Neuralstem Announces Pricing of $7.5 Million Underwritten Public Offering

On July 25, 2019 Neuralstem, Inc. (Nasdaq: CUR) ("Neuralstem" or the "Company") reported the pricing of its underwritten public offering of an aggregate of 2,777,777 units at a public offering price of $2.70 per unit for gross proceeds of approximately $7,500,000, before deducting discount and commissions and estimated offering expenses (Press release, Neuralstem, JUL 25, 2019, View Source [SID1234537765]). Each unit is comprised of one share of common stock (or common stock equivalent), one short-term warrant to purchase one share of common stock and one long-term warrant to purchase one share of common stock (collectively, a "warrant combination"). In addition, the Company has granted the underwriters a 45-day option to purchase up to an additional 416,666 shares of common stock and/or additional 416,666 warrant combinations at the public offering price per share and per warrant combination, before deducting underwriting discounts and commissions.

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H.C. Wainwright & Co. is acting as the sole book-running manager for the offering.

Each short-term warrant has an exercise price of $2.70 per share, is exercisable immediately and terminates on December 31, 2020. Each long-term warrant has an exercise price of $2.70 per share and is exercisable immediately for five years from the issuance date. The shares of common stock (or common stock equivalents), the short-term warrants and long-term warrants comprising the units will be immediately separable upon issuance and will be issued separately. This offering is expected to close on or about July 30, 2019, subject to customary closing conditions.

The net proceeds of the offering are expected to be approximately $6.6 million, after deducting underwriting discounts and commissions and estimated offering expenses. The Company intends to use the net proceeds of the offering for the further development of our stem cell and small molecule assets, advancement of the Company’s acquisition and in-licensing strategy and general corporate purposes.

The securities described above are being offered by the Company pursuant to a registration statement (file no. 333-232273) previously filed with and declared effective by the Securities and Exchange Commission (the "SEC") on July 25, 2019. The offering is being made only by means of a prospectus forming part of the effective registration statement. A preliminary prospectus relating to the securities being offered has been filed with the SEC and is available on the SEC’s website at www.sec.gov and a final prospectus will be filed with the SEC. Electronic copies of the final prospectus relating to the offering may be obtained, when available, from H.C. Wainwright & Co., LLC, 430 Park Avenue, 3rd Floor, New York, NY 10022, by telephone at (646) 975-6996 or by email at [email protected], or at the SEC’s website at www.sec.gov.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

Pulse Biosciences to Report Second Quarter 2019 Operational Highlights and Financial Results

On July 25, 2019 Pulse Biosciences, Inc. (Nasdaq: PLSE) ("Pulse Biosciences" or the "Company"), a novel bioelectric medicine company bringing to market its proprietary CellFX System reported that the Company will report second quarter 2019 operational highlights and financial results on Thursday, August 8, 2019 (Press release, Pulse Biosciences, JUL 25, 2019, View Source [SID1234537764]). Pulse Biosciences management will host a conference call at 4:30 p.m. Eastern Time (ET) / 1:30 p.m. Pacific Time (PT).

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Analysts and investors can participate in the conference call by dialing (844) 494-0190 (domestic) and (508) 637-5580 (international) using the conference ID# 9229379. The conference call can also be accessed live on the Investor Relations section of the Pulse Biosciences website at www.PulseBiosciences.com.

IMV Inc. to Announce Second Quarter 2019 Results and Host a Conference Call and Webcast on August 9, 2019

On July 25, 2019 IMV Inc. ("IMV" or the "Corporation") (Nasdaq: IMV; TSX: IMV), a clinical stage immunotherapy company, reported that it will hold a conference call and webcast on Friday, August 9, 2019 at 8:00 a.m. ET to discuss the company’s second quarter 2019 financial and operational results (Press release, IMV, JUL 25, 2019, View Source [SID1234537763]).

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Financial analysts are invited to join the conference call by dialing (844) 461-9932 (U.S. and Canada) or (636) 812-6632 (international) using the conference ID: 7148568.

Other interested parties will be able to access the live audio webcast at this link: View Source The webcast will be recorded and available on the IMV website for 30 days following the call.

Verastem Oncology Signs an Exclusive License Agreement with Sanofi for the Development and Commercialization of COPIKTRA® (duvelisib) in Russia and CIS, Turkey, the Middle East and Africa

On July 25, 2019 Verastem, Inc. (NASDAQ: VSTM) operating as Verastem Oncology, (or "the Company"), reported their entry into an exclusive licensing agreement with Sanofi to develop and commercialize Verastem Oncology’s COPIKTRA (duvelisib), an oral inhibitor of phosphoinositide 3-kinase (PI3K), and the first approved dual inhibitor of PI3K-delta and PI3K-gamma, for the treatment of all oncology indications in Russia and CIS, Turkey, the Middle East and Africa (Press release, Verastem, JUL 25, 2019, View Source [SID1234537762]).

