Lilly Announces the Early Tender Results of Its Pending Cash Tender Offer for Up to $1.5 Billion Combined Aggregate Principal Amount of Its Outstanding Debt Securities and Removal of the Note Caps for Its 3.950% Notes due 2049 and Its 4.150% Notes due 2059

On September 21, 2021 Eli Lilly and Company (NYSE: LLY) reported the early tender results of its previously announced cash tender offer for specified series of its outstanding debt securities (Press release, Eli Lilly, SEP 21, 2021, View Source [SID1234590111]). Lilly also announced that it has removed the previously announced note caps setting forth the maximum principal amounts of its 4.150% Notes due 2059 and its 3.950% Notes due 2049 that Lilly will accept for purchase pursuant to the tender offer. Except as described in this press release, all other terms of the tender offer as described in the Offer to Purchase, dated September 7, 2021 (the "Offer to Purchase"), and the related Letter of Transmittal remain unchanged.

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A total of $2,016,575,000 in aggregate principal amount of the notes listed in the table below were validly tendered and not validly withdrawn on or before 5:00 p.m., New York City time, on September 20, 2021, the early tender date for the tender offer. The table below sets forth the aggregate principal amount of each series of notes subject to the tender offer that was validly tendered and not validly withdrawn on or prior to the early tender date.

Title of Security

CUSIP No.

Acceptance Priority Level

Principal Amount Outstanding

Principal Amount Tendered

Approximate Percentage of Outstanding Amount Tendered

Anticipated Principal Amount to be Accepted for Purchase

4.150% Notes due 2059

532457 BU1

1(1)

$1,000,000,000

$408,714,000

40.87%

$408,714,000

3.950% Notes due 2049

532457 BT4

2(2)

$1,500,000,000

$541,847,000

36.12%

$541,847,000

7.125% Notes due 2025

532457 AM0

3

$229,692,000

$12,221,000

5.32%

$12,221,000

6.770% Notes due 2036

532457 AP3

4

$174,445,000

$15,880,000

9.10%

$15,880,000

5.950% Notes due 2037

532457 BC1

5

$284,112,000

$17,284,000

6.08%

$17,284,000

5.550% Notes due 2037

532457 BA5

6

$476,152,000

$31,420,000

6.60%

$31,420,000

5.500% Notes due 2027

532457 AZ1

7

$377,505,000

$13,181,000

3.49%

$13,181,000

4.650% Notes due 2044

532457 BG2

8

$43,016,000

$4,680,000

10.88%

$4,680,000

3.950% Notes due 2047

532457 BR8

9

$436,129,000

$89,177,000

20.45%

$89,177,000

3.875% Notes due 2039

532457 BS6

10

$360,745,000

$120,492,000

33.40%

$120,492,000

3.700% Notes due 2045

532457 BJ6

11

$412,467,000

$25,668,000

6.22%

$25,668,000

3.375% Notes due 2029

532457 BV9

12

$1,150,000,000

$369,771,000

32.15%

$219,436,000

3.100% Notes due 2027

532457 BP2

13

$401,450,000

$54,408,000

13.55%

$0

2.750% Notes due 2025

532457 BH0

14

$560,646,000

$146,108,000

26.06%

$0

2.350% Notes due 2022

532457 BQ0

15

$750,000,000

$165,724,000

22.10%

$0


(1)

Lilly has removed the previously announced note cap setting forth the maximum principal amount of 4.150% Notes due 2059 that Lilly will accept for purchase pursuant to the tender offer.

(2)

Lilly has removed the previously announced note cap setting forth the maximum principal amount of 3.950% Notes due 2049 that Lilly will accept for purchase pursuant to the tender offer.

Subject to the conditions in the Offer to Purchase, notes validly tendered and not validly withdrawn at or prior to the early tender date with Acceptance Priority Level 12 have been accepted for purchase using a proration factor of approximately 59.4%.

The settlement date for the notes accepted for purchase by Lilly in connection with the early tender date is currently expected to be September 22, 2021.

Lilly expects to determine the pricing terms of the tender offer at 10:00 a.m., New York City time, on September 21, 2021, unless extended. The tender offer is scheduled to expire at 11:59 p.m., New York City time, on October 4, 2021, unless extended or terminated earlier.

Holders of notes subject to the tender offer who validly tendered and did not validly withdraw their notes on or prior to the early tender date are eligible to receive the applicable total consideration, which includes an early tender premium of $30 per $1,000 principal amount of notes validly tendered by such holders that are accepted for purchase by Lilly. Accrued and unpaid interest from the last interest payment date for the applicable series of notes to, but excluding, the applicable settlement date will be paid in cash in respect of all validly tendered notes accepted for purchase by Lilly in the tender offer.

