Quest Diagnostics Reports Fourth Quarter and Full Year 2024 Financial Results; Provides Guidance for Full Year 2025; Increases Quarterly Dividend 6.7% to $0.80 Per Share

On January 30, 2025 Quest Diagnostics Incorporated (NYSE: DGX), a leading provider of diagnostic information services, reported financial results for the fourth quarter and full year ended December 31, 2024 (Press release, Quest Diagnostics, JAN 30, 2025, View Source [SID1234649962]).

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"In the fourth quarter, we delivered impressive revenue growth of nearly 15%, including approximately 5% organic growth, while also improving our profitability," said Jim Davis, Chairman, CEO, and President. "For the full year, we drove revenue growth of close to 7%, including approximately 3% from organic growth. Our team completed eight acquisitions, including LifeLabs in Canada, expanded our advanced diagnostics portfolio, and extended our geographic and market reach with new clinical, consumer and health plan customers."

Mr. Davis continued: "Our guidance for 2025 reflects our confidence in the core strength of our business, continuing robust utilization, and the momentum from acquisitions completed in 2024. These dynamics position us favorably to accelerate revenue and earnings growth in 2025."

Select 2024 full year accomplishments:

Completed eight acquisitions, including LifeLabs in Canada and four hospital outreach lab acquisitions.
Extended our health plan access to over 90% of in-network lives nationwide, including in new geographies through collaborations with Elevance Health and Sentara Health Plans, which took effect January 1, 2025.
Grew our Advanced Diagnostics portfolio, adding the sensitive p-tau217 and p-tau181 biomarkers to our AD-Detect blood-based test menu for assessing Alzheimer’s disease risk, and launching the first H5 avian influenza test from a commercial laboratory based on a pandemic preparedness contract from the U.S. Centers for Disease Control and Prevention.
Engaged approximately 75 academic, health system and community oncology centers in our Haystack MRD Early Experience Program, which provided oncologists with advanced access to our Haystack MRD blood test for aiding in the early detection of minimal residual disease from solid tumor cancers. We are now transitioning these organizations to a commercial program and are focused on expanding utilization among oncologists.
Expanded our questhealth.com consumer-initiated test platform to include approximately 135 tests, including micronutrient deficiencies and high-risk Lipoprotein(a) cholesterol testing.
Deployed automation and AI technologies across diverse laboratory, customer service and administrative areas, including automating core laboratory processes at three major regional laboratories, improving quality, customer experiences and productivity.

Three Months Ended December 31,

Twelve Months Ended December 31,

2024

2023

Change

2024

2023

Change

(dollars in millions, except per share data)

Reported:

Net revenues

$ 2,621

$ 2,288

14.5 %

$ 9,872

$ 9,252

6.7 %

Diagnostic information services revenues

$ 2,556

$ 2,221

15.1 %

$ 9,614

$ 8,976

7.1 %

Revenue per requisition

0.2 %

1.3 %

Requisition volume

13.9 %

5.5 %

Organic requisition volume

0.6 %

0.7 %

Operating income (a)

$ 361

$ 267

35.3 %

$ 1,346

$ 1,262

6.7 %

Operating income as a percentage of net revenues (a)

13.8 %

11.7 %

2.1 %

13.6 %

13.6 %

— %

Net income attributable to Quest Diagnostics (a)

$ 222

$ 192

15.1 %

$ 871

$ 854

2.0 %

Diluted EPS (a)

$ 1.95

$ 1.70

14.7 %

$ 7.69

$ 7.49

2.7 %

Cash provided by operations

$ 464

$ 527

(12.3) %

$ 1,334

$ 1,272

4.8 %

Capital expenditures

$ 123

$ 72

73.9 %

$ 425

$ 408

4.4 %

Adjusted (a):

Operating income

$ 409

$ 338

21.2 %

$ 1,541

$ 1,457

5.8 %

Operating income as a percentage of net revenues

15.6 %

14.8 %

0.8 %

15.6 %

15.8 %

(0.2) %

Net income attributable to Quest Diagnostics

$ 253

$ 245

3.7 %

$ 1,011

$ 994

1.8 %

Diluted EPS

$ 2.23

$ 2.15

3.7 %

$ 8.93

$ 8.71

2.5 %

(a)

For further details impacting the year-over-year comparisons related to operating income, operating income as a percentage of net revenues, net income attributable to Quest Diagnostics, and diluted EPS, see note 2 of the financial tables attached below.

