On October 26, 2021 Ubiquigent Limited (Ubiquigent) reported the extension and expansion of its long-term collaboration with Bristol Myers Squibb (Press release, Ubiquigent, OCT 26, 2021, https://www.ubiquigent.com/ubiquigent-extends-and-expands-drug-discovery-collaboration-with-bristol-myers-squibb/ [SID1234591961]). Under the terms of the agreement, Ubiquigent will provide Bristol Myers Squibb with increased access to its deubiquitylase (DUB) enzyme inhibitor drug discovery platform to provide further support to additional therapeutic areas.

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The central role of ubiquitylation in diverse cellular processes, including but not limited to protein degradation, makes the enzymes responsible for ubiquitylation and de-ubiquitylation highly attractive drug targets with the potential to address a wide range of human pathologies.

Recently, there has been further growing interest in the development of modulators of various components of the ubiquitin-proteasome system (UPS) for therapeutic benefit. Strategies that are being actively pursued include the exploitation of the UPS via PROTACs and molecular glues to target the undruggable proteome and the development of DUB inhibitors.

Ubiquigent has established itself as a respected global partner in the UPS field with a particular focus on the development of DUB inhibitors, with an established track record of supporting the drug discovery efforts of its partners via access to its Drug Discovery Screening Platform and by providing access to its own developing portfolio of novel DUB inhibitors as part of larger partnerships.

Ubiquigent’s CEO, Jason Mundin commented: "We are delighted to have the opportunity to build on our existing relationship with Bristol Myers Squibb in this rapidly evolving field to provide additional support to the development of novel DUB inhibitors for patients with unmet medical needs."

On October 26, 2021 Rigel Pharmaceuticals, Inc. (Nasdaq:RIGL) reported that it will report its third quarter 2021 financial results after market close on Tuesday, November 2, 2021 (Press release, Rigel, OCT 26, 2021, View Source [SID1234591960]). Rigel senior management will follow the announcement with a live conference call and webcast at 4:30pm Eastern Time (1:30pm Pacific Time) to discuss the financial results and give an update on the business.

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Participants can access the live conference call by dialing 877-407-3088 (domestic) or 201-389-0927 (international). The conference call and accompanying slides will also be webcast live and can be accessed from the Investor Relations section of the company’s website at www.rigel.com. The webcast will be archived and available for replay for 90 days after the call via the Rigel website.

On October 26, 2021 Purple Biotech Ltd. ("Purple Biotech", or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies by overcoming tumor immune evasion and drug resistance, reported the expansion of an existing research agreement, led by Menashe Bar-Eli, Ph.D., Professor, Department of Cancer Biology, at The University of Texas MD Anderson Cancer Center, and will evaluate the potential efficacy of the combination of NT219, a dual inhibitor, novel small molecule that simultaneously targets IRS1/2 and STAT3, and immuno-oncology drugs, such as anti-CTLA4 or anti-PD1/PDL1 antibodies (Press release, Purple Biotech, OCT 26, 2021, View Source [SID1234591959]).

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"Previously completed preclinical studies have shown that NT219 is able to overcome resistance to certain treatment approaches, with results demonstrating sensitization of various tumor types to the approved therapies," said Hadas Reuveni, Ph.D., VP Research and Development of Purple Biotech. "This new research leverages preclinical data depicting the interface of the lymphoid and myeloid systems within the biology, as well as a target in human cancer. It provides an opportunity to address the alterations of metabolism of both the tumor and the responsive human immune system, altering a "cold" tumor unresponsive to immune oncology approaches into a responsive "hot" one. This collaboration will also provide an opportunity to assess potential synergies mitigating anti-apoptotic mechanisms associated with TGFbeta and the canonical WNT pathway."

"Our prior preclinical studies with NT219 demonstrated its effect on the STAT3 and IRS pathways and the encouraging clinical data presented at ASCO (Free ASCO Whitepaper) 2021 supports the further evaluation of potentially combining NT219 with immunotherapy agents," said Dr. Reuveni. "We look forward to understanding the potential impact of such combinations through this expanded research collaboration. Based on the profile of NT219 and the data generated to date, we believe there are multiple potential benefits that can be derived by combining NT219 with certain immuno-oncology drugs."

"We are thrilled to expand this collaboration, and we believe that combining NT219 with immune-oncology backbone therapies is an important path forward for our NT219 clinical program," said Isaac Israel, Chief Executive Officer of Purple Biotech. "The collaboration is an important step in the translational work that could support the advancement of this potential treatment into the clinic. We recently presented promising initial clinical data for NT219 as a monotherapy treatment for advanced solid tumors and look forward to the availability of additional top-line data from the first part of this ongoing Phase 1/2 clinical trial."

Previous research conducted by Dr. Bar-Eli demonstrated that treatment of mice-bearing melanoma with early generation compounds of NT219 inhibited tumor growth and metastasis by blocking STAT3 and IGF1R/IRS signaling. The inhibition of downstream pro-angiogenic and pro-invasion factors in-vivo, such as VEGF, MMP-2 and IL-8, was shown, as well as the suppression of macrophage recruitment to the tumor microenvironment.

On October 26, 2021 PTC Therapeutics, Inc. (NASDAQ: PTCT) reported that management will present a company overview at the Credit Suisse 30th Annual Healthcare Conference on Tuesday, Nov. 9 at 8:00 a.m. ET (Press release, PTC Therapeutics, OCT 26, 2021, View Source [SID1234591958]).

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The presentation will be webcast live on the Events and Presentations page on the Investor section of PTC Therapeutics’ website at View Source and will be archived for 30 days following the presentation. It is recommended that users connect to PTC’s website several minutes prior to the start of the webcast to ensure a timely connection.

On October 26, 2021 Prescient Therapeutics (ASX: PTX) CEO Steven Yatomi-Clarke reported at the AusBiotech Investment Conference 2021 (Press release, Prescient Therapeutics, OCT 26, 2021, https://prescienttherapeutics.investorportal.com.au/2021/09/20/prescient-therapeutics-ausbiotechs-investment-conference-presentation?utm_source=rss&utm_medium=rss&utm_campaign=prescient-therapeutics-ausbiotechs-investment-conference-presentation [SID1234591957]).

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Steven introduced Prescient Therapeutics to a new range of investors, touching on results of the recent PTX100 study and explaining our next-gen CAR-T platform, OmniCAR.