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Akari Therapeutics Selected to Showcase Novel PH1 ADC Payload Platform at Leading Global Oncology, ADC and Healthcare Forums

On September 8, 2026 Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulator payloads, reported that the Company has been selected to participate in five prominent oncology, ADC and healthcare industry and investor conferences in the United States and China during September 2026.

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These speaking engagements position Akari’s proprietary PH1 ADC payload technology in front of leading global pharmaceutical and biotechnology companies focused on ADCs, potential strategic partners, and healthcare investors at a time when the industry is increasingly focused on novel payloads and next-generation ADC technologies.

Through these various presentations and expert panels, Akari expects to highlight the potential of its PH1 platform to enable differentiated ADCs, discuss emerging strategies for improving ADC efficacy and safety, and explore opportunities for global R&D collaboration, platform partnerships, and its pipeline expansion.

"We believe being selected to actively participate in these conferences and discussions reflects growing interest in novel ADC payload technologies and key unmet needs around ADC therapy sequencing," said Abizer Gaslightwala, President and Chief Executive Officer of Akari Therapeutics. "These key conferences in September give us an exceptional opportunity to put the PH1 ADC payload and Akari’s next-generation ADC strategy in front of potential partners across pharma and biotechnology companies and strategic healthcare investors. We believe the next wave of ADC innovation will be driven in significant part by differentiated payloads, and we are excited to showcase the potential and opportunity for Akari’s ADC payload targeting RNA splicing. As we advance AKTX-101 toward the clinic, these forums also provide an important opportunity to deepen strategic relationships and demonstrate the broader potential of our PH1 payload platform."

Oncology & Immunology Innovation Partnering & Licensing Summit

Dates: September 9–10, 2026

Location: Boston, Massachusetts

Panel: Thursday, September 10, 2026, at 8:30 AM ET

Panel Title: Reflecting on the First Attempts with Novel Payloads & What We Are Doing Differently Now

Session: Novel Payloads & Combinations as the New Value Driver in ADCs

Participant: Abizer Gaslightwala, President and Chief Executive Officer, Akari Therapeutics

Mr. Gaslightwala will participate in a discussion focused on the evolution of novel ADC payloads and how emerging technologies could help address limitations associated with current ADCs. The session places Akari directly within a broader industry conversation around novel payloads as potential drivers of the next generation of ADC innovation.

H.C. Wainwright 28th Annual Global Investment Conference

Dates: September 14–16, 2026

Location: New York, NY

Format: Pre-recorded fireside chat and investor meetings

The fireside chat will provide an opportunity for management to discuss Akari’s PH1 payload platform, advancement of AKTX-101 and the Company’s broader strategy for next-generation ADC development.

The pre-recorded fireside chat will be available beginning September 11, 2026. Access the fireside chat here.

Investors interested in meeting with Akari management during the conference are encouraged to contact their H.C. Wainwright representative to request a meeting.

BioCon China 2026

Dates: September 15–16, 2026

Location: Shanghai, China

Keynote Presentation: Tuesday, September 15, 2026, from 10:45–11:15 AM (CST)

Presentation Title:

From Big Pharma to Biotech: Differentiated Value of Next-Gen ADCs and China Collaboration Opportunities

Participant: Abizer Gaslightwala, President and Chief Executive Officer, Akari Therapeutics

In addition to the keynote presentation, Mr. Gaslightwala will participate in a speaker panel titled, Opportunities, Partnership Options & Critical Success Factors for Global Collaboration of Chinese‑Innovated Assets: A Multinational Pharma Perspective, focused on the evolving value of differentiated ADC technologies and opportunities for collaboration between global biotechnology companies and the Chinese biopharmaceutical industry.

2026 Global XDC Innovation Conference

Dates: September 17–19, 2026

Location: WuXi, China

Presentation: Saturday, September 19, 2026,

Presentation Title: Novel ADC Payloads Designed to Target RNA Splicing to Drive Differentiated Efficacy and Safety and New Options for ADC Therapy Sequencing

Session: Session IV – XDC New Modalities: BsADC, Dual-Payload ADC, AOC, and Beyond

Participant: Abizer Gaslightwala, President and Chief Executive Officer, Akari Therapeutics

At the Global XDC Innovation Conference, Akari will specifically showcase its approach to developing ADC payloads designed to target RNA splicing and the potential implications for efficacy, safety and therapeutic sequencing. The presentation will position PH1 within the emerging landscape of next-generation ADC technologies being developed.

