Servier delivers solid performance in 2024/25 and confirms its forecasts for 2030

On January 27, 2026 Servier, an independent international pharmaceutical group governed by a foundation, reported its financial results for the 2024/25 financial year and recapped the highlights that led to such significant growth.

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Olivier Laureau, President of Servier, said: "The solid results from our 2024/25 financial year put us one important step closer to achieving our 2030 objectives. They validate the relevance of our differentiated innovation strategy to serve patients and the commitment of our employees. These results also underscore the success of the Group’s transformation, which began 10 years ago, involving significant investments in innovation and international expansion. Our long-term vision is made possible by the fact that we are governed by a foundation."

Excerpt from the Group’s audited results[1] (financial year ending September 30, 2025)

EUR Million

2024/25

2023/24

Evolution

Group Revenue

6,860

5,902

+16.2 %

Brand-name business revenue

5,307

4,494

+18.1 %

Generics business revenue

1,553

1,408

+10.3 %

Operating EBITDA

1,931

1,312

+47.2 %

EBITDA margin

28.2 %

22.2 %

+6.0 pts

Recurring operating income

1,415

965

46.8 %

Net income

659

404

63.4 %

In the 2024/25 financial year, Group revenue reached €6.9 billion, exceeding the €6 billion target. This 16.2% increase over the previous year reflects the Group’s growth momentum and ability to provide patients with an ever-increasing number of medicines.

Revenue growth resulted from a 16.9% increase in sales volume, or €1 billion, compared to 12.6% for FY 2023/24. There was also an unfavorable currency effect of 2.0%, equivalent to €118 million, (compared with an unfavorable impact of 3.5% in the previous year), as well as a positive price effect of 1.3%, equal to €76 million (compared with 1.7% for the 2023/24 financial year).

EBITDA[2] for the 2024/25 financial year amounted to €1.9 billion, corresponding to a 28.2% revenue margin compared to 22.2% in 2023/24. This increase was driven by significant growth in medicine sales during the financial year, particularly in oncology, combined with effective cost control across the Group. By 2023/24, the Group had already exceeded its 2024/25 target of achieving a 21.7% EBITDA margin.

Consistent with strategy, Servier remains confident in its ability to achieve global annual revenues of €10 billion by 2030 and an EBITDA margin of at least 30%.

Growth fueled by oncology performance in the United States

The 2024/25 financial year was highlighted by several advances in oncology and partnership agreements signed, reflecting the Group’s dedication to developing new therapeutic solutions for patients with rare cancers. In line with the Group’s strategy, oncology continues to grow and now accounts for 32.2% of Group revenue, compared with 24.2% in 2023/24. Oncology revenues amounted to €2.21 billion in 2024-25, an increase of 54.6%. This growth stems from a significant increase in oncology sales volume following the launch of Voranigo in the United States.

Medicine sales in cardiometabolism and venous diseases underscore the Group’s historic, ongoing commitment in this area. As a result, sales rose by 1.8% to €2.968 billion, boosted by strong sales performance for Daflon in venous diseases.

European Union revenues account for 40.5% of Group revenue and show a 9.2% increase over the previous financial year. The US subsidiary remained the Group’s leading operating unit, with revenues of €1.496 billion in 2024/25, compared with €879 million in 2023/24, reflecting growth of 70.3%. The US market generated 21.8% of Group revenue.

Pascal Lemaire, Executive Vice President Finance at Servier, said: "The Group’s 2024/25 financial year results mirror our successful international growth, particularly our oncology business in the United States. They reward the risks taken as part of our targeted strategy and our policy of investing in R&D in rare diseases in oncology and in neurology where there are unmet patient needs. Our results are also a testament to Servier’s decision to raise its growth targets for 2030, particularly to reach €10 billion in revenue."

Targeted, collaborative R&D to enhance and strengthen the pipeline

In 2024/25, the innovation strategy focused on renewing and sustaining our research and development pipeline through both internal and external growth.

Incorporating AI (artificial intelligence) and data throughout the medicine development chain has now become part of Servier’s ambition to improve R&D productivity to serve patients. AI helps researchers navigate biological complexity and speed up the development of treatments for the right patient at the right time, particularly in rare diseases in oncology and neurology.

