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Phanes Therapeutics’ anti-CD47 antibody patent granted in the US

On August 2, 2022 Phanes Therapeutics, Inc. (Phanes), an emerging leader in innovative discovery research and clinical development in oncology, reported that the U.S. Patent and Trademark Office (USPTO) has granted the patent (Patent No. US 11,401,329) of its anti-CD47 antibodies (Press release, Phanes Therapeutics, AUG 2, 2022, View Source [SID1234617318]). The patent relates to the invention of anti-CD47 monoclonal antibodies and bispecific antibodies comprising an anti-CD47 arm, including PT886, an anti-claudin18.2/anti-CD47 bispecific antibody being developed for gastric and pancreatic cancers, and PT217, an anti-DLL3/anti-CD47 bispecific antibody being developed for the treatment of small cell lung cancer.

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Phanes has received clearance from the US FDA to commence Phase I studies with PT886 in June 2022 and expect to file IND with PT217 this year. Both PT886 and PT217 have been granted orphan drug designation from the FDA in June this year.

"This is the sixth Phanes patent granted this year." said Dr. Ming Wang, PhD, MBA, Founder and CEO of Phanes Therapeutics. "As Phanes expands from a research to a clinical development stage organization, we expect to have additional patent applications issued, further strengthening the intellectual property portfolio and competitiveness of our pipeline."

Evogene Financial Results and Earnings Announcement Schedule for the Second Quarter of 2022

On August 2, 2022 Evogene Ltd. (NASDAQ: EVGN) (TASE: EVGN), a leading computational biology company aiming to revolutionize life-science product development across several market segments, reported that it will release its financial results for the second quarter of 2022 on Wednesday, August 31, 2022 (Press release, Evogene, AUG 2, 2022, View Source [SID1234617317]).

On the day of the announcement, Company management will host a conference call to discuss the results at 9:00 AM Eastern time, 4:00 PM Israel time.

To access the conference call, please dial +1-888-281-1167 toll free from the United States, or +972-3-918-0609 internationally. Access to the call will also be available via live webcast through the Company’s website at www.evogene.com.

A replay of the conference call will be available approximately two hours following the completion of the call. To access the replay, please dial +1-888-326-9310 toll free from the United States, or +972-3-925-5901 internationally. The replay will be accessible through September 2, 2022, and an archive of the webcast will be available on the webcast link for the following twelve months.

Envisagenics is Awarded Another SBIR Grant From the National Cancer Institute to Commercialize its AI/ML Platform for Immunotherapy Development

On August 2, 2022 Envisagenics, Inc., a New York-based biotechnology company leveraging artificial intelligence (AI) and RNA-splicing analytics for discovery and development of disease specific therapeutics, reported that it was awarded a Small Business Innovation Research (SBIR) Direct to Phase II grant from the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) (Press release, Envisagenics, AUG 2, 2022, View Source [SID1234617315]). This grant will provide $2 million over 2 years to commercialize Envisagenics’ proprietary drug discovery platform, SpliceIOTM, for the discovery of novel targets for immuno-oncology (IO) therapeutic development. SpliceIO is one of the latest AI drug discovery platforms developed by Envisagenics, which complements the SpliceCore platform for the discovery of splicing drug targets using RNA-seq data.

"What the SpliceCore platform does for antisense drugs, SpliceIO is doing for IO drugs. SpliceIO discovers splicing-derived neoantigens for immunotherapies using RNA-seq data as a sole input," said Martin Akerman, Ph.D., Chief Technology Officer and Co-founder of Envisagenics. "This funding will help scale Envisagenics’ target pipeline by enabling validation of IO targets at the protein level, a critical step for advancing candidate targets to the next stage of development."

Envisagenics will apply its platform to identify splicing-derived neoantigens in BRCA1/2 carriers at-risk for developing breast cancer and develop a high-throughput approach to validate its findings using proteomic data. Within the scope of this grant, Envisagenics will collaborate with researchers at Northwestern University Feinberg School of Medicine: Dr. Seema Khan (Co-Leader of the Cancer Prevention Program of the Lurie Comprehensive Cancer Center and Bluhm Family Professor of Cancer Research) and Dr. Susan Clare (Research Associate Professor of Surgery). "We are excited to collaborate with Envisagenics to apply its innovative technology leveraging splicing analytics for neoantigen discovery in BRCA1/2 carriers, an exemplar population for prophylactic intervention, given their high risk of developing breast or ovarian cancers, and the increasing recognition that immune interventions are particularly appropriate in the cancer prevention arena," said Dr. Khan.

Envisagenics was previously awarded Phase I and Phase II grants from the National Institute of General Medical Sciences (NIGMS, NIH) to develop the SpliceCore software platform. A Phase I SBIR grant was also awarded by the NCI to expand SpliceCore’s capabilities for discovery of splicing-derived neoantigens. "We are grateful for the NIH’s continued support of innovative technologies and enabling AI-driven biotechnology companies like Envisagenics to continue to develop next generation technologies to accelerate the discovery and development of therapies for patients in need," said Maria Luisa Pineda, Ph.D., Chief Executive Officer and Co-founder of Envisagenics.

PERRIGO ANNOUNCES QUARTERLY DIVIDEND

On August 2, 2022 Perrigo Company plc (NYSE: PRGO), a leading global provider of Consumer Self-Care Products, reported that its Board of Directors declared a quarterly dividend of $0.26 per share, payable on September 20, 2022, to shareholders of record on September 2, 2022 (Press release, Perrigo Company, AUG 2, 2022, View Source [SID1234617314]).

AMGEN TO WEBCAST INVESTOR MEETING AT WCLC 2022

On August 2, 2022 Amgen (NASDAQ: AMGN) reported that it will host a webcast call for the investment community in conjunction with the International Association for the Study of Lung Cancer (IASLC) 2022 World Conference on Lung Cancer (WCLC) at 12:00 p.m. ET on Monday, Aug. 8, 2022 (Press release, Amgen, AUG 2, 2022, View Source [SID1234617313]). David M. Reese, M.D., executive vice president of Research and Development at Amgen, along with members of Amgen’s clinical development team, will discuss the data being presented on LUMAKRAS (sotorasib) in combination with immunotherapy and in combination with a SHP2 inhibitor in non-small cell lung cancer, as well as tarlatamab data in small cell lung cancer.

The webcast, as with other selected presentations regarding developments in Amgen’s business given by management at certain investor and medical conferences, can be found on Amgen’s website, www.amgen.com, under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen’s Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event.