Supernus to Provide Preliminary Fourth Quarter and Full Year 2021 Financial Results and Host Conference Call on February 28, 2022

On February 22, 2022 Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, reported that the Company expects to report preliminary fourth quarter and full year 2021 financial results and full year 2022 financial guidance after the market closes on Monday, February 28, 2022 (Press release, Supernus, FEB 22, 2022, View Source [SID1234608813]).

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Jack Khattar, President and CEO, and Tim Dec, Senior Vice President and CFO, will host a conference call to present the preliminary fourth quarter and full year 2021 financial results and full year 2022 financial guidance on Monday, February 28, 2022 at 4:30 p.m. ET. Following management’s prepared remarks and discussion of financial results, the call will be open for questions.

Rigel Announces Conference Call and Webcast to Report Fourth Quarter and Year End 2021 Financial Results and Business Update

On February 22, 2022 Rigel Pharmaceuticals, Inc. (Nasdaq:RIGL) reported that it will report its fourth quarter and year end 2021 financial results after market close on Tuesday, March 1, 2022 (Press release, Rigel, FEB 22, 2022, View Source [SID1234608812]). Rigel senior management will follow the announcement with a live conference call and webcast at 4:30pm Eastern Time (1:30pm Pacific Time) to discuss the financial results and give an update on the business.

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Participants can access the live conference call by dialing 877-407-3088 (domestic) or 201-389-0927 (international). The conference call and accompanying slides will also be webcast live and can be accessed from the Investor Relations section of the company’s website at www.rigel.com. The webcast will be archived and available for replay for 90 days after the call via the Rigel website.

Revolution Medicines to Report Financial Results for Fourth Quarter and Full Year 2021 After Market Close on February 28, 2022

On February 22, 2022 Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing novel targeted therapies for RAS-addicted cancers, reported that it will report financial results for the fourth quarter and full year 2021 on February 28, 2022, after market close (Press release, Revolution Medicines, FEB 22, 2022, View Source [SID1234608811]). The company will host a conference call and webcast at 4:30 p.m. Eastern Time during which members of Revolution Medicines’ senior management team will discuss financial results for the quarter and full year, and review recent corporate developments.

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To listen to the live webcast, or access the archived webcast, please visit the "Events & Presentations" page of Revolution Medicines’ website at: View Source Following the live webcast, a replay will be available on the Company’s website for at least 14 days.

To listen to the live conference call, please dial (833) 423-0425 or (918) 922-3069 and request the Revolution Medicines call (conference ID: 9672794).

Entry into a Material Definitive Agreement

On February 22, 2022 (the "Closing Date"), Poseida Therapeutics, Inc., its wholly-owned subsidiary (collectively, the "Company"), and Oxford Finance LLC ("Oxford") reported that it entered into a loan and security agreement (the "Loan Agreement"), pursuant to which Oxford provided the Company with a term loan in the aggregate principal amount of $60.0 million (the "Term Loan") on the Closing Date (Filing, 8-K, Poseida Therapeutics, FEB 22, 2022, View Source [SID1234608810]). Also on the Closing Date, the Company used a portion of the proceeds from the Term Loan to repay in full all indebtedness, liabilities and other obligations under, and terminated that certain loan and security agreement, dated July 25, 2017, as amended, restated, supplemented or otherwise modified from time to time, by and between the Company and Oxford (the "2017 Loan Agreement"). The Company currently anticipates the remaining net proceeds of approximately $28.3 million from the Term Loan will be used for working capital and to fund its general business requirements.

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The Term Loan will mature on February 1, 2027 (the "Maturity Date") and will have interest-only payments through April 1, 2025, followed by 23 equal monthly payments of principal and unpaid accrued interest. Upon the satisfaction of certain conditions set forth in the Loan Agreement, the interest only period may be extended through April 1, 2026, followed by 11 equal monthly payments of principal and unpaid accrued interest. The Term Loan will bear interest at a floating per annum rate equal to the greater of: (i) 7.94%, and (ii) the sum of (a) the 30-day U.S. Dollar LIBOR rate reported in The Wall Street Journal on the last business day of the month that immediately precedes the month in which the interest will accrue plus (b) 7.83%.

The Company will be required to make a final payment of 7.5% of the original principal balance of the Term Loan, payable on the earlier of: (i) the Maturity Date, (ii) acceleration of the Term Loan, or (iii) the prepayment of the Term Loan. The Loan Agreement provides for an option to prepay all or in increments of $5.0 million, of the borrowed amounts, provided that the Company will be obligated to pay a prepayment fee equal to 1.0% of the outstanding principal balance of the Term Loan if prepayment is made after the funding date through and including the second anniversary of the funding date, after which no prepayment penalty would be applied.

