On April 17, 2026 Abbott (NYSE: ABT) reported it will present new data at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026 demonstrating continued advancements in its multi-biomarker, multi-cancer early detection (MCED) program supporting the commercially available Cancerguard test. Additionally, the AACR (Free AACR Whitepaper) Cancer Prevention Research Award for Outstanding Journal Article will recognize a publication on MCED multiyear outcomes from the DETECT-A study.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Multi-biomarker approach enables broader and earlier cancer detection
New data demonstrate how combining methylation (M) and protein (P) biomarkers improves cancer detection across stages, with each biomarker contributing independently to overall performance. Cancerguard is currently the only commercially available MCED test designed with a multi-biomarker class approach, combining methylation and protein signals to improve detection.

In a prospectively collected case-control study, nearly half of positive cancer signals were driven by methylation alone (47.1%), with additional detection from protein-only (7.4%) and combined biomarker signals (45.5%), supporting broader detection across cancer types and stages.1 In early-stage disease, many cancer signals were detected by a single biomarker class, demonstrating how each contributes uniquely to overall detection. Notably, none of the 2.6% false-positive results were positive for both biomarkers.1

"We designed Cancerguard as the first-of-its-kind multi-biomarker test because no one signal tells the whole story," said Tom Beer, M.D., chief medical officer, multi-cancer early detection, Abbott’s cancer diagnostics business. "By combining biomarkers, we can detect cancer earlier, when it matters most."

AACR recognizes impactful MCED research with journal award
The AACR (Free AACR Whitepaper) Cancer Prevention Research Award for Outstanding Journal Article will be presented to the authors of a 2024 Cancer Prevention Research publication reporting multi-year outcomes from the DETECT-A study, the first large prospective interventional trial of a blood-based MCED test. The study identified nine cancer types, including several without routine screening, and showed that, after a median follow-up of approximately four years, all patients treated for stage I or II cancers remained alive and cancer-free.2,3

The award recognizes the significance of these multi-year outcomes data in advancing evidence for the clinical impact of MCED, an area where long-term outcomes data have historically been limited.

"Long-term follow-up provides critical insight into how multi-cancer early detection can shape the future of cancer screening," said Beer. "With nearly 70 percent of cancers occurring in types without recommended screening, these findings highlight the potential for MCED to increase early detection and improve outcomes."4

About the DETECT-A study
The DETECT-A (Detecting cancers Early Through Elective mutation-based blood Collection and Testing) study was the first-ever large, prospective, interventional study to use a blood test to detect multiple types of cancer in a real-world setting. The DETECT-A study enrolled more than 10,000 women with no history of cancer to determine if a blood test in combination with standard-of-care screenings could detect cancers before signs and symptoms appeared. The CancerSEEK test, the MCED test studied in DETECT-A, was the forerunner to the Cancerguard test.

About the Cancerguard test
Cancerguard is a laboratory-developed test (LDT) designed to detect multiple cancers, including the most aggressive cancers, in early stages from a simple blood draw. It integrates two classes of biomarkers to enable broader detection and follows a streamlined, imaging-based diagnostic pathway to help reduce unnecessary follow-up procedures. Developed with high specificity to minimize false positives, the test helps detect a wide range of cancers, including those that lack guideline-recommended screening options.5 The Cancerguard test has not been cleared or approved by the U.S. Food and Drug Administration or any other regulatory authority. To learn more, visit cancerguard.com.

(Press release, Abbott, APR 17, 2026, View Source [SID1234664465])

On April 16, 2026 IteriaBiopharma reported the closing of a Series Seed financing round of €5 million, contributed by Inveready, Xesgalicia and the founding partners. With this capital injection, the biotechnology company covers its financial requirements to complete the preclinical development and the first clinical trial of ITR-251, a novel drug for the treatment of patients with metastatic castration-resistant prostate cancer, as well as to advance its two early-stage research programmes in lung, pancreatic and colorectal cancer.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The company, headquartered in Touro (A Coruña), was founded in 2024 by GalChimia (led by its CEO and founder Carme Pampín), Julio Castro (founder and CEO of Palobiofarma), and Ramon Bosser, who serves as CEO of Iteria.

The goal of Iteria Biopharma is to discover and develop novel drugs against advanced metastatic cancers in which existing drugs are no longer effective, through the use of unconventional medicinal chemistry approaches.

