Sprint Bioscience licenses the cancer drug program Vps34 to Deciphera Pharmaceuticals

On August 3, 2021 Sprint Bioscience AB (publ) reported that the company has licensed its cancer drug program Vps34 to the US pharmaceutical company Deciphera Pharmaceuticals (Press release, Sprint Bioscience, AUG 3, 2021, View Source [SID1234585600]). The license agreement covers exclusive global rights to the program. The agreement has a total potential value of up to USD 277 million, plus additional tiered percentage royalties ranging from the mid-single-digits to the low-double-digits on the sales of a future drug from the program, if approved. On signing of the agreement, Sprint Bioscience will receive an upfront payment of USD 4 million, which will be entered into the accounts for the third quarter of 2021.

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The chosen partner, Deciphera Pharmaceuticals Inc., founded in 2003, is a pharmaceutical company focused on delivering important new medicines to patients for the treatment of cancer. The company has an approved product on the market in multiple geographies, as well as three product candidates in clinical development. The company is listed on the Nasdaq Global Select Market with a market cap of approximately USD 2 billion. With a clear focus on improving the lives of people living with cancer and demonstrated expertise in bringing a new drug to market, Deciphera is considered to be an extremely attractive partner for the Sprint Biosciences Vps34 program. Deciphera will assume full responsibility for resource allocation as it continues research efforts, and for taking the program to the clinic and further onto the market.

"Today’s announcement represents Deciphera’s focus to discover, develop, and deliver important new medicines to patients for the treatment of cancer, as well as an effort to complement our robust internal research programs with partnership opportunities such as this one. This Vps34 program fits well with our growing pipeline, and enhances our efforts to explore the potential for regulating autophagy in cancer," said Dan Flynn, Executive Vice President and Chief Scientific Officer (CSO) of Deciphera Pharmaceuticals.

Deciphera will now take over the program’s continued development and all associated costs.

"The licensing agreement with Deciphera Pharmaceuticals is the most comprehensive to date that Sprint Bioscience has signed and further proof of our ability to continuously generate groundbreaking programs with great commercial potential. We have an increasing number of programs in our portfolio where well-funded partners take over responsibility and all costs for continued development at an early stage, while we are eligible for milestone payments when the programs achieve predetermined goals. As the number of out-licensed programs increases and further develops, we create more and more opportunities for revenues. The total revenue potential from our active licensing agreements has now increased to approximately USD 747 million, plus royalty payments," said Erik Kinnman, CEO of Sprint Bioscience.

In addition to the upfront payment, Sprint Bioscience is entitled to payments linked to predefined milestones during the project’s further development, regulatory process and commercialization of a drug. With the upfront, the total value of these payments amounts up to USD 277 million.Should the program result in an approved drug, Sprint Bioscience is also entitled to tiered percentage royalties ranging from the mid-single-digits to the low-double-digits on the sales of a future drug from the program, if approved.

This disclosure contains information that Sprint Bioscience is obliged to make public pursuant to the EU Market Abuse Regulation (EU nr 596/2014). The information was submitted for publication, through the agency of the contact person, on 03-08-2021 22:15 CET.

EVERSANA Sponsors Patient Assistance & Access Programs 2021 Virtual Event

On August 3, 2021 EVERSANA and other industry leaders reported at the PAP – Patient Assistance & Access Programs 2021 Virtual Event August 17–19 as we discuss how to break through affordability barriers to streamline operational complexities, enhance patient access and optimize stakeholder collaboration (Press release, EVERSANA, AUG 3, 2021, View Source [SID1234585599]).

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Backed by 22 years of content, PAP is the premier event for influential stakeholders to collaborate on how to further access to care, understand current changes in policy and optimize PAPs for better patient outcomes. With a blend of live and on-demand content, this three-day event is designed to provide you with the latest industry updates and opportunities to expand your network and collaborate with a multi-stakeholder audience.

EVERSANA is proud to participate in this year’s session, "Industry Disruptors — Stay on the Pulse of Trends in Co-pay Exclusions, Accumulators and Maximizers," featuring Joe Bachstadt, Vice President of Patient Services Affordability.

Joe Bachstadt

Vice President, Patient Services Affordability

On Thursday, August 19, at 1 pm EST, Joe will discuss the:

Evolution and current landscape of co-pay accumulator and maximizer models.
Patient and business impact of accumulators in the ability to access drugs, as well as the legal challenges.
New workarounds entering the market that are adding pressure to manufacturer PAPs.

