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ImmunoPrecise attending HubXchange East 2021

On June 10, 2021 ImmunoPrecise reported that it is attending HubXchange East being held in Boston May 17th-19th (Press release, ImmunoPrecise Antibodies, JUN 10, 2021, View Source [SID1234583816]). HubXchange specializes in delivering high-level content, intelligence and connections to the global Life Sciences community by hosting outstanding business Xchanges. These meetings are a series of highly-interactive roundtable discussions bringing together executives and senior academics over the course of one day.

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ImmunoPrecise to Present at Antibody Engineering & Therapeutics Europe

On June 10, 2021 ImmunoPrecise Antibodies reported that At this year’s Antibody Engineering & Therapeutics Europe, Dr. Debby Kruijsen will be present the scientific briefing Identification of Unique Antibodies by Parallel Sourcing Chicken and Human B-cell Repertoires Using Innovative Technologies (Press release, ImmunoPrecise Antibodies, JUN 10, 2021, View Source [SID1234583815]). Our team will also be showcasing the scientific poster Successful rabbit mAb CDR-grafting: The first step towards clinically suitable monoclonal antibodies.

The event will be hosted virtually June 8th-10th, 2021.

First Patient enrolled in the SAKK Investigator-Initiated Phase 1b trial of Docetaxel Micellar in Advanced Prostate Cancer

On June 10, 2021 Oasmia Pharmaceutical AB, an innovation-focused specialty pharmaceutical company, reported that the first patient has been dosed in a Phase 1b clinical trial of Oasmia’s Docetaxel micellar in patients with advanced prostate cancer (Press release, Oasmia, JUN 10, 2021, View Source [SID1234583814]). The trial is being conducted by the Swiss Group for Clinical Cancer Research (SAKK).

Oasmia’s Docetaxel micellar is a solvent-free formulation of docetaxel developed to avoid the need for the solubility enhancers in solvent based docetaxel, and the mandatory high-dose steroid premedication, while providing an effective treatment option. Prostate cancer is a significant and increasingly prevalent health problem worldwide and is the leading cause of male cancer deaths.

The SAKK 67/20 trial (NCT04629781) is an open-label, multicenter, single-stage Phase 1b trial at major hospitals in Switzerland, recruiting 18 chemotherapy-naïve patients with metastatic castration resistant prostate cancer (mCRPC) with adequate bone marrow, liver and renal function. The primary objective of this trial is to determine the maximum tolerated dose of Docetaxel micellar in patients with mCRPC and the secondary objectives are to evaluate safety, assess the preliminary anti-tumor activity, and to characterize the pharmacokinetics in this population.

The Swiss Group for Clinical Cancer Research (SAKK) is a non-profit organization, which has been conducting clinical trials in oncology since 1965. Its primary objective is to research new cancer therapies, to develop existing treatments further and to improve the chances of a cure for patients with cancer. For more information, please visit www.sakk.ch.

Professor Markus Jörger, President Project Group Developmental Therapeutics at
SAKK commented: "It is a significant step to have dosed the first patient in this Phase 1b trial of Docetaxel micellar in advanced prostate cancer patients. Docetaxel micellar has the potential to remove the need for pretreatment with corticosteroids, thereby not adding more steroid to patients who have had significant prior steroid administration leading to marked bone fragility, exacerbated by cancer metastases in the bone, or may have steroid-related metabolic issues."

Heidi B. Ramstad, M.D., Chief Medical Officer of Oasmia, commented: "We are pleased to be partnering with SAKK on this trial which we believe is an important step towards evaluating whether Docetaxel micellar can be a treatment option for patients with advanced prostate cancer, without the mandatory steroid use that is necessary with existing, solvent-based docetaxel formulations."

Theratechnologies To Host Key Opinion Leader Event To Discuss Its Sort1+ Technology™ For the Treatment Of All Sortilin-Expressing Cancers

On June 10, 2021 Theratechnologies Inc. (Theratechnologies) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, reported that it will host a key opinion leader (KOL) webinar on the Company’s SORT1+ Technology and TH1902, its lead investigational peptide-drug conjugate (PDC) for treating sortilin-expressing advanced solid tumors, on Monday, June 21, 2021 at 11:00 a.m. Eastern Time (Press release, Theratechnologies, JUN 10, 2021, View Source [SID1234583813]).

The webinar will feature a presentation by KOL Richard Béliveau, Ph.D., Université du Québec à Montréal, who will discuss the science of receptor-mediated cancer therapy and the discovery of sortilin as a novel target in cancer treatment. Dr. Béliveau will be available to answer questions following the formal presentations. Theratechnologies’ President and Chief Executive Officer Paul Lévesque and Senior Vice President and Chief Medical Officer Christian Marsolais, Ph.D. will also give an update on its oncology program.

SORT1+ Technology is a new class of cancer treatment targeting all sortilin-expressing cancers by linking approved anticancer drugs to a proprietary peptide that specifically binds to the sortilin receptor. The PDC is internalized by the sortilin receptor and the therapeutic agent is released directly inside the cancer cell.

TH1902 was granted fast track designation by the U.S. Food and Drug Administration (FDA) as a single agent for the treatment of all advanced solid tumors expressing sortilin that are refractory to standard therapy and is currently being evaluated in a Phase 1 clinical trial.

Vernalis and Servier achieve two milestones in their oncology drug discovery collaboration

On June 10, 2021 Vernalis and Servier reported the achievement of one research and one pre-clinical milestone in their oncology drug discovery collaboration, triggering undisclosed milestone payments to Vernalis (Press release, Servier, JUN 10, 2021, View Source;utm_medium=rss&utm_campaign=vernalis-and-servier-achieve-two-milestones-in-their-oncology-drug-discovery-collaboration [SID1234583812]).

Vernalis and Servier’s partnership has been running successfully since 2007. The collaboration takes advantage of Vernalis’ proprietary fragment and structure-based drug discovery platform, and of Servier’s expertise in medicinal chemistry, cancer biology and pharmacology to bring innovation in oncology one step further.

The collaboration focuses on complicated molecular targets, some of which, like Mcl-1, were considered as undruggable until recently. Previously, has been announced the discovery of the first generation of Mcl-1 inhibitors which have entered clinical trials (published in Nature, 538: 477; ACS Omega, 4: 8892; J Med Chem, 63: 13762). The pre-clinical milestone announced today corresponds to a second generation, selective Mcl-1 inhibitor entering pre-clinical development. The research milestone relates to success in early drug discovery against another challenging, promising but undisclosed target.

These milestones further validate our fragment and structure-based drug discovery platform as well as the strength and success of our relationship with Servier. We look forward to working together to develop exciting new cancer treatment opportunities to add to the already disclosed success in targeting Bcl-2 and Mcl-1", commented James Murray, Research Director at Vernalis.

"These research and clinical milestones are the result of highly interactive joint efforts between chemists, biochemists and biologists from both companies and hopefully will lead to new treatments for cancer patients," Olivier Geneste, Head of Apoptosis and Targeted Therapies Research Program in Oncology at Servier commented. "They illustrate well the innovative freedom that Servier has kept through its important investment in R&D."

Under the current agreement, Vernalis receives fees for work undertaken as well as research and development milestones and potentially royalties on sales.