal to the Benchmark, which will initially be three-month LIBOR plus 0.650% per annum, and will mature on November 21, 2022. The 2021 Notes will bear interest at a rate of 2.150% per annum and will mature on November 19, 2021. The 2022 Notes will bear interest at a rate of 2.300% per annum and will mature on November 21, 2022. The 2024 Notes will bear interest at a rate of 2.600% per annum and will mature on November 21, 2024. The 2026 Notes will bear interest at a rate of 2.950% per annum and will mature on November 21, 2026. The 2029 Notes will bear interest at a rate of 3.200% per annum and will mature on November 21, 2029. The 2039 Notes will bear interest at a rate of 4.050% per annum and will mature on November 21, 2039. The 2049 Notes will bear interest at a rate of 4.250% per annum and will mature on November 21, 2049.

The Offering was conducted in connection with AbbVie’s previously announced acquisition (the "Acquisition") of Allergan plc ("Allergan"). AbbVie expects to use the net proceeds from the Offering to fund a portion of the aggregate cash consideration due to Allergan shareholders in connection with the Acquisition and to pay related fees and expenses, with any remaining net proceeds being used for general corporate purposes. If (i) the Acquisition has not been consummated on or prior to January 30, 2021 or (ii) prior to such date, AbbVie notifies the Trustee that it will not pursue the consummation of the Acquisition, then AbbVie will be required to redeem all of the Notes then outstanding at a special mandatory redemption price equal to 101% of the aggregate principal amount of the Notes, plus accrued and unpaid interest, if any, to, but not including, the applicable special mandatory redemption date.

Following the closing of the Offering, the commitments under the bridge credit facility entered into by AbbVie, as borrower, on June 25, 2019 were reduced to $2,200,360,000 as a result of AbbVie receiving net cash proceeds from the issuance of the Notes.

The foregoing summary of the Notes does not purport to be complete and is qualified in its entirety by reference to the full text of (i) the Base Indenture attached as Exhibit 4.1 hereto; (ii) the Supplemental Indenture attached as Exhibit 4.2 hereto; and (iii) the forms of the Notes attached as Exhibits 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 4.10, 4.11 and 4.12 hereto, the terms of which are in each case incorporated herein by reference.

BIOGEN TO PRESENT AT THE EVERCORE ISI 2ND ANNUAL HEALTHCONX CONFERENCE

On November 21, 2019 Biogen Inc. (Nasdaq: BIIB) reported that it will present at the Evercore ISI 2nd Annual HealthCONx Conference (Press release, Biogen, NOV 21, 2019, http://investors.biogen.com/news-releases/news-release-details/biogen-present-evercore-isi-2nd-annual-healthconx-conference [SID1234551616]). The webcast will be live on Tuesday, December 3, at 11:45a.m. ET, with Anirvan Ghosh, Ph.D., Senior Vice President and Head of Research and Early Development at Biogen. To access the live webcast, please visit Biogen’s Investors section at www.investors.biogen.com. An archived version of the webcast will be available following the presentation.

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iOmx Therapeutics’ iOTarg™ Genetic Screening Platform Featured in Podium Presentation at PEGS Europe 2019

On November 21, 2019 iOmx Therapeutics AG (iOmx), a biopharmaceutical company developing cancer therapeutics based on novel immune checkpoint targets, reported that its Vice President, Antibody Development, Stefanie Urlinger, PhD, delivered a podium presentation highlighting the discovery of IGSF11, a novel immune checkpoint molecule on tumor cells, using its iOTarg discovery platform at the 11th PEGS Europe Protein & Antibody Engineering Summit (PEGS Europe 2019) in Lisbon, 12-18 November, 2019 (Press release, iOmx Therapeutics, NOV 21, 2019, View Source [SID1234551604]).

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The podium presentation, titled, "A Comprehensive Screening Platform to Identify the Next Generation of Cancer Immunotherapy Targets," reports the identification of IGSF11, a postulated VISTA interaction partner, as an important immune checkpoint molecule on tumor cells using iOTarg, the company’s proprietary, high-throughput target discovery platform. In an MC38 murine colon adenocarcinoma mouse model, CRISPR knockout of IGSF11 resulted in a >70% reduction in tumor growth, independently validating the target. Interestingly, patients refractory to anti-PD1 or anti-CTLA4 therapies overexpress IGSF11 and exhibit poor progression-free survival.

