Phase I Clinical Trial Application of Novel Targeted Anti-Cancer Drug ZHB015 for Injection Approved by the NMPA

On December 20 2024, Zonhonbio reported its class 1 innovative biological drug, ZHB015 for injection, has received the "Clinical Trial Approval Notice" from China’s NAtional medical products administration (NMPA) (Press release, Zonhon Biopharma Institute, DEC 20, 2024, View Source [SID1234656086]). ZHB015 for injection is an original research and development by Zonhonbio, with completely independent intellectual property rights both domestically and internationally. It is a bispecific antibody drug developed using innovative targets and has been approved for use in advanced malignant solid tumors.

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LaNova Medicines Initiates Pivotal Clinical Trial for LM-108 in China

On December 20, 2024 LaNova Medicines Ltd. reported the initiation of its first pivotal clinical trial for LM-108 (anti-CCR8 mAb) in China (Press release, LaNova Medicines, DEC 20, 2024, View Source [SID1234656019]).

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This clinical study (CTR20250219) is a Phase II, single-arm, multicenter, open-label trial primarily evaluating the efficacy and safety of LM-108 in combination with Toripalimab in patients with unresectable or metastatic MSI-H/dMMR advanced solid tumors who have failed prior treatment with anti-PD-1/PD-L1 therapies.

Termination of a Material Definitive Agreement.

On December 20, 2024, Kronos Bio, Inc. (the "Company") reported to have entered into a Transition Agreement and Mutual General Release (the "Transition Agreement") with Genentech, Inc. and F. Hoffmann-La Roche Ltd (together, "Genentech"), pursuant to which the Company and Genentech agreed to void and cancel all of the parties’ respective rights and obligations under the Collaboration and License Agreement between the parties dated January 6, 2023 (the "Collaboration Agreement") (Filing, Kronos Bio, DEC 20, 2024, View Source [SID1234649329]). Pursuant to the Transition Agreement, the Company will transfer and assign to Genentech all small molecule compounds, materials, data, and intellectual property generated by the Company in connection with the two discovery research programs ("Program Materials") conducted by the Company under the Collaboration Agreement, but excluding the Company’s proprietary drug discovery platform. The Company also granted to Genentech a perpetual, irrevocable, non-exclusive and fully paid up license under certain related intellectual property owned or controlled by the Company that is necessary or reasonably useful to exploit the Program Materials. The Transition Agreement has the effect of terminating the Collaboration Agreement, and provides for a general release of any actual or potential claims between the Company and Genentech relating thereto. In addition, the Transition Agreement cancels and voids any and all downstream payment obligations between the parties relating to or arising from the Collaboration Agreement or any programs or compounds arising thereunder. The Company has made a one-time payment in connection with the termination of the Collaboration Agreement, which is intended to support the transition of all activities under the Collaboration Agreement to Genentech.

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The foregoing is a summary description of certain terms of the Transition Agreement and does not purport to be complete, and is qualified in its entirety by reference to the full text of the Transition Agreement to be filed, with confidential terms redacted, as an exhibit to the Company’s Annual Report on Form 10-K for the year ending December 31, 2024.

Foresight Diagnostics to Present at 43rd Annual J.P. Morgan Healthcare Conference

On December 20, 2024 Foresight Diagnostics, Inc. ("Foresight") a leading diagnostics company specializing in the development of ultra-sensitive minimal residual disease (MRD) detection, reported that CEO, Jake Chabon, will present at the 43rd Annual J.P. Morgan Healthcare Conference on Wednesday, January 15, 2025, at 7:30am Pacific Time (Press release, Foresight Diagnostics, DEC 20, 2024, View Source [SID1234649248]).

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Foresight Diagnostics will be hosting meetings at the LifeSci Corporate Access Event from January 13-15, 2025, and will also be available for additional meetings on January 16. To schedule a meeting with the Company, please contact [email protected].

Gilead Sciences to Present at Upcoming Investor Conference

On December 20, 2024 Gilead Sciences, Inc. (Nasdaq: GILD) reported that its executives will be speaking at the following investor conference (Press release, Gilead Sciences, DEC 20, 2024, View Source [SID1234649247]):

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J.P. Morgan Healthcare Conference on Monday, January 13, 2025 beginning at 11:15 a.m. Pacific Time
The live webcast can be accessed at investors.gilead.com and the replay will be available for at least 30 days following the presentation.