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ImaginAb Announces Publication of Data on First-In-Human Imaging in Patients with Solid Malignancies in The Journal of Nuclear Medicine

On October 8, 2019 ImaginAb Inc., a clinical-stage immuno-oncology imaging company, reported publication of its data in leading peer-reviewed medical radiology publication, The Journal of Nuclear Medicine (JNM) (Press release, ImaginAb, OCT 8, 2019, View Source [SID1234540122]).

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The paper entitled "First-in-human imaging with 89Zr-Df-IAB22M2C anti-CD8 minibody in patients with solid malignancies: preliminary pharmacokinetics, biodistribution, and lesion targetingi" reports the results from a first in-vivo clinical study to assess the safety, tolerability, and efficacy of ImaginAb’s lead product, CD8 tracer, 89Zr-Df-IAB22M2C, in visualizing the immune system.

The data from the Phase I trial reported in the paper demonstrated 89Zr-Df-IAB22M2C was well tolerated with no immediate or delayed side effects observed. In conclusion, the study found 89Zr- Df-IAB22M2C imaging to be safe and with favorable kinetics for early imaging. The biodistribution suggested successful targeting of CD8+ T cell-rich tissues. The observed targeting of tumor lesions suggests this may be informative for CD8+ T cell accumulation within tumors.

Lead author of the study, Neeta Pandit-Taskar, MD, Nuclear Medicine Physician at Memorial Sloan Kettering Cancer Center, said: "This novel imaging agent has the potential to non-invasively assess the presence of CD8 T cells in patients’ tumors and results of this initial assessment are encouraging. With more research, this technology may ultimately serve a critical role as a biomarker of immunotherapy outcome and inform clinical trials of novel immunotherapies that act mechanistically through the presence of CD8 T cells."

Ian Wilson, CEO of ImaginAb, added: "We are delighted that this paper has been published in The Journal of Nuclear Medicine, a highly regarded publication in the field of imaging and radiology. Our pioneering clinical trial involving patients at leading cancer therapy centers, Memorial Sloan Kettering Cancer Center, University of Pennsylvania, and Honor Health, are furthering ImaginAb’s goal to provide target-specific imaging agents to predict, inform, monitor and enable treatment of cancer disease more effectively."

ImaginAb’s lead product, CD8 tracer 89Zr-Df-IAB22M2C, is a first in class imaging agent that visualizes the immune system using non-invasive, whole-body in vivo PET imaging of CD8 T cells. Currently, in Phase II multi-center clinical trials at world-renowned imaging and cancer centers in North America, the 89Zr-Df-IAB22M2C immunoPET agent detects and visualizes CD8 T cells using ImaginAb’s ‘minibody’ technology. This provides highly-specific, quantitative assessment of the immunological status of individual cancer lesions within a patient, potentially enabling treatment to be tailored quickly and specifically to the needs of that patient.

Publication details: doi: 10.2967/jnumed.119.229781

For further information, please contact:

ImaginAb
Ian Wilson, CEO
Salli Walker, External Partnership Manager
Email: [email protected]
Phone: +1 310 645 1211

Optimum Strategic Communications
Mary Clark, Supriya Mathur
Email: [email protected]
Phone: +44 20 3950 9144

Veracyte to Release Third Quarter 2019 Financial Results and Business Progress on October 22, 2019

On October 8, 2019 Veracyte, Inc. (Nasdaq: VCYT) reported that it will release its financial results for the third quarter 2019 and business progress after the close of market on Tuesday, October 22, 2019 (Press release, Veracyte, OCT 8, 2019, View Source [SID1234540118]). Company management will host a conference call and webcast to discuss its financial results and provide a general business update at 5:00 p.m. Eastern time on the same day.

The conference call will be webcast live from the company’s website and will be available via the following link: View Source The webcast should be accessed 10 minutes prior to the conference call start time. A replay of the webcast will be available for one year following the conclusion of the live broadcast and will be accessible on the company’s website at View Source

The conference call can be accessed as follows:

U.S./Canada participant dial-in number (toll-free):

(855) 541-0980

International participant dial-in number:

(970) 315-0440

Conference I.D.:

8767084

Illumina to Announce Third Quarter 2019 Financial Results on Thursday, October 24, 2019

On October 8, 2019 Illumina, Inc. (NASDAQ:ILMN) reported that it will issue results for third quarter 2019 following the close of market on Thursday, October 24, 2019 (Press release, Illumina, OCT 8, 2019, View Source [SID1234540116]).

