On August 31, 2021 NanoString Technologies, Inc. (NASDAQ: NSTG), a leading provider of life science tools for discovery and translational research, reported a peer-reviewed publication using the GeoMx Digital Spatial Profiler (DSP), published in the journal Cell (Press release, NanoString Technologies, AUG 31, 2021, View Source [SID1234587053]).

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The study, "Spatially organized multicellular immune hubs in human colorectal cancer," was led by Drs. Karin Pelka, Matan Hofree, and Jonathan Chen at the Broad Institute of MIT and Harvard. They used single cell transcriptomics, in situ hybridization, and GeoMx DSP to assess the mechanisms governing interactions between colorectal tumor cells and tumor-infiltrating immune cells.

The study investigated a cohort of 28 mismatch repair-proficient tumors and 34 mismatch repair-deficient colorectal cancer samples. In a subset of these tumors with a high number of potentially tumor-reactive T cells, the authors quantified cellular programs defined by single cell RNA-seq and mapped their interactions using the GeoMx Cancer Transcriptome Atlas (CTA) assay across 135 regions of interest, thus revealing the spatial transcriptional regulation that organizes immune-malignant cell networks. The auto segmentation capabilities of the DSP, which allows for tissue compartment-based profiling based on cellular phenotype, were essential to localizing transcriptional signatures to specific cell populations.

"To validate the interaction between malignant and T cell programs, we performed spatially-indexed transcript profiling on our patient tumor sections. We observed a positive correlation between interferon stimulated gene expression in malignant epithelial areas and CXCL13 expression in adjacent non-epithelial areas across all regions. From our single cell RNA-seq data we knew that CXCL13 was specifically expressed by chronically stimulated, potentially tumor-reactive T cells," said Pelka. "These findings further support potential interactions between malignant cells and T cells in this hub via a chemokine mediated network," added co-author Jonathan Chen, Massachusetts General Hospital.

"This study demonstrates the power of combining conventional single cell gene expression and GeoMx Digital Spatial Profiling enabled by Next Generation Sequencing readout," said Brad Gray, NanoString’s president and chief executive officer.

The GeoMx DSP enables researchers to rapidly and quantitatively characterize tissue morphology with a high-throughput, high-plex RNA and protein profiling system that preserves precious samples for future analyses. NanoString and its collaborators have presented DSP data in dozens of abstracts at major scientific meetings and in more than 60 peer-reviewed publications, demonstrating DSP’s utility to address a wide range of biological questions in FFPE and frozen tissues. Interested parties can learn more about DSP by visiting View Source

On August 31, 2021 PharmaCyte Biotech, Inc. (NASDAQ: PMCB), a biotechnology company focused on developing cellular therapies for cancer and diabetes using its signature live-cell encapsulation technology, Cell-in-a-Box, reported that its clinical trial product, CypCaps, remains stable and active at 18 months after completing the 18-month timepoint of ongoing product stability testing required by the U.S. Food and Drug Administration (FDA) (Press release, PharmaCyte Biotech, AUG 31, 2021, View Source [SID1234587052]). This means that the product has a shelf life of at least 18 months when stored at -80oC. The next scheduled timepoint in the ongoing testing will be after 2 years of storage at -80oC.

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PharmaCyte’s Chief Executive Officer, Kenneth L. Waggoner, said of the completed 18-month timepoint in its ongoing stability study, "We are pleased to announce these extended stability conditions, which will be included in our updated package of information that we provide to the FDA with the goal of lifting the clinical hold on our Investigational New Drug application (IND). This is an important development and enables simpler distribution and more flexibility at our clinical trial sites in the U.S. for our planned Phase 2b clinical trial in locally advanced, inoperable pancreatic cancer should the FDA grant us an open IND."

Analysis after 18 months in storage at -80oC, the unfrozen CypCaps product passed all the specified tests, including cell viability, enzyme activity, cell potency, pH, label check, capsule appearance and integrity. This ongoing stability study was initiated prior to the submission to the FDA of the Company’s IND. The information and data from the stability study will form part of the updated package of information that PharmaCyte will provide to the FDA, together with data from additional studies requested by the FDA.

As noted in a recent review article in "Frontiers in Medicine" by Meneghel and colleagues, stable cryopreservation is a key element in the successful delivery of live cell-based therapies. Meneghel J, Kilbride P and Morris GJ (2020) Cryopreservation as a Key Element in the Successful Delivery of Cell-Based Therapies—A Review. Front. Med. 7:592242. doi: 10.3389/fmed.2020.592242

To learn more about PharmaCyte’s pancreatic cancer treatment and how it works inside the body to treat locally advanced inoperable pancreatic cancer, we encourage you to watch the company’s documentary video complete with medical animations at: View Source

On August 31, 2021 Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company, reported that management will be participating in fireside chats at the following investor conferences (Press release, Sangamo Therapeutics, AUG 31, 2021, View Source [SID1234587051]):

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2021 Virtual Wells Fargo Healthcare Conference
Date: Friday, September 10th at 3:20 p.m. Eastern Time
H.C. Wainwright & Co. 23rd Annual Global Investment Conference
Date: Monday, September 13th at 7:00 a.m. Eastern Time
Morgan Stanley 19th Annual Global Healthcare Conference
Date: Wednesday, September 15th at 10:15 a.m. Eastern Time
For presentations that are webcast live, an access link will be available on the Sangamo Therapeutics website in the Investors and Media section under Events and Presentations. The presentations will also be available on the Sangamo Therapeutics website after the event.

On August 31, 2021 Exact Therapeutics AS ("EXACT-Tx", Euronext Growth: EXTX), a clinical stage precision medicine company evaluating Acoustic Cluster Therapy (ACT) across multiple therapeutic areas, reported that its Chief Executive Officer, Dr Rafiq Hasan, will be presenting at the Pareto Securities 12th Annual Healthcare Conference on Wednesday, 1 September at 12.00pm CET (Press release, Exact Therapeutics, AUG 31, 2021, View Source [SID1234587049]).

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About EXACT-Tx

EXACT-Tx is a clinical stage Norwegian biotech company developing a technology platform for targeted therapeutic enhancement – Acoustic Cluster Therapy (ACT). ACT sonoporation is a unique approach to ultrasound-mediated, targeted drug enhancement – with the potential to significantly amplify the clinical utility of a wide range of therapeutic agents across a multitude of indications including within oncology (chemotherapy, immunotherapy), infectious diseases, and neurological conditions. www.exact-tx.com

About ACT

ACT is a proprietary formulation consisting of microbubbles and microdroplets that are activated through the application of ultrasound with the consequent increase in targeted delivery of a co-administered therapeutic agent.

ACT is supported by a strong and broad preclinical package demonstrating therapeutic enhancement in multiple oncology models (pancreatic, breast, colon, prostate) as well as blood-brain barrier penetration.

Initial focus of the company is oncology, however the ACT platform has potential across therapeutic areas (infectious diseases, CNS, immunotherapy) and product classes.

On August 31, 2021 Veracyte, Inc. (Nasdaq: VCYT), a global diagnostics company, reported that Marc Stapley, chief executive officer, and Rebecca Chambers, chief financial officer, reported that it will participate in a fireside chat at the Morgan Stanley Virtual 19th Annual Global Healthcare Conference on Tuesday, September 14, at 3:30 p.m. Eastern Time (Press release, Veracyte, AUG 31, 2021, View Source [SID1234587048]).

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A live audio webcast of the company’s presentation will be available by visiting Veracyte’s website at View Source Replays of the webcast will be available for 90 days following the conclusion of the live presentation broadcast.