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Vizgen to Present Spatial Multi-Omics Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting

On November 6, 2025 Vizgen, Inc., a spatial multi-omics innovator accelerating biological discovery and new drug development, reported that it will present new spatial multi-omics data at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 40th Annual Meeting on November 7-10, 2025 in National Harbor, Maryland. The company will showcase how researchers can generate a combination of high-quality RNA and protein data via Vizgen’s bioinformatics technology.

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Vizgen combined results from MERFISH 2.0 gene expression data generated on the MERSCOPE Ultra with data collected from InSituPlex (ISP) multiplex immunofluorescence (mIF) in sequential sections to decode the complexity of the tumor-immune microenvironment (TiME). In its session on November 7th at SITC (Free SITC Whitepaper), Vizgen will delve into how to co-register two established high-quality datasets to fuel multi-omic research.

"Vizgen is empowering researchers to use the power of spatial multi-omics to gain valuable new insights, and we’re excited to share the latest data at SITC (Free SITC Whitepaper) to demonstrate what is possible to significantly advance research," said Jiang He, VP & Portfolio Owner, Reagents & Sci. Affairs, at Vizgen. "The scientific community in attendance at SITC (Free SITC Whitepaper) 2025 will get a first look at data that improves the understanding of the tumor-immune microenvironment through a unified approach with spatial multi-omics. Vizgen offers a complete solution to study the tumor microenvironment."

POSTERS
Details of the posters at the Gaylord National Resort and Convention Center at SITC (Free SITC Whitepaper) 2025 are as follows:

Abstract Number: 101
Title: Combining Vizgen’s MERSCOPE gene expression profiling and InSituPlex multiplex immunofluorescence (mIF) to reveal functional compartmentalization within the tumor microenvironment (TME)
Session Date: Friday, November 7, 2025
Session Time: Between 12:15 p.m. and 1:45 p.m. ET (Lunch session) and between 5:35 p.m. and 7 p.m. (PM reception)
Presenter: Angela Vasaturo, Director of Scientific Affairs at Vizgen

Abstract Number: 102
Title: New developments in spatial transcriptomics using MERFISH 2.0 unlock insights into the tumor microenvironment
Session Date: Saturday, November 8, 2025
Session Time: Between 12:15 p.m. and 1:45 p.m. ET (Lunch session) and between 5:35 p.m. and 7 p.m. (PM reception)
Presenter: Amanda Burke, PhD, Field Application Scientist, Vizgen

Abstract Number: 84
Title: Enabling scalable tumor microenvironment (TME) profiling with 8-plex InSituPlex multiplex immunofluorescence (mIF) on ZEISS Axioscan 7 spatial biology
Session Date: Saturday, November 8, 2025
Session Time: Between 12:15 p.m. and 1:45 p.m. ET (Lunch session) and between 5:10 p.m. and 6:35 p.m. (PM reception)
Presenter: Kevin Hwang, Ph.D., Senior Scientist, Research at Vizgen

Abstract Number: 88
Title: Establishing a robust and reproducible automated mIF workflow for spatial biology using ZEISS SlideStream and Ultivue by Vizgen’s InSituPlex assays
Session Date: Saturday, November 8, 2025
Session Time: Between 12:15 p.m. and 1:45 p.m. ET (Lunch session) and between 5:35 p.m. and 7 p.m. (PM reception)
Presenter: Cassandra Kysilovsky, Ph.D., Associate Scientist at Vizgen

In exhibit hall booth #838, Vizgen representatives will be showcasing a spatial multi-omic workflow that combines spatial transcriptomics, spatial proteomics, and AI-enhanced data science.

(Press release, Vizgen, NOV 6, 2025, View Source [SID1234659619])

AbCellera Reports Q3 2025 Business Results

On November 6, 2025 AbCellera (Nasdaq: ABCL) reported financial results for the third quarter of 2025. All financial information in this press release is reported in U.S. dollars, unless otherwise indicated.

"AbCellera successfully delivered on two corporate priorities this quarter by starting activities at our new clinical manufacturing facility and substantially completing our platform investments," said Carl Hansen, Ph.D., founder and CEO of AbCellera. "We ended the quarter with approximately $680 million dollars in available liquidity to execute on our strategy and will continue to prioritize advancing our two lead programs through Phase 1 clinical studies and building our pipeline."

Q3 2025 Business Summary

Generated a net loss of $57.1 million, compared to a net loss of $51.1 million in 2024.
Expanded the leadership team with the appointment of Sarah Noonberg, M.D., Ph.D., as Chief Medical Officer.
ABCL635 and ABCL575 continue to progress through Phase 1 clinical trials.
Reached a cumulative total of 103 partner-initiated program starts with downstreams.
Key Business Metrics

Cumulative Metrics

September 30, 2024

September 30, 2025

Change %

Partner-initiated program starts with downstreams

103

Molecules in the clinic

AbCellera started discovery on an additional partner-initiated program with downstreams to reach a cumulative total of 103 partner-initiated program starts with downstreams in Q3 2025 (up from 95 on September 30, 2024). AbCellera and its partners have advanced a cumulative total of 18 molecules into the clinic (up from 14 on September 30, 2024).

Discussion of Q3 2025 Financial Results

Revenue – Total revenue was $9.0 million, compared to $6.5 million in Q3 2024.
Research & Development (R&D) Expenses – R&D expenses were $55.0 million, compared to $41.0 million in Q3 2024. A greater proportion of R&D expenses are used on internal programs, including $15.0 million of specific investments in two internal programs in the third quarter.
Sales & Marketing (S&M) Expenses – S&M expenses were $2.9 million, compared to $3.1 million in Q3 2024.
General & Administrative (G&A) Expenses – G&A expenses were $22.1 million, compared to $19.1 million in Q3 2024.
Net Loss – Net loss of $57.1 million, or $(0.19) per share on a basic and diluted basis, compared to net loss of $51.1 million, or $(0.17) per share on a basic and diluted basis, in Q3 2024.
Liquidity – $523 million of total cash, cash equivalents, and marketable securities and approximately $159 million in available non-dilutive government funding, bringing total available liquidity to approximately $680 million to execute on AbCellera’s strategy.
Conference Call and Webcast

AbCellera will host a conference call and live webcast to discuss these results today at 2:00 p.m. Pacific Time (5:00 p.m. Eastern Time).

The live webcast of the earnings conference call can be accessed on the Events and Presentations section of AbCellera’s Investor Relations website. A replay of the webcast will be available through the same link following the conference call.

(Press release, AbCellera, NOV 6, 2025, View Source [SID1234659618])

AN2 Therapeutics to Participate in Fireside Chat at Evercore HealthCONx Conference

On November 6, 2025 AN2 Therapeutics, Inc. (Nasdaq: ANTX), a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from its boron chemistry platform, reported that Eric Easom, Co-Founder, Chairman, President and CEO, will participate in a fireside chat at the 8th Annual Evercore HealthCONx Conference being held from December 2-4, 2025.

Details of the event are as follows:

Eric Easom, Co-Founder, Chairman, President and CEO, will participate in a fireside chat on Wednesday, December 3, 2025 at 10:50 AM ET, and members of management will be available for 1X1 meetings.

A webcast can be accessed on the Investors section of the AN2 Therapeutics website at www.an2therapeutics.com. An archived replay will be available for at least 30 days following the presentation.

(Press release, AN2 Therapeutics, NOV 6, 2025, View Source [SID1234659617])

Eilean Therapeutics to Present First-in-Class, Wild-Type-Sparing JAK2-JH2/V617F Inhibitor ZE74-0282 at ASH 2025 and Initiate Clinical Studies in December 2025

On November 6, 2025 Eilean Therapeutics LLC, a biotechnology company developing next-generation precision medicines for cancer and immune-inflammatory diseases, reported the upcoming presentation of preclinical data for its first-in-class, wild-type–sparing JAK2-JH2/V617F inhibitor ZE74-0282 at the 67th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting. The company also confirmed plans to initiate first-in-human clinical studies in December 2025.

Background

The JAK2 V617F mutation is the most common recurring driver mutation in classical myeloproliferative neoplasms (MPNs)—including polycythemia vera, essential thrombocytosis, and myelofibrosis—and is also present in subsets of other myeloid malignancies. The mutation, located in the JH2 pseudokinase domain, causes constitutive hyperactivation of JAK2 signaling.

Approved JAK inhibitors such as ruxolitinib and fedratinib target the JH1 kinase domain, offering symptomatic relief but lacking selectivity for the mutant form. This non-selective inhibition disrupts wild-type (WT) JAK2 signaling essential for normal hematopoiesis, limiting both long-term efficacy and tolerability.

About ZE74-0282

ZE74-0282 is a novel, small-molecule inhibitor rationally designed through in-silico and AI-driven molecular pharmacology to selectively target the JH2 domain of mutant JAK2 V617F while sparing WT JAK2 and other JAK family kinases.

Key non-clinical findings include:

Picomolar potency and > 500-fold selectivity for JAK2 V617F JH2 versus WT JAK2 JH2 in cellular assays.
100× selective inhibition of pSTAT5 phosphorylation and proliferation in BaF3 JAK2 V617F and SET-2 JAK2 V617F cells, with minimal effect on WT cells.
Nanomolar potency in selectively reducing pSTAT5 in myeloid cells from human JAK2 V617F⁺ MPN whole-blood assays, with no effect on lymphoid cells—confirming wild-type sparing. In contrast, ruxolitinib suppressed signaling across both lineages.
Selective inhibition of colony formation from JAK2 V617F/ASXL1-mutant progenitors, without affecting WT JAK2 progenitors, in murine colony-forming assays.
Superior tumor growth inhibition and stronger in-vivo pSTAT5 suppression compared with fedratinib in xenograft models.
Linear pharmacokinetics and toxicokinetics in DRF and GLP toxicology studies, demonstrating safety, tolerability, and a broad therapeutic window supporting optimal clinical dose selection.
Conclusion

ZE74-0282 is the first-in-class, JH2-domain–specific JAK2 inhibitor that selectively targets mutant JAK2 V617F while preserving normal JAK2-mediated hematopoietic signaling. Its differentiated selectivity profile and favorable pharmacology indicate a superior therapeutic index compared with JH1-directed inhibitors. These data support ZE74-0282 as a potentially disease-modifying therapy for patients with JAK2 V617F-driven myeloproliferative disorders.

Eilean Therapeutics plans to initiate its first-in-human clinical study of ZE74-0282 in December 2025.

(Press release, Eilean Therapeutics, NOV 6, 2025, View Source [SID1234659616])

Whitehawk Therapeutics Reports Third Quarter 2025 Financial Results and Recent Highlights

On November 6, 2025 Whitehawk Therapeutics, Inc. (Nasdaq: WHWK), an oncology therapeutics company applying advanced technologies to established tumor biology to efficiently deliver improved antibody drug conjugate (ADC) cancer treatments, reported financial results for the third quarter ended September 30, 2025, and provided recent corporate progress.

"The third quarter was marked by executional focus, and we remain on track with our planned IND filings for HWK-007 and HWK-016 by the end of the year. We continue to deploy capital efficiently, maintaining strong financial discipline as we prepare to enter the clinic and deliver potentially value-creating milestones," said Dave Lennon, PhD, President and CEO of Whitehawk Therapeutics. "I’m proud of our role in adding to the scientific understanding of PTK7 with the data we presented at AACR (Free AACR Whitepaper)-NCI-EORTC. Confirming PTK7 as the third most highly expressed tumor marker among clinically validated and emerging ADC targets, these data underscore the tremendous opportunity we have with our first ADC candidate, HWK-007, to make a difference for the nearly 750,000 patients in the US with PTK7-expressing cancers."

Recent Operational Highlights:

Presented real-world analysis at AACR (Free AACR Whitepaper)-NCI-EORTC confirming PTK7 as a broadly expressed, clinically relevant target across solid tumors. The analysis was part of a collaboration between Whitehawk and Tempus AI.

On track to bring all three assets to IND by mid-2026. IND submissions are planned by year-end 2025 for HWK-007 and HWK-016. An IND for HWK-206 is expected by mid-2026.

Focused execution and capital efficiency support anticipated runway into 2028. Based on current plans, cash position enables initial clinical data readouts across the portfolio.
Third Quarter 2025 Financial Results:

Cash, cash equivalents and short-term investments as of September 30, 2025, were $162.6 million as compared to $47.2 million as of December 31, 2024. Cash is anticipated to fund operations into 2028 based on current plans.

Net loss for the three months ended September 30, 2025, was $17.7 million as compared to $12.5 million for the three months ended September 30, 2024.

(Press release, Whitehawk Therapeutics, NOV 6, 2025, View Source [SID1234659615])