BIO-TECHNE ANNOUNCES EXCLUSIVE DEVELOPMENT AND LICENSE AGREEMENT WITH THERMO FISHER SCIENTIFIC FOR EXOTRU® KIDNEY TRANSPLANT REJECTION ASSAY

On February 22, 2022 Bio-Techne Corporation (NASDAQ: TECH) reported an agreement with Thermo Fisher Scientific to exclusively complete development of and commercialize the ExoTRU kidney transplant rejection test developed by Exosome Diagnostics, a Bio-Techne brand (Press release, Bio-Techne, FEB 22, 2022, View Source [SID1234608818]).

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ExoTRU is a non-invasive multigene urine based liquid biopsy assay that provides critical allograft health information to assist clinician decision making in managing kidney transplant patients and optimizing patient care. The assay has the potential to discriminate between T-cell mediated rejection (TCMR) and antibody mediated rejection (ABMR), which is critical to improving patient management and outcomes. ExoTRU was developed in collaboration with the Azzi Laboratory at the Transplantation Research Center at Brigham and Women’s Hospital, Harvard Medical School.

"We continue to demonstrate the utility of exosomes as a source of significant clinical value for non-invasive testing. ExoTRU is another great example of this potential, with this assay filling a significant unmet need in the area of kidney transplant patient care," commented Kim Kelderman, President of Bio-Techne’s Diagnostics and Genomics Segment. "Thermo Fisher is the ideal partner to complete development of and commercialize ExoTRU, with its trusted reputation and established transplant center relationships creating the ideal channel to drive awareness and adoption of this best-in-class assay."

"We see tremendous potential for ExoTRU to improve the care offered to kidney transplant patients and scale into a market leading liquid biopsy test," said John Sos, Senior Vice President and President, Specialty Diagnostics at Thermo Fisher Scientific. "We look forward to partnering with Bio-Techne to bring this important innovation to market.

Viewpoint Molecular Targeting® to Present at the B. Riley Radiation Oncology Investor Day

On February 22, 2022 Viewpoint Molecular Targeting, Inc. ("Viewpoint" or the "Company"), a precision oncology company developing alpha-particle therapies and complementary diagnostic imaging agents, reported that Thijs Spoor, Chief Executive Officer of Viewpoint, will participate in a fireside chat at the B. Riley Radiation Oncology Investor Day today, February 22, 2022 at 1:30 PM ET (Press release, Viewpoint Molecular Targeting, FEB 22, 2022, https://viewpointmt.com/viewpoint-molecular-targeting-to-present-at-the-b-riley-radiation-oncology-investor-day/ [SID1234608817]).

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The B. Riley Securities Radiation Oncology Investor Day, being held virtually on Tuesday, February 22nd, is designed to provide insights into the current state and future direction of the radiation oncology field by bringing together innovative companies and independent experts. The event features fireside chats with key public and private companies working in the space as well as an expert KOL panel discussion. Topics are expected to range from understanding and overcoming supply chain and logistical challenges unique to radiopharmaceuticals, to the potential competitive and/or complementary roles of external beam and targeted radiotherapies.

To register and for more information about the event, please visit the event website.

Viewpoint Molecular Targeting® Appoints Thijs Spoor as Chief Executive Officer

On February 22, 2022 Viewpoint Molecular Targeting, Inc. ("Viewpoint" or the "Company"), a precision oncology company developing alpha-particle therapies and complementary diagnostic imaging agents, reported the appointment of Thijs Spoor, MBA as its Chief Executive Officer (Press release, Viewpoint Molecular Targeting, FEB 22, 2022, https://viewpointmt.com/viewpoint-molecular-targeting-appoints-thijs-spoor-as-chief-executive-officer/ [SID1234608816]).

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"We are incredibly pleased to welcome Thijs to the executive leadership team. His expertise and successful track record of advancing clinical programs, raising capital, and generating value for stakeholders will be a valuable asset as we propel Viewpoint to its next phase of growth," said Dr. Michael Schultz, co-founder and Chief Science Officer of Viewpoint Molecular Targeting. Frances L. Johnson, MD, co-founder and COO of Viewpoint Molecular Targeting, added, "We founded Viewpoint Molecular Targeting with the goal of bringing the best possible diagnostic and therapeutic drugs to cancer patients. Our achievements have been recognized through grant awards, peer-reviewed publications, and regulatory authorizations. As we continue to develop these agents in human trials, we are thrilled to attract a terrific team of people and are pleased to welcome Thijs as the latest addition to the team."

Mr. Spoor joins the Viewpoint team having most recently served as the President and CEO of KBP Biosciences, a global, clinical-stage biotechnology company focused on discovering, developing, and commercializing innovative small-molecule therapeutics for the treatment of serious cardiorenal and infectious diseases. While at KBP, Mr. Spoor led all operations for major fund-raising and IPO readiness upon completion and publication of Phase 2b trial data. He drove the company’s small molecule clinical development programs including toxicology, clinical pharmacology, Phase 2 studies and discussions with regulators. Prior to that, Mr. Spoor served as the President and CEO of AzurRx BioPharma, where he led its spin-off, NASDAQ IPO, completion of animal studies, regulatory approvals and multiple Phase 2 studies. Mr. Spoor also served as the President and CEO of FluoroPharma Medical, which he took public, as well as a Health and Life Sciences strategy consultant to Fortune 500 companies at Oliver Wyman. Mr Spoor worked on Wall Street as an equity research analyst at JP Morgan and Credit Suisse where he covered biotechnology stocks and medical device companies. He started his career with a formal training in nuclear pharmacy which led to increasing commercial leadership roles in the imaging business at GE Healthcare (Amersham) in cardiology and oncology. Mr. Spoor holds a Pharmacy degree from the University of Toronto and an MBA from Columbia Business School.

