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Aura Biosciences to Present Preclinical Data Highlighting AU‑011’s Potential to Target a Broad Number of Tumor Types at the 2022 AACR Annual Meeting

On March 8, 2022 Aura Biosciences Inc. (NASDAQ: AURA), a clinical-stage biotechnology company developing a novel class of virus-like drug conjugate (VDC) therapies for multiple oncology indications, reported the presentation of preclinical data for its first VDC product candidate, AU-011 which is being developed for the treatment of life-threatening cancers with high unmet need, including primary choroidal melanoma and non-muscle invasive bladder cancer (Press release, Aura Biosciences, MAR 8, 2022, View Source [SID1234609710]). The results demonstrate the potential wide applicability of AU-011 in targeting a number of solid tumor types and will be presented as part of the 2022 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, being held April 8-13, 2022 in New Orleans, LA.

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"The data that will be presented at AACR (Free AACR Whitepaper) provide evidence for AU-011’s activity in tumors that express specifically modified heparan-sulfate proteoglycans on the tumor cell surface. Activity was observed in every tumor type tested, indicating that there are numerous solid tumors we can consider to expand the clinical development of AU-011, including those derived from neural or epithelial lineages," said Dr. Cadmus Rich, Chief Medical Officer and Head of R&D of Aura Biosciences. "The correlative gene expression analysis has deepened our understanding of the genes and biological pathways involved in the expression of HSPGs by different types of tumor cells."

Details for the poster presentation are as follows:

Title: Biological Assessment of the Virus-Like Drug Conjugate AU-011 to Specifically Target a Breadth of Human Cancer Types
Presenter: Rhonda Kines, Aura Biosciences
Poster Session: ETO1 Drug Discovery
Date and time: April 8, 2022, 1:00 PM ET
Location: E-poster
Session Category: Experimental and Molecular Therapeutics
Session Title: Drug Discovery
Abstract Number: 5331

Asher Bio to Showcase Continued Progress with Lead Program AB248 and Growing Pipeline of Precisely-Targeted Immunotherapies at AACR Annual Meeting 2022

On March 8, 2022 Asher Biotherapeutics, a biotechnology company developing precisely-targeted immunotherapies for cancer, autoimmune, and infectious diseases, reported plans to present new data for multiple research programs across its portfolio of cis-targeted immunotherapies at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022, being held in New Orleans, Louisiana, April 8-13, 2022 (Press release, Asher Biotherapeutics, MAR 8, 2022, View Source [SID1234609709]).

The presentations provide additional data supporting the best-in-class potential of AB248, Asher Bio’s CD8-targeted IL-2 immunotherapy, and further validate the company’s cis-targeting platform, demonstrating its ability to rapidly generate highly selective molecules that target multiple immunomodulators to a diverse set of immune cell types. Asher Bio expects to file an investigational new drug application for AB248, its CD8-targeted IL-2 immunotherapy, in the third quarter of 2022 and for AB821, its CD8-targeted IL-21 immunotherapy, in the second half of 2023.

Details of the poster presentations are as follows:

Presentation Title: AB248 is a CD8+ T cell selective IL-2 designed for superior safety and anti-tumor efficacy
Session Title: Immunomodulatory Agents and Interventions 2
Session Date & Time: Tuesday, April 12, 2022 from 1:30 p.m. – 5:00 p.m. CT (11:30 a.m. – 3:00 p.m. PT)
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 37
Abstract Number: 3518

Title: Selective activation of CD8+ T cells by a CD8-targeted IL-21 results in enhanced anti-tumor efficacy and safety
Session Title: Therapeutic Antibodies 1
Session Date & Time: Tuesday, April 12, 2022 from 9:00 a.m. – 12:30 p.m. CT (7:00 a.m. – 10:30 a.m. PT)
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 37
Abstract Number: 2882

Title: CAR-targeted IL-2 drives selective CAR-T cell expansion and improves anti-tumor efficacy
Session Title: Adoptive Cell Therapy 1
Session Date & Time: Sunday, April 10, 2022 from 1:30 p.m. – 5:00 p.m. CT (11:30 a.m. – 3:00 p.m. PT)
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 36
Abstract Number: 561

The abstracts are now available on the AACR (Free AACR Whitepaper) conference website.