The Company’s obligations under the Loan Agreement are secured by a first priority security interest in substantially all of the Company’s current and future assets, other than its intellectual property. In addition, the Company has agreed not to encumber its intellectual property, except as permitted by the Loan Agreement. Prior to termination of the Loan Agreement, the Company is subject to a number of affirmative and restrictive covenants, generally consistent with the 2017 Loan Agreement, including covenants regarding dispositions of property, business combinations or acquisitions, restrictions on dividends and distributions, restrictions on indebtedness, liens and investments among other customary covenants, in each case subject to limited exceptions.

The foregoing description of the Loan Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Loan Agreement, which will be filed as an exhibit with the Securities and Exchange Commission to Poseida Therapeutics, Inc.’s Annual Report on Form 10-K for the year ending December 31, 2021.

PharmaMar to Host Key Opinion Leader Webinar on Small Cell Lung Cancer: “Small Cell Lung Cancer: Today, until Tomorrow, US & EU”

On February 22, 2022 PharmaMar (MSE: PHM) reported that it will host a key opinion leader (KOL) webinar addressed to investors and analysts, entitled "Small Cell Lung Cancer: Today, until Tomorrow, US & EU" on Wednesday, March 9th at 1pm EST/7pm CET (Press release, PharmaMar, FEB 22, 2022, View Source [SID1234608809]).

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The webinar will feature presentations by Key Opinion Leaders (KOLs) Professor Dr. Benjamin Besse from Institut Gustave Roussy, Villejuif, France and Dr. Jacob Sands from Dana Farber Cancer Institute, Boston. They will discuss the latest research in SCLC and the current landscape in various lines of treatment, including the first-line and relapsed settings. They will also discuss the various unmet medical needs of patients and physicians and present their view on the future treatment paradigm.

This event follows the initiation by PharmaMar of a global randomized phase III study of Zepzelca (lurbinectedin) monotherapy or in combination with irinotecan in relapsed Small Cell Lung Cancer (SCLC) (NCT05153239)1. This trial is expected to serve in a confirmatory capacity in the US following lurbinectedin’s accelerated FDA approval in 2020, as well as a registrational capacity for EMA and other regulatory bodies.

In addition, North America partner Jazz Pharmaceuticals along with its partner Roche Pharmaceuticals initiated a Phase III study assessing the safety and efficacy of lurbinectedin as a first-line maintenance treatment in Small Cell Lung Cancer (SCLC) (NCT05091567)2. If successful, the trial could support an FDA supplemental new drug application, and potentially allow PharmaMar to submit a dossier for registration to the European Medicines Agency. PharmaMar holds full commercial rights for lurbinectedin in Europe and most territories outside the United States and Canada.

The numbers to connect to the teleconference are +34 91 901 16 44 (from Spain), +1 646 664 1960 (from USA or Canada) or +44 20 3936 2999 (other countries). Participant access code: 620352.

The teleconference will be available on PharmaMar’s website by visiting the Events Calendar section of the company’s website at www.pharmamar.com

A recording of the webcast will be made available to accredited investors. To request a link, please feel free to reach out to [email protected].

About Professor Dr. Benjamin Besse

Dr. Benjamin Besse is Professor of Medical Oncology at Paris-Saclay University, Orsay, France and a full-time cancer specialist at Gustave Roussy Cancer Campus, Villejuif, France. Currently, Dr. Besse is Head of the Cancer Medicine Department at Gustave Roussy Cancer Campus and Chair of the EORTC Lung Group. He coordinates the French network for thymic malignancy. His main research interests are application of molecular abnormalities to personalize treatment, circulating biomarkers, early drug development in thoracic tumors and thymic malignancies. He has authored/co-authored more than 250 peer-reviewed papers.

About Dr. Jacob Sands

Dr. Jacob Sands received his MD from the University of Cincinnati in 2005. He completed his residency in internal medicine at the University of California, Davis and fellowship training in hematology/oncology also at the University of California, Davis. He joined the faculty in the Lowe Center for Thoracic Oncology at Dana-Farber in 2017. His research focuses on improved diagnostics and treatments for small cell lung cancer as well as improving lung screening and assisting in the development of lung screening programs throughout the country.