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BeiGene to Present at Upcoming Investor Conferences

On March 4, 2019 BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160), a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly targeted and immuno-oncology drugs for the treatment of cancer, reported the company will present at two upcoming investor conferences BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160), a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly targeted and immuno-oncology drugs for the treatment of cancer, reported the company will present at two upcoming investor conferences:

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The Cowen and Company 39th Annual Health Care Conference in Boston on Monday, March 11th at 4:10 p.m. ET; and
The 2019 Barclays Global Healthcare Conference in Miami on Wednesday, March 13th at 3:20 p.m. ET.
Live webcasts can be accessed from the investors section of BeiGene’s website at View Source and archived replays will be available for 90 days following the event.:

3SBio and TLC Form Exclusive Partnership to Commercialize Two NanoX™ Products in Mainland China

On March 3, 2019 3SBio Inc. ("3SBio") (HKEX: 1530) and Taiwan Liposome Company, Ltd. ("TLC") (Nasdaq: TLC, TWO: 4152) reported an exclusive partnership to commercialize in mainland China two liposomal products utilizing TLC’s proprietary NanoX technology platform in the therapeutic areas of oncology and severe infectious diseases (Press release, 3SBio, MAR 3, 2019, View Source [SID1234553911]). Under this alliance, TLC and 3SBio will cooperate to obtain regulatory approvals in mainland China, and TLC will utilize its commercial-scale manufacturing capabilities to supply the two liposomal products for 3SBio to commercialize in mainland China. The two companies also agreed to further collaboration in researching and developing other novel liposomal products in the therapeutic areas of osteoarthritis, pain management, ophthalmology, and oncology.

"3SBio’s partnership with TLC reflects the continuous execution of our strategy to introduce novel therapeutics which addresses significant unmet medical needs of cancer patients in China," said Dr. Jing Lou, Chairman and Chief Executive Officer of 3SBio. He added, "We intend to seek regulatory approval for the two liposomal products to treat patients with cancer and severe infectious diseases in the near future. We believe both candidates have strong commercial potential due to the lower toxicity profile of TLC’s liposomal formulations and will complement 3SBio’s oncology therapeutic and supportive care portfolio while leveraging 3SBio’s commercial platform with over 2,500 sales and marketing professionals across China."

Under the terms of the agreement, TLC is eligible to receive up to US$25 million in upfront payments for each product and subsequent regulatory and sales milestone payments. TLC is also eligible a share of the potential profits from product sales. Additional financial terms were not disclosed.

"We are excited to have 3SBio as a partner to collaborate on the advancement of our NanoX technology-based products," commented TLC President George Yeh. "This opportunity is an endorsement to the competency of our NanoX platform, which was applied to products that have been approved for sale in Taiwan. With this partnership, we are able to take full advantage of NanoX’s manufacturing capabilities to expand our commercial framework. We believe that 3SBio’s prominent position in China’s biotech industry, coupled with the commercial capacities at our contract manufacturing organizations’ facilities in Australia and Taiwan, will lead to the successful launch and commercialization of these products in mainland China."

Discontinued Operations – Sale of our Commercial Product Portfolio

On March 1, 2019, Spectrum Pharmaceuticals reported that it completed the sale of our seven then-commercialized drugs, including FUSILEV, KHAPZORY, FOLOTYN, ZEVALIN, MARQIBO, BELEODAQ, and EVOMELA (the "Commercial Product Portfolio") to Acrotech Biopharma LLC ("Acrotech") (the "Commercial Product Portfolio Transaction") (Press release, Spectrum Pharmaceuticals, MAR 1, 2019, View Source [SID1234538580]). Upon closing Spectrum Pharmaceuticals received $158.8 million in an upfront cash payment (of which $4 million is held in escrow). Spectrum Pharmaceuticals is also entitled to receive up to an aggregate of $140 million upon Acrotech’s achievement of certain regulatory (totaling $40 million) and sales-based milestones (totaling $100 million) relating to the Commercial Product Portfolio.
These Condensed Consolidated Financial Statements are recast for all periods presented to reflect the sale of the assets and liabilities associated with their Commercial Product Portfolio, as well as the corresponding revenue-deriving activities and allocable expenses of this commercial business within "discontinued operations" – see Note 11. Spectrum have presented their face financial statements in general conformity with our historical format, even where presented values are $-0- within continuing.

