Sonnet BioTherapeutics Announces Pricing of $4.55 Million Underwritten Public Offering

On October 25, 2023 Sonnet BioTherapeutics Holdings, Inc. (NASDAQ:SONN) ("we," "us," "our," "Sonnet" or the "Company"), a clinical-stage company developing innovative targeted biologic drugs, reported the pricing of an underwritten public offering of 2,843,750 shares of common stock (or pre-funded warrants to purchase shares of common stock in lieu of shares of common stock) and investor warrants to purchase up to an aggregate of 5,687,500 shares of common stock (Press release, Sonnet BioTherapeutics, OCT 25, 2023, View Source [SID1234636333]). Each share of common stock (or pre-funded warrant in lieu thereof) is being sold together with two investor warrants at a combined offering price of $1.60, for total gross proceeds of approximately $4.55 million, before underwriting discounts and commissions and offering expenses payable by Sonnet. Each investor warrant is exercisable for one share of common stock at an exercise price of $1.60 per share for a period of five years from the date of issuance. The offering is expected to close on or about October 27, 2023, subject to the satisfaction or waiver of customary closing conditions. The offering is being led by existing investors.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Chardan and Ladenburg Thalmann & Co. Inc. are acting as joint book-running managers in connection with the offering.

Sonnet anticipates using the net proceeds from the offering for research and development, including clinical trials, working capital and general corporate purposes.

The securities will be offered pursuant to a registration statement on Form S-1, as amended (File No. 333-274581), which was declared effective by the Securities and Exchange Commission (the "SEC") on October 24, 2023. The offering is being made solely by means of a prospectus. A preliminary prospectus relating to and describing the terms of the offering has been filed with the SEC and is available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus and, when available, copies of the final prospectus relating to this offering can be obtained at the SEC’s website at www.sec.gov or from Chardan Capital Markets, LLC, 17 State Street, Suite 2130, New York, New York 10004, at (646) 465-9000, or by email at [email protected] or by contacting Ladenburg Thalmann & Co. Inc., Prospectus Department, 640 Fifth Avenue, 4th Floor, New York, New York 10019 or by email at [email protected].

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction.

Sensei Biotherapeutics to Present Initial Clinical Data from Dose Escalation Trial of SNS-101 at 2023 SITC Annual Meeting

On October 25, 2023 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), a clinical stage immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer patients, reported that it will present initial safety and pharmacokinetic monotherapy clinical data from its Phase 1/2 trial of SNS-101, a conditionally active, human monoclonal antibody targeting the immune checkpoint VISTA (V-domain Ig suppressor of T cell activation), in a late-breaking poster presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 38th Annual Meeting, being held in San Diego, Calif., from November 1 – 5, 2023 (Press release, Sensei Biotherapeutics, OCT 25, 2023, View Source [SID1234636332]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Presentation Details:

Title: A phase 1/2 study of safety, tolerability, and pharmacokinetics of SNS-101, a pH-sensitive anti-VISTA mAb, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors
Presentation Type: Poster (late-breaking abstract)
Abstract Number: 1532
Date and Time: Saturday, November 4, 2023, at 9 a.m. PT – 8:30 p.m. PT
Location: Exhibit Halls A and B1 – San Diego Convention Center
Lead authors: Shiraj Sen, M.D., Ph.D. and F. Donelson Smith, Ph.D.

A copy of the presentation materials will be added to the "Events & Presentations" section of the Company’s Investor Relations website at www.senseibio.com following the presentation.

Regeneron Announces Investor Conference Presentations

On October 25, 2023 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) reported that it will webcast management participation as follows (Press release, Regeneron, OCT 25, 2023, View Source [SID1234636331]):

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

BMO Biopharma Spotlight Series: Oncology at 9:30 a.m. ET on Wednesday, November 8, 2023

Truist Securities BioPharma Symposium at 3:20 p.m. ET on Wednesday, November 8, 2023

UBS Biopharma Conference at 11:00 a.m. ET on Thursday, November 9, 2023

Jefferies London Healthcare Conference at 2:30 p.m. GMT (9:30 a.m. ET) on Wednesday, November 15, 2023

The sessions may be accessed from the "Investors & Media" page of Regeneron’s website at View Source Replays and transcripts of the webcasts will be archived on the Company’s website for at least 30 days.

Panbela reported acceptance of Polyamine Inhibitor CAR-T Combination Abstract for Online Publication

On October 25, 2023 Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical stage company developing disruptive therapeutics for the treatment of patients with urgent unmet medical needs, reported that an abstract about SBP-101 and CPP1X (also known as DFMO or Eflornithine) research in multiple myeloma (cell lines), has been accepted for an online publication on the American Society of Hematology (ASH) (Free ASH Whitepaper) meeting site in the November supplemental issue of the journal Blood (Press release, Panbela Therapeutics, OCT 25, 2023, https://panbela.com/press-release/acceptance-of-polyamine-inhibitor-car-t-combination-abstract-for-online-publication/?utm_source=rss&utm_medium=rss&utm_campaign=acceptance-of-polyamine-inhibitor-car-t-combination-abstract-for-online-publication [SID1234636330]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The work reflects the company’s on-going collaboration with researchers from The University of Texas MD Anderson Cancer Center and will become part of the permanent ASH (Free ASH Whitepaper) and Blood abstracts archive.

• Additional meeting information can be found on the ASH (Free ASH Whitepaper) website: View Source

• The abstract will also be available on the company’s website at View Source once the information has been released by ASH (Free ASH Whitepaper).

Larkspur Biosciences to Present New Mechanistic Data on the Role of Pin1 in Modulating the Fibroblast – Cancer Axis at SITC 2023

On October 25, 2023 Larkspur Biosciences, a biotechnology company building precision therapies to outsmart cancer, reported that data supporting development of a novel investigational therapy targeting Pin1 will be featured in a poster presentation at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) (SITC 2023) on November 3 in San Diego, CA (Press release, Larkspur Biosciences, OCT 25, 2023, View Source [SID1234636329]). The data look at how the potential therapy will target Pin1 to program fibroblasts to drive a pro-immune response at the tumor.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Larkspur Biosciences was founded to pursue targets shared by cancer and immune cells that the cancer hijacks to evade immunity. Our data at SITC (Free SITC Whitepaper) 2023 demonstrates that Pin1 is a promising cancer–fibroblast target to pursue for therapeutic interventions," said Catherine Sabatos-Peyton, PhD, CEO of Larkspur Biosciences. "Standard of care immunotherapy has revolutionized cancer treatment, but less than 30 percent of patients respond. At Larkspur, we believe there is an opportunity to leverage targets shared by both the cancer and the immune system as a more effective way to activate the immune system against cancer."

Presentation Details:

Poster: Abstract 1433
Title: "Targeting peptidyl-prolyl isomerase Pin1 to modulate cancer-associated fibroblast phenotype and TGF-beta signaling "
Time: Friday, November 3, 12-1:30pm and 5:10-6:40pm PT
Location: San Diego Convention Center, Exhibit Halls A and B1
Presenter: Melvyn Chow, PhD, Associate Director, Biology, Larkspur Biosciences