Kiniksa Pharmaceuticals to Present at 2021 Cantor Fitzgerald Virtual Global Healthcare Conference

On September 21, 2021 Kiniksa Pharmaceuticals, Ltd. (Nasdaq: KNSA) reported that it will present at the 2021 Cantor Fitzgerald Virtual Global Healthcare Conference on Tuesday, September 28, 2021 at 10:40 a.m. Eastern Time (Press release, Kiniksa Pharmaceuticals, SEP 21, 2021, View Source [SID1234590166]).

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A live webcast of Kiniksa’s presentation will be accessible through the Investors & Media section of the company’s website at www.kiniksa.com. A replay of the webcast will also be available on Kiniksa’s website within approximately 48 hours after the event.

SHINE’s new name highlights technology competencies and multiple phase opportunities

On September 22, 2021 SHINE Medical Technologies LLC reported that the company has changed its name to SHINE Technologies LLC (Press release, Shine Medical Technologies, SEP 22, 2021, View Source [SID1234590122]).

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SHINE’s new name highlights the company’s core technological competencies, skilled team and focus as a next-generation nuclear technology company. SHINE is pursuing a four-phase strategy for the development of nuclear fusion technology to achieve its ultimate goal: producing fusion energy. SHINE’s technology is currently being applied to advanced industrial inspection services and medical isotope production, phases I and II of the company’s four-phase approach, respectively.

"Our long-term goal is to create and deploy systems that produce clean fusion energy, and we are continuing to grow towards that goal by commercializing more near-term applications of fusion," said Greg Piefer, SHINE’s founder and CEO. "In addition, our merger with Phoenix earlier this year strengthened our position by enabling us to integrate a key technological capability that supports our near- and long-term plans."

Phoenix commercialized phase I, advanced industrial inspection services, over a decade ago by utilizing its fusion-based technology for nondestructive testing. These applications take neutron images or perform other assay measurements of modern materials in detail, ensuring that the quality and safety needs of clients in the aerospace, defense and energy industries are met.

SHINE’s phase II involves the application of fusion to the production of medical isotopes. The company expects to produce diagnostic isotopes for heart disease and other applications and is producing therapeutic isotopes for certain cancers. SHINE anticipates producing these isotopes at commercial scale at facilities on its campus in Janesville, Wis.

"The goal of each phase of our approach is to create social and economic value while building additional capacity and capability, and deepening our scientific understanding of fusion technology as we progress to clean energy production," Piefer said.

SHINE’s next step will be to explore the use of its technology to recycle nuclear waste in phase III. Carbon-free nuclear power currently faces a major political obstacle because it produces radioactive waste, some of which can last for millions of years. If successful, SHINE’s phase III is expected to help mitigate this problem by recycling a portion of this waste and using fusion to shorten the half-life on long-lived waste forms. Importantly, SHINE’s work in this phase could help fission power become a more sustainable form of carbon-free energy.

The goal of phase IV is to generate clean, abundant and affordable fusion energy. SHINE believes its achievement of this goal will be built on the strength of its skilled team, including their experience with challenging nuclear technology projects, the breadth of the company’s unique technological capabilities, and the experience expected to be gained from operating many powerful fusion systems in the field during phase III.

"We are excited that our new name more clearly reflects our core technological competencies, strong team and long-term ambitions," Piefer said. "SHINE was founded on differentiated technology, and a unique, lean and phased approach to developing nuclear technology. It’s great to be telling the world more about the company we’ve built, with an updated brand that reflects it."

Lilly Announces the Early Tender Results of Its Pending Cash Tender Offer for Up to $1.5 Billion Combined Aggregate Principal Amount of Its Outstanding Debt Securities and Removal of the Note Caps for Its 3.950% Notes due 2049 and Its 4.150% Notes due 2059

On September 21, 2021 Eli Lilly and Company (NYSE: LLY) reported the early tender results of its previously announced cash tender offer for specified series of its outstanding debt securities (Press release, Eli Lilly, SEP 21, 2021, View Source [SID1234590111]). Lilly also announced that it has removed the previously announced note caps setting forth the maximum principal amounts of its 4.150% Notes due 2059 and its 3.950% Notes due 2049 that Lilly will accept for purchase pursuant to the tender offer. Except as described in this press release, all other terms of the tender offer as described in the Offer to Purchase, dated September 7, 2021 (the "Offer to Purchase"), and the related Letter of Transmittal remain unchanged.

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A total of $2,016,575,000 in aggregate principal amount of the notes listed in the table below were validly tendered and not validly withdrawn on or before 5:00 p.m., New York City time, on September 20, 2021, the early tender date for the tender offer. The table below sets forth the aggregate principal amount of each series of notes subject to the tender offer that was validly tendered and not validly withdrawn on or prior to the early tender date.

Title of Security

CUSIP No.