Targeted innovation driving growth in oncology

The 2024/25 financial year was once again noteworthy for several marketing authorizations in oncology around the world, bolstering the Group’s ability to develop new therapeutic solutions for rare forms of cancer with unmet medical needs, and get them to patients.

Following approvals in the United States, Australia, Japan, and Brazil, Voranigo has now been approved in Europe, bringing the total number of countries to nearly 45. Used to treat patients with a rare form of brain cancer, Voranigo is currently administered to more than 5,500 patients in the United States and around the world through early access programs. Alongside this, Tibsovo, a targeted therapy in hematology, has been approved for marketing in Japan.

In addition, the Group has finalized three significant partnership agreements that demonstrate its focus on advancing targeted oncology therapies and the value creation potential of its R&D. The Group entered into a licensing agreement with Black Diamond Therapeutics to develop and commercialize a targeted therapy for solid tumors, including non-small cell lung cancer. Additionally, the acquisition of a precision therapy from Chinese biopharmaceutical company BioNova Pharmaceuticals Ltd also enabled the Group build on its leadership in acute leukemia. And finally, Servier joined forces with IDEAYA Biosciences to make Darovasertib available to patients. This is a potential treatment for uveal melanoma, which is a rare type of eye cancer.

Featuring in the Top 10 of the PatientView Survey[3] and obtaining the leading position in the oncology category are recognition of the Group’s unwavering dedication to patients and patient advocacy groups.

Aspiring to be a leading force in neurology

Building on its ongoing transformation, the Group aims to establish a leading neurology franchise by developing a robust pipeline in rare neurological diseases modeled on its oncology strategy. Servier is targeting three main types of neurological diseases associated with a genetic and/or immuno-inflammatory mechanism: refractory epilepsy, rare movement disorders, and neuromuscular diseases. Servier R&D is focused on small molecules that target messenger RNA, particularly antisense oligonucleotides (ASOs), as well as pharmacological molecules and monoclonal antibodies. To date, the neurology pipeline comprises eight research projects and three projects in development.

Servier has initiated a Phase 1 clinical trial for a product to treat developmental and epileptic encephalopathy (DEE) in children, a rare form of epilepsy that is resistant to conventional anticonvulsant drugs. In the field of DEE, the Group has also partnered with University College London to test ASOs from Servier in innovative cell models, called brain assembloids, which replicate key aspects of human brain development and function.

Leveraging the strength of its global resources, Servier also intends to become a partner of choice for innovative biotech companies in the development of new drugs that slow or halt the progression of rare neurological disorders and significantly improve patient quality of life.

Over the past year, the Group has therefore enriched its pipeline with the acquisition of a first asset in autism spectrum disorder (ASD) from biotech company Kaerus Bioscience Ltd. This asset is a potential treatment for Fragile X syndrome, the most common genetic cause of ASD, for which there are currently no treatment options.

Innovation continues with a focus on improving patient adherence to cardio-metabolic therapies

Servier maintains its position as the world’s leading pharmaceutical company in hypertension[4]. Cardiometabolism and venous diseases accounted for 43.3% of consolidated revenues in FY 2024/25, with performance driven by sales of Daflon as well as growth in Single Pill Combinations (SPCs), which make it possible for patients with multiple and chronic conditions to take their various treatments in a single pill.

Several marketing authorization applications were submitted in many countries for an extended-release triple therapy in hypertension and its first quadruple therapy. These innovations are designed to address the issue of treatment non-adherence, a major health challenge for the nearly 50% of patients with chronic diseases who do not follow their prescribed treatment plans exactly[5], which also places a financial burden on health care systems. Among other initiatives, Servier partnered with 14 institutions to sponsor the first World Adherence Day.

Claude Bertrand, Executive Vice President Research and Development at Servier: "Our differentiated approach is paying off. Following major oncology launches in 2025 that consolidate our expertise in rare cancers, we are investing in rare neurological diseases while continuing our innovations in Single Pill Combinations (SPCs) in cardiometabolism. All our R&D projects are clinically grounded and focused on critical unmet medical needs, leveraging recent scientific and technological inflection points. They represent decisive and sustainable choices with one ultimate beneficiary: the patient."