"The Viewpoint team has done a tremendous job executing on its research and development initiatives and advancing its precision oncology therapeutics and complementary diagnostic imaging agents. I joined Viewpoint because I believe we have the potential to bring disruptive oncology treatment options to patients and physicians. I am really excited to have the support of such a strong board of directors and work with such a terrific team at Viewpoint to progress our robust pipeline and maximize the value across all stakeholders," added Mr.

Sysmex Inostics Introduces CLIA-Validated Highly Sensitive HNSCC-SEQ Testing Services for Head and Neck Cancer at the 2022 Molecular Medicine Tri-Conference

On February 22, 2022 Sysmex Inostics, a global leader in the liquid biopsy revolution for oncology, reported that it will introduce HNSCC-SEQ, a highly sensitive Plasma-Safe-SeqS and Next Generation Sequencing (NGS) assay service for head and neck squamous cell carcinomas (HNSCC), at the annual 2022 Molecular Medicine Tri-Conference being held Monday, February 21st through Wednesday, February 23rd in San Diego, California (Press release, Sysmex Inostics, FEB 22, 2022, View Source [SID1234608815]). The assay has a turn-around-time of 7-10 days and is available to researchers and clinicians.

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Sysmex Inostics senior director of medical affairs, Dr. Fred Jones stated, "We see a huge opportunity for researchers and clinicians with our HNSCC-SEQ and HPV-SEQ assays being used in tandem to appropriately identify patients’ tumor mutational drivers." Jones added, "We know the human papillomavirus (HPV) fuels a growing percentage of head and neck cancers, but there is also an unmet need to track HNSCC tumors via circulating tumor DNA (ctDNA) that are HPV-negative – that’s where HNSCC-SEQ comes in. This HNSCC panel helps researchers and clinicians identify patients quickly and accurately for the appropriate therapy and avoiding over-treatment."

HNSCC develop from the mucosal tissue in the oral cavity, pharynx, and larynx and are the most common malignancies that arise in the head and neck regions.¹ HNSCC-SEQ was designed for HPV-negative patients and can be used to detect novel therapeutic targets and frequently occurring driver mutations for treatment response monitoring. HNSCC-SEQ delivers high-sensitivity mutation detection in HNSCC with a limit of detection of 0.05% MAF.2

HNSCC-SEQ can identify head and neck cancer mutational drivers from the genes: CDKN2A, EGFR, ERBB2, FGFR3, HRAS, KRAS, NOTCH1, PIK3CA, PTEN, and TP53, many of which are actively being pursued as therapeutic targets.3

Dr. Jones will discuss how Plasma-Safe-SeqS technology, including HNSCC-SEQ, can aid cancer drug development, treatment guidance and monitoring, in addition to post-treatment recurrence monitoring during the 2022 Molecular Medicine Tri- Conference’s C4B- Clinical Biomarkers & Companion Diagnostics presentation track in session room Indigo 206 on Tuesday, February 22nd at the Hilton San Diego Bayfront. More information about the presentation can be viewed here.

2022 Multidisciplinary Head and Neck Cancers Symposium
Additionally, Dr. Ari Rosenberg, Assistant Professor of Medicine at the University of Chicago will present findings from his study using Sysmex Inostics HPV-SEQ test at the 2022 Multidisciplinary Head and Neck Cancers Symposium being held February 24th through 26th in Phoenix, Arizona. The poster titled ‘Dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer receiving response-adaptive treatment’ will be presented Thursday, February 24th. More information can be viewed here.

HNSCC-SEQ and HPV-SEQ are available as a testing service provided by the Sysmex Inostics CLIA lab in Baltimore. MD.

Syndax to Announce Fourth Quarter and Year-end 2021 Financial Results and Host Conference Call and Webcast on March 1, 2022

On February 22, 2022 Syndax Pharmaceuticals, Inc. ("Syndax," the "Company" or "we") (Nasdaq: SNDX), a clinical-stage biopharmaceutical company developing an innovative pipeline of cancer therapies, reported that it will release its fourth quarter and year-end 2021 financial results on Tuesday, March 1, after the close of the U.S. financial markets (Press release, Syndax, FEB 22, 2022, View Source [SID1234608814]).

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In connection with the earnings release, Syndax’s management team will host a conference call and live audio webcast at 4:30 p.m. ET on Tuesday, March 1, to discuss the Company’s financial results and provide a general business update.

The live audio webcast and accompanying slides may be accessed through the Events & Presentations page in the Investors section of the Company’s website at www.syndax.com. Alternatively, the conference call may be accessed through the following: