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Endocyte Announces Presentation of Phase 2 Data from Investigator-Initiated Prostate Cancer Trial of 177Lu-PSMA-617 at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting

On May 16, 2018 Endocyte, Inc. (Nasdaq:ECYT), a biopharmaceutical company developing targeted therapeutics for personalized cancer treatment, reported that a poster with data from the Peter MacCallum Cancer Centre will be presented on Endocyte’s lead investigational therapy at the 2018 ASCO (Free ASCO Whitepaper) Annual Meeting on Saturday, June 2, 2018 (Press release, Endocyte, MAY 16, 2018, View Source [SID1234526737]). Updated data from the phase 2 study of 177Lu-PSMA-617 as a potential treatment for metastatic castration-resistant prostate cancer (mCRPC), including data from an additional 20 patient expansion cohort, will be highlighted by the poster.

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"We are very pleased that we continue to see high rates of PSA response, even in heavily pre-treated patients," said Mike Sherman, president and CEO of Endocyte. "In the 50 patients receiving 177Lu-PSMA-617, 62% had a greater than 50% reduction in their PSA levels. Further, 44% of patients had a PSA reduction of 80% or greater. We look forward to sharing more information on this phase 2 trial at ASCO (Free ASCO Whitepaper). We recently reported median overall survival of 13.5 months for the first cohort of 30 patients enrolled. The median overall survival in the total 50 patients is not yet meaningful as follow-up in the second cohort of 20 patients is between 6 and 9 months at the time of cutoff. Updated survival metrics will be presented at a future medical conference as that data matures."

ASCO Presentation Details:

Abstract #: 5040 (Poster Board: #267)
Title: Lutetium-177 PSMA617 theranostics in metastatic castrate-resistant prostate cancer (mCRPC): Interim results of a phase II trial.
When: Saturday, June 2, 2018 at 1:15 p.m. – 4:45 p.m. CDT
Session Title: Genitourinary (Prostate) Cancer
Location: Hall A

Webcast Investor Event and 177Lu-PSMA-617 Panel Discussion:

The Company will host a reception and webcast panel discussing 177Lu-PSMA-617 for investors and analysts on Monday, June 4, 2018 from 6:00 p.m.- 8:00 p.m. CDT. Panelists scheduled to participate at the event include:

Alison Armour, M.B., Ch.B., B.Sc, M.Sc, M.D., F.R.C.P., F.R.C.R., Chief Medical Officer, Endocyte
Johann S de Bono, M.D., M.Sc, Ph.D, F.R.C.P., Regius Professor of Cancer Research; Professor, The Royal Marsden NHS Foundation Trust (UK)
Oliver Sartor, M.D., C.E. & Bernadine Laborde Professor for Cancer Research; Medical Director, Tulane Cancer Center
A live audio webcast of the event can be accessed by visiting "Events & Presentations" under the Investors & News section of Endocyte’s website at www.endocyte.com. The webcast will be archived shortly after the live event, and a replay will be available on the Company’s website for at least 90 days following the event.

Website Information:

Endocyte routinely posts important information intended for investors on its website, www.endocyte.com, in the "Investors & News" section. Endocyte uses this website as a means of disclosing material information in legal compliance with its disclosure obligations under Regulation FD. Accordingly, investors should monitor the "Investors & News" section of Endocyte’s website, in addition to following the company’s press releases, SEC filings, public conference calls, presentations and webcasts. The information contained on, or that may be accessed through, the Endocyte website is not incorporated by reference into, and is not a part of, this document.

Allergan to Present at the Bernstein Strategic Decisions Conference

On May 16, 2018 Allergan plc (NYSE: AGN), a leading global biopharmaceutical company, reported that Chairman and CEO Brent Saunders will present at the Bernstein 34th Annual Strategic Decisions Conference in New York, NY (Press release, Allergan, MAY 16, 2018, View Source(1) [SID1234526735]). The presentation will begin at 10:00 a.m. Eastern Time on Wednesday, May 30, 2018.