At a global level, prostate cancer is the second most common tumour in men, with 1.47 million new cases and approximately 400,000 deaths annually — figures projected to rise to 2.4 million diagnoses by 2040 due to population ageing. While overall survival rates are high, these fall dramatically to 38% in metastatic cases, making the development of new drugs a critical priority. Therapeutic innovation is not only the key to rendering advanced disease chronic and improving quality of life, but the only effective pathway to curbing the impact of global mortality in the coming decades.
This capital injection will enable Iteria Biopharma to complete the regulatory preclinical development of its drug for metastatic prostate cancer and initiate a first Phase 1 clinical trial in patients with this condition in early 2027, as well as to advance the identification of candidate drugs for its two other projects in pancreatic, colorectal and lung cancer, with the aim of initiating their preclinical development over the next two years.

Ramon Bosser, CEO and co-founder of the company, stated: «We are very pleased with the support of venture capital firms with the experience and soundness of Inveready and Xesgalicia, which — together with the capital contributed by the founders since the inception of the project and the support of public grants awarded by the MICINN and the CDTI — will represent a major boost for the advancement of Iteria’s projects. It also establishes a very strong foundation for its future progression, and we hope it will provide solutions for patients with high unmet need.»
"Iteria Biopharma stands out for the scientific and operational excellence of its founding and management team and, in line with our investment strategy, is developing disruptive treatments for unmet medical needs in oncology patients with metastasis," added Sara Secall, General Partner at Inveready.

Raquel Rodríguez, CEO of Xesgalicia, added: «The investment in Iteria Biopharma is part of the Xunta de Galicia’s strategy for consolidating the biotechnology sector, supporting innovative Galician initiatives based on excellence and led by a team of recognized track record.

Carme Pampín and Julio Castro, co-founders of Iteria Biopharma, added: «It is a great satisfaction for us to be part of this project, following a first successful experience in this field, and to accompany it from its inception in the execution of its growth strategy. This new phase represents a significant milestone for the team, and we face it with the motivation of replicating the success achieved previously.

On April 16, 2026, Rigel Pharmaceuticals, Inc. ("Rigel") reported to have received written notice from Eli Lilly and Company ("Lilly") of Lilly’s election to terminate that certain License and Collaboration Agreement, dated February 18, 2021 (the "Agreement"), between Rigel and Lilly.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Pursuant to the terms of the Agreement, Lilly has elected to terminate the Agreement in its entirety. The termination will become effective June 15, 2026.

The Agreement granted Lilly an exclusive worldwide license to develop and commercialize ocadusertib (previously R552), an investigational, potent and selective receptor interacting serine/threonine protein kinase 1 ("RIPK1") inhibitor, for the treatment of non-central nervous system ("non-CNS") diseases, and additional RIPK1 inhibitors for the treatment of central nervous system ("CNS") diseases. The Agreement also provided for collaboration between the parties on development activities, as well as potential milestone payments and royalties to Rigel.

Following the effective date of termination, the Agreement will terminate in accordance with its terms, including the cessation of Lilly’s rights to the licensed compounds, subject to any applicable transition provisions. Rigel expects to regain full rights to the licensed compounds and related programs upon termination.

Rigel is currently evaluating the impact of the termination. Following termination of the Agreement, including the prior termination of the CNS disease program under the Agreement, effective in November 2025, the Company does not expect to receive future milestones or royalties under the Agreement.

(Filing, Rigel, APR 16, 2026, View Source [SID1234664622])

On April 16, 2026 Enveric Biosciences, Inc. (NASDAQ: ENVB) ("Enveric" or the "Company"), a biotechnology company advancing novel neuroplastogenic small-molecule therapeutics to address psychiatric and neurological disorders, reported that it has entered into definitive agreements for the purchase and sale of 2,222,223 shares of its common stock (or pre-funded warrants in lieu thereof), Series I warrants to purchase up to an aggregate of 2,222,223 shares of common stock and short-term Series J warrants to purchase up to an aggregate of 2,222,223 shares of common stock, at a purchase price of $2.25 per share (or pre-funded warrant in lieu thereof) and accompanying warrants in a private placement priced at-the-market under Nasdaq rules. The warrants will have an exercise price of $2.00 per share and will be exercisable immediately upon issuance. The Series I warrants will expire five years after the effective date of the Resale Registration Statement (as defined below) and the short-term Series J warrants will expire eighteen months after the effective date of the Resale Registration Statement.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

The aggregate gross proceeds to the Company from the offering are expected to be approximately $5 million before deducting placement agent fees and other offering expenses payable by the Company. The potential additional gross proceeds to the Company from the Series I warrants and the short-term Series J warrants, if fully exercised on a cash basis, will be approximately $8.9 million. No assurance can be given that any of the warrants will be exercised, or that the Company will receive cash proceeds from the exercise of the warrants. The closing of the offering is expected to occur on or about April 17, 2026, subject to the satisfaction of customary closing conditions. The Company intends to use the net proceeds from the offering for product development, working capital and general corporate purposes.