In accordance with the terms of the tender offer, the withdrawal date was 5:00 p.m., New York City time, on September 20, 2021. As a result, tendered notes may no longer be withdrawn, except in certain limited circumstances where additional withdrawal rights are required by law.

The tender offer is being conducted on the terms and subject to the conditions set forth in the Offer to Purchase and the related Letter of Transmittal, as supplemented by this press release.

Lilly has retained BofA Securities, Inc. and Citigroup Global Markets Inc. to serve as lead dealer managers for the tender offer, and Barclays Capital, Inc., BNP Paribas Securities Corp. and Deutsche Bank Securities Inc. to serve as co-dealer managers. Lilly has retained Global Bondholder Services Corporation to serve as tender agent and information agent for the tender offer.

Requests for documents relating to the tender offer may be directed to Global Bondholder Services Corporation by telephone at +1 (866) 470-3900, by email at [email protected] or in writing at 65 Broadway, Suite 404, New York, NY 10006. Questions regarding the tender offer may be directed to BofA Securities, Inc. toll-free at +1 (888) 292-0070 or collect at +1 (980) 387-3907 or to Citigroup Global Markets Inc. toll-free at +1 (800) 558-3745 or collect +1 (212) 723-6106.

This press release is for informational purposes only and is not an offer to purchase, the solicitation of an offer to sell any notes. The tender offer is being made only pursuant to the Offer to Purchase and the information in this press release is qualified by reference to the Offer to Purchase. In any jurisdiction where the laws require the tender offer to be made by a licensed broker or dealer, the tender offer will be deemed made on behalf of Lilly by the dealer managers, or one or more registered brokers or dealers under the laws of such jurisdiction. None of Lilly or its affiliates, their respective boards of directors, the Dealer Managers, Global Bondholder Services Corporation or the trustee with respect to any series of notes is making any recommendation as to whether holders should tender any notes in response to the tender offer, and neither Lilly nor any such other person has authorized any person to make any such recommendation. Holders must make their own decision as to whether to tender any of their notes, and, if so, the principal amount of notes to tender.

In addition, this press release is not an offer to sell or the solicitation of an offer to buy any securities. No offer, solicitation, purchase or sale will be made in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. Any such securities will be offered only by means of a prospectus, including a prospectus supplement relating to such securities, meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

Black Diamond Therapeutics to Present at the 2021 Cantor Fitzgerald Virtual Global Healthcare Conference

On September 21, 2021 Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of MasterKey therapies, reported that its President and Chief Executive Officer, David M. Epstein, Ph.D., will present an update about the Company’s progress at the 2021 Cantor Fitzgerald Virtual Global Healthcare Conference on Tuesday, September 28, 2021 at 4:40 PM ET (Press release, Black Diamond Therapeutics, SEP 21, 2021, View Source [SID1234590110]).

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A live webcast of the presentation can be accessed by visiting the investor relations section of the Company’s website, www.blackdiamondtherapeutics.com. A replay of the presentation will also be available and archived on the site for three weeks.

Vigeo Therapeutics Provides Clinical Update for Lead Asset VT1021 and Welcomes New Chief Executive Officer

On September 21, 2021 Vigeo Therapeutics, a clinical-stage immuno-oncology company pioneering novel cancer therapies, reported completion of the Phase 1/2 dose expansion studies evaluating its lead asset VT1021 in recurrent glioblastoma (rGBM) and pancreatic cancer (Press release, Vigeo Therapeutics, SEP 21, 2021, View Source [SID1234590109]).

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VT1021 is a first-in-class, dual-modulating compound that both blocks the CD47 immune checkpoint and reprograms the CD36 receptor to induce tumor cell apoptosis and inhibit angiogenesis. In the completed open-label, multicenter Phase 1/2 study (NCT03364400), the safety and preliminary anti-tumor efficacy of single-agent VT1021 was evaluated in subjects enrolled in both dose escalation and dose expansion cohorts. The escalation cohort included all-comers, and the expansion cohorts focused on rGBM and pancreatic cancer, among other indications.

Phase 1/2 Results in Recurrent Glioblastoma and Pancreatic Cancer

In the rGBM expansion cohort, single-agent VT1021 demonstrated complete tumor regression in multiple subjects and partial response in other subjects, with multiple subjects remaining on trial for well over 9 months. While the expansion study has concluded, these subjects will continue to receive VT1021 in an open label extension study.

In the pancreatic cancer expansion cohort, single-agent VT1021 demonstrated tumor reduction in multiple subjects with measurable disease. Moreover, VT1021 was able to reprogram the tumor immune microenvironment from immune-suppressive to immune-responsive.

Vigeo plans to present the results of both of these studies at medical meetings during the fourth quarter of 2021. The company is expected to initiate a global, Phase 2/3 registration study evaluating VT1021 in newly diagnosed and recurrent GBM patients by the end of 2021. In parallel, Vigeo plans to initiate efficacy studies in additional solid tumor indications, including pancreatic cancer, during the first half of 2022.

