CALL FOR SMALL MOLECULES AS TOOL COMPOUNDS

On August 12, 2014 CRT reported that it’s research reagents team has been commercialising reagents for the past 30 years (Press release, Cancer Research Technology, AUG 12, 2014, View Source [SID1234523518]). Recently CRT has expanded into commercialising Small Molecules as Tool Compounds. CRT is uniquely placed to commercialise these Small Molecules thanks to our in-house production, handling and storage facilities and can take all responsibility for maintenance and distribution.

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Over the past year, CRT has commercialised a total of 14 Small Molecules generated in collaboration with five universities. These compounds are now widely available to the life sciences research community via four global reagents companies: Abcam, Tocris, BioVision and Kerafast.

The commercialisation of these compounds has led to further academic collaborations, compound sharing and increased visibility of the originating research groups. One of the compounds is currently being reconsidered for clinical trials due to the new data generated by sharing the compound via CRT’s commercialisation model.

We’re looking for published or unpublished small molecules that can be used by other research groups as tool compounds for their own studies:

Compounds impacting cancer as well as non-cancer research
Compounds that exhibit good potency and selectivity
Compounds generated from current or old/de-prioritised projects
Compounds for which you routinely get MTA requests
Compounds do not always need to be towards a novel target or the lead candidate in your discovery programme
The research group should be happy to share details (structure, technical and production data) about the compounds on a non-confidential basis.

If you are interested in finding out more, please contact [email protected]. Further information about CRT’s research reagents business can be found here.

10-Q – Quarterly report [Sections 13 or 15(d)]

Dendreon has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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(Filing, 10-Q, Akebia , AUG 11, 2014, View Source [SID:1234505291])

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!


10-Q – Quarterly report [Sections 13 or 15(d)]

Dendreon has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission (Filing 10-Q , Dendreon, AUG 11, 2014, View Source [SID1234500693]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Genmab Announces New Phase III Study of Daratumumab in Front Line Multiple Myeloma

On August 11, 2014 Genmab reported that its collaboration partner, Janssen Biotech plans to start a new Phase III study of daratumumab in multiple myeloma (Press release Genmab, AUG 11, 2014, View Source [SID:1234500695]). The study (MMY3008) will compare daratumumab in combination with lenalidomide and dexamethasone to lenalidomide and dexamethasone alone as front line treatment for patients who are not considered candidates for stem cell transplantation (SCT). The study is planned to start in the first half of 2015. The first Phase III study in front line multiple myeloma was announced in July and is expected to start towards the end of this year. Today’s news is the fourth daratumumab Phase III study to be announced.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"This new study of daratumumab in front line multiple myeloma is part of the extensive development plan created under our collaboration with Janssen Biotech for our CD38 antibody daratumumab," said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab.

About the MMY3008 study
This Phase III study is a randomized, open-label, multicenter study and will include approximately 700 newly diagnosed, chemotherapy naïve multiple myeloma patients ineligible for stem cell transplantation (SCT). Patients will be randomized to receive either daratumumab combined with lenalidomide (an immunomodulatory agent) and dexamethasone (a corticosteroid) or lenalidomide and dexamethasone alone. The primary endpoint of the study is progression free survival (PFS).