5th Annual ROTH Healthcare Opportunities Conference

Date: September 29, 2026

Location: New York, New York

Format: Investor meetings

Akari will conclude its September conference schedule at the 5th Annual ROTH Healthcare Opportunities Conference, where management expects to meet with healthcare investors and discuss the Company’s PH1 platform, advancement of AKTX-101 and broader ADC development strategy.

Investors interested in meeting with Akari management during the conference are encouraged to contact their ROTH representative to request a meeting.

Advancing a Differentiated Approach to the Next Generation of ADCs

Akari’s participation across these conferences comes as the Company advances AKTX-101, its lead Trop2-targeting ADC, through IND-enabling development toward a planned first-in-human clinical trial by mid-2027.

Unlike ADCs utilizing traditional microtubule inhibitor or DNA-damaging payloads, Akari’s proprietary PH1 payload is designed to target RNA splicing, providing a differentiated mechanism intended to induce cancer cell death while activating both innate and adaptive immune responses.

Beyond AKTX-101, Akari is developing AKTX-102, targeting CEACAM5, and is exploring the broader potential of its PH1 technology across next-generation ADC architectures and development strategies.

(Press release, Akari Therapeutics, SEP 8, 2026, View Source [SID1234670614])

Rznomics Reports Major Advances in High-Efficiency Circular RNA Production in Nucleic Acids Research

On September 7, 2026 Rznomics Inc.(KOSDAQ: 476830), a biopharmaceutical company specializing in the development of RNA-based gene therapies, reported a major breakthrough in the high-efficiency production of circular RNA (circRNA) – a rapidly emerging modality in next-generation RNA therapeutics.

The research was published online in Nucleic Acids Research (NAR), a premier international journal in the fields of nucleic acid research and molecular biology, on September 4, 2026. The article is titled "Target Site Selection and P1 Engineering Enable Highly Efficient Circular RNA Production via End-to-End Self-Targeting and Splicing".

The study highlights a substantial enhancement in the circRNA production efficiency of Rznomics’ proprietary Self-Targeting and Splicing (STS) technology, which enables RNA molecules to spontaneously form a circular structure during in vitro transcription.

Unlike conventional linear RNA, circRNA features a covalently closed-loop structure, rendering it highly resistant to enzymatic degradation. This superior stability makes circRNA a highly promising platform for a broad spectrum of RNA-based medicines, including vaccines and protein therapeutics.

However, circularization efficiency generally decreases as RNA length increases. This limitation restricts the size of genes that can be practically accommodated and poses a challenge for efficient large-scale manufacturing.

To address this limitation, the Rznomics research team systematically screened target sites for self-circularization and implemented an engineering strategy to optimize the P1 construct involved in the self-circularization reaction.

The study revealed that self-circularization efficiency fluctuates significantly depending on the location of the target site, even within the same RNA sequence, demonstrating that optimal target site selection is a key factor for high-yield circRNA production. The researchers further engineered the P1 construct by sequentially introducing a short polyA10 sequence and an antisense sequence designed to strengthen interaction with the target site, improving self-circularization efficiency by up to approximately seven-fold compared with the original STS design.

Notably, in experiments using Factor VIII RNA approximately 7.8 kilo-nucleotides in length, the optimized STS method achieved approximately a two-fold higher circularization efficiency than the widely used Permuted Intron–Exon (PIE) method.

These findings demonstrate that integrating strategic target-site selection with P1 construct engineering enables efficient circRNA production not only for relatively short RNAs but also for large RNAs approaching 8 kilo-nucleotides. Rznomics anticipates that this technology could serve as a broadly applicable platform for the development of circRNA-based therapeutics and vaccines.

Dr. Kyung Hyun Lee, first and co-corresponding author of the study, stated, "By establishing a foundation for the efficient and robust production of circRNA even from large RNA molecules, we expect this technology to help broaden the potential horizons of circRNA application."

