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Phosplatin Therapeutics to Present at 2021 BIO Digital

On June 10, 2021 Phosplatin Therapeutics Inc., a clinical stage pharmaceutical company focused on oncology therapeutics, reported that it has been selected to deliver a presentation on the development program of its lead candidate, PT-112, an immunogenic cell death (ICD) inducer, at 2021 BIO Digital, the premier biotech event (Press release, Phosplatin, JUN 10, 2021, View Source [SID1234583852]). BIO Digital is scheduled June 10-11 and 14-18, 2021, and presentations will be available on-demand throughout the event.

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Robert Fallon, President and Chief Executive Officer, will present the company and its lead clinical candidate, PT-112, a novel small molecule conjugate of pyrophosphate with a pleiotropic mechanism of action that promotes immunogenic cell death (ICD) in the tumor microenvironment. The presentation will be available to registered attendees beginning at 9 am ET on June 10.

"We’re looking forward to presenting PT-112 at BIO so that investors and potential partners can understand our encouraging results to date, which include drug responses in several tumor types of heavily pre-treated patients with advanced metastatic disease," said Fallon. "Data reported from three Phase 1 studies demonstrate feasibility and activity, both as a monotherapy and in combination with PD-L1 immune checkpoint inhibition. We’re currently in Phase 2 clinical trials evaluating PT-112’s optimal dosing for a planned pivotal study, as well as preliminary evidence of efficacy, alongside extensive correlative research using sophisticated liquid sampling technology platforms."

Attendees at BIO Digital will be able to view Phosplatin’s Company Presentation before live meetings in the BIO One-on-One Partnering system begin on June 14. To meet with Phosplatin at BIO Digital, information is available here.

About PT-112

PT-112 is a novel small molecule conjugate of pyrophosphate that possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to dendritic cells and lead to downstream immune effector cell recruitment in the tumor microenvironment. PT-112 represents the best-in-class small molecule inducer of this immunological form of cancer cell death and is currently under Phase II development. Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone. The ﬁrst in-human study of PT-112 demonstrated an attractive safety proﬁle and evidence of long-lasting responses among heavily pre-treated patients and won "Best Poster" within the Developmental Therapeutics category at the ESMO (Free ESMO Whitepaper) 2018 Annual Congress. The combination Phase Ib dose escalation study of PT-112 with PD-L1 checkpoint inhibitor avelumab in solid tumors was reported in an oral presentation at the ESMO (Free ESMO Whitepaper) 2020 Virtual Congress. The Phase I study in patients with relapsed or refractory multiple myeloma presented at ASH (Free ASH Whitepaper) is the third completed Phase I study of PT-112. Monotherapy phase 2 development is ongoing in mCRPC, and the PD-L1 combination study is ongoing in a dose confirmation cohort of non-small cell lung cancer (NSCLC) patients.

Precigen to Present at the JMP Securities Life Sciences Conference

On June 10, 2021 Precigen, Inc. (Nasdaq: PGEN), a biopharmaceutical company specializing in the development of innovative gene and cell therapies to improve the lives of patients, reported Helen Sabzevari, PhD, President and CEO of Precigen, will participate in a fireside chat at the annual JMP Securities Life Sciences Conference on Thursday, June 17, 2021 at 11:00 AM ET (Press release, Precigen, JUN 10, 2021, View Source [SID1234583851]).

Participants may access the live webcasts of the virtual events through Precigen’s website in the Events & Presentations section at investors.precigen.com/events-presentations.

Immunicom Presents Promising Clinical Trial Data at AACR in Late-Stage Breast Cancer Patients Treated with Novel Non-Pharmaceutical Immunotherapy

On June 10, 2021 Immunicom, Inc., a global biotech company reported that it is redefining immuno-oncology with breakthrough non-pharmaceutical subtractive immunotherapy treatments designed to preserve quality-of-life while being treated, presented preliminary data from its late-stage, metastatic triple-negative breast cancer (mTNBC) clinical trial at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021 (Press release, Immunicom, JUN 10, 2021, View Source [SID1234583843]). AACR (Free AACR Whitepaper)’s Annual Meeting is one of the world’s premier scientific gatherings of cancer specialists and researchers, attracting more than 20,000 participants annually.

Immunicom is investigating its FDA-designated breakthrough Immunopheresis therapy, which is a filtration-based subtractive treatment designed to capture sTNF-R proteins that are shed by cancer cells and inhibit a patient’s natural anti-tumor immune activity. Immunicom presented data for the first cohort of mTNBC patients treated with Immunopheresis which showed an 80% decrease of the inhibitory sTNF-R proteins and observed a sustained quality-of-life while on therapy with minimal side effects.

"Current cancer treatments have significant toxicities and can dramatically diminish a patient’s quality-of-life, especially in patients with late-stage disease that have received multiple prior courses of therapy," said Amir Jafri, Immunicom CEO and Founder. "We are studying an innovative emerging therapy which could signal a new era for cancer treatment that employs a novel immunotherapeutic approach which is especially well-tolerated by these fragile patients."

