On April 9, 2018 Kura Oncology, Inc. (Nasdaq:KURA), a clinical-stage biopharmaceutical company focused on the development of precision medicines for oncology, reported that three abstracts relating to the company’s lead product candidate, tipifarnib, and ERK inhibitor, KO-947, will be presented at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2018, which will be held from April 14-18, 2018 in Chicago (Press release, Kura Oncology, APR 9, 2018, View Source [SID1234525219]).The following abstracts are now available on the AACR (Free AACR Whitepaper) website at www.aacr.org.

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Tipifarnib is Highly Active in HRAS Mutant Lung Squamous Carcinoma Tumor
Models (Abstract # 4917)
Session Category: Experimental and Molecular Therapeutics
Session Title: Pharmacokinetics and Pharmacodynamics
Session Date and Time: Tuesday, April 17, 2018, 1:00 p.m. – 5:00 p.m.
Location: McCormick Place South, Exhibit Hall A, Poster Section 41

11q13 Amplification Selects for Sensitivity to the ERK Inhibitor KO-947 in
Squamous Cell Carcinomas (Abstract # 3885)
Session Category: Experimental and Molecular Therapeutics
Session Title: Pharmacogenetics and Pharmacogenomics
Session Date and Time: Tuesday, April 17, 2018, 8:00 a.m. – 12:00 p.m.
Location: McCormick Place South, Exhibit Hall A, Poster Section 37

Preclinical Activity of Tipifarnib in Cutaneous T-cell Lymphoma (Abstract # 1873)
Session Category: Experimental and Molecular Therapeutics
Session Title: Experimental Agents and Combinations for Hematologic Malignancies 2
Session Date and Time: Monday, April 16, 2018, 8:00 a.m. – 12:00 p.m.
Location: McCormick Place South, Exhibit Hall A, Poster Section 38

Following presentation at the meeting, the posters will be available on Kura’s website at www.kuraoncology.com.

On April 9, 2018 IONTAS Limited (IONTAS), a leader in the discovery and optimisation of fully human antibodies, reported that it will collaborate with IGEM Therapeutics (IGEM), an immuno-oncology company developing novel immunoglobulin E (IgE) antibodies to treat cancer (Press release, IGEM Therapeutics, APR 9, 2018, View Source [SID1234525218]). The project will add to IGEM’s pipeline of drugs and expand upon IGEM-F, an IgE targeting ovarian and other cancers, currently in a Phase 1/2a study. IONTAS will utilise its proprietary antibody discovery technology to help IGEM identify novel IgE antibodies against two targets.

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IgE antibodies have been shown to permeate tumour tissue more effectively, exhibit enhanced effector functions and stimulate significantly greater levels of cytotoxicity and phagocytosis than IgG antibodies. IONTAS will apply its proprietary antibody discovery libraries and technologies to identify specific, high-affinity antibodies against two tumour-associated targets. Functional screening of IgE-formatted antibodies will be carried out to identify the most appropriate candidates for therapeutic development.

John McCafferty, CEO at IONTAS, commented: "This collaboration capitalises on the antibody discovery capabilities at IONTAS which enable the generation of high-quality therapeutic antibodies using phage-display or mammalian-display. We maintain a strong interest in developing novel therapeutic approaches and recognise IgE therapeutics as an important addition to the armoury of novel cancer therapies. We are delighted to have the opportunity to work with fellow innovators at IGEM on these two exciting projects."

Tim Wilson, CEO at IGEM, commented: "IONTAS was selected as our development partner of choice because of their extensive experience and track record in delivering therapeutic antibodies. The combination of the IGEM IgE platform and the discovery capability of IONTAS will rapidly expand our portfolio of antibodies and help meet our ambitions to progress new leads into the clinic."

On April 9, 2018 Horizon Pharma plc (Nasdaq:HZNP) reported that its first-quarter financial results will be released on Wednesday, May 9, 2018 (Press release, Horizon Pharma, APR 9, 2018, View Source [SID1234525217]). Following the announcement, Horizon’s management will host a live webcast at 8 a.m. Eastern Time to review the Company’s financial and operating results.

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The live webcast and replay may be accessed at View Source Please connect to the Company’s website at least 15 minutes before the live webcast to ensure adequate time for any software download that may be needed to access the webcast.

On April 9, 2018 Genocea Biosciences, Inc. (NASDAQ:GNCA), a biopharmaceutical company developing neoantigen cancer vaccines, reported upcoming presentations at the 2018 Annual Meeting of the American Association for Cancer Research (AACR) (Free AACR Whitepaper) (AACR 2018), taking place April 14-18, 2018 in Chicago, IL (Press release, Genocea Biosciences, APR 9, 2018, View Source [SID1234525216]).

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Poster 15: "Neoantigen identification using the ATLAS T cell profiling platform highlights the need to empirically define neoantigens"
Vaccines Session 1, Immunology Track
Sunday, April 15, 2018 from 1 pm to 5 pm CDT
Link to abstract

Poster 5718: "Ex vivo ATLAS-identification of neoantigens for personalized cancer immunotherapy in mouse melanoma"
Neoantigens in Cancer Session, Immunology Track
Wednesday, April 18, 2018 from 8 am to 12 pm CDT

On April 9, 2018 Constellation Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company developing tumor-targeted and immuno-oncology therapies based on its pioneering research and development in cancer epigenetics, reported a $100 million financing (Press release, Constellation Pharmaceuticals, APR 9, 2018, View Source [SID1234525214]). New investors include Cormorant Asset Management, Deerfield Management, Fidelity Management and Research Company, Hillhouse Capital, NS Investment, OrbiMed, Sirona Capital, and Venrock Healthcare Partners. Current investors, including The Column Group, Third Rock Ventures, Venrock, SROne, University of California Investment Office, Topspin Partners, and Casdin Capital, also participated in the financing.

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"We are thrilled to welcome this new group of high-quality investors, and we are grateful for the continued support from our existing investors. Their strategic guidance and financial support will be instrumental to help accomplish our goal of improving outcomes for cancer patients," said Jigar Raythatha, president and chief executive officer of Constellation Pharmaceuticals. "This financing gives us additional flexibility and runway to pursue the clinical development of CPI-1205 and CPI-0610, our lead product candidates, as well as advance other novel molecules from our cancer epigenetics platform into development."

The company plans to utilize the proceeds of this financing to advance multiple clinical trials across its portfolio. Specifically, the ongoing ProSTAR and ORIOn-E trials are designed to demonstrate the potential for CPI-1205 to enhance the effectiveness of current-generation androgen inhibitors in metastatic castration-resistant prostate cancer and cancer immunotherapies in other solid tumors, respectively. The company also plans to progress CPI-0610, a clinical-stage candidate, as a treatment for myelofibrosis either as a monotherapy or in combination with a JAK inhibitor.

Additionally, Constellation Pharmaceuticals plans to advance its second-generation EZH2 program into the clinic and identify more experimental therapies derived from its epigenetics discovery platform.