On the same day, at 2:00 pm Pacific Time (5:00 pm Eastern Time) Francis deSouza, President and Chief Executive Officer, and Sam Samad, Senior Vice President and Chief Financial Officer, will host a conference call with analysts, investors, and other interested parties to discuss financial and operating results.

Conference Call Details

The conference call will begin at 2:00 pm Pacific Time (5:00 pm Eastern Time) on Thursday, October 24, 2019. Interested parties may access the live teleconference through the Investor Relations section of Illumina’s website under the "company" tab at www.illumina.com. Alternatively, individuals can access the call by dialing 1 (866) 211-4597 or 1 (647) 689-6853 outside North America, both with conference ID 2388693.

A replay of the conference call will be posted on Illumina’s website after the event and will be available for at least 30 days following.

Median Technologies’ Q3 Performance Shows Steady Growth, Validates the Strategy Adopted in 2018 (unaudited Figures)

On October 8, 2019 Median Technologies (Paris:ALMDT), The Imaging Phenomics Company, reported an update on its performance unaudited figures – in the third quarter of 2019 (Press release, MEDIAN Technologies, OCT 8, 2019, View Source [SID1234540115]).

As of September 30th, 2019, the cumulated revenue for 2019 was € 6.3 million. In the first three quarters of 2019, the company has already generated equivalent revenues to the full 2018 year (€ 6.3 million). Sales in the third quarter 2019 grew to € 2.3 million, making it the fourth quarter in a row that the company experienced steady growth. Median’s revenue came solely from its iCRO1 business.

As of September 30th, 2019, the order backlog reached € 35.9 million, an increase of € 5.2 million since June 30th, 2019 and an increase of € 12.2 million compared to December 31st, 2018.

Considering the company’s positive performance and the Research Tax Credit payment (€ 1.6 million) received in July, the company increased its cash and cash equivalents to € 8.3 million, compared to € 7.9 million as of June 30th, 2019. The company’s cash burn rate has been steadily declining since the second half of 2018, down to € 0.4 million per month this quarter. The EIB (European Investment Bank) loan is expected to be finalized in Q4, 2019.

In the third quarter, the iCRO business exceeded the mark of 100 clinical studies contracted with biopharmaceutical sponsors, with a growing number of phase III studies and immuno-oncology trials (+45%). The company is experiencing an increase in repeat business with large biopharmaceutical companies, which shows a great deal of trust in Median’s performance, quality and competitiveness.

Meanwhile, Median continued to develop its imaging phenomics platform iBiopsy. A demo was successfully featured at the annual conference of the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) (ESMO – September 27th to 30th, 2019, Barcelona, Spain), creating a lot of traction and interest by pharma groups.

"Our continued iCRO excellent performance validates the strategic decisions we made in 2018. Our iCRO business is demonstrating its capacity for sustainable growth and profitability," said Fredrik Brag, CEO and co-founder of Median. "With iBiopsy, Median is at the forefront of the development of non-invasive biomarker diagnostic solutions, which are currently generating great interest from US investors. Liquid biopsy companies have multibillion-dollar valuations. In oncology, the two obvious oncology non-invasive biomarker diagnostic solutions are liquid biopsies and imaging and we intend to become the leader in imaging", he added.

Personalis, Inc. to Present at Advances in Immuno-Oncology Congress USA 2019

On October 8, 2019 Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for cancer, reported that the company will present at Advances in Immuno-Oncology Congress USA 2019 in San Diego on October 8th at 2:50 PM PDT (Press release, Personalis, OCT 8, 2019, View Source [SID1234540114]).

The presentation, titled "Advancing Precision Oncology Biomarker Discovery with a Multidimensional Immunogenomics Platform," will describe the Personalis universal cancer immunogenomics platform, ImmunoID NeXT. In addition to an overview, the presentation will cover preliminary data from an ongoing study in which this platform is being used to evaluate IO-related biomarkers and potential tumor escape mechanisms in a cohort of melanoma patients treated with anti-PD-1 therapy.

ImmunoID NeXT is the first platform to enable comprehensive analysis of both a tumor and its immune microenvironment from a single sample. The platform can be used to investigate the key tumor- and immune-related areas of cancer biology, consolidating multiple oncology biomarker assays into one. This maximizes the biological information that can be generated from a precious tumor specimen.

The presentation will be delivered by Kedar Hastak, Ph.D., Field Application Scientist.