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IMV to Showcase its DPX® Delivery Technology in Two Presentations at the AACR Annual Meeting 2022

On March 9, 2022 IMV Inc. (Nasdaq: IMV; TSX: IMV), a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, reported that the Company will showcase its DPX delivery technology in two presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana (Press release, IMV, MAR 9, 2022, View Source [SID1234609763]).

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"Data to be presented suggest that our DPX delivery platform instructs an innate immune response involving NK cells in addition to the previously recognized role for T and B cells," said Jeremy Graff, Ph.D., Chief Scientific Officer at IMV Inc. "This finding supports our clinical strategy to combine our lead compound with other therapies that have a complementary mechanism of action to increase tumor destruction while preserving a favorable safety profile." Translational research using both clinical samples from the DeCidE ovarian cancer trial and tissues from pre-clinical models will be presented showing for the first time that natural killer (NK) cells play a distinct role in promoting anti-tumor responses to the company’s lead DPX-peptide immunotherapeutic, Maveropepimut-S.

In an oral presentation in a late-breaking session about immunotherapeutic combinations, Dr. Olivier Rixe will present safety and efficacy data from the IMV Phase 2 basket study evaluating MVP-S in combination with pembrolizumab and cyclophosphamide in patients with advanced, metastatic bladder cancer. Presentations Details Dr. Rixe and members from the IMV team will attend the conference and both presentations will be available on the conference platform and on the IMV website under the Scientific Publications & Posters section.

NK cells are involved in promoting anti-tumor responses to DPX-peptide immunotherapy

Presenter: Moamen Bydoun, Ph.D., Senior Research Scientist at IMV
Poster Number: 623
Date/Time: Sunday Apr. 10, 2022, 1:30 p.m. – 5:00 p.m. CST

Safety, preliminary efficacy and pharmacodynamic (PD) analysis of maveropepimut-S, intermittent low-dose cyclophosphamide and pembrolizumab in patients with advanced, metastatic bladder cancer

Presenter: Olivier Rixe, M.D., Ph.D., Quantum Santa Fe, New Mexico
Session Title: Immunotherapy Combination Strategies in Clinical Trials
Presentation Number: CT035
Session Date and Time: Tuesday Apr. 12, 2022, 2:30 p.m. – 4:30 p.m. CST

Portage Biotech Announces Presentation of PORT-5 (STI-001) Late-Breaking Data at AACR 2022 Annual Meeting

On March 9, 2022 Portage Biotech Inc. (NASDAQ: PRTG) ("Portage" or the "Company"), a clinical-stage immuno-oncology company developing therapies to improve patient lives and increase survival by avoiding and overcoming cancer treatment resistance, and Stimunity, an early-stage biotech company focused on the development of a unique STING agonist based on virus-like particles, reported data from a collaboration on a STINGactivating therapy, PORT-5 (STI-001) will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2022 Annual Meeting taking place April 8-13, 2022, in New Orleans, Louisiana (Press release, Portage Biotech, MAR 9, 2022, View Source [SID1234609762]).

"The stimulator of interferon genes (STING) pathway is a well-recognized immune-boosting pathway and has long been an area of interest in cancer treatment, but STING-activating therapies have historically been limited in clinical trials due to delivery challenges," said Dr. Ian Walters, chief executive officer of Portage. "We are grateful that the scientific committee found the research on our systemically delivered STING-based therapy, PORT-5, to be highly significant and timely to be included in the late-breaking session for AACR (Free AACR Whitepaper) and look forward to sharing further updates in the coming months."

Presentation Details
Abstract Title: Cellular selectivity of STING stimulation determines priming of anti-tumor T cell responses
Abstract Number: 7829
Presenter: Bakhos Jneid, Institut Curie
Session Title: Late-Breaking Research: Experimental and Molecular Therapeutics 2
Session Date/Time: April 13, 2022, 9:00am – 12:30pm CT
Location: Poster Section 16

Vaccinex, Inc. Announces Upcoming Presentation at the 2022 American Association for Cancer Research Meeting Updating the Phase 1b Segment of the KEYNOTE-B84 Study of Pepinemab in Combination with KEYTRUDA (pembrolizumab) in Patients with Recurrent or Meta

On March 9, 2022 Vaccinex, Inc. (Nasdaq: VCNX), a clinical-stage biotechnology company pioneering a differentiated approach to treating cancer and neurodegenerative disease through the inhibition of SEMA4D, reported that it has been selected for poster presentation related to the phase 1b segment of its KEYNOTE-B84 study of pepinemab in combination with KEYTRUDA (pembrolizumab) in patients with recurrent or metastatic head and neck cancer during the upcoming 2022 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Meetings (2022 AACR (Free AACR Whitepaper)), taking place from April 8th to April 13th in New Orleans via in person and virtual attendance (Press release, Vaccinex, MAR 9, 2022, View Source [SID1234609761]).

