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Oncoinvent Announces Advancement of Radspherin® to Fourth Dose Level Cohort in Ongoing RAD-18-001 Phase 1 Trial in Ovarian Cancer Patients

On September 28, 2021 Oncoinvent AS, a clinical stage company advancing a pipeline of radiopharmaceutical products across a variety of solid cancers, reported that the trial Safety Monitoring Committee approved its first-in-human Phase 1 clinical study of Radspherin in ovarian cancer patients suffering from peritoneal carcinomatosis to progress to the fourth level dose cohort (Press release, Oncoinvent, SEP 28, 2021, View Source [SID1234590413]). Enrollment in this cohort, where patients will receive 7 MBq of Radspherin, is expected to begin imminently.

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"The progression of the RAD-18-001 study to the fourth dose level, continues to build our confidence as we continue to develop Radspherin for treatment peritoneal carcinomatosis, an area of high unmet need," said Jan A. Alfheim, Chief Executive Officer of Oncoinvent. "we will now start dosing patients at the 7 MBq dose level, a dose level that has been found to be safe in colorectal cancer patients."

About RAD-18-001

The phase 1 open-label, dose-escalation clinical trial is designed to assess the dose, safety and tolerability of Radspherin, an α-emitting radionuclide therapy, administered into the intraperitoneal cavity in subjects with peritoneal carcinomatosis from ovarian cancer following complete cytoreductive surgery. Key objectives in the study include determining maximum tolerated dose, abdominal biodistribution, and preliminary anti-tumor activity. Please refer to www.clinicaltrials.gov for additional clinical trial details.

About Radspherin

Radspherin is a novel alpha-emitting radioactive microsphere suspension designed for treatment of metastatic cancers in body cavities. The radium-224 based therapeutic, Radspherin has shown strong and consistent anticancer activity at doses being essentially non-toxic in preclinical studies. It is anticipated that the product can potentially be used to treat several forms of metastatic cancer.

Gennao Bio to Participate in Chardan’s 5th Annual Genetic Medicines Conference

On September 28, 2021 Gennao Bio, a privately held genetic medicines company developing first-in-class, targeted nucleic acid therapeutics, reported that management will participate in Chardan’s 5th Annual Genetic Medicines Conference, being held virtually from October 4-5, 2021 (Press release, Gennao Bio, SEP 28, 2021, View Source [SID1234590412]). The details are as follows:

Event: Chardan’s 5th Annual Genetic Medicines Conference
Panel: RNA: RNA-based Targeted Delivery Approaches
Location: Virtual
Date: Tuesday, October 5, 2021
Time: 3:00 PM ET

Members of the Gennao Bio management team will also host investor meetings during the conference. A webcast of the panel discussion will be available on the company’s website at www.gennao.com for 30 days following the event.

Gamida Cell to Host Virtual Event Highlighting GDA-201 and NAM-Enabled, Genetically Modified NK Cell Therapy Pipeline

On September 28, 2021 Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, reported that it will host a virtual event detailing the company’s proprietary NAM-enabled natural killer (NK) cell therapy pipeline on Tuesday, October 26, 2021 at 8:00 a.m. ET (Press release, Gamida Cell, SEP 28, 2021, View Source [SID1234590411]).

During the event, the company will highlight updates on the clinical development of GDA-201, its lead cryopreserved, off-the-shelf cell therapy candidate for the treatment of patients with follicular and diffuse large b-cell lymphomas, and Gamida Cell’s new development programs leveraging next-generation, NAM-enabled, genetically modified NK cells in development for solid tumors and hematological cancers. Specifically, Gamida Cell will provide an update on the following genetically modified NK cell therapies:

GDA-301, a CISH knockout and membrane-bound IL-15 NK cell construct that has demonstrated increased potency against leukemia and multiple myeloma cell lines
GDA-501, a CAR-HER2 NK cell construct that has shown increased cytotoxicity against an ovarian tumor cell line
GDA-601, a CD38 knockout + CD38 CAR NK cell construct that has yielded increased cytotoxicity against a multiple myeloma cell line
The event will feature management presentations and participation by the following speakers:

Jeff Miller, M.D., Professor of Medicine, Division of Hematology, Oncology and Transplantation at University of Minnesota
Veronika Bachanova, M.D., Ph.D., Hematologist/Oncologist at University of Minnesota Health
Patient treated with GDA-201
The live event will be available at the following link. A replay of the webcast will be available on the "Investors & Media" section of Gamida Cell’s website at www.gamida-cell.com, and will be available for at least 14 days following the event.

About GDA-201

Gamida Cell applied the capabilities of its nicotinamide (NAM)-based cell expansion technology to develop GDA-201, an innate NK cell immunotherapy for the treatment of hematologic and solid tumors in combination with standard of care antibody therapies. GDA-201, the lead candidate in the NAM-enabled NK cell pipeline, has demonstrated promising initial clinical trial results, as reported at the 2020 American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting & Exposition1. GDA-201 addresses key limitations of NK cells by increasing the cytotoxicity and in vivo retention and proliferation in the bone marrow and lymphoid organs. Furthermore, GDA-201 improves antibody-dependent cellular cytotoxicity (ADCC) and tumor targeting of NK cells. For more information on the clinical study of GDA-201, please visit View Source and www.clinicaltrials.gov.