Acceptance Priority Level

Principal Amount Outstanding

Principal Amount Tendered

Approximate Percentage of Outstanding Amount Tendered

Anticipated Principal Amount to be Accepted for Purchase

4.150% Notes due 2059

532457 BU1

1(1)

$1,000,000,000

$408,714,000

40.87%

$408,714,000

3.950% Notes due 2049

532457 BT4

2(2)

$1,500,000,000

$541,847,000

36.12%

$541,847,000

7.125% Notes due 2025

532457 AM0

3

$229,692,000

$12,221,000

5.32%

$12,221,000

6.770% Notes due 2036

532457 AP3

4

$174,445,000

$15,880,000

9.10%

$15,880,000

5.950% Notes due 2037

532457 BC1

5

$284,112,000

$17,284,000

6.08%

$17,284,000

5.550% Notes due 2037

532457 BA5

6

$476,152,000

$31,420,000

6.60%

$31,420,000

5.500% Notes due 2027

532457 AZ1

7

$377,505,000

$13,181,000

3.49%

$13,181,000

4.650% Notes due 2044

532457 BG2

8

$43,016,000

$4,680,000

10.88%

$4,680,000

3.950% Notes due 2047

532457 BR8

9

$436,129,000

$89,177,000

20.45%

$89,177,000

3.875% Notes due 2039

532457 BS6

10

$360,745,000

$120,492,000

33.40%

$120,492,000

3.700% Notes due 2045

532457 BJ6

11

$412,467,000

$25,668,000

6.22%

$25,668,000

3.375% Notes due 2029

532457 BV9

12

$1,150,000,000

$369,771,000

32.15%

$219,436,000

3.100% Notes due 2027

532457 BP2

13

$401,450,000

$54,408,000

13.55%

$0

2.750% Notes due 2025

532457 BH0

14

$560,646,000

$146,108,000

26.06%

$0

2.350% Notes due 2022

532457 BQ0

15

$750,000,000

$165,724,000

22.10%

$0


(1)

Lilly has removed the previously announced note cap setting forth the maximum principal amount of 4.150% Notes due 2059 that Lilly will accept for purchase pursuant to the tender offer.

(2)

Lilly has removed the previously announced note cap setting forth the maximum principal amount of 3.950% Notes due 2049 that Lilly will accept for purchase pursuant to the tender offer.

Subject to the conditions in the Offer to Purchase, notes validly tendered and not validly withdrawn at or prior to the early tender date with Acceptance Priority Level 12 have been accepted for purchase using a proration factor of approximately 59.4%.

The settlement date for the notes accepted for purchase by Lilly in connection with the early tender date is currently expected to be September 22, 2021.

Lilly expects to determine the pricing terms of the tender offer at 10:00 a.m., New York City time, on September 21, 2021, unless extended. The tender offer is scheduled to expire at 11:59 p.m., New York City time, on October 4, 2021, unless extended or terminated earlier.

Holders of notes subject to the tender offer who validly tendered and did not validly withdraw their notes on or prior to the early tender date are eligible to receive the applicable total consideration, which includes an early tender premium of $30 per $1,000 principal amount of notes validly tendered by such holders that are accepted for purchase by Lilly. Accrued and unpaid interest from the last interest payment date for the applicable series of notes to, but excluding, the applicable settlement date will be paid in cash in respect of all validly tendered notes accepted for purchase by Lilly in the tender offer.

In accordance with the terms of the tender offer, the withdrawal date was 5:00 p.m., New York City time, on September 20, 2021. As a result, tendered notes may no longer be withdrawn, except in certain limited circumstances where additional withdrawal rights are required by law.

The tender offer is being conducted on the terms and subject to the conditions set forth in the Offer to Purchase and the related Letter of Transmittal, as supplemented by this press release.

Lilly has retained BofA Securities, Inc. and Citigroup Global Markets Inc. to serve as lead dealer managers for the tender offer, and Barclays Capital, Inc., BNP Paribas Securities Corp. and Deutsche Bank Securities Inc. to serve as co-dealer managers. Lilly has retained Global Bondholder Services Corporation to serve as tender agent and information agent for the tender offer.

Requests for documents relating to the tender offer may be directed to Global Bondholder Services Corporation by telephone at +1 (866) 470-3900, by email at [email protected] or in writing at 65 Broadway, Suite 404, New York, NY 10006. Questions regarding the tender offer may be directed to BofA Securities, Inc. toll-free at +1 (888) 292-0070 or collect at +1 (980) 387-3907 or to Citigroup Global Markets Inc. toll-free at +1 (800) 558-3745 or collect +1 (212) 723-6106.

This press release is for informational purposes only and is not an offer to purchase, the solicitation of an offer to sell any notes. The tender offer is being made only pursuant to the Offer to Purchase and the information in this press release is qualified by reference to the Offer to Purchase. In any jurisdiction where the laws require the tender offer to be made by a licensed broker or dealer, the tender offer will be deemed made on behalf of Lilly by the dealer managers, or one or more registered brokers or dealers under the laws of such jurisdiction. None of Lilly or its affiliates, their respective boards of directors, the Dealer Managers, Global Bondholder Services Corporation or the trustee with respect to any series of notes is making any recommendation as to whether holders should tender any notes in response to the tender offer, and neither Lilly nor any such other person has authorized any person to make any such recommendation. Holders must make their own decision as to whether to tender any of their notes, and, if so, the principal amount of notes to tender.