Last but not least, the creation of Servier’s venture capital fund — Servier Ventures — will also help further the Group’s R&D strategy by strengthening direct, early access to innovation in its target therapeutic areas and fueling the long-term pipeline. Through investment and support for innovative start-ups, this fund gives Servier the opportunity to position itself as a partner of choice within the biotech ecosystem, promoting the development of new and innovative medicines.

(Press release, Servier, JAN 27, 2026, View Source [SID1234662305])

Boehringer Ingelheim and Simcere partner to advance a dual-target antibody treatment to address unmet needs in inflammatory bowel disease

On January 27, 2026 Simcere Pharmaceutical Group Ltd. ("Simcere") (HKEX: 2096) and Boehringer Ingelheim, reported a license and collaboration agreement to develop SIM0709, a pre-clinical TL1A/IL23p19 bispecific antibody from Simcere, for the treatment of inflammatory bowel disease (IBD).

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Globally, it is estimated that more than three million people are affected by IBD, a lifelong, progressive condition leading to frequent hospitalization and surgeries, significantly impacting patients’ quality of life. Current medical options cannot fully prevent or reverse these complications, leaving a clear unmet need. Through this partnership, Boehringer and Simcere aim to advance an innovative approach to potentially redefine treatment possibilities and improve outcomes for patients worldwide.

SIM0709 is a long-acting humanized bispecific antibody developed by Simcere using its proprietary multi-specific antibody platform. It simultaneously targets tumor necrosis factor ligand superfamily member 15 (TL1A) and interleukin-23 (IL-23), thereby blocking two core pathways that drive the onset and progression of IBD. Both in vitro primary cell studies and in vivo animal studies, SIM0709 demonstrated superior synergistic efficacy, even outperforming the combination of the two corresponding monotherapies.

Carine Boustany, US Innovation Unit Site Head and Global Head of Immunology and Respiratory Diseases at Boehringer Ingelheim said, "In IBD, too many patients continue to progress and experience severe complications despite currently available anti-inflammatory therapies. We are excited to join forces with Simcere to accelerate the development of this therapeutic as a potential life changing option for patients living with IBD."

"Simcere’s bispecific antibody SIM0709 was engineered with our proprietary multi-specific antibody platform with first-in-class potential for IBD treatment. Partnering with Boehringer Ingelheim, with its long‑term commitment and deep expertise in immunology, positions the compound for rigorous global development," said Gaobo Zhou, Chief Investment Officer, Simcere Pharmaceutical Group. "Together we aim to accelerate the clinical development and advance a treatment option that could improve outcomes for patients world-wide affected by IBD."

Under the terms of the agreement Boehringer receives global rights to the asset, excluding greater China. Simcere is eligible to receive an upfront payment as well as success-based development, regulatory and sales milestones up to EUR 1,058 million, as well as royalties on net sales outside of the Greater China territory.

This marks Simcere’s second out- licensing transaction in the autoimmune field. As of January 2026, Simcere has completed a total of 5 out-licensing deals for its self-developed novel drug technologies, with a total potential transaction value of approximately $4.6 billion.

(Press release, Boehringer Ingelheim, JAN 27, 2026, View Source [SID1234662304])

Insilico Medicine and Qilu Pharmaceutical Reach Near $120 Million Drug Development Collaboration to Accelerate Novel Cardiometabolic Therapies

On January 27, 2026 Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, and Qilu Pharmaceutical Group, a major comprehensive modern pharmaceutical enterprise in China, as well as its subsidiary Shanghai Qilu Pharmaceutical Research Center, reported a strategic partnership on innovative drug development, leveraging Insilico’s proprietary Pharma.AI platform to jointly develop small molecule inhibitors, focusing on specific targets for cardiometabolic disease management.

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According to the agreement, Insilico Medicine will utilize its proprietary Pharma.AI platform to focus on the design and optimization of novel small molecules for treating metabolic diseases, while Qilu Pharmaceutical Group will be responsible for subsequent development and commercialization procedures. The total contract value approaches $120 million, including development and commercialization milestone payments, as well as single-digit royalties based on net sales.