GDA-201 is an investigational therapy, and its safety and efficacy have not been established by the FDA or any other health authority.

Castle Biosciences President and CEO Derek Maetzold Will Deliver Keynote Presentation During Arizona Bioscience Week

On September 28, 2021 Castle Biosciences, Inc. (Nasdaq: CSTL), a dermatologic diagnostics company providing personalized genomic information to inform treatment decisions, reported that Derek Maetzold, president and chief executive officer, will deliver the keynote presentation during Arizona Bioscience Week, taking place from Oct. 3-9, 2021 (Press release, Castle Biosciences, SEP 28, 2021, View Source [SID1234590410]). Arizona Bioscience Week is presented by the Arizona Bioindustry Association (AZBio) and the Arizona Commerce Authority.

As demonstrated through Arizona Bioscience Week, Arizona’s bioscience industry is committed to discovering, developing and delivering innovative medicines, medical devices and healthcare technologies that make life better for people in Arizona and around the world.

"As we continue to grow the bioscience industry in Arizona, we are grateful for companies like Castle Biosciences, who are committed to patient care and supporting the future business leaders of tomorrow," said Joan Koerber-Walker, president and chief executive officer of AZBio. "Derek’s and Castle’s success are a testament to the power and importance of having a strong vision from the beginning – keeping patient care at the forefront of business – and we are excited to hear Derek share his story with other up-and-comers in the life science industry."

"I am honored to have the opportunity to keynote Arizona Bioscience Week," said Derek Maetzold, president and CEO of Castle Biosciences. "This event benefits AZAdvances, part of the Opportunity Through Entrepreneurship Foundation that is providing not only funding but also mentorship for the life science innovators of tomorrow. Castle is proud to support this organization, future innovation and the Arizona bioscience community."

Maetzold’s keynote presentation will take place during the AZAdvances Innovation Showcase on Oct. 6. To register or learn more about the events taking place during Arizona Bioscience Week, visit View Source

About Arizona Bioindustry Association

The Arizona Bioindustry Association (AZBio) is a not-for-profit, 501(c)(6) trade association supporting the growth of Arizona’s life science sector. AZBio member organizations in the fields of business, research and education, health care delivery, economic development, government and other professions involved in the biosciences are the key drivers of the growth of Arizona’s life science sector. As the unified voice of our industry in Arizona, AZBio strives to make Arizona a place where bioscience organizations can grow and succeed.

AZBio works nationally and globally with the Advanced Medical Technology Association (AdvaMed), the Biotechnology Innovation Organization (BIO), the Medical Device Manufacturers Association (MDMA), the Pharmaceutical Research and Manufacturers of America (PhRMA) and leading patient advocacy organizations.

Through these relationships, AZBio has access to information, contacts, resources, cost saving programs and the global bioscience and medtech community.

Kintara Announces Closing of $15.0 million Offering Priced at a Premium to Market

On September 28, 2021 Kintara Therapeutics, Inc. (Nasdaq: KTRA) ("Kintara" or the "Company"), a biopharmaceutical company developing novel cancer therapies for patients who are failing, or are resistant to, current treatment regimens reported the closing of its previously announced registered direct offering, priced at-the-market under Nasdaq rules, with several healthcare-focused institutional investors of 12,000,000 shares of its common stock (or common stock equivalents) and warrants to purchase up to an aggregate of 12,000,000 shares of common stock, at a combined offering price of $1.25 per share and associated warrant (Press release, Kintara Therapeutics, SEP 28, 2021, View Source [SID1234590409]). The warrants have an exercise price of $1.25 per share and are exercisable for three and one half years from the date of issuance. The gross proceeds to the Company totaled approximately $15 million, before deducting placement agent fees and offering expenses.

H.C. Wainwright & Co. acted as the exclusive placement agent for the offering.

The Company currently intends to use the net proceeds from the offering for funding its clinical studies, working capital and other general corporate purposes, including, but not limited to, funding acquisitions or investments in businesses, products or technologies that are complementary to the Company’s businesses, products and technologies.

The securities described above were offered by the Company pursuant to a "shelf" registration statement on Form S-3 (File No. 333-254662) filed with the Securities and Exchange Commission (SEC) on March 24, 2021 and declared effective on April 1, 2021. The offering of the securities described herein was made only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. A final prospectus supplement and accompanying prospectus relating to the securities being offered was filed with the SEC. Electronic copies of the final prospectus supplement and accompanying prospectus may be obtained on the SEC’s website at View Source or by contacting H.C. Wainwright & Co., LLC, 430 Park Avenue, 3rd Floor, New York, NY 10022, by telephone at (646) 975-6996, or email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.