Dr. Seong-Wook Lee, CEO of Rznomics and co-corresponding author, added, "This milestone further advances our proprietary circRNA platform and strengthens its potential for practical applications. Moving forward, we plan to expand its utility across diverse therapeutic areas, including CAR-T therapies."

(Press release, Rznomics, SEP 7, 2026, View Source [SID1234670610])

Nerviano Medical Sciences announces participation at WCLC 2026 with a poster presentation

On September 7, 2026 Nerviano Medical Sciences S.r.l. ("NMS"), a global oncology-focused biopharmaceutical company, reported its participation in the upcoming World Conference on Lung Cancer ("WCLC") of the International Association for the Study of Lung Cancer ("IASLC"), taking place in Seoul, Republic of Korea, from September 12 to 15, 2026.

At the meeting, NMS will present a scientific poster featuring its proprietary PARP7 inhibitor, atamparib.

Title: "A Phase Ib/II Study of Atamparib, a PARP7 Inhibitor, in Patients with Advanced Solid Tumors"

Presenter: Dr. Xinru Chen, Shanghai East Hospital

Poster Section: Clinical Trials in Progress

Poster Board Number: P2-372

Abstract Control Number: 606

Date & Time: Monday, September 14, 2026 at 10:30 AM KST / UTC +9

Link to full poster abstract: View Source

This ongoing phase 1b/2 trial is evaluating atamparib, a potential, orally bioavailable, selective PARP7 inhibitor. Through its unique dual mechanism of action, atamparib disrupts KRAS-driven and other oncogenic signaling pathways, while activating innate immune responses. The study is currently exploring higher dose levels and generating proof-of-concept data in selected patients with advanced or metastatic NSCLC adenocarcinoma.

We look forward to engaging with the scientific community at the IASLC 2026 WCLC and sharing insights from our work.

About Atamparib

Atamparib was acquired by NMS from Ribon Therapeutics in November 2024 (previously RBN 2397/ONO 7119). It has demonstrated a favorable tolerability profile in prior Phase I/II clinical evaluation (NCT04053673, NCT05127590, JRCT2031210373). Supported by new preclinical data and early signs of clinical activity, NMS is advancing atamparib for the treatment of advanced or metastatic solid tumors, with the goal of addressing significant unmet medical needs as a single agent and in combination regimens.

20260912-NMS WCLC Poster Presentation

(Press release, Nerviano Medical Sciences, SEP 7, 2026, View Source [SID1234670609])

Defence Therapeutics Provides Updates on Sharing Agreement

On September 4, 2026 Defence Therapeutics Inc. ("Defence" or the "Company"), (CSE: DTC, OTCQB: DTCFF, FSE: DTC), a publicly traded biotechnology and precision intracellular drug-delivery company, reported an update on its sharing agreement dated March 6, 2026 (the "Sharing Agreement") with Sorbie Bornholm LP ("SBLP") previously described in the Company’s news releases of March 9 and February 27, 2026.

On March 6, 2026, the Company completed a non-brokered private placement in which it issued 17,445,455 units of the Company ("Units") at a price of $0.55 per unit for gross proceeds of $9,595,000.25 (the "Offering"). Of the Units issued under the Offering, 10,909,091 Units were subscribed for by SBLP and Sorbie Investments LLP for gross proceeds of $6,000,000 (the "Proceeds"). The common shares comprised in the Units (the "Placement Shares") were allotted to SBLP and Sorbie Investments LLP.

Pursuant to the Sharing Agreement, the Company would receive 18 monthly cash settlements (each, a "Settlement"), each determined by reference to a benchmark price of $0.7332 per common share. The amount payable to the Company under each Settlement is calculated based on a volume weighted average price for 20 trading days prior to each Settlement (the "20 Day VWAP") relative to the benchmark price, with the maximum permitted discount to the market price at the time. If the 20 Day VWAP is below the benchmark price, the Company will receive less than the monthly amount of $333,333; if the 20 Day VWAP exceeds the benchmark price, the Company will receive more than the monthly amount of $333,333. The final amount of each Settlement will depend on the Company’s future share price, which is subject to market fluctuations and may vary over time.

