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OncoMyx Announces Presentations at SITC 2021 of New Data Demonstrating the Potential of a Multi-Armed Myxoma Virus as a Novel Oncolytic Immunotherapy for Solid Tumors and Heme Malignancies

On October 19, 2021 OncoMyx Therapeutics, a privately-held oncolytic immunotherapy company, reported two poster presentations at the upcoming Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 36th Annual Meeting being held November 10-14, 2021, both virtually and in Washington, D.C (Press release, OncoMyx Therapeutics, OCT 19, 2021, View Source [SID1234594855]).

Onsite posters will be presented in the Poster Hall at the Walter E. Washington Convention Center. The posters will be available for onsite viewing November 12-14 from 7am to 5pm EST. Even numbered posters will be presented Saturday, November 13. ePosters will be on display on the SITC (Free SITC Whitepaper) 2021 virtual meeting platform from 7am EST on Friday, November 12 until the virtual meeting platform is closed on January 9, 2022.

Titles of the presentations are as follows:

(742) Multi-armed myxoma virus induces potent anti-tumor responses in vitro and in vivo
(744) Multi-armed myxoma virus has therapeutic potential for treatment of multiple myeloma
Full abstracts will be available on November 9th on the SITC (Free SITC Whitepaper) 2021 Annual Meeting website. Posters for both presentations will be available on OncoMyx’s website on November 12th.

About Oncolytic Immunotherapy and Myxoma Virus

Oncolytic viruses (OV) selectively replicate in and lyse tumor cells and provide stimulation to the immune system, representing a promising therapeutic option in development to treat cancers that do not respond well tOncolytic viruses (OV) selectively replicate in and lyse tumor cells and provide stimulation to the immune system, representing a promising therapeutic option in development to treat cancers that do not respond well to treatment with immune checkpoint inhibitors. Myxoma virus (MYXV) is a member of the Pox family of double stranded DNA viruses. The natural host of MYXV is a subset of rabbits and hares, but MYXV is able to infect cancer cell lines of humans and other species. The genome of MYXV is relatively large and is amenable to engineering for expression of transgenic proteins, making it an excellent oncolytic virus for introduction of immunomodulatory proteins.

Point32Health and Takeda Collaborate on One of the First Value-Based Agreements in Oncology

On October 20, 2021 Point32Health and Takeda Pharmaceuticals America, Inc. reported that they have signed an innovative risk-sharing agreement around Takeda’s ALUNBRIG (brigatinib), a potent and selective tyrosine kinase inhibitor (TKI) that is approved for adult patients with anaplastic lymphoma kinase-positive (ALK+) metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test (Press release, Takeda, OCT 20, 2021, View Source [SID1234594767]).

The agreement will make ALUNBRIG broadly available to Point32Health’s more than two million members – with Takeda standing behind the medicine with a unique outcomes-based structure. The agreement is among the first risk-sharing contracts in oncology and the very first in ALK+NSCLC.

"Given the importance of facilitating cutting-edge oncology treatment and also the reality that not all patients show a positive response, reimbursement for oncology treatments is an area that is prime for innovative financing approaches," said Michael Sherman, MD, chief medical officer and executive vice president, Point32Health. "We’re excited to be able to demonstrate the value of ALUNBRIG as a treatment option for people with ALK+ NSCLC. Collaborating with Takeda to share risk makes this agreement a crucial milestone in bringing cost-effectiveness to cancer care."

"Takeda is committed to identifying and collaborating with payers on innovative and bold solutions that help ensure patients have access to our transformative therapeutics," said Dion Warren, vice president, head, U.S. Business Unit, Takeda Oncology. "Through this collaboration, Point32Health is able to allow broader access to ALUNBRIG because Takeda stands behind the value of its medicine and is willing to minimize the financial risk."

BC Platforms Expands Partnership with Thailand’s Bumrungrad International Hospital

On October 20, 2021 BC Platforms (BCP), a global leader in healthcare data management and analytics, reported an expanded partnership with Bumrungrad International Hospital (Bangkok, Thailand), one of the largest private hospitals in Southeast Asia and a world leader in healthcare delivery and pioneering clinical research (Press release, Debiopharm, OCT 20, 2021, View Source [SID1234591830]).

