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FierceBiotech Names Pandion Therapeutics as One of Its “Fierce 15” Biotech Companies of 2018

On October, 2018 Pandion Therapeutics reported that it has been named by FierceBiotech as one of 2018’s Fierce 15 biotechnology companies, designating it as one of the most promising private biotechnology companies in the industry (Press release, Pandion Therapeutics, OCT 2, 2018, View Source [SID1234529780]).

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Pandion is developing a new class of drugs to treat diseases with high unmet medical need, including inflammatory bowel disease, autoimmune liver disease, kidney diseases, type 1 diabetes, and autoimmune skin conditions. Pandion’s approach is shifting the paradigm from systemic immunosuppression to therapies that act locally at the site of disease to restore immune homeostasis.

"We are delighted to be recognized by FierceBiotech as one of their Fierce 15," said Dr Anthony Coyle, CEO and President of Pandion. "We are building an exciting, energetic and bold company with a dynamic and diverse team, and we are privileged to be making new drugs that we believe will meaningfully impact the lives of many patients."

The Fierce 15 celebrates the spirit of being "fierce"—championing innovation and creativity, even in the face of intense competition. This is FierceBiotech’s 16th annual Fierce 15 selection.

An internationally recognized daily report reaching a network of over 285,000 biotech and pharma industry professionals, FierceBiotech provides subscribers with an authoritative analysis of the day’s top stories. Every year FierceBiotech evaluates hundreds of private companies from around the world for its annual Fierce 15 list, which is based on a variety of factors such as the strength of its technology, partnerships, venture backers and a competitive market position.

FierceBiotech names Tmunity as one of its “Fierce 15” Biotech Companies of 2018

On October 2, 2018 Tmunity Therapeutics, Inc., a private clinical-stage biotherapeutics company focused on saving and improving lives by delivering the full potential of next-generation T cell immunotherapy, reported that it has been named by FierceBiotech as one of 2018’s Fierce 15 biotechnology companies, designating it as one of the most promising private biotechnology companies in the industry (Press release, Tmunity Therapeutics, OCT 2, 2018, View Source [SID1234529776]).

Tmunity was founded on an exclusive collaboration and license agreement with the University of Pennsylvania, offering proprietary technologies and the unparalleled expertise in first-in-patient cell and gene therapies of its scientific founders, led by Carl H. June, MD. Today, Tmunity is uniquely positioned to integrate the best technologies and pursue multiple approaches to engineered T cell therapies simultaneously in order to advance treatments into the clinic rapidly, optimize and scale manufacturing, pursue regulatory approvals aggressively, and thus deliver them effectively to patients.

"We are honored to receive this recognition for our approach in creating smarter T cells to overcome current challenges and deliver breakthrough medicines to patients, faster and with better outcomes," said Usman "Oz" Azam, MD, President and Chief Executive Officer of Tmunity. "This has been a transformational year for our company with the expansion of our management, scientific and manufacturing teams, moving our novel science into the clinic and preparing for commercial success. We congratulate all of the companies in the 2018 ‘Fierce 15’ class and support their efforts to develop medicines that offer hope to patients."

The Fierce 15 celebrates the spirit of being "fierce" – championing innovation and creativity, even in the face of intense competition. This is FierceBiotech’s 16th annual Fierce 15 selection.

FierceBiotech names Arrakis Therapeutics as one of its “Fierce 15” Biotech Companies of 2018

On October 2, 2018 Arrakis Therapeutics reported that it has been named by FierceBiotech as one of 2018’s Fierce 15 biotechnology companies, designating it as one of the most promising private biotechnology companies in the industry (Press release, Arrakis Therapeutics, OCT 2, 2018, View Source [SID1234529774]).

Arrakis is pioneering the discovery of a new class of medicines called RNA-targeted small molecules, or rSMs. Based on new understandings of the structure of RNA, Arrakis is designing rSMs that directly bind and modify the biological function of RNA to treat disease, opening up new therapeutic potential to reach valuable drug targets that are not accessible with today’s medicines.

"We are honored to be selected as a Fierce 15 company and recognized for Arrakis’ pioneering approach to target RNA with small molecule drugs," said Michael Gilman, PhD, chief executive officer of Arrakis Therapeutics. "This award is a tribute to the fierce commitment of our outstanding team of scientific leaders, employees, and investors who are making it possible for us to transform the way that RNA is targeted and bring innovative treatments to patients."