The Company has received the first Settlement in the amount of $182,623.49 as of the settlement date of August 14, 2026, against 606,060 Placement Shares released to SBLP. As of today, 10,303,031 Placement Shares are held in escrow in connection with the Sharing Agreement and there are 17 Settlement payments remaining.

(Press release, Defence Therapeutics, SEP 4, 2026, View Source;utm_medium=rss&utm_campaign=defence-therapeutics-provides-updates-on-sharing-agreement [SID1234670605])

Guardant Health Announces Landmark FDA Approval of Guardant360® CDx as Companion Diagnostic for AstraZeneca’s ETCAMAH™ (camizestrant) in Advanced Breast Cancer

On September 4, 2026 Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, reported that the U.S. Food and Drug Administration (FDA) has approved Guardant360 CDx as a companion diagnostic (CDx) to identify patients with hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer harboring tumors with ESR1 mutations before radiographic progression who may benefit from treatment with ETCAMAH (camizestrant), AstraZeneca’s next-generation oral selective estrogen receptor degrader (SERD). Guardant360 CDx is the first FDA-approved liquid biopsy CDx for longitudinal testing in breast cancer, and this approval represents a major shift from therapy selection and switching post-radiographic progression to adaptive cancer management and early interception using pre-radiographic progression circulating tumor DNA (ctDNA) testing.

The approval is based on data from the pivotal SERENA-6 clinical trial, which introduced a first-of-its-kind treatment strategy using ctDNA monitoring to detect emerging ESR1 resistance mutations before radiographic disease progression. Patients who switched to ETCAMAH in combination with continuing a cyclin-dependent kinase (CDK) 4/6 inhibitor versus continuing treatment with an aromatase inhibitor with a CDK4/6 inhibitor following ESR1 mutation detection experienced a 56% reduction in the risk of progression or death. The trial demonstrated the clinical value of proactively identifying disease progression earlier than radiographic imaging and adapting therapy earlier in the course of disease.

"This approval represents a landmark shift in how we define disease progression and reinforces the transformative role of liquid biopsy in guiding therapy decisions earlier at a critical moment in a breast cancer patient’s treatment journey," said Helmy Eltoukhy, Guardant Health chairman and co-CEO. "The SERENA-6 paradigm opens a new frontier in how cancer is managed, with potential application across different diseases and therapies."

Approximately 37,000 women in the U.S. living with advanced HR-positive breast cancer being treated with an aromatase inhibitor could potentially benefit from this new therapeutic approach leading to better progression-free survival and outcomes.

Advancing a New Precision Medicine Paradigm

Historically, biomarker testing in advanced cancer most often occurred after clinical or radiographic progression. The SERENA-6 study demonstrated the value in a fundamentally different approach: ctDNA surveillance during first-line endocrine therapy to identify the emergence of resistance before overt disease progression.

Patients enrolled in the study underwent serial testing with Guardant360 CDx every three months while receiving an aromatase inhibitor with a CDK4/6 inhibitor. Upon detection of an ESR1 mutation before radiographic progression, eligible patients were transitioned to camizestrant-based treatment. Patients treated under this new paradigm experienced 74% longer median progression-free survival (16.0 vs. 9.2 months) with a 47% reduction in risk of deterioration in global health status and quality of life.

Strategic Collaboration with AstraZeneca

The approval reflects a multi-year collaboration between Guardant Health and AstraZeneca focused on integrating Guardant Health products and capabilities into clinical development.

Guardant Health supported the study through its FDA-approved Guardant360 CDx platform, providing high-sensitivity ESR1 mutation detection capabilities across serial testing timepoints. The collaboration enabled accessible, scalable biomarker testing designed to support rapid clinical decision-making and broad patient access.

This latest FDA approval for Guardant360 CDx marks the 29th CDx indication across multiple tumor types globally, building on the platform’s increasing clinical utility and broad coverage by Medicare and commercial payers, representing more than 300 million covered lives.

About Guardant360 CDx

Guardant360 CDx is the first FDA-approved liquid biopsy for comprehensive genomic profiling. It detects multiple genomic alterations across all solid tumors and is approved as a companion diagnostic for therapies in non-small cell lung cancer, breast cancer, and colorectal cancer.

(Press release, Guardant Health, SEP 4, 2026, View Source [SID1234670603])