Dividend Increased

Quest Diagnostics’ Board of Directors has authorized a 6.7% increase in its quarterly dividend from $0.75 to $0.80 per share, or $3.20 per share annually, effective with the dividend payable on April 21, 2025 to shareholders of record of Quest Diagnostics common stock on April 7, 2025. The company has raised its dividend annually since 2011.

Guidance for Full Year 2025

The company estimates its full year 2025 guidance in the table below. The company has included a presentation that includes additional guidance information on the Events and Presentations page of its investor relations website, which can be found at www.QuestDiagnostics.com/investor.

Low

High

Net revenues

$10.70 billion

$10.85 billion

Net revenues increase

8.4 %

9.9 %

Reported diluted EPS

$8.34

$8.59

Adjusted diluted EPS

$9.55

$9.80

Cash provided by operations

Approximately $1.45 billion

Capital expenditures

Approximately $500 million

Note on Non-GAAP Financial Measures

As used in this press release the term "reported" refers to measures under accounting principles generally accepted in the United States ("GAAP"). The term "adjusted" refers to non-GAAP operating performance measures that exclude special items such as restructuring and integration charges, amortization expense, excess tax benefits ("ETB") associated with stock-based compensation, gains and losses associated with changes in the carrying value of our strategic investments, and other items.

Non-GAAP adjusted measures are presented because management believes those measures are useful adjuncts to GAAP results. Non-GAAP adjusted measures should not be considered as an alternative to the corresponding measures determined under GAAP. Management may use these non-GAAP measures to evaluate our performance period over period and relative to competitors, to analyze the underlying trends in our business, to establish operational budgets and forecasts and for incentive compensation purposes. We believe that these non-GAAP measures are useful to investors and analysts to evaluate our performance period over period and relative to competitors, as well as to analyze the underlying trends in our business and to assess our performance. The additional tables attached below include reconciliations of non-GAAP adjusted measures to GAAP measures.

Conference Call Information

Quest Diagnostics will hold its quarterly conference call to discuss financial results beginning at 8:30 a.m. Eastern Time today. The conference call can be accessed by dialing 888-455-0391 within the U.S. and Canada, or 773-756-0467 internationally, passcode: 7895081; or via live webcast on our website at www.QuestDiagnostics.com/investor. We suggest participants dial in approximately 10 minutes before the call.

A replay of the call may be accessed online at www.QuestDiagnostics.com/investor or, from approximately 10:30 a.m. Eastern Time on January 30, 2025 until midnight Eastern Time on February 13, 2025, by phone at 866-360-8701 for domestic callers and 203-369-0179 for international callers. Anyone listening to the call is encouraged to read our periodic reports, on file with the Securities and Exchange Commission, including the discussion of risk factors and historical results of operations and financial condition in those reports.

Mersana Therapeutics to Participate in the Guggenheim SMID Cap Biotech Conference

On January 30, 2025 Mersana Therapeutics, Inc. (NASDAQ: MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, reported that members of management will participate in a fireside chat at the Guggenheim SMID Cap Biotech Conference on February 6, 2025 at 1:30 p.m. ET (Press release, Mersana Therapeutics, JAN 30, 2025, View Source [SID1234649961]). A live webcast of this event will be available on the Investors & Media section of Mersana’s website at www.mersana.com, and an archived replay will be available for approximately 90 days following the event.

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Manhattan BioSolutions Initiates NCI PIVOT Collaboration in Pediatric Cancers

On January 30, 2025 Manhattan BioSolutions, Inc. ("MABS"), an emerging biotechnology company developing new classes of precision biologics that harness natural host defense mechanisms, reported that its RNA-targeting therapeutic, MABS-139, will be evaluated in pediatric cancer models through the National Cancer Institute (NCI) Pediatric Preclinical in Vivo Testing (PIVOT) Program (Press release, Manhattan BioSolutions, JAN 30, 2025, View Source [SID1234649960]).

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The PIVOT consortium, coordinated by The Jackson Laboratory, brings together leading pediatric cancer research centers to systematically evaluate promising therapies using extensively characterized patient-derived xenograft models. The studies with MABS-139 will be conducted at the University of Texas Health Science Center San Antonio, one of the PIVOT participating institutions. The collaboration, formalized through a Material Transfer Agreement with NCI, involves a two-phase research plan. In the first phase, PIVOT investigators will conduct tolerability study to confirm the dosing regimen. In the second phase, comprehensive efficacy testing will be conducted utilizing patient-derived xenograft models of pediatric cancers including Ewing sarcoma, malignant rhabdoid tumor, rhabdomyosarcoma, and hepatoblastoma. The research plan employs PIVOT’s innovative single mouse trial design to efficiently evaluate anti-tumor activity.

