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Applied BioMath, LLC to Present at Bio-IT World Conference & Expo

On September 14, 2021 Applied BioMath (www.appliedbiomath.com), the industry-leader in applying systems pharmacology and mechanistic modeling, simulation, and analysis to de-risk drug research and development reported their participation at the Bio-IT World Conference & Expo occurring virtually and in Boston, MA September 20-22, 2021 (Press release, Applied BioMath, SEP 14, 2021, View Source;expo-301376645.html [SID1234587699]).

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John Burke, PhD, Co-founder, President and CEO of Applied BioMath will present "Applied BioMath Assess – An Early Feasibility Assessment Tool for Biotherapeutics" within the Software Applications and Services track on Tuesday, September 21st at 10:30 a.m. ET. In this presentation, Dr. Burke will demonstrate Applied BioMath Assess*, an interactive, web-based application that helps assess the difficulties and risks in developing a therapeutic very early-on. Dr. Burke will explain how Applied BioMath Assess can help project teams answer questions such as:

How does affinity impact target inhibition? Will it impact TMDD if membrane bound?
How does dosing interval impact success criteria?
How does target expression, especially in the site of action, impact design criteria?
How to think about therapeutic index prior to Lead Generation?
"Applied BioMath Assess provides rational go/no-go guidance while also helping project teams manage their resources efficiently," said Dr. Burke. "Our software has an exciting roadmap and will continue to evolve as we add new drug modality models and tools to best inform therapeutic R&D."

Additionally, Sharvari Gujja, Senior Principal Scientist, Bioinformatics at Applied BioMath will present a poster titled, "Leveraging ML/AI Tools for Robust Identification of Potential Biomarkers in Drug Response." The poster provides an overview of Applied BioMath’s open source, easy-to-use and flexible command line interface (CLI) to access the state-of-the-art Machine Learning and Deep Learning frameworks to build predictive models for assessing cancer drug response using gene expression data from The Cancer Genome Atlas Program (TCGA) and Genomics of Drug Sensitivity in Cancer (GDSC).

Tyra Announces Pricing of Upsized Initial Public Offering

On September 14, 2021 Tyra Biosciences, Inc. (Nasdaq: TYRA), a precision oncology company focused on developing purpose-built therapies to overcome tumor resistance and improve outcomes for patients with cancer, reported the pricing of its upsized initial public offering of 10,800,000 shares of common stock at an initial public offering price of $16.00 per share (Press release, Tyra Biosciences, SEP 14, 2021, View Source [SID1234587698]). All of the shares are being offered by Tyra. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Tyra, are expected to be $172.8 million. The shares are expected to begin trading on the Nasdaq Global Select Market on September 15, 2021 under the ticker symbol "TYRA." The offering is expected to close on September 17, 2021, subject to the satisfaction of customary closing conditions. In addition, Tyra has granted the underwriters a 30-day option to purchase up to an additional 1,620,000 shares of common stock at the initial public offering price, less underwriting discounts and commissions.

BofA Securities, Jefferies and Cowen are acting as joint book-running managers for the offering.

Registration statements relating to the offering have been filed with the Securities and Exchange Commission and became effective on September 14, 2021. The offering will be made only by means of a prospectus. When available, copies of the final prospectus may be obtained from BofA Securities, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, North Carolina 28255-0001, Attention: Prospectus Department, or by email at [email protected]; from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, or by email at [email protected] or by telephone at 877-821-7388; or from Cowen and Company, LLC, c/o Broadridge Financial Solutions, Attention: Prospectus Department, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (833) 297-2926, or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any offer or sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

Vipergen Establishes Research Partnership with PhoreMost Focused on DNA Encoded Library (DEL)-Based Drug Discovery

On September 14, 2021 Vipergen, a leading provider of small-molecule drug discovery services based on DNA-encoded library (DEL) technologies, reported the signing of a multi-target drug discovery agreement with PhoreMost (Press release, PhoreMost, SEP 14, 2021, View Source [SID1234587697]). Under the terms of the agreement, Vipergen will apply its high-fidelity DEL technology platforms to identify novel small-molecule compounds that bind to selected PhoreMost protein targets. PhoreMost will select hits for development into novel therapeutics for oncology. PhoreMost will retain exclusive rights to globally commercialize any products resulting from the collaboration. Financial details of the agreement were not disclosed.