Details are shown below:
Abstract title: Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE B84)
Presenter: Terrence Fisher, PhD, VP Clinical Science
Abstract: CT111
Session: Phase II Clinical Trials 1
Date and Time: Monday Apr 11, 2022 9:00 AM – 12:30 PM, CST
Venue: New Orleans Ernest N. Morial Convention Center, New Orleans, LA, USA

Vaccinex has global commercial and development rights to pepinemab, and is sponsor of the KEYNOTE-B84 study which is being performed in collaboration with Merck Sharp & Dohme Corp, a subsidiary of Merck and Co, Inc. Kenilworth, NJ, USA. Additional information about the study is available at: clinicaltrials.gov link.

KEYTRUDA is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co. Inc., Kenilworth, NJ, USA.

About Pepinemab
Pepinemab is a humanized IgG4 monoclonal antibody that inhibits SEMA4D, which regulates tumor immunity. Preclinical and clinical data show that pepinemab promotes infiltration/activation of dendritic cells/ CD8+ T-cells and reverses immunosuppression within the tumor.

Results of a Phase 1b/2 study to evaluate the combination of pepinemab with checkpoint inhibitor, BAVENCIO, avelumab (Merck KGaA) were presented at ASCO (Free ASCO Whitepaper) 2020 and were highlighted in the July 2021 publication of Clinical Cancer Research. Vaccinex reported that results of the Phase 1b/2 CLASSICAL-Lung trial showed a 25-33% Overall Response Rate (ORR) for patients with difficult to treat PD-L1 low/negative tumors treated with combination therapy and highlighted reason to anticipate a potentially greater response in cancer indications with higher levels of myeloid suppressor cells including R/M HNSCC. The study report also indicated that pepinemab did not increase immune-related toxicities of BAVENCIO but increased penetration of cytotoxic T cells. The publication is available electronically at: Clinical Cancer Research.

Infinity Pharmaceuticals to Present at the 32nd Annual Oppenheimer Healthcare Conference

On March 9, 2022 Infinity Pharmaceuticals, Inc. (NASDAQ: INFI), a clinical-stage biotechnology company developing eganelisib, a first-in-class, oral, immuno-oncology macrophage reprogramming therapeutic, reported that management will be presenting a corporate overview and participating in 1-on-1 meetings in the 32nd Annual Oppenheimer Healthcare Conference taking place virtually on March 16th, 2022 (Press release, Infinity Pharmaceuticals, MAR 9, 2022, View Source [SID1234609760]).

32nd Annual Oppenheimer Healthcare Conference (virtual)

Date: March 16th, 2022

Time: 2:40pm – 3:10pm ET

Speaker: Adelene Perkins, Chief Executive Officer

Format: Company Presentation

Webcast Registration Link.

*a replay will be available following the presentation for 90 days

Jane Huang, M.D., Joins Prelude Therapeutics as President and Chief Medical Officer

On March 9, 2022 Prelude Therapeutics Incorporated (Nasdaq: PRLD) a clinical-stage precision oncology company, reported that Jane Huang, M.D., has been appointed to the newly created position of President and Chief Medical Officer, effective on April 4, 2022 (Press release, Prelude Therapeutics, MAR 9, 2022, View Source [SID1234609759]). Dr. Huang is currently Chief Medical Officer, Hematology, at BeiGene, Ltd., a global, science-driven biotechnology company developing oral small molecules and monoclonal antibodies for cancer.

"We are pleased to announce that Dr. Huang will be joining Prelude. Jane’s deep experience in oncology drug development and her strategic leadership throughout the lifecycle of multiple products resulting in successful global regulatory approvals will be of great value to Prelude," stated Kris Vaddi, Ph.D., Chief Executive Officer of Prelude.

Dr. Vaddi added, "With multiple distinct precision oncology programs underway, our growing pipeline offers tremendous promise. I am confident in Jane’s ability to build and lead high-performing cross-functional clinical development teams, and her strong relationships and recognized leadership within the cancer research community will be instrumental in achieving our goals to rapidly advance compounds through proof-of-concept and into potential registration trials."

"I am impressed by the strong execution of the Prelude R&D team and its ability to bring multiple proprietary and potentially best-in-class small molecule compounds forward. Their strategic selection of clinically relevant targets involved in many underserved cancers is equally impressive. This level of performance gives me confidence that Prelude is uniquely resourced to make a meaningful difference in the lives of cancer patients," stated Dr. Huang.

Most recently, Dr. Huang served as Chief Medical Officer of Hematology at BeiGene, Ltd. where she created a global development organization encompassing clinical pharmacology to global product safety and had strategic oversight of the development of five hematology medicines. During her tenure with BeiGene, she oversaw the approval of zanubrutinib in three diseases spanning more than 45 countries and was responsible for the first approval of tislelizumab in Hodgkin’s lymphoma. Prior to joining BeiGene in 2016, Dr. Huang served as Vice President, Clinical Development at Acerta Pharma, where she oversaw global clinical development of the BTK inhibitor, acalabrutinib. Prior to this, she worked at Genentech, where she played a leading role in drug development programs for multiple therapies throughout all stages of development, including, Rituxan, Avastin, Kadcyla, Venclexta and Gazyva. She is board certified in hematology, oncology, and internal medicine and is Adjunct Clinical Assistant Professor at Stanford University. Dr. Huang was recently named one of the 20 most influential women in biopharma R&D by Endpoints News.