"Participation in the NCI PIVOT Program provides an extensive and invaluable level of expertise in preclinical pediatric cancer testing, and we are excited that MABS-139 was selected for evaluation after a diligent review process," said Dr. Borys Shor, CEO of Manhattan Bio. "Our novel agent degrades cancer-associated RNA which plays a fundamental role in promoting tumor growth, metastasis and resistance to current therapies. We are actively exploring this approach alongside other innovative payloads in our ADC development programs. This collaboration could potentially support a path to a rare disease pediatric voucher while generating valuable insights about addressing aggressive childhood cancers with limited treatment options."

Keros Therapeutics to Present at the Guggenheim SMID Cap Biotech Conference

On January 30, 2205 Keros Therapeutics, Inc. ("Keros") (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta ("TGF-ß") family of proteins, reported that Keros’ Chair and Chief Executive Officer Jasbir S. Seehra, Ph.D., will participate in a fireside chat presentation at the Guggenheim SMID Cap Biotech Conference on Thursday, February 6, 2025 at 10:00 a.m. Eastern time (Press release, Keros Therapeutics, JAN 30, 2025, View Source [SID1234649959]).

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A live audio webcast of the fireside chat presentation will be available at
View Source and an archived replay will be accessible in the Investors section of the Keros website at View Source for up to 90 days following the conclusion of the event.

Kazia Therapeutics announces the launch of a groundbreaking trial with paxalisib in
combination with immunotherapy in women with advanced breast cancer

On January 30, 2025 Kazia Therapeutics Limited (NASDAQ: KZIA) an oncology-focused drug development company, reported the regulatory approval and launch of a clinical trial evaluating the combination of paxalisib and immunotherapy in patients with advanced breast cancer (Press release, Kazia Therapeutics, JAN 30, 2025, View Source [SID1234649958]). This novel treatment combination offers what is believed to be a unique approach to targeting this highly aggressive and treatment-resistant type of breast cancer.

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The ABC-Pax (Advanced Breast Cancer – Paxalisib) study is the first known trial conducted to assess the safety and efficacy of paxalisib in combination with KEYTRUDA (pembrolizumab) or LYNPARZA (olaparib) in women with triple negative breast cancer. ABC-Pax is a multi-centre, open-label phase 1b study that will enroll 24 patients from top cancer centres in Queensland, Australia and patients will receive the combination therapy for up to 12 months.

The ABC-Pax study stems from pivotal research led by QIMR Berghofer scientists in collaboration with Kazia Therapeutics, which combined its drug candidate, paxalisib, with immunotherapy in pre-clinical models. The team discovered that this combination approach triggers a novel molecular program by epigenetic re-programming of dormant cancer cells, making them visible to the immune system, while also reinvigorating the immune cells to fight the tumour cells. These new preclinical data were presented at San Antonio Breast Cancer Symposium on December 12, 2024, and highlight the potential therapeutic synergies between paxalisib and checkpoint inhibitor pembrolizumab (KEYTRUDA), as well as between paxalisib and poly (ADP-ribose) polymerase inhibitor olaparib (LYNPARZA), when used in combination in a preclinical model of immunotherapy-resistant triple negative breast cancer. The clinical trial is open for enrollment at the Royal Brisbane and Women’s Hospital and plans to expand to other sites in Australia.

Kazia Therapeutics CEO, Dr John Friend, said the novel combination treatment may have the potential to transform the treatment of triple-negative breast cancer and other aggressive tumour types.

"The novelty of the science that Professor Rao has proposed with this dual combination of paxalisib and immunotherapy could advance the treatment of women with aggressive breast cancer, and we are excited to support this unique clinical study," Dr John Friend, CEO Kazia Therapeutics said.

QIMR Berghofer’s Professor Sudha Rao said, "There is no cure for triple negative breast cancer and the life expectancy for these women is tragically short. We want to identify treatments to extend the duration and quality of life of these patients. The hope is to prolong patient survival through the new combined therapy, which targets the dormant cancer cells that drive the spread and recurrence of the disease and rejuvenates the immune system to more effectively fight the cancer."

The ABC-Pax trial will also evaluate a non-invasive liquid biopsy digital pathology platform developed by Professor Rao and her team, which can monitor the behaviour of cancer cells and immune cells in real time from a blood sample.

"By regularly analysing blood samples from trial participants using our liquid biopsy digital pathology platform, we can track the effectiveness of the treatment in real time. We believe this approach represents a major advance in precision medicine by offering a faster and more accurate way to monitor patient progress," Professor Rao said.