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Under the terms of the agreement, Verastem Oncology shall receive an upfront payment of $5 million USD. Verastem Oncology is also eligible to receive up to an additional $42 million USD in development and sales milestone payments, plus double-digit percentage royalties based on future net sales of COPIKTRA in the licensed territories. Sanofi will receive exclusive rights to develop and commercialize COPIKTRA, and hold the marketing authorization and product license for COPIKTRA, in the licensed territories. Sanofi will also have the right to collaborate with Verastem Oncology on certain global development and clinical trial activities.

"Sanofi brings world-class capabilities in developing and commercializing products, making them an ideal partner to bring COPIKTRA to patients in these territories," said Dan Paterson, President and Chief Operating Officer of Verastem Oncology. "Establishing this third partnership outside the U.S. validates the global potential of COPIKTRA and underscores our commitment to bring COPIKTRA to patients worldwide."

David Khougazian, Head of Sanofi Genzyme, China & Emerging Markets, commented, "As a specialty care leader, we welcome partnerships that have the potential to bring value for patients and caregivers. This agreement adds to our pipeline an oncology medicine with an innovative mechanism of action and a significant potential of new hope for the patients suffering from those types of blood malignancies with high unmet medical need. Partnering with Verastem Oncology for the development and commercialization of COPIKTRA is consistent with our goals to deliver enhanced patient care and to expand our presence in oncology in Emerging Markets."

COPIKTRA was approved in September 2018 by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) after at least two prior therapies. In addition, COPIKTRA has been granted accelerated approval by the FDA for the treatment of adult patients with relapsed or refractory follicular lymphoma (FL) after at least two prior systemic therapies. Accelerated approval in FL was based on overall response rate and continued approval may be contingent upon verification and description of clinical benefit in confirmatory trials. COPIKTRA includes a Boxed Warning for fatal and serious toxicities including infections, diarrhea or colitis, cutaneous reactions and pneumonitis. See full Prescribing Information for complete Boxed Warning and other important safety information.

M2Gen® Donates $3M for Inaugural ORIEN NOVA Grants to Support Cancer Research Projects

On July 25, 2019 M2Gen, a health informatics solutions company focused on accelerating the discovery, development and delivery of precision medicine, reported a $3 million donation to fund seven team science research projects as part of the Oncology Research Information Exchange Network (ORIEN) New Oncologic Visionary Awards (NOVA) program (Press release, M2Gen, JUL 25, 2019, View Source [SID1234537761]). Each project will bring together researchers from a variety of leading cancer centers around the country, including ORIEN’s founding members, Moffitt Cancer Center and The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, to address some of cancer’s toughest questions. Each of the awarded projects are led by ORIEN Member institutions, an alliance of key oncology stakeholders dedicated to breaking down the silos that can inhibit discovery and progress. The ORIEN NOVA program was designed to advance research by encouraging collaborative multidisciplinary team science across the ORIEN members, allowing researchers to share information and expertise, to ultimately improve patient care.

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"Cancer is a complicated disease, and no single entity can solve it alone – innovative partnerships and access to data are the keys to answering cancer’s toughest questions," said William S. Dalton, PhD, MD, Executive Chair of M2Gen. "We’ve initiated the ORIEN NOVA program to give researchers and physician scientists the opportunity to access all of the resources of ORIEN’s research alliance, breaking down barriers between institutions to enable rapid learning and accelerate research efforts and discovery to bring new treatments to patients. Together with the Community Foundation of Tampa Bay, we have setup the ORIEN Foundation in March of this year to support future NOVA awards which will help facilitate ongoing research collaborations across ORIEN members for years to come."

More than 60 proposals were received from ORIEN cancer center faculty across the United States. Three ORIEN Avatar NOVA grants totaling $2 million and four ORIEN Investigator Initiated Proposal (IIP) NOVA grants totaling $1 million were selected after a scientific, peer-review of the proposed projects. Selected projects included those that demonstrated the potential for high-impact cancer research, as well as utilization of new data analytics and data acquisition tools. To view the full list of ORIEN Member recipients, please click here ORIEN NOVA.

"We are honored that our research project, led by Dr. Donghai Dai, was selected for the ORIEN NOVA grant, and grateful to M2Gen for their continued efforts to support collaborative research in the oncology field," said George Weiner, MD, Director of Holden Comprehensive Cancer Center. "We are eager to address the development of intra-tumor driver mutation prevalence and this funding gives us a runway to accelerate this valuable work."

"The future of science lies in collaboration and our team is thrilled to work alongside seven other leading cancer centers to advance Non-Hodgkin Lymphoma research as a result of ORIEN’s NOVA grant program," said Walter Curran Jr., MD, Executive Director of Winship Cancer Institute of Emory University.

Selected research projects were reviewed, scored and chosen by a scientific review panel consisting of ORIEN scientists and external researchers from cancer centers across the country.

For more information on ORIEN NOVA program, please visit View Source

If you are interested in supporting the ORIEN Foundation’s effort to accelerate cancer research, please visit the Community Foundation of Tampa Bay website: View Source