The securities described above are being offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Securities Act") and/or Regulation D promulgated thereunder and, along with the shares of common stock underlying the warrants sold in the offering, have not been registered under the Securities Act or applicable state securities laws. Accordingly, such securities may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws. Pursuant to a registration rights agreement, the Company has agreed to file one or more registration statements with the SEC covering the resale of the unregistered securities to be issued in the offering (the "Resale Registration Statement").

This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

(Press release, Enveric Biosciences, APR 16, 2026, View Source [SID1234664469])

On April 16, 2026 Nula Therapeutics (previously called Apollo Alpha), a biotechnology company developing a new class of medicines targeting the nuclear envelope of cells in order to treat chronic disease and extend healthspan, reported its launch with an up to $20 million award from the U.S. Advanced Research Projects Agency for Health (ARPA-H) under its PROSPR (PROactive Solutions for Prolonging Resilience) program, bringing total funding to more than $30 million. Additionally, Nula Therapeutics announced its plans for a phase 1b clinical trial with its lead, small molecule asset NLT-101 in Q4, 2026 in metabolic dysfunction, as the company works to address a broad spectrum of chronic, age-related diseases.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Nula is built on a fundamental insight: the integrity of the nuclear envelope, the structure that organizes DNA and governs gene expression, plays a central role in maintaining cellular identity and metabolic homeostasis. Degeneration or dysfunction of the nuclear envelope results in metabolic dysfunction and age-related decline. Restoring function of the nuclear envelope represents a novel strategy to treat chronic disease biology. By developing targeted small molecules that restore the nuclear envelope, Nula aims to treat unmet patient needs and extend healthspan across conditions including metabolic disease, metabolic dysfunction-associated steatohepatitis (MASH), and neurodegeneration. With a clinic-ready asset, NLT-101, and a clinical study planned to begin later this year, Nula is positioned to generate meaningful data in support of its vision of next-generation medicines for chronic diseases.

"The nuclear envelope is one of the most fundamental and underexplored regulators of cellular health, and we believe it represents one of the most promising frontiers in medicine," said Christopher R. Shepard, Ph.D., Chief Executive Officer of Nula Therapeutics and Principal Investigator on the Award. "Today’s announcement marks not only our debut as a company, but a significant external validation of our science. The ARPA-H award will allow us to rigorously explore NLT-101’s potential to preserve functional health across multiple organ systems, while our core clinical program in metabolic dysfunction moves forward in parallel."

Nils Regge, Founder and General Partner at Apollo Health Ventures, added, "PROSPR is highly relevant to our mission at Apollo Health Ventures. Establishing the evidence base and a clear regulatory pathway for therapeutics that improve healthspan, intrinsic capacity, and functional resilience is foundational to the field of longevity biotechnology. We are excited to see Nula’s program paving the way, and we look forward to seeing the company demonstrate the potential of NLT-101 beyond its initial clinical indication, with implications across multiple age-related conditions."

About the ARPA-H PROSPR Award

Under the ARPA-H PROSPR program, Nula Therapeutics will pursue a concurrent work stream designed to evaluate NLT-101’s impact on intrinsic capacity – a composite measure of physical, cognitive, sensory, and psychological function across multiple organ systems. Specific program objectives include:

Evaluation of NLT-101 in aged preclinical models across multiple intrinsic capacity domains
Advancement of NLT-101 through translational pharmacology and IND-enabling studies
Development of biomarker-driven strategies to quantify functional preservation and therapeutic response
This program integrates functional performance measures and systems-level biomarker analysis to build a robust translational dataset supporting potential clinical development in healthspan-focused indications, while Nula’s primary clinical development program in metabolic dysfunction advances along a well-established regulatory path.

The program culminates in a 12-month, randomized, placebo-controlled clinical study in healthy older adults, with Intrinsic Capacity as the primary endpoint. By assessing intrinsic capacity alongside emerging surrogate biomarkers, the initiative aims to help define measurable, regulatory-relevant endpoints for therapeutics targeting aging biology and functional resilience, potentially accelerating and streamlining future development programs.

(Press release, Nula Therapeutics, APR 16, 2026, View Source [SID1234664463])