Based on these findings, iOmx is developing a novel anti-IGSF11 antibody as monotherapy in patients with solid tumor indications that are resistant to PD-1/PD-L1 therapies. The company presented data showcasing their IGSF11-specific antibodies which block the interaction to VISTA and exhibit strong immune lysis of tumor cells in vitro. Additionally, beyond IGSF11, iOTarg resulted in the identification of other novel immune checkpoint targets and unique immune evasion biologies against which iOmx is pursuing first-in-class drug development projects – all in the pre-clinical stage.

"Current limitation of the approved immune checkpoint inhibitors to induce response in majority of cancer patients requires us to identify and drug additional key vulnerabilities in refractory tumors," said Nisit Khandelwal, Ph.D., co-founder and Senior Vice President of iOmx Therapeutics. "PEGS Europe 2019 Summit is an ideal event to showcase the ability of iOmx’ iOTarg genetic screening platform to systematically identify novel and druggable immune checkpoint targets, such as IGSF11, that are expressed by PD-L1 non-responsive tumors. Based on our findings, we have initiated pre-clinical development of a first-in-class IGSF11-targeting antibody that eliminates tumor induced immune suppression, especially in anti-PD-1 refractory tumors. Furthermore, we continue to investigate new immuno-oncology targets with our unique iOTarg discovery engine."

Tikcro Technologies Reports Third Quarter 2019 Results

On November 21, 2019 Tikcro Technologies Ltd. (OTCQB: TIKRF), a pre-clinical stage developer of antibodies for cancer immune-therapy, reported its financial results for the third quarter ended September 30, 2019 (Press release, Tikcro, NOV 21, 2019, View Source [SID1234551603]).

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"We have concluded the pre-clinical development stage of our anti-CTLA-4 antibody, which shows strong comparative results in cancer treatment assays," said Aviv Boim, CEO of Tikcro. "At this stage, we plan to reduce operating expenses. We expect to close our lab facilities and cease pre-clinical development efforts, which incurred $546,000 of R&D expenses in the previous twelve-month period. Due to the significant costs associated with production and clinical trials as well as the evolution of the immune therapy antibody market, we will continue to explore strategic opportunities for this antibody program and other alternatives."

Financial Results for the Third Quarter Ended September 30, 2019
Net loss for the third quarter of 2019 was $237,000, or $0.02 per diluted share, compared to a net loss of $266,000, or $0.03 per diluted share, for the same period last year.

As of September 30, 2019, the company reported $4.45 million in cash, cash equivalents and short-term bank deposits.

CNS Pharmaceuticals Filed Request with FDA for Pre-IND Meeting for Berubicin

On November 21, 2019 CNS Pharmaceuticals, Inc. (NASDAQ: CNSP) ("Company"), a biotechnology company specializing in the development of novel treatments for brain tumors, reported a Pre-IND meeting request for Berubicin for IV for the Treatment of Glioblastoma Multiforme to the US Food and Drug Administration Division of Oncology Products 2, Center for Drug Evaluation and Research (Press release, CNS Pharmaceuticals, NOV 21, 2019, View Source [SID1234551602]).

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In its request, the Company outlined its rationale for the continued investigation of the compound and detailed key questions for the FDA, including its permission to utilize the supply of Berubicin acquired from Reata Pharmaceuticals Inc. in the planned upcoming Phase II clinical trial. The company has performed a preliminary purity testing and analysis on Reata’s supply of Berubicin and verified that it is 99.9% pure.

"We believe that utilizing the supply of Berubicin we acquired from Reata could offer the Company significant costs savings and eliminate the excess risk and time associated with manufacturing complex drugs," stated CEO of CNS, John M. Climaco.

About Berubicin
Berubicin is an anthracycline, a class of drugs among the most powerful chemotherapy drugs and effective against more types of cancer than any other class of chemotherapeutic agents. Anthracyclines are designed to damage the DNA of targeted cancer cells by interfering with the action of the topoisomerase II, a critical enzyme enabling cell proliferation. Berubicin was developed at the MD Anderson Cancer Center (MDACC), the world’s largest cancer research facility. Berubicin appeared to demonstrate one Durable Complete Response in a Phase I human clinical trial conducted by a prior developer.