Arcus Biosciences Presents Data from its Pipeline at Multiple Scientific Conferences

On March 8, 2022 Arcus Biosciences, Inc. (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focused on developing differentiated molecules and combination therapies for people with cancer, reported several poster presentations at upcoming scientific conferences that support the ongoing investigation of its clinical and preclinical pipeline (Press release, Arcus Biosciences, MAR 8, 2022, View Source [SID1234609708]).

"Scientific exchange fosters progress in research, and we value the opportunity to contribute to the advancement of cancer research by presenting early data that support the clinical approach to investigating our molecules," said Terry Rosen, Ph.D., Chief Executive Officer of Arcus. "The AB521 data presented at the ESMO (Free ESMO Whitepaper) TAT Congress confirm its potential to have an improved clinical profile compared to that of the approved HIF-2a inhibitor; we plan to advance this molecule into a Phase 1/1b study in patients with clear-cell renal cell carcinoma in mid-2022. Etrumadenant, quemliclustat and zimberelimab are already being investigated in randomized and late-stage studies across common cancers like colon, lung, pancreas and prostate."

ESMO Targeted Anticancer Therapies Congress, March 7-8, 2022

Title: AB521, a Clinical-Stage, Potent, and Selective Hypoxia-Inducible Factor (HIF)-2α Inhibitor, for the Treatment of Renal Cell Carcinoma
Abstract number: 252

American Society for Clinical Pharmacology & Therapeutics (ASCPT), March 16-18, 2022

Title: A Mechanistic Pharmacokinetic-Pharmacodynamic (PK-PD) Model of Quemliclustat (AB680), a Small-Molecule Inhibitor of CD73, in Healthy Volunteers and Patients with Gastrointestinal Malignancies
Abstract number: P-102

Title: Population Pharmacokinetics and Pharmacodynamics of Etrumadenant (AB928) in Healthy Volunteers and Cancer Patients
Abstract number: P-196

Title: Population Pharmacokinetics of Zimberelimab (AB122) and Dose Justification by Model Informed Drug Development (MIDD) Approach
Abstract number: P-032

American Association for Cancer Research, April 8-13, 2022

Title: Inhibition of CD39 Results in Elevated ATP and Activation of Myeloid Cells to Promote Anti-Tumor Immunity
Abstract number: 4151

Title: Dual A2aR/A2bR Antagonism with Etrumadenant (AB928) Eliminates the Suppressive Effects of Adenosine on Immune and Cancer Cells in the Tumor Microenvironment
Abstract number: 2728

Title: HPK1 Inhibition Enhances T Cell Activation and Relieves the Immunosuppressive Phenotype of Inhibitory Signals Found in the Tumor Microenvironment
Abstract number: 5762

Arcus Clinical Study Overview

Trial
Name

Arms

Setting

Status

NCT No.

Lung Cancer

ARC-7

zim vs. zim + dom vs. zim +
dom + etruma

1L NSCLC (PD-L1 ≥ 50%)

Ongoing
Randomized
Phase 2

NCT04262856

PACIFIC-8

durva ± dom

Curative-Intent Stage 3 NSCLC

Ongoing
Registrational
Phase 3

NCT05211895

ARC-10

chemo vs. zim vs. zim + dom

1L NSCLC (PD-L1 ≥ 50%)

Ongoing
Registrational
Phase 3

NCT04736173

Colon Cancer

ARC-9

etruma + zim + mFOLFOX vs.
SOC

2L/3L/3L+ CRC

Ongoing
Randomized
Phase 2

NCT04660812

Pancreatic Cancer

ARC-8

quemli + zim + gem/nab-pac
vs. quemli + gem/nab-pac

1L, 2L PDAC

Ongoing
Randomized
Phase 1/1b

NCT04104672

Prostate Cancer

ARC-6

etruma + zim + SOC vs. SOC

2L/3L CRPC

Ongoing
Randomized
Phase 2

NCT04381832

Various

ARC-12

AB308 + zim

Advanced Malignancies

Ongoing
Phase 1/1b

NCT04772989

ARC-14

AB521

Healthy Volunteer

Ongoing
Phase 1

NCT05117554

Carbo/pem: carboplatin/pemetrexed; dom: domvanalimab; durva: durvalumab; etruma: etrumadenant; gem/nab-pac: gemcitabine/nab-paclitaxel; quemli: quemliclustat; R/R: relapsed/refractory; SOC: standard of care; zim: zimberelimab CRC: colorectal cancer; CRPC: castrate-resistant prostate cancer; NSCLC: non-small cell lung cancer; PDAC: pancreatic ductal adenocarcinoma

