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Advaxis to Present at the American Association for Cancer Research (AACR) 2021 Annual Meeting

On March 12, 2021 Advaxis, Inc. (Nasdaq: ADXS), a clinical-stage biotechnology company focused on the development and commercialization of immunotherapy products, and Precision for Medicine, a specialized services company supporting next generation approaches to drug development and commercialization, reported that they will present data on a) the development of a novel flow immunophenotyping assay to accurately evaluate total PD-1 expression as a pharmacodynamic biomarker during PD-1 blockade treatment with pembrolizumab and b) the correlation of changes in T cell populations with the clinical activity observed in the ongoing ADXS-503 clinical trial, in a poster presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021, taking place virtually from April 10-15, 2021 (Press release, Advaxis, MAR 12, 2021, View Source [SID1234576575]).

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Details on the posters and corresponding abstracts are shown below. All posters will be made available on the conference website on April 10, 2021.

Title: Evaluation of total PD-1 expression using multi-color flow cytometry in metastatic non-small cell lung cancer patients treated with multi-neoantigen vector (ADXS-503) alone and in combination of pembrolizumab to assess T-cell & T-cell memory subsets
Session Category: Immunology
Session Title: Immune Monitoring / Clinical Correlates
Abstract Number: 1671

The full text of the abstract is available on the AACR (Free AACR Whitepaper) Annual Meeting 2021 website.

CymaBay Therapeutics to Report Fourth Quarter and Full Year 2020 Financial Results on Thursday, March 25, 2021

On March 12, 2021 CymaBay Therapeutics, Inc. (NASDAQ: CBAY), a clinical-stage biopharmaceutical company focused on developing therapies for liver and other chronic diseases with high unmet need, reported that it will host a conference call and live audio webcast on Thursday, March 25, 2021 at 4:30 p.m. Eastern Time to discuss financial results for the fourth quarter and year ended December 31, 2020 and to provide a business update (Press release, CymaBay Therapeutics, MAR 12, 2021, View Source [SID1234576574]).

Conference Call Details
To access the live conference call, please dial 877-407-0784 from the U.S. and Canada, or 201-689-8560 internationally, Conference ID# 13715944. To access the live and subsequently archived webcast of the conference call, go to the Investors section of the company’s website at View Source

CTI BioPharma to Report Fourth Quarter and Full Year 2020 Financial Results on March 17, 2021

On March 12, 2021 CTI BioPharma Corp. (CTI BioPharma) (NASDAQ: CTIC) reported that management plans to report its fourth quarter and full year 2020 financial results on Wednesday, March 17, 2021, after the close of the U.S. financial markets (Press release, CTI BioPharma, MAR 12, 2021, View Source [SID1234576566]). Following the announcement, members of the management team will host a conference call and webcast to discuss the results and provide a general corporate update at 4:30 p.m. ET (1:30 p.m. PT).

CTI BioPharma Corp. Logo (PRNewsFoto/Cell Therapeutics, Inc.)
To access the live call by phone please dial (877) 735-2860 (domestic) or (602) 563-8791 (international); the conference ID is 9095063. A live audio webcast of the event may also be accessed through the "Investors" section of CTI’s website at www.ctibiopharma.com. A replay of the webcast will be available for 30 days following the event.

Health Canada Clears Pacylex Pharmaceuticals for New Phase 1 Clinical Trial to Evaluate PCLX-001 Capsules in the Treatment of Hematologic and Solid Tumor Cancers

On March 11, 2021 Pacylex Pharmaceuticals, an oncology company unlocking a new approach to cancer therapy, reported the receipt of a No Objection Letter from Health Canada on March 8, 2021, opening the way for a planned Phase 1 Trial of PCLX-001 in relapsed/refractory B-cell Non-Hodgkin Lymphoma and advanced solid malignancies (Press release, Pacylex Pharmaceuticals, MAR 11, 2021, View Source [SID1234645064]). Pacylex is developing this NMT inhibitor, PCLX-001, as a first in class therapy for various cancers. PCLX-001 is believed to be the first NMT inhibitor that will be clinically tested.

Three principal investigators will oversee the clinical study at three clinical sites in Canada: Dr. John Kuruvilla at Princess Margaret Cancer Centre in Toronto, Dr. Randeep Sangha at the Cross Cancer Institute in Edmonton and Dr. Laurie Sehn at the British Columbia Cancer Center in Vancouver.

"Health Canada approval to conduct this trial is an exciting step in bringing PCLX-001 into the clinic. As a