Immunicom’s presentation "Extracorporeal pulldown of soluble TNFRs to unleash the activity of endogenous TNFα in chemorefractory triple-negative breast cancer patients – first-in-human experience" was presented by the study’s Chief Investigator, Piotr Wysocki, MD, PhD, Department Head of Oncology at the Jagiellonian University – Medical College Hospital in Krakow and President of the Polish Society of Clinical Oncology, and will be available online until June 21, 2021, details as follows:
View Source!/9325/presentation/5206

New AI-Based Clinical Trial Matching Solution, Deep Lens’ Viper™, Expanding Offering to Cancer Patients at Norton Healthcare

On June 10, 2021 Deep Lens reported a collaboration that will integrate Deep Lens’ artificial intelligence (AI)-based clinical trial screening and matching solution VIPER , into cancer research (Press release, Deep Lens, JUN 10, 2021, View Source [SID1234583842]). VIPER uses proprietary cloud-based technology to facilitate, triage and accelerate the clinical trial recruitment process. The technology will be used at Norton Cancer Institute, the largest provider of cancer care in the Louisville, Ky., area. VIPER will be used to streamline the patient recruitment process by minimizing resource constraints and enabling immediate access to a greater number of clinical trials.

It is estimated that more than 15,000 oncology clinical trials are actively recruiting patients; however, patient participation in these trials is often as low as three percent. The challenges associated with accrual to cancer-focused research studies are complex and have been magnified by the current global pandemic. VIPER automates the clinical trial screening process and seamlessly matches patients — at the time of diagnosis — to appropriate trials through the ingestion and analysis of customized genomic, electronic medical record and pathology data.

"Deep Lens is committed to making it easier for cancer patients to find trials that may optimize their care and potentially impact the course of their disease," said Greg Andreola, chief revenue officer for Deep Lens. "We are confident that VIPER will help reinforce Norton Cancer Institute’s prominent reputation in Kentucky and Southern Indiana and we look forward to bringing more opportunities for patients to receive access to cutting-edge therapies in development."

Deep Lens’ VIPER integrates directly into electronic medical records such as Epic, molecular data feeds (Caris, Foundation, and in-house labs) and pathology feeds to automatically identify qualified patients for clinical trials. Any practice that utilizes Epic can easily integrate VIPER and all other Deep Lens screening services free of charge.

InterVenn Biosciences Announces Clinical Validation of World’s First Glycoproteomic Diagnostic Test

On June 10, 2021 InterVenn Biosciences reported it has completed clinical and analytical validation in compliance with standards set by the Clinical Laboratory Improvement Amendments (CLIA) and the College of American Pathologists (CAP) of GLORITM, a liquid-biopsy diagnostic test capable of differentiating between malignant and benign female pelvic tumors (Press release, InterVenn Biosciences, JUN 10, 2021, View Source [SID1234583840]). This test marks a significant milestone for InterVenn as it seeks to establish its proprietary mass-spectrometry-based, AI-powered technology as a scalable clinical platform capable of efficiently deploying glycoproteomic diagnostic tests for a range of indications.

GLORI is a laboratory-developed test (LDT) that has been validated using both retrospective patient samples and samples collected prospectively in InterVenn’s ongoing VOCAL clinical trial. Development of GLORI was advanced after compelling positive results were obtained in an interim analysis of the VOCAL trial. With an overall accuracy of 86%, GLORI outperforms all other currently available blood-based tests used to manage patients with suspected ovarian cancer.

"The company started by leveraging the decades-long work and accomplishments of its scientific co-founders, Drs. Carolyn Bertozzi and Carlito Lebrilla, and complementing them with a powerful, AI-driven data processing engine, to build a revolutionary discovery platform for analyzing the glycoproteome at unprecedented speed and scale, and, for the first time, making glycoproteomics accessible for actionable clinical research," said Erwin Estigarribia, InterVenn’s COO. "In less than three years InterVenn has successfully interrogated more than a dozen medical conditions, assayed thousands of patient blood samples, and established definitive evidence for the ubiquitous biological impact and, in parallel, for the clear clinical utility of glycoproteomics. This gave us the confidence to embark on our first prospective clinical trial, VOCAL; and the results generated, now reflected in the translational productization of data into GLORI as a fully validated LDT, are of course extremely gratifying. They are a major step forward not only for InterVenn and its platform, but also for basic and clinical science: this is the first-ever clinical glycoproteomic test and, most importantly, for women’s health, and for patients in need of better options."

"With the validation of GLORITM as the world’s first glycoproteomic LDT we have clearly demonstrated that glycoproteomics can be used to develop high-performance diagnostic solutions and that InterVenn has reached a new stage of operational maturity," said Aldo Carrascoso, InterVenn’s CEO. "We are now looking to accelerate the development of new liquid-biopsy assays in our product pipeline, including a precision-medicine test for immuno-oncology therapy, leveraging the opportunities for which GLORITM has paved the way."

The VOCAL clinical trial reached full enrollment of the targeted patient cohort in South-East Asia earlier this year, with the completion of the trial’s additional recruitment of patients in the US and Australia anticipated by the end of the year.

InterVenn has not yet announced a date for commercial availability of GLORI as it seeks to create a harmonized approach for market introduction of all products currently in its pipeline.