"We appreciate the recognition and excitement about Arrakis’ vision to interrogate the vast and largely unexplored transcriptome to identify new disease intervention points that we can target with rSMs," said Jennifer C. Petter, PhD, Founder and Chief Scientific Officer of Arrakis Therapeutics.

The Fierce 15 celebrates the spirit of being "fierce" – championing innovation and creativity, even in the face of intense competition. This is FierceBiotech’s 16th annual Fierce 15 selection.

FierceBiotech Names Jnana Therapeutics As One Of Its “Fierce 15” Biotech Companies Of 2018

On October 2, 2018 Jnana Therapeutics reported that it has been named by FierceBiotech as one of 2018’s Fierce 15 biotechnology companies, designating it as one of the most promising private biotechnology companies in the industry (Press release, Jnana Therapeutics, OCT 2, 2018, View Source [SID1234529773]).

Jnana Therapeutics was launched in 2017 to build the first drug discovery platform targeting the solute carrier (SLC) family of metabolite transporters, which are the gates used by the cell to control metabolite movement. The company is taking a comprehensive approach to understanding SLCs and their underlying biology in order to unlock a new wave of druggable targets. From there, they are discovering and developing medicines to modulate critical disease pathways to improve outcomes for patients with severe diseases.

"We are pleased to be recognized as a Fierce 15 company, an award which reflects the innovative nature of our drug discovery platform and its potential to unlock SLC transporters as a novel therapeutic target class," said Joanne Kotz, Ph.D., Cofounder and President at Jnana. "Our purpose at Jnana is to push the frontiers of scientific knowledge by pioneering the comprehensive understanding and targeting of the SLC transporter family, which has never been systematically addressed in drug development, and create a new class of medicines that make a positive impact on patients and their families."

The Fierce 15 celebrates the spirit of being "fierce" – championing innovation and creativity, even in the face of intense competition. This is FierceBiotech’s 16th annual Fierce 15 selection.

FierceBiotech names Kronos Bio as one of its “Fierce 15” Biotech Companies of 2018

On October 2, 2018 Kronos Bio, Inc. (Kronos), a Two River portfolio company, reported that it has been named by FierceBiotech as one of 2018’s Fierce 15 biotechnology companies, designating it as one of the most promising private biotechnology companies in the industry for its pursuit of novel therapies against some of the most important and intractable targets in cancer research (Press release, Kronos Bio, OCT 2, 2018, View Source [SID1234529766]).

"It is an honor to have Kronos named by FierceBiotech as one of their Fierce 15 biotechnology companies for 2018," said Norbert Bischofberger, Ph.D., President and Chief Executive Officer of Kronos. "Fierce adeptly describes our pursuit of targets many have viewed as ‘undruggable.’ We believe our small molecule microarray (SMM) technology will enable us to engage recalcitrant targets and develop innovative therapies for cancer and other life altering diseases."

The foundation of Kronos was built on over a decade of research into high-throughput screening strategies for chemical modulators of transcription factors and other recalcitrant targets in oncology. By combining small molecule microarrays with extensive know-how in biological assay development, Kronos’ technology platform enables high-throughput screens of chemical libraries against target proteins in a more physiologically relevant context. As a result, a single screening assay can identify compounds that bind or interfere with target protein activity directly, disrupt protein-protein or protein-DNA interactions, or indirectly modulate target protein activity by binding to co-factors or
other protein complex members. This approach is ideally suited for rapid discovery of unique ligands that can be utilized in the generation of novel modulators or degraders of historically challenging targets such as transcription factors.

The Fierce 15 celebrates the spirit of being "fierce" – championing innovation and creativity, even in the face of intense competition. This is FierceBiotech’s 16th annual Fierce 15 selection. An internationally recognized daily report reaching a network of over 285,000 biotech and pharma industry professionals, FierceBiotech provides subscribers with an authoritative analysis of the day’s top stories. Every year FierceBiotech evaluates hundreds of private companies from around the world for its annual Fierce 15 list, which is based on a variety of factors such as the strength of its technology, partnerships, venture backers and a competitive market position