Transition Bio, Inc., Expands Leadership Team, Names CEO, CTO, COO

On October 12, 2021 Transition Bio, Inc. (the Company) reported that named several critical additions to its leadership team, including naming Gregory Miller as Chief Executive Officer (CEO), Prof. Tuomas Knowles as Chief Technology Officer (CTO), and Martin Kulander as Chief Operating Officer (COO) (Press release, Transition Therapeutics, OCT 12, 2021, View Source [SID1234591116]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Mr. Miller is a Boston-based biotechnology executive with extensive experience in value creation and corporate development transactions. He was previously Chief Business Officer at Atalanta Therapeutics and brings a successful track record in leading significant liquidity events as well as establishing strategic industry partnerships and collaborations. Greg will also join the Board of Directors.

Prof. Knowles, a Scientific Co-Founder and Director, will assume the role of CTO. He takes on this critically important position in addition to his current academic responsibilities at the University of Cambridge. Tuomas will lead the Company’s technology and data platform strategy as well as the overall direction of the CondensomicsTM platform.

Martin Kulander has joined as Chief Operating Officer (COO) where he will oversee the Company’s business operations. Mr. Kulander joins from AstraZeneca, where he held a range of leadership roles in the oncology commercial and R&D organizations, working on product development strategy and business development. Prior to AstraZeneca, Martin was a member of the investment team at Malin plc, and before that a strategy consultant at Trinity Life Sciences.

Joseph Grosso joins the team as Vice President of Oncology Translation from Bristol Myers Squibb, where he held positions of increasing leadership responsibility. Most recently, he led the development of Breyanzi, an approved CD19 CAR T therapy, across hematological indications. Dr. Grosso brings significant scientific leadership and translational experience in immuno-oncology to the Company. He received his B.S. in Microbiology and Immunology at the University of Rochester and earned his Ph.D. in Microbiology and Immunology from the University of Miami. His post-doctoral training was at Johns Hopkins University School of Medicine where he focused on novel checkpoint molecules including LAG-3 and PD-1 in tumor tolerance models.

The Company also announced that Dr. Sarah Teichmann, who recently joined the Company as a Scientific Co-Founder, will join its Board of Directors.

Kelly Martin, Executive Chairman, commented, "Over the last 12 to 18 months, we have been precisely focused on building a technology and data platform within the world of condensates cell biology. Our advancement to-date – in terms of speed and capability – has exceeded all of our internal expectations." Martin commented further, "Given our accelerated progress, this is the right time to aggressively add unique talent at all levels of the Company. Greg, Martin, Tuomas, Sarah, and Joe are all superb additions to the team."

Mr. Miller added, "The Company’s goal is quite straight forward: To be the leading technology and data driven company in the condensates cell biology space. Our discovery engine generates and learns from proprietary data of unparalleled breadth and depth, down to the single condensate level. The opportunities resulting from our discovery and analytical expertise will be second to none." Miller continued, "The team I am joining is world class and the output of their collective effort, in a such a short period of time, has been incredible. It’s an honor to be part of this company at this stage of its journey."

CG Oncology to Present Two Programs at The Society for Immunotherapy of Cancer (SITC) 2021 Annual Meeting

On October 12, 2021 CG Oncology, Inc., a clinical-stage biotechnology company focused on developing oncolytic immunotherapies for patients with advanced cancer, reported that acceptance of an oral presentation and a poster presentation at The Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting, held virtually and in-person in Washington, DC, November 10-14, 2021 (Press release, CG Oncology, OCT 12, 2021, View Source [SID1234591115]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

CG Oncology will present preliminary safety and efficacy data from CORE1, an ongoing Phase 2 clinical trial of CG0070 in combination with KEYTRUDA (pembrolizumab), for the treatment of patients with Non-Muscle-Invasive Bladder Cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG).

Under a previously announced clinical collaboration with Merck relating to the investigation of CG0070 used in combination with pembrolizumab, the goal of CORE1, which will enroll up to 35 patients, is to evaluate the safety and efficacy of CG0070 plus KEYTRUDA for the treatment of NMIBC unresponsive to BCG.

More information about the study can be found at www.clinicaltrials.gov (NCT04387461).

Details of the oral presentation are as follows:

CORE1: Phase 2, Single Arm Study of CG0070 Combined with Pembrolizumab in Patients with Non Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)
Abstract Number: 955
Presenter: Roger Li, M.D., Moffitt Cancer Center
Session Date & Time: Saturday, November 13, 2021 from 12:15-12:30pm EST
Category: Late-Breaking Oral Abstract Session

In addition, CG Oncology will present an overview of trial design and methodology of BOND3, an ongoing global Phase 3 trial with CG0070 as a monotherapy for the treatment of patients with NMIBC unresponsive to BCG. The goal of BOND3, which will enroll 110 patients, is to evaluate the safety and efficacy of CG0070 as a monotherapy for the treatment of NMIBC unresponsive to BCG.