Perrigo Announces Quarterly Dividend

On August 3, 2021 Perrigo Company plc (NYSE; TASE: PRGO), a leading global provider of Quality, Affordable Self-Care Products, reported that its Board of Directors declared a quarterly dividend of $0.24 per share, payable on September 21, 2021 to shareholders of record on September 3, 2021 (Press release, Perrigo Company, AUG 3, 2021, View Source [SID1234585598]).

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MannKind Corporation to Participate in the BTIG Virtual Biotechnology Conference 2021

On August 3, 2021 MannKind Corporation (Nasdaq: MNKD), a company focused on the development and commercialization of inhaled therapeutic products for patients with endocrine and orphan lung diseases, reported that its Chief Executive Officer, Michael Castagna, PharmD, will participate in a Fireside Chat in the BTIG Virtual Biotechnology Conference 2021 on Tuesday, August 10, 2021 at 12:30 PM (ET) (Press release, Mannkind, AUG 3, 2021, View Source [SID1234585597]).

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BTIG hosted events are intended for prospective and existing BTIG clients only. To listen to the live event, please contact your BTIG representative with interest.

Cassava Sciences Reports Second Quarter 2021 Financial Results

On August 3, 2021 Cassava Sciences, Inc. (Nasdaq: SAVA), a clinical-stage biotechnology company focused on Alzheimer’s disease, reported financial results for the second quarter ended June 30, 2021 (Press release, Pain Therapeutics, AUG 3, 2021, View Source [SID1234585595]). Net loss for the second quarter ended June 30, 2021, was $5.1 million, or $0.13 per share, compared to a net loss of $1.1 million, or $0.05 per share, for the same period in 2020. Net cash used in operations was $7.4 million during the first six months of 2021. Net cash use for operations for full-year 2021 is expected to be approximately $20 to $25 million, consistent with previous financial guidance. Cash and cash equivalents were $278.3 million as of June 30, 2021, with no debt.

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Remi Barbier, President & CEO, and Eric Schoen, Chief Financial Officer, will host a conference call to review financial results and to preview the Company’s growth strategy.

The conference call is scheduled to begin at 9:00 am ET on Tuesday, August 3, 2021. Please dial in 15 minutes in advance to ensure a timely connection to the call.

Financial Highlights for Second Quarter 2021

At June 30, 2021, cash and cash equivalents were $278.3 million, compared to $93.5 million at December 31, 2020, with no debt.

Net cash used in operations during the six months ended June 30, 2021 was $7.4 million, net of reimbursements received from the National Institutes of Health (NIH) grant awards.

Research grant funding reimbursements of $0.9 million were received from NIH and recorded as a reduction in research and development (R&D) expenses. This compared to $1.1 million of NIH grant receipts received for the same period in 2020.

Net cash use for operations for full year 2021 is expected to be approximately $20 to $25 million. Net cash use in 2021 is expected to be driven by higher headcount and personnel expenses, manufacturing costs around large-scale drug supply, professional services expenses related to clinical programs, and operating costs such as insurance, office space and IT related expenses.

R&D expenses were $3.9 million compared to $0.6 million for the same period in 2020. This increase was due primarily to costs related to manufacture of clinical trial supplies in anticipation of launching a Phase 3 clinical program in simufilam, costs of an on-going open-label study in simufilam, as well as increased personnel expenses.

General and administrative (G&A) expenses were $1.2 million compared to $0.8 million for the same period in 2020. This increase was due primarily to higher annual shareholder meeting and insurance costs compared to the prior year.
About Simufilam
Simufilam is a proprietary, small molecule (oral) drug that restores the normal shape and function of altered filamin A (FLNA), a scaffolding protein, in the brain. Altered FLNA in the brain disrupts the normal function of neurons, leading to Alzheimer’s pathology, neurodegeneration and neuroinflammation. The underlying science for simufilam is published in peer-reviewed journals, including Journal of Neuroscience, Neurobiology of Aging, Journal of Biological Chemistry, Neuroimmunology and Neuroinflammation and Journal of Prevention of Alzheimer’s Disease. Cassava Sciences is also developing an investigational diagnostic, called SavaDx, to detect Alzheimer’s disease with a simple blood test. Simufilam and SavaDx were both developed in-house. Both product candidates are substantially funded by peer-review research grant awards from the National Institutes of Health (NIH).

Cassava Sciences owns worldwide development and commercial rights to its research programs in Alzheimer’s disease, and related technologies, without royalty obligations to any third party.

About Alzheimer’s Disease
Alzheimer’s disease is a progressive brain disorder that destroys memory and thinking skills. As of 2020, there were approximately 50 million people worldwide living with dementia, a figure expected to increase to 150 million by 2050.1 The annual global cost of dementia is now above $1 trillion, according to Alzheimer’s Disease International, a charitable organization.