MaxCyte Announces Multi-Drug Clinical & Commercial Agreement with Kite, a Gilead Company

On March 1, 2019 MaxCyte, the global cell-based medicines and life sciences company, reported that it has expanded its relationship with Kite, a Gilead Company, by entering into a multi-drug clinical and commercial agreement (Press release, MaxCyte, MAR 1, 2019, View Source [SID1234537626]). Under the terms of the agreement, Kite will use MaxCyte’s Flow Electroporation Technology to enable non-viral cell engineering for development of multiple CAR-T drug candidates for up to 10 targets.

"We’re excited to take our relationship with Kite further into product development, providing the company the ability to leverage MaxCyte’s versatile cell engineering platform to enable the power of gene-editing for clinical and commercial development of critical new CAR-T therapeutics," said Doug Doerfler, President & CEO of MaxCyte, Inc.

The expansion of the Kite-MaxCyte relationship builds on an existing research agreement announced in November 2018. Under the terms of the new license agreement, Kite obtains non-exclusive clinical and commercial-use rights to MaxCyte’s cell engineering platform to develop CAR-T therapies, and MaxCyte will receive development and approval milestones and sales-based payments in addition to other licensing fees.

Applied DNA Subsidiary LineaRx and Takis/Evvivax Progress Linear DNA for Use as Cancer Vaccine Candidates

On March 1, 2019 Applied DNA Sciences Inc. (NASDAQ: APDN) ("Applied DNA"), a leader in large-scale PCR-based DNA manufacturing, reported that LineaRx, Inc. ("LineaRx"), its wholly-owned subsidiary focused on next-generation biotherapeutics, will ship TK7 and ConTRT amplicons to Takis/Evvivax next week as part of the companies’ Joint Development Agreement ("JDA") entered into in September 2018 (Press release, Applied DNA Sciences, MAR 1, 2019, View Source [SID1234533907]).

Per the JDA, LineaRx and Takis/Evvivax will jointly develop linear DNA expression amplicons for TK7 and ConTRT, two of Takis/Evvivax’s anti-cancer vaccine candidates, utilizing LineaRx’s validated linear DNA technology. Linear DNA amplicons carrying the DNA sequences for Takis/Evvivax vaccine candidates will be delivered to pre-clinical animal models via Takis/Evvivax’s proprietary electroporation technology.

In 2018, LinearRx and Takis/Evvivax’s collaboration showed immunogenicity in mice that were vaccinated with linear DNA against the human protein telomerase that is over-expressed in more than 85% of all cancers. "This year we are using ConTRT, an improved version of our telomerase vaccine and a unique personalized approach which includes an epitope-prediction pipeline and a delivery strategy to achieve an extremely effective cancer vaccine over what has been done previously," said Dr. Luigi Aurisicchio, CEO of Takis/Evvivax. "Each expression amplicon will undergo rigorous quality subject matter testing, immunogenicity testing, followed by a tumor challenge, with results planned for publication later this year."

"Our collaborations with Takis/Evvivax and other therapy developers are helping to validate LineaRx’s novel technology as a viable alternative to bacterially-produced plasmids, with the potential for increased patient safety and reduced costs, using new quality control protocols for large-scale PCR production at LineaRx. We believe that linear DNA and the establishment of new quality attributes for this new therapeutic field will change the way gene and immune therapies will be performed," stated Dr. James Hayward, president and CEO of Applied DNA. "Our implementation of testing for new quality attributes will support our preparation to approach FDA to seek approval for clinical study. Our know-how in the fields of therapeutic linear DNA production and the standardized PCR platforms in use at LineaRx enable us to create novel expression amplicons. We are extremely pleased with the progress we are making with Takis/Evvivax under our JDA."