The presentation will be webcast live and can be accessed on Allergan’s Investor Relations website at View Source;. The webcast can also be accessed through the following URL: https://cc.talkpoint.com/bern0…

An archived version will be available within approximately 3 hours of the live presentation, and can be accessed at the same location for 180 days

Bavarian Nordic to Host First Quarter 2018 Results Conference Call

On May 16, 2018 Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) reported its 2018 first quarter results on Thursday, May 24, 2018 (Press release, Bavarian Nordic, MAY 16, 2018, View Source [SID1234526732]).

The management of Bavarian Nordic will host a conference call at 2:00 pm CEST (8:00 am EDT) on the same day to present the interim results followed by a Q&A session. A live and replay version of the call and relevant slides will be available at http://bit.ly/2KzQlN2.

To join the Q&A session dial one of the following numbers and state the participant code 8332812: Denmark: +45 35 15 81 21, UK: +44 (0) 330 336 9411, USA: +1 323-794-2551.

Contacts
Europe: Rolf Sass Sørensen, Vice President Investor Relations & Communications. Phone +45 61 77 47 43
U.S.: Seth Lewis, Vice President, Investor Relations & Communications. Phone: +1 978 341 5271

Bavarian Nordic Announces Acceptance of Abstracts and Oral Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting

On May 16, 2018 Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) reported the acceptance of 4 poster presentations and one podium presentation at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting held June 1-5, 2018 in Chicago Illinois (Press release, Bavarian Nordic, MAY 16, 2018, View Source [SID1234526731]). These abstracts are now publicly available online at View Source

"We are very proud to participate in ASCO (Free ASCO Whitepaper), the pre-eminent oncology meeting of the year. We look forward to sharing our progress with the medical community. This includes our phase 3 study of PROSTVAC, which while disappointing in its result, will still provide a number of academic and clinical learnings to the treatment field of prostate cancer, including the advancements in overall survival seen by current standards of care" said Paul Chaplin, President and CEO of Bavarian Nordic.

"Importantly, the additional posters accepted at ASCO (Free ASCO Whitepaper) may provide insights into our future development strategies. One study demonstrates the ability of PROSTVAC to drive increased numbers of T cells into newly diagnosed prostate cancer. Another study demonstrated that PROSTVAC combined with nivolumab is safe and has adequate clinical data in advanced metastatic castration resistant prostate cancer to proceed to the planned evaluation of this combination in the neoadjuvant setting of newly diagnosed disease, in cooperation with National Cancer Institute and Bristol-Myers Squibb," Dr. Chaplin concluded.

Presentation and Poster Titles are as follows:

Effect of rilimogene galvacirepvec/rilimogene glafolivec (PROSTVAC) on intra/peritumoral immune infiltrate in patients with localized prostate cancer undergoing radical prostatectomy. (Abstract number 5083)
Poster Session: Genitourinary (Prostate) Cancer. June 2, 2018 from 1:15PM – 4:45PM CDT
Combination of a therapeutic cancer vaccine (PROSTVAC) and immune checkpoint inhibitors in prostate cancer. (Abstract number 5084)
Poster Session: Genitourinary (Prostate) Cancer. June 2, 2018 from 1:15 PM – 4:45 PM CDT
A trial of CV301 in combination with anti-PD-1 therapy versus anti-PD-1 therapy in subjects with non-small cell lung cancer. (Abstract number TPS9108)
Poster Session: Lung Cancer-Non-Small Cell Metastatic. June 3, 2018 from 8:00AM -11:30AM CDT
A sequential cohort study of combination immunotherapy with BN-brachyury vaccine, M7824, ALT-803 and epacadostat in metastatic castration-resistant prostate cancer (mCRPC) (QuEST1). (Abstract number TPS3130)
Poster Session: Developmental Therapeutics – Immunotherapy. June 4, 2018 from 8:00AM-11:30AM CDT
Results of PROSPECT: A randomized phase 3 trial of PROSTVAC-V/F (PRO) in men with asymptomatic or minimally symptomatic metastatic, castration-resistant prostate cancer. (Abstract number 5006)
Oral Abstract Session: Genitourinary (Prostate) Cancer. June 4, 2018 from 3:00 PM-6:00 PM CDT

