On October 9, 2023 Kaiyue Life reported the company and other institutions jointly published a paper titled "Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents" in the classic journal of medicinal chemistry, Bioorganic and Medicinal Chemistry Letters (BMCL) (Press release, KeYe Life Technologies, OCT 9, 2023, View Source;article_id=84 [SID1234644610]).

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Recently, a collaborative paper titled "Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents" co-authored by Kaiyue Life Sciences, the University of Macau, Southern University of Science and Technology, and Heya Pharmaceuticals was published online in BMCL, a long-established journal of medicinal chemistry.

The RNA helicase DHX33 has been identified as a key player in promoting cancer development. Genetic deletion of DHX33 significantly blocks tumorigenesis. Importantly, its helicase activity was found to be critical for exerting cellular functions. In this study, a helicase-based high-throughput screening (HTS) technique was used to discover DHX33 inhibitors from the Chembridge chemical library containing 15,000 small molecules. We discovered a lead compound containing a benzimidazole ring that showed some selectivity for DHX33. Further structural optimization led to the design and synthesis of a series of mimetic inhibitors. Considering the potential role of DHX33 in cancer development, we evaluated these compounds based on their cytotoxic activity against U251-MG cancer cells in vitro. Among them, compound IVa (KY386) was identified as a selective inhibitor of DHX33 helicase with strong anticancer activity and moderate metabolic stability. These results support the important role of DHX33 inhibitors in the development of novel anticancer drugs.

On October 9, 2023 InCephalo AG reported the company , University of Basel and VitroScan receive a competitive Eurostars grant (€2.3M) to accelerate the development of promising new drugs for Glioblastoma patients – CLEIO (Press release, InCephalo Therapeutics, OCT 9, 2023, View Source [SID1234644133]).

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The consortium led by InCephalo AG has received the competitive Eurostar grant. The Swiss – Dutch consortium consist of three collaborating partners: InCephalo AG, University of Basel and VitroScan.
In the CLEIO project: The first-in-kind Compartment Locked and Effective ImmunOtherapy against glioblastoma, the consortium will: i) study the effect of InC01 (InCephalo’s primary asset) treatment on established ex- vivo GBM models based on patient tissue, ii) discover new biomarkers for the response and non-response of InC01, and iii) drive clinical Phase II trial design through stratification of patient populations.

«We are excited to receive this grant as will allow us to de-risk our
clinical development at such an early stage» says Dr. Carlo Bertozzi,
CEO and co-founder of InCephalo.

Willemijn Vader, CEO VitroScan:

«It is a great opportunity for VitroScan to collaborate with these partners and integrate our expertise to develop predictive tools for new novel treatment options for glioblastoma patients».

Prof. G. Hutter, Neurosurgeon and Group leader at both the Unversity of Basel and the University Hospital in Basel:

«As a treating physician, I see that novel therapeutic modalities are needed for brain cancer patients. In this collaboration, we are actively working to push InC01, a promising new modality, closer to the patient and on the way learn more about which patients are more likely to react».

On October 9, 2023 Coeptis Therapeutics Holdings, Inc. (NASDAQ: COEP) ("Coeptis" or "the Company"), a biopharmaceutical company developing innovative cell therapy platforms for cancer, reported that Dan Yerace, Director and Vice President of Operations, will participate in a panel titled, "Ambitious Innovation: Emerging Cell and Gene Therapies," at the BioFlorida Conference on Thursday October 12th from 11:50 AM-12:50 PM (Press release, Coeptis Therapeutics, OCT 9, 2023, View Source [SID1234635732]).

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Details of the panel discussion are as follows:

Event:

BioFlorida Conference

Date & Time:

October 12, 2023, at 11:50 AM, EDT

Panel Title

Ambitious Innovation: Emerging Cell and Gene Therapies

Location:

Sawgrass Marriott Golf Resort & Spa, Ponte Vedra Beach, FL

On October 9, 2023 Ossium Health reported that Kevin Caldwell, CEO, Co-Founder & President, will present at the annual Cell & Gene Meeting on the Mesa to be held October 10-12 in Carlsbad, California and live streamed globally (Press release, Ossium Health, OCT 9, 2023, View Source [SID1234635731]).

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Organized by the Alliance for Regenerative Medicine, the Cell & Gene Meeting on the Mesa is a three-day conference featuring more than 120 dedicated company presentations by leading public and private companies, highlighting technical and clinical achievements over the past 12 months in the areas of cell therapy, gene therapy, gene editing, tissue engineering, and broader regenerative medicine technologies, as well as over 100 panelists and featured speakers.

Kevin will provide attendees with a first glimpse inside Ossium’s landmark clinical study recently launched in collaboration with the National Marrow Donor Program (NMDP) / Be The Match. This study’s initiation serves as a major milestone for the blood cancer community as it will provide safety and efficacy data on Ossium’s bone marrow and unlock a new source of on-demand bone marrow for patients. In addition, Kevin will provide an update on Ossium’s phase 1 study of allogeneic bone marrow-derived cell therapy for the treatment of steroid-refractory acute graft versus host disease and Ossium’s upcoming launch of OssiGraft, a next-generation viable bone allograft.

The following are specific details regarding Ossium Health’s presentation at the conference:

Event: 2023 Cell & Gene Meeting on the Mesa

Date: Wednesday, October 11, 2023

Time: 5:15 – 5:30 pm Pacific Time

Location: Ecolab Life Sciences Ballroom
Park Hyatt Aviara Resort, 7100 Aviara Resort Dr., Carlsbad, CA 92011

Virtual attendance is available which includes a livestream of Ossium Health’s presentation and the ability to view all conference sessions on-demand. Please visit View Source for full information including registration.

Complimentary attendance at this event is available for credentialed investors and members of the media only. Investors should contact Savannah Bryant at [email protected] and interested media should contact Stephen Majors at [email protected].

On October 9, 2023 Circle Pharma, a biopharmaceutical company advancing the discovery and development of intrinsically cell-permeable macrocycles, reported an upcoming poster presentation at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), taking place from October 11-15, 2023, in Boston, MA (Press release, Circle Pharma, OCT 9, 2023, View Source [SID1234635730]).

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Details of the presentation are as follows:
Title:

Novel orally bioavailable macrocycles that target cyclin A and B elicit antitumor activity in breast cancer patient-derived xenograft models

Presenter:

Mariana Paes Dias, Vall d’Hebron Institute of Oncology, Barcelona, Spain

Abstract Number:

LB_C04

Session:

Poster Session C

Date/Time:

Saturday, Oct. 14, 12:30-4:00 p.m.

ABOUT CIRCLE PHARMA’S CYCLIN A/B INHIBITOR PROGRAM

Circle Pharma has developed an orally bioavailable macrocycle with dual cyclin A and B inhibitory activity that drives synthetic lethality in multiple tumor types. In biochemical and cellular studies, Circle’s cyclin A/B inhibitor has been shown to potently and selectively disrupt the protein-protein interaction between Cyclins A and B and their key substrates, including E2F (a substrate of Cyclin A) and Myt1 (a substrate of Cyclin B). Preclinical studies have demonstrated the ability of these cyclin A/B inhibitors to cause pronounced tumor regression in multiple xenograft models. Circle Pharma plans to file an investigational new drug (IND) application with the U.S. Food and Drug Administration (FDA) for its clinical candidate, CID-078, and initiate clinical development in 2024.