In addition, this press release is not an offer to sell or the solicitation of an offer to buy any securities. No offer, solicitation, purchase or sale will be made in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. Any such securities will be offered only by means of a prospectus, including a prospectus supplement relating to such securities, meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

Black Diamond Therapeutics to Present at the 2021 Cantor Fitzgerald Virtual Global Healthcare Conference

On September 21, 2021 Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of MasterKey therapies, reported that its President and Chief Executive Officer, David M. Epstein, Ph.D., will present an update about the Company’s progress at the 2021 Cantor Fitzgerald Virtual Global Healthcare Conference on Tuesday, September 28, 2021 at 4:40 PM ET (Press release, Black Diamond Therapeutics, SEP 21, 2021, View Source [SID1234590110]).

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A live webcast of the presentation can be accessed by visiting the investor relations section of the Company’s website, www.blackdiamondtherapeutics.com. A replay of the presentation will also be available and archived on the site for three weeks.

Vigeo Therapeutics Provides Clinical Update for Lead Asset VT1021 and Welcomes New Chief Executive Officer

On September 21, 2021 Vigeo Therapeutics, a clinical-stage immuno-oncology company pioneering novel cancer therapies, reported completion of the Phase 1/2 dose expansion studies evaluating its lead asset VT1021 in recurrent glioblastoma (rGBM) and pancreatic cancer (Press release, Vigeo Therapeutics, SEP 21, 2021, View Source [SID1234590109]).

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VT1021 is a first-in-class, dual-modulating compound that both blocks the CD47 immune checkpoint and reprograms the CD36 receptor to induce tumor cell apoptosis and inhibit angiogenesis. In the completed open-label, multicenter Phase 1/2 study (NCT03364400), the safety and preliminary anti-tumor efficacy of single-agent VT1021 was evaluated in subjects enrolled in both dose escalation and dose expansion cohorts. The escalation cohort included all-comers, and the expansion cohorts focused on rGBM and pancreatic cancer, among other indications.

Phase 1/2 Results in Recurrent Glioblastoma and Pancreatic Cancer

In the rGBM expansion cohort, single-agent VT1021 demonstrated complete tumor regression in multiple subjects and partial response in other subjects, with multiple subjects remaining on trial for well over 9 months. While the expansion study has concluded, these subjects will continue to receive VT1021 in an open label extension study.

In the pancreatic cancer expansion cohort, single-agent VT1021 demonstrated tumor reduction in multiple subjects with measurable disease. Moreover, VT1021 was able to reprogram the tumor immune microenvironment from immune-suppressive to immune-responsive.

Vigeo plans to present the results of both of these studies at medical meetings during the fourth quarter of 2021. The company is expected to initiate a global, Phase 2/3 registration study evaluating VT1021 in newly diagnosed and recurrent GBM patients by the end of 2021. In parallel, Vigeo plans to initiate efficacy studies in additional solid tumor indications, including pancreatic cancer, during the first half of 2022.

Jim Mahoney, Chief Executive Officer of Vigeo, commented, "VT1021 is a first-in-class anti-cancer agent that works by stimulating the expression of Tsp-1 which then binds with high affinity to CD47, blocking the "do not eat me" signal, and to CD36, which leads to a cascade of beneficial changes within the tumor microenvironment (TME) that further enhance anti-tumor effects. We, along with the PI’s who conducted the trials, are very excited by what we have observed to date in the two expansion studies."

Mr. Mahoney was appointed Chief Executive Officer in February of this year. Jing Watnick, PhD, MBA, Vigeo founder and previous CEO, is remaining on as the COO and will focus her efforts on developing the clinical and preclinical assets.

Prior to joining Vigeo as CEO, Mr. Mahoney served as a member of the Vigeo Board of Directors since 2015. In his new role, Mr. Mahoney will lead the development of Vigeo’s corporate strategy and will drive a disciplined growth strategy as Vigeo executes on its clinical programs.

Mr. Mahoney has over 30 years of senior executive experience at various biotechnology, healthcare and specialty chemicals companies. Most recently, he was an Operating Partner at Ara Partners, a private equity investment firm. Prior to that he served as CEO and President at Novomer Inc., Surface Logix Inc., and Prolinx Inc. and was a founding senior executive at Dade Behring Inc. Earlier, he held executive positions at Baxter International and FMC Corporation. Mr. Mahoney received his BS degree from the University of Massachusetts, Amherst, and holds an MBA from Northwestern University’s J.L. Kellogg School of Management and an MMA in international economics from the University of Southern California.

About VT1021
Vigeo’s lead asset, VT1021, is a first-in-class dual modulating compound that blocks the CD47 immune checkpoint and activates CD36, which induces apoptosis and increases the M1:M2 macrophage ratio. VT1021 achieves this through stimulation of thrombospondin-1 (Tsp-1). The goal of these dual-modulating effects is conversion of immuno-suppressive, or "cold," tumors that don’t respond to immuno-oncology agents, to immuno-stimulated, or "hot," tumors that are potentially more receptive to immuno-oncology agents. Vigeo is developing VT1021 as a therapeutic agent across a range of cancers, with a current focus on solid tumors.