More information about the study can be found at www.clinicaltrials.gov (NCT04452591).

Details of the poster presentation are as follows:

A phase 3, single-arm study of CG0070 in subjects with non-muscle invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG)
Abstract Number: 426
Presenter: Edward Uchio, M.D., UC Irvine Health, Department of Urology
Session Date & Time: Friday, November 12, 2021 and Saturday, November 13, 2021 from 7:00am-8:30pm EST
Category: Poster Abstract Session

Full abstracts of both presentations will be available on the SITC (Free SITC Whitepaper) website on November 10, 2021.

4D pharma to Participate in Jefferies Virtual Next Generation IBD Therapeutics Summit

On October 12, 2021 4D pharma plc (AIM: DDDD, NASDAQ, LBPS), a pharmaceutical company leading the development of Live Biotherapeutic products (LBPs), a novel class of drug derived from the microbiome, reported that 4D management will present at the Jefferies Virtual Next Generation IBD Therapeutics Summit being held on October 19, 2021 (Press release, 4d Pharma, OCT 12, 2021, View Source [SID1234591114]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A webcast of the presentation will be available on the ‘Events’ section of the 4D pharma website at www.4dpharmaplc.com beginning Tuesday, October 19, 2021 at 8:00 a.m. ET (1:00 p.m. BST).

Biognosys Supports Cancer Scout, a Large-Scale Multi-Omics Research Project to Accelerate Personalized Cancer Medicine

On October 12, 2021 Biognosys, a leader in next-generation proteomics solutions for drug discovery and development, reported that it is supporting Cancer Scout as Proteomics provider (Press release, Biognosys, OCT 12, 2021, View Source [SID1234591113]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Cancer Scout is a large-scale joint research project led by University Medical Center Göttingen and Siemens Healthineers. The project received funding of EUR 10 million by the German Federal Ministry of Education and Research (BMBF)1.

The objective of Cancer Scout is to provide a new Artificial Intelligence tool for precision medicine in the fight against cancer. The research project will analyze and combine genomics, proteomics, and pathology data through Artificial Intelligence to generate a "digital biopsy" of molecular changes in tumors. Identifying these molecular changes can support early and accurate cancer diagnosis and predict personalized therapies for a patient’s tumor.

Oliver Rinner, PhD, CEO and founder of Biognosys states: "We are excited to be part of this visionary multi-omics research project and contribute to the development of more personalized clinical diagnostics and therapies for cancer with our proteomics solutions."

Biognosys was selected as the provider for the Proteomics data analysis in Cancer Scout, based on its unique technologies and workflows for large-scale proteomics, comprehensive quality standards for clinical research, and extensive expertise in precision oncology.

Biognosys’ discovery proteomics platform utilizes proprietary, patented Hyper Reaction Monitoring (HRM) mass spectrometry technology to quantify complete proteomes with unmatched precision, depth, and reproducibility. This solution can be applied with high throughput in large-scale studies involving thousands of samples from a broad range of clinical sample types.

Professor Philipp Ströbel, Director of Pathology at the University Hospital Göttingen, comments: "Combining digital pathology with proteomics and other omics data is essential to identify the full spectrum of molecular changes in tumors and enable truly personalized cancer care."

Christian Wolfrum, Head of New Business Development and Planning at Siemens Healthineers, adds: "We are excited to work with Biognosys to generate novel scientific insights in Cancer Scout and translate these into personalized cancer care solutions for clinical practice."

Myovant Sciences to Host Second Fiscal Quarter 2021 Earnings Conference Call at 8:30 a.m. Eastern Time on October 26, 2021

On October 12, 2021 Myovant Sciences (NYSE: MYOV), a healthcare company focused on redefining care for women and for men, reported it will host a webcast and conference call to discuss corporate updates and financial results for its second fiscal quarter 2021, ended September 30, 2021 (Press release, Myovant Sciences, OCT 12, 2021, https://investors.myovant.com/news-releases/news-release-details/myovant-sciences-host-second-fiscal-quarter-2021-earnings [SID1234591112]). The webcast and conference call will be held at 8:30 a.m. Eastern Time / 5:30 a.m. Pacific Time on October 26, 2021.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Investors and the general public may access a live webcast of the call by visiting the investor relations page of Myovant’s website at investors.myovant.com. Institutional investors and analysts may also participate in the conference call by dialing 1-800-532-3746 in the U.S. or +1-470-495-9166 from outside the U.S.

A replay of the webcast, along with the earnings press release and presentation materials, will be archived on Myovant’s investor relations website.