Jim Mahoney, Chief Executive Officer of Vigeo, commented, "VT1021 is a first-in-class anti-cancer agent that works by stimulating the expression of Tsp-1 which then binds with high affinity to CD47, blocking the "do not eat me" signal, and to CD36, which leads to a cascade of beneficial changes within the tumor microenvironment (TME) that further enhance anti-tumor effects. We, along with the PI’s who conducted the trials, are very excited by what we have observed to date in the two expansion studies."

Mr. Mahoney was appointed Chief Executive Officer in February of this year. Jing Watnick, PhD, MBA, Vigeo founder and previous CEO, is remaining on as the COO and will focus her efforts on developing the clinical and preclinical assets.

Prior to joining Vigeo as CEO, Mr. Mahoney served as a member of the Vigeo Board of Directors since 2015. In his new role, Mr. Mahoney will lead the development of Vigeo’s corporate strategy and will drive a disciplined growth strategy as Vigeo executes on its clinical programs.

Mr. Mahoney has over 30 years of senior executive experience at various biotechnology, healthcare and specialty chemicals companies. Most recently, he was an Operating Partner at Ara Partners, a private equity investment firm. Prior to that he served as CEO and President at Novomer Inc., Surface Logix Inc., and Prolinx Inc. and was a founding senior executive at Dade Behring Inc. Earlier, he held executive positions at Baxter International and FMC Corporation. Mr. Mahoney received his BS degree from the University of Massachusetts, Amherst, and holds an MBA from Northwestern University’s J.L. Kellogg School of Management and an MMA in international economics from the University of Southern California.

About VT1021
Vigeo’s lead asset, VT1021, is a first-in-class dual modulating compound that blocks the CD47 immune checkpoint and activates CD36, which induces apoptosis and increases the M1:M2 macrophage ratio. VT1021 achieves this through stimulation of thrombospondin-1 (Tsp-1). The goal of these dual-modulating effects is conversion of immuno-suppressive, or "cold," tumors that don’t respond to immuno-oncology agents, to immuno-stimulated, or "hot," tumors that are potentially more receptive to immuno-oncology agents. Vigeo is developing VT1021 as a therapeutic agent across a range of cancers, with a current focus on solid tumors.

HemoShear Therapeutics Advancing Several Novel Compounds for Horizon Therapeutics plc Gout Discovery Pipeline

On September 21, 2021 HemoShear Therapeutics, Inc., a privately held clinical stage biotechnology company, reported that it has earned a milestone payment for the advancement of potential lead product candidates for the treatment of gout under its collaboration with Horizon Therapeutics plc (Nasdaq: HZNP) (Press release, Horizon Therapeutics, SEP 21, 2021, View Source [SID1234590108]). This milestone marks the fourth payment that HemoShear has earned, following previous payments for the identification and validation of two novel gout drug targets in accordance with the Horizon exclusive drug discovery agreement established in January 2019.

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"Horizon has been a great partner throughout this collaboration," said Brian Wamhoff, PhD, chief operating officer of HemoShear. "By combining Horizon’s expertise in gout with HemoShear’s REVEAL-TxTM drug discovery platform, we are managing a research program that has generated new insights into the disease process, identified novel gout targets and generated several first-in-class modulators of these targets."

Under the terms of the agreement, HemoShear received an upfront payment and R&D funding, and Horizon received exclusive access to HemoShear’s proprietary disease modeling platform, to discover new therapeutics for gout. Successful development and commercialization of multiple therapies by Horizon will make HemoShear eligible to receive milestone payments of potentially more than $500 million plus royalties. Further financial terms were not disclosed.

Gout is a chronic, progressive inflammatory form of arthritis affecting more than nine million people in the United States that is caused by excess uric acid in the body and needs to be managed aggressively. If uric acid levels in the blood remain elevated, crystals can form and deposit in the joints, which can lead to severe pain, tenderness, stiffness, swelling and joint damage. In addition to the joint damage, urate crystals can also deposit in other organs of the body, and if left unmanaged, gout can lead to significant tissue damage. Uncontrolled gout occurs when people living with gout continue to have high levels of uric acid and gout symptoms despite the use of standard oral urate-lowering therapies.

Thermo Fisher Scientific to Present at the JP Morgan 12th Annual U.S. All Stars Conference on September 22, 2021

On September 21, 2021 Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, announced that Marc N. Casper, chairman, president and chief executive officer, will present virtually at the JP Morgan 12th Annual U.S . All Stars Conference on Wednesday, September 22, 2021 at 9:00 a.m. (EDT) (Press release, Thermo Fisher Scientific, SEP 21, 2021, View Source [SID1234590107]).

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You can access the webcast of the presentation via the Investors section of our website, www.thermofisher.com.