ODONATE THERAPEUTICS ANNOUNCES PRESENTATIONS AT THE 2018 AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO) ANNUAL MEETING

On May 16, 2018 Odonate Therapeutics, Inc. (NASDAQ: ODT), a pharmaceutical company dedicated to the development of best-in-class therapeutics that improve and extend the lives of patients with cancer, reported that there will be two poster presentations on tesetaxel at the 2018 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting to be held June 1 – 5, 2018 in Chicago, Illinois (Press release, Odonate Therapeutics, MAY 16, 2018, View Source [SID1234526730]). Abstracts for these presentations were made publicly available today and can be found on the ASCO (Free ASCO Whitepaper) website at View Source and by clicking the titles below.

Presentation Details:

Abstract 1042 (Poster Board #123): Activity of Tesetaxel, an Oral Taxane, Given as a Single-agent in Patients (Pts) with HER2-, Hormone Receptor + (HR+) Locally Advanced or Metastatic Breast Cancer (MBC) in a Phase 2 Study
Presenter:Andrew Seidman, M.D.
Poster Session: Breast Cancer – Metastatic
Date/Time:Saturday, June 2, 2018 / 8:00AM – 11:30AM (CT)
Location: Hall A

Abstract TPS1106 (Poster Board #184a): CONTESSA: A Multinational, Multicenter, Randomized, Phase 3 Registration Study of Tesetaxel in Patients (Pts) with HER2-, Hormone Receptor + (HR+) Locally Advanced or Metastatic Breast Cancer (MBC)
Presenter:Joyce O’Shaughnessy, M.D.
Poster Session: Breast Cancer – Metastatic
Date/Time:Saturday, June 2, 2018 / 8:00AM – 11:30AM (CT)
Location: Hall A

About Tesetaxel

Tesetaxel is an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes, which are widely used in the treatment of cancer. Tesetaxel has several potential therapeutic advantages over currently available taxanes, including: oral administration with a low pill burden and a patient-friendly dosing regimen; no history of hypersensitivity (allergic) reactions; and robust activity against chemotherapy-resistant tumors. More than 500 patients have been treated with tesetaxel across 22 clinical studies. In patients with locally advanced or metastatic breast cancer (MBC), tesetaxel was shown to have robust single-agent antitumor activity in two, multicenter, Phase 2 studies.

About CONTESSA

CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel, an investigational, orally administered taxane, in patients with locally advanced or metastatic breast cancer (MBC). CONTESSA will compare tesetaxel dosed orally at 27 mg/m2 on the first day of a 21-day cycle plus a reduced dose of capecitabine (1,650 mg/m2/day dosed orally on days 1-14 of a 21-day cycle) to the approved dose of capecitabine alone (2,500 mg/m2/day dosed orally on days 1-14 of a 21-day cycle) in approximately 600 patients randomized 1:1 with human epidermal growth factor receptor 2 (HER2) negative, hormone receptor (HR) positive MBC previously treated with a taxane in the neoadjuvant or adjuvant setting. Capecitabine is an oral chemotherapy agent that is considered a standard-of-care treatment in MBC. Where indicated, patients must have received endocrine therapy with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor. The primary endpoint is progression-free survival (PFS) assessed by an Independent Radiologic Review Committee (IRC). CONTESSA’s secondary efficacy endpoints are overall survival, objective response rate (ORR) assessed by IRC, disease control rate assessed by IRC and patient-reported outcomes. To learn more, please visit www.contessastudy.com.