Scorpion Therapeutics to Present Mutant-Selective PI3Kα Program at AACR Annual Meeting 2022

On March 8, 2022 Scorpion Therapeutics, Inc. ("Scorpion Therapeutics"), a pioneering oncology company redefining the frontier of precision medicine through its Precision Oncology 2.0 strategy, reported that it will share preclinical proof-of-concept data for STX-H1047-PI3Kα, its lead program targeting the H1047X-mutant form of phosphoinositide 3-kinase alpha ("PI3Kα"), in a late-breaking poster presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) ("AACR") Annual Meeting 2022 in New Orleans, Louisiana, taking place April 8 – 13, 2022 (Press release, Scorpion Therapeutics, MAR 8, 2022, View Source [SID1234609707]).

"We are excited to present preclinical data demonstrating the potentially best-in-class profile of our lead program, STX-H1047-PI3Kα. PI3Kα is an established cancer target and one of the most highly mutated targets in cancer. However, approved therapeutic options are limited by significant metabolic side effects and an inability to treat tumors that have progressed into the central nervous system," said Axel Hoos, M.D., Ph.D., CEO of Scorpion Therapeutics. "Consistent with our Precision Oncology 2.0 strategy, we designed STX-H1047-PI3Kα to specifically address these limitations, in hopes of delivering safer and more effective medicines to patients living with certain solid tumors. We look forward to informing the oncology community of our progress during AACR (Free AACR Whitepaper), as we work towards submitting an investigational new drug application for STX-H1047-PI3Kα in 2023."

Details of the poster presentation are as follows:

Presentation Title: Discovery and Characterization of a Mutant Selective PI3KαH1047X Inhibitor with a Best-In-Class Profile
Session Title: Late-Breaking Research: Experimental and Molecular Therapeutics 2
Abstract Number: LB194
Poster Board Number: 7
Date & Time: Wednesday, Apr 13, 2022 at 9:00 a.m. – 12:30 p.m. CT (10:00 a.m. – 1:30 p.m. ET)
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 16

The abstract and poster presentation will be published online at 12:00 p.m. CT (1:00 p.m. ET) on April 8, 2022 on the AACR (Free AACR Whitepaper) website at www.aacr.org.

MEI Pharma Announces Acceptance of Two Abstracts for Presentation at the American Association for Cancer Research (AACR) Annual Meeting 2022

On March 8, 2022 MEI Pharma, Inc. (NASDAQ: MEIP), a late-stage pharmaceutical company focused on advancing new therapies for cancer, reported that two abstracts highlighting data from two oncology drug candidates in its pipeline will be presented at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022 to be held April 8 – 13, 2022 (Press release, MEI Pharma, MAR 8, 2022, View Source [SID1234609706]).

Details of the poster presentations:

Title: Efficacy and immune profiling of the PI3K delta inhibitor zandelisib (ME-401) in a preclinical model of chronic lymphocytic leukemia (CLL)
Authors: Dr. Maharaj, et. al.
Date: Friday, April 8, 2022, 8:30 AM ET
Abstract ID: 5496

Summary of results: data from preclinical studies with zandelisib ex vivo in normal human T cells and in vivo in a murine CLL model suggest that zandelisib has immunomodulatory properties on human T cells including decreased activation and expression of suppressive markers such as PD-1 and CTLA-4 on inducible regulatory (Tregs) and CD4+ T cells. In the murine CLL model, a reduction in Treg numbers, markers of terminal memory differentiation and T-cell exhaustion on CD4+ and CD8+ T cells, as well as improvement in overall survival was observed.

Title: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML
Authors: Katie Hurrish, et. al.
Date: Wednesday, April 13, 2022, 10:00 AM – 1:30 PM ET
Abstract ID: 3785

Summary of results: data from in vitro and in vivo preclinical studies evaluating the combination of ME-344 with venetoclax in standard-of-care-resistant acute myeloid leukemia (AML) cell lines and relapsed or refractory (R/R) AML patient samples suggest that ME-344, both alone and in combination with venetoclax, inhibits purine biosynthesis, suppresses oxidative phosphorylation, induces apoptosis and decreases Mcl-1, which together target metabolic vulnerabilities of AML cells.