"Applying Vipergen’s suite of leading technologies for DNA-encoded library synthesis and screening, we aim to optimize our success rate for discovering novel, high-quality small drug molecules for several oncology targets that were previously considered undruggable," said Rich Boyce, Vice President of Drug Discovery at PhoreMost. "We look forward to collaborating with the Vipergen team in our mission to deliver a diverse range of more effective and safe therapies for cancer patients."

"We are delighted to partner with PhoreMost in its unique mission to develop a pipeline of transformative new therapies for cancer patients by identifying novel drug molecules for binding sites that have eluded conventional target discovery," said Nils Hansen, PhD, Chief Executive Officer of Vipergen. "In particular, Vipergen’s newest platform—which enables screening DNA-encoded small-molecule libraries inside living cells, under physiologically relevant conditions—significantly expands our ability to discover novel small molecules against challenging targets."

Compugen to Present at the Cantor Global Healthcare Conference

On September 14, 2021 Compugen Ltd. (NASDAQ: CGEN), a leader in predictive discovery and development of first-in-class therapeutics for cancer immunotherapy, reported that management will present at the Cantor Global Healthcare Conference on Thursday, September 30, 2021 at 1:20 pm ET (Press release, Compugen, SEP 14, 2021, View Source [SID1234587695]).

A live webcast of the presentation will be available on the Investor Relations section of Compugen’s website at www.cgen.com. A replay will be available following the event.

DNAtrix Announces the Appointment of David Liebowitz, M.D., Ph.D., as Chief Medical Officer

On September 14, 2021 DNAtrix, a biotech company advancing virus-driven immunotherapies for cancer, reported the appointment of David Liebowitz, M.D., Ph.D., an industry veteran with over 20 years of experience in oncology drug and viral vaccine development, as chief medical officer (Press release, DNAtrix, SEP 14, 2021, View Source [SID1234587694]).

"We are thrilled to welcome Dave to the executive leadership team at DNAtrix," said Jeffrey Knapp, chief executive officer of DNAtrix. "Dave has expertise in developing products that elicit immune responses against targets of interest through various therapeutic modalities, including viral-based vaccines. His deep experience leading oncology drug development programs for innovative, young, as well as established biopharmaceutical companies – such as Amgen — will prove invaluable as we advance our pipeline with multiple product candidates being studied in several tumor types and two programs in pivotal stage development."

Prior to joining DNAtrix, Dr. Liebowitz was most recently vice president of Clinical Oncology at Xencor, Inc. From 2012 to 2018, he served as the chief medical officer for Vaxart, Inc., a novel vaccine development company. He was previously the Chief Scientific and Medical Officer for Vivaldi Biosciences, an influenza vaccine and therapeutics biotechnology company. Prior to that, he was the executive vice president of Research and Development at Galileo Pharmaceuticals, and he also served as co-CEO of Galileo for a period of time. Prior to joining Galileo, Dr. Liebowitz was at Amgen, where he was the director of research responsible for all oncology and vascular biology drug discovery and development programs at their Washington research site. He also managed external development collaborations and licensing activities. Dr. Liebowitz joined Amgen through their acquisition of Immunex, where he held several senior positions in clinical and preclinical development. Prior to joining Immunex, he was an associate investigator in the Abramson Cancer Institute at the University of Pennsylvania, where he was director of their immunotherapy and cellular therapy programs targeting cancer and chronic viral diseases. Dr. Liebowitz was an early recipient of a grant from the Bill and Melinda Gates foundation. He began his academic career as an assistant professor of Medicine and Virology at the University of Chicago, and was the director of the Bone Marrow Transplantation Program. Dr. Liebowitz has B.S. and M.S. degrees in Biology from Emory University, an M.D. with honors and a Ph.D. in Molecular Genetics and Cell Biology, both from the University of Chicago.

Dr. Liebowitz added, "I am impressed by the compelling clinical data for the company’s lead drug candidate, DNX-2401, in diffuse intrinsic pontine glioma (DIPG) and recurrent glioblastoma (rGBM), two tumor types that have been notoriously difficult to treat and where therapeutic advances are desperately needed. Given the promise demonstrated with these programs, I also believe there is tremendous potential to leverage DNAtrix’s oncolytic adenoviral platform further for the treatment of other tumor types, and the company has studies underway evaluating therapeutic activity in additional cancers, such as colorectal cancer."