Akari Therapeutics Releases CEO Corner Highlighting Strategic WhiteHawk Collaboration and the Expanding Opportunity for Dual-Payload ADC Innovation

On August 4, 2026 Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulator payloads, reported a new CEO Corner segment featuring President and Chief Executive Officer Abizer Gaslightwala discussing the Company’s recently announced strategic research collaboration with WhiteHawk Therapeutics and why the Company believes scientifically driven collaborations will play an increasingly important role in advancing the next generation of ADC innovation.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

In the segment, Mr. Gaslightwala discusses how the ADC landscape continues to evolve beyond the development of individual payload technologies toward collaborative strategies designed to combine complementary mechanisms of action. He explains why Akari believes bringing together differentiated scientific approaches has the potential to accelerate innovation, generate meaningful translational insights and expand future therapeutic opportunities beyond what may be achieved through a single technology alone.

At the center of the discussion is Akari’s recently announced strategic research collaboration with WhiteHawk Therapeutics, which combines Akari’s proprietary PH1 spliceosome-modulating payload with WhiteHawk’s differentiated TOP1 inhibitor ADC platform to evaluate a novel dual-payload strategy. Mr. Gaslightwala explains why the Company believes evaluating two potentially best-in-class payload technologies together represents an innovative scientific approach with the potential to broaden therapeutic activity while further demonstrating the versatility and broad applicability of Akari’s PH1 platform.

Beyond the collaboration itself, the CEO Corner explores the growing pharmaceutical industry interest in differentiated payload technologies capable of addressing important unmet needs across oncology. Mr. Gaslightwala discusses how strategic collaborations can provide additional opportunities to expand scientific validation of novel payload platforms while creating new pathways for innovation through partnerships with organizations that share a common vision for advancing ADC science.

Looking ahead, Mr. Gaslightwala outlines Akari’s continued focus on advancing AKTX-101, the Company’s lead TROP2-targeting ADC, toward planned Phase 1 clinical evaluation while continuing to expand the scientific foundation supporting its proprietary PH1 spliceosome-modulating payload platform. He emphasizes that the Company’s internal development programs and strategic collaborations represent complementary components of a broader strategy to establish PH1 as a differentiated payload platform with the potential to support multiple future therapeutic applications.

(Press release, Akari Therapeutics, AUG 4, 2026, View Source [SID1234669652])

Q1 FY2026 Financial Results and Business Update

On August 3, 2026 Eisai reported first quarter 2026 financial results.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

(Presentation, Eisai, AUG 3, 2026, View Source [SID1234670767])

Consolidated Financial Report for the Three-Month Period Ended June 30, 2026

On August 3, 2026 Eisai reported consolidated Financial Report for the Three-Month Period Ended June 30, 2026.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

(Press release, Eisai, AUG 3, 2026, View Source [SID1234670766])

Consolidated Financial Summary (IFRS) Fiscal 2026 Second Quarter

On August 3, 2026 Kyowa Hakko Kirin reported Consolidated Financial Summary (IFRS) Fiscal 2026 Second Quarter.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

(Press release, Kyowa Hakko Kirin, AUG 3, 2026, View Source [SID1234670611])

Adlai Nortye Announces Clinical Trial Notification Submission and HREC Approval for the Phase I Clinical Trial of Pan-RAS(ON) Inhibitor ADC AN4035 in Australia

On August 3, 2026 Adlai Nortye Ltd. (NASDAQ: ANL) ("Adlai Nortye" or the "Company"), a clinical-stage biotechnology company focused on the development of innovative cancer therapies, reported that it has submitted a Clinical Trial Notification (CTN) to Australia’s Therapeutic Goods Administration (TGA) and received approval from the Human Research Ethics Committee (HREC) to commence its phase I clinical trial evaluating AN4035, a CEACAM5-targeting, pan-RAS(ON) inhibitor-based antibody drug conjugate (ADC) for the treatment of CEACAM5-enriched RAS-addicted solid tumors.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"AN4035 is a first-in-class CEACAM5-targeting ADC armed with a pan-RAS(ON) inhibitor payload, and is our first drug candidate to demonstrate proof-of-concept of our RASiCA (RAS Inhibitor Conjugated Antibody) platform." said Dr. Archie Tse, President, Head of Research & Development. "To our knowledge, AN4035 is the first pan-RAS(ON) ADC to enter the clinic globally. We believe that utilizing targeted delivery via an ADC could localize pan-RAS(ON) inhibitor activity to the tumor while minimizing systemic RAS pathway inhibition, which could potentially both widen the therapeutic window and enable rational combinations. We are excited to see this asset advance into clinical development and the potential benefit it may bring to our patients globally."

This global phase I trial will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of AN4035 as monotherapy and in combination with cetuximab in patients with CEACAM5-enriched, RAS-addicted solid tumors. CEACAM5 is an antigen that is overexpressed in colorectal, pancreatic, and lung cancers, which frequently harbor RAS mutations. Adlai Nortye is also filing investigational new drug (IND) applications for AN4035 with the U.S. Food and Drug Administration (FDA) and China National Medical Products Administration (NMPA). Patient dosing with AN4035 is expected to begin in the second half of 2026.

About AN4035

AN4035 is a first-in-class ADC targeting CEACAM5 and armed with a highly potent pan-RAS(ON) inhibitor payload. In preclinical studies, AN4035 demonstrated nanomolar to picomolar cytotoxicity in CEACAM5-positive / RAS-addicted cancer cell lines, along with a robust bystander killing effect. It also exhibited potent anti-tumor activity with deep regression in CDX/PDX models, favorable developability with desirable pharmacokinetic properties, and enhanced target-mediated tumor retention with improved tumor selectivity over normal tissue — resulting in an overall favorable therapeutic index. Adlai Nortye is evaluating AN4035 in a global phase I trial in patients with CEACAM5-enriched RAS-addicted solid tumors.

(Press release, Adlai Nortye Biopharma, AUG 3, 2026, View Source [SID1234669633])