Weikang Tao, PhD, Board Member, Group VP & Head of Global R&D, Qilu Pharmaceutical Group said, "As a leading pharmaceutical company in China, Qilu has always attached great importance to the quick advancement of AI technology, in particular, the application of AI in drug R&D and its potential. Insilico is a well-known biotech in AI-powered drug R&D with advanced AI technology and application capabilities. This collaboration marks a deepening of our partnership, evolving from initial software licensing to in-depth, R&D collaboration. We look forward to the smooth progress of this innovative drug discovery and development project through the synergy of Qilu’s extensive R&D experience and capabilities and Insilico’s advanced AI platform and expertise, thereby to address unmet medical needs and to bring new hope to patients worldwide."

Alex Zhavoronkov, PhD, Founder and Chief Executive Officer, Chief Business Officer of Insilico Medicine said, "We are pleased to see Insilico Medicine and Qilu Pharmaceutical further deepen their strategic collaboration driven by generative AI. Recently, Insilico Medicine unveiled its proprietary cardiometabolic portfolio at the BIO-Europe conference, covering 8 drug candidates ranging from hit to IND-enabling stage, all driven by Pharma.AI in their development process. I believe that strategies targeting cardiometabolic diseases have the potential to generate the first drugs to achieve large-scale healthspan extension, and I look forward to AI technology accelerating innovation in the field and maximizing potential."

Based on drug discovery and development, software solution licensing, and innovative expansion beyond drug development, Insilico Medicine continues to validate its diversified business model, securing software licensing agreements with 13 of the world’s top 20 multinational pharmaceutical companies, establishing research collaborations with upfront payments of tens of millions of dollars with Fosun Pharma and Sanofi; and reaching pipeline out-licensing deals with Exelixis and Menarini Group, with total transaction values exceeding $2 billion. Notably, Qilu Pharmaceutical first started using PandaOmics in 2021, thus leading to the near $120 million collaboration today, which will further deepen the empowering role of the artificial intelligence platform and drive innovative therapy development with even higher efficiency.

In 2016, Insilico first described the concept of using generative AI for the design of novel molecules in a peer-reviewed journal, which laid the foundation for the commercially available Pharma.AI platform. Since then, Insilico keeps integrating technical breakthroughs into Pharma.AI platform, which is currently a generative AI-powered solution spanning across biology, chemistry, medicine development and science research. Powered by Pharma.AI, Insilico has nominated 22 developmental/preclinical candidates (DC/PCC) in its comprehensive portfolio of over 30 assets since 2021, with the most advanced candidate Rentosertib achieving positive results in Phase IIa clinical trials, achieving the first proof-of-concept for AI-driven drug development in the clinical stage.

(Press release, Insilico Medicine, JAN 27, 2026, https://www.prnewswire.com/news-releases/insilico-medicine-and-qilu-pharmaceutical-reach-near-120-million-drug-development-collaboration-to-accelerate-novel-cardiometabolic-therapies-302671276.html [SID1234662303])

BridGene Biosciences Raises $28 Million in Series B+ Financing to Accelerate Clinical Development of BGC-515 and Platform Expansion

On January 27, 2026 BridGene Biosciences, Inc., a leader in the discovery and development of small molecule drugs for traditionally "hard-to-drug" targets, reported the recent completion of a $28 million Series B+ financing round. The round was led by Bayland Capital, with participation from GTJA Investment Group, Proxima Ventures, and existing investors Lapam Capital and Grains Valley Venture Capital.

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Proceeds from the financing will be used to advance BGC-515, a covalent TEAD inhibitor for solid tumors, through ongoing clinical development and toward Phase 2. The funding will also support the company’s second program, expected to enter the clinic in 2027, and accelerate the development of additional programs in oncology and autoimmune diseases. In addition, the financing enhances BridGene’s capacity to expand strategic collaborations and further validate the broad applicability of its proprietary IMTAC chemoproteomic platform across oncology, immunology, and neurology.

"Our recent financing provides important resources to advance our lead program, BGC-515, a covalent TEAD inhibitor, through Phase 2 clinical development," said Ping Cao, Ph.D., CEO and co-founder of BridGene Biosciences. "This funding will also enable us to progress additional pipeline programs toward the clinic and further expand the reach of our IMTAC chemoproteomic platform through strategic collaborations, as we continue to translate our discoveries into transformative therapies for patients."