The extended partnership, first formed in February 2019, builds on clinical sample management functionalities and existing automated workflows for genotype-based wellness reporting and NGS-based neonatal screening supported by BCP solutions. Bumrungrad will now utilize BCP’s Personalized Medicine Platform, powered by BC|GENOME, to implement end-to-end clinical NGS workflows for germline and somatic tumour testing, enabling data-driven personalized care for patients. Additionally, BCP will provide its Discovery and Research Platform, BC|INSIGHT, for curating and analysing clinical and omics data in a secure format to enhance translational research capabilities at Bumrungrad and boost research collaborations. Bumrungrad will also become a BCP data partner, for which it will contribute valuable, diverse data samples for research.

Dr Teeradache Viangteeravat, Director of Research and Development at Bumrungrad International Hospital, commented: "At Bumrungrad we have a commitment to provide precision medicine using big data; genomic and other omics data. We require a big data platform to support sample management, data processing, informatics pipelines, reporting and structured storage. BC Platforms is a world leader in this space and are able to provide a suite of integrated solutions, which support our strategic objectives and also support searching of genotypic and phenotypic data, for collaborative research projects. We are proud to be working with BC Platforms to provide a world class Precision Medicine Platform to continue to deliver the high-quality support our patients and clinicians demand."

Nino da Silva, Deputy Managing Director, BCP, said: "We are delighted to expand our partnership with Bumrungrad, making full use of our platforms to accelerate the shift towards precision medicine in southeast Asia. This powerful NGS infrastructure will deliver whole genome analysis to Bumrungrad’s clinical healthcare production system while supporting advanced clinical research. This is another great example of how we are partnering on an international level to seamlessly connect genomics healthcare and research."

SpringWorks Therapeutics to Collaborate with Ab Magnitude on Target Identification and Discovery of Next-Generation Targeted Oncology Therapeutics

On October 20, 2021 SpringWorks Therapeutics, Inc. (Nasdaq: SWTX), a clinical-stage biopharmaceutical company focused on developing life-changing medicines for patients with severe rare diseases and cancer, reported that it has entered into a collaboration agreement with Ab Magnitude Ventures Group, LLC and Ab Magnitude Fund, LP (collectively, "Ab Magnitude") for the development of next-generation targeted oncology therapeutics (Press release, SpringWorks Therapeutics, OCT 20, 2021, View Source [SID1234591821]). Ab Magnitude is led by Yibing Shan, Ph.D., a leading structural computational biologist who was a founding member of D.E. Shaw Research, a pioneering computational biochemistry research company. Dr. Shan’s simulations of protein structural dynamics have previously yielded important insights on the activity of key oncogenic proteins and the identification of novel binding sites suitable for small molecule therapies. SpringWorks and Ab Magnitude will collaborate on target discovery and initial hit finding to advance next generation oncology therapeutics. In addition, the parties will also collaborate on a portfolio of novel EGFR inhibitors recently in-licensed by SpringWorks from the Dana-Farber Cancer Institute with Ab Magnitude supporting optimization and characterization of the portfolio using its computational platform.

"We believe that Dr. Shan’s track record of identifying novel druggable targets for the design of new cancer therapies is unparalleled and represents a natural complement to our strategy of developing differentiated targeted therapies on behalf of cancer patients," said Badreddin Edris, Ph.D., Chief Operating Officer of SpringWorks. "We look forward to collaborating with Ab Magnitude and we believe that by incorporating these cutting-edge computational approaches into our early-stage drug discovery and development capabilities, we will be well positioned to continue expanding our emerging preclinical pipeline and advancing promising candidates into the clinic."

"I am excited to collaborate with SpringWorks on discovering novel oncology therapeutics using computational molecular and structural modeling approaches and to further optimizing the portfolio of novel EGFR inhibitors that SpringWorks recently in-licensed," said Dr. Shan. "This collaboration has the potential to expedite discovery of novel oncology therapeutics and advancement of promising therapeutic candidates by integrating Ab Magnitude’s computational modeling and target identification expertise with a vertically-integrated biopharmaceutical partner that has the capital resources and expertise to optimize promising candidates to development candidate stage and into clinical studies."

Under the terms of this agreement, Ab Magnitude is eligible for low single-digit percentage royalties on future net sales of products or other realizations of value arising from the collaboration.