"We are excited to lead this financing round for BridGene Biosciences," said Yuexing Su, Founding Partner of Bayland Capital. "BridGene’s IMTAC platform represents a powerful and differentiated approach to drug discovery, enabling the company to discover small molecules against traditionally undruggable targets. With a growing pipeline led by the covalent TEAD inhibitor BGC-515 and multiple follow-on programs across oncology and autoimmune diseases, we believe BridGene is well positioned to deliver transformative therapies to patients and generate substantial value in the biopharmaceutical field."

(Press release, Bridgene Biosciences, JAN 27, 2026, View Source [SID1234662302])

Preclinical Results of the Anti-CTLA-4 Switch Antibody ROSE12 Published in the Journal for ImmunoTherapy of Cancer

On January 27, 2026 Chugai Pharmaceutical Co., Ltd. (TOKYO: 4519) reported that the preclinical study results of ROSE12, an anti-CTLA-4 switch antibody discovered by Chugai and currently being evaluated in a Phase I clinical study in patients with solid tumors, have been published in the Journal for ImmunoTherapy of Cancer. The Journal for ImmunoTherapy of Cancer is a prestigious academic journal in the field of cancer immunotherapy, published by the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper).

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"ROSE12, a novel anti-CTLA-4 FcγRs binding-enhanced antibody activated by extracellular adenosine triphosphate, shows tumor selective regulatory T-cell depletion and antitumor efficacy without systemic immune activation"
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This study demonstrated the following:

ROSE12, an anti-CTLA-4 antibody that binds to CTLA-4 in an ATP-dependent manner and selectively depletes Tregs in tumors where ATP is present at high concentrations, was discovered
ROSE12 binds to CTLA-4 in the presence of ATP, exhibits antibody-dependent cellular cytotoxicity (ADCC) activity, and depletes Tregs. In contrast, ROSE12 does not bind to CTLA-4 or exhibit activity in the absence of ATP (in vitro studies)
ROSE12 demonstrated antitumor efficacy in mouse models bearing multiple cancer cell lines, including those resistant to existing immune checkpoint inhibitors (mouse studies)
ROSE12 reduced systemic immune reactions mediated by mechanisms such as Treg depletion in normal tissues (mouse studies)
ROSE12 was confirmed to be tolerable in toxicity studies using monkeys
About ROSE12
ROSE12 is an anti-CTLA-4 switch antibody utilizing Chugai’s proprietary antibody engineering technology, Switch-Ig. It is designed to recognize adenosine triphosphate (ATP), which is known to be present at high concentrations in tumor tissues, as a switch molecule to become activated and selectively deplete regulatory T cells (Tregs) that highly express CTLA-4. Phase I clinical study in patients with solid tumors is currently underway to demonstrate that ROSE12 exerts antitumor efficacy while avoiding systemic immune-related adverse events through its tumor-selective mechanism of action.
ROSE12 was discovered using Chugai’s drug discovery technologies, originating from the joint research project with Professor Shimon Sakaguchi, Distinguished Honorary Professor of the University of Osaka and Specially Appointed Professor at the Immunology Frontier Research Center (IFReC), a leading authority in Treg research.

About Switch-Ig
Switch-Ig is a technology that enhances the disease site selectivity of antibodies. Conventional antibodies can bind to target antigens not only at disease sites but also in normal tissues, potentially causing problems such as adverse events. Switch-Ig antibodies are designed to bind to target antigens in the presence of molecules (switch molecules) that are selectively present at high concentrations at disease sites, and are less likely to react with target antigens in normal tissues where the concentration of switch molecules is low. By using this technology, antibodies can be made to react selectively at disease sites, which is expected to reduce toxicity issues caused by binding to normal tissues.

About Regulatory T Cells (Tregs)
Tregs play a central role in immune suppression and are one of the important target cells in cancer immunotherapy. The primary role of Tregs is to regulate the activity of other immune cells. For example, they suppress excessive immune responses. However, reduced Treg function can disrupt the balance of the immune system, potentially leading to autoimmune diseases, such as IPEX syndrome*, rheumatoid arthritis, type-1 diabetes, and multiple sclerosis. Conversely, overactive Tregs can suppress antitumor immune responses, potentially worsening cancer.

(Press release, Chugai, JAN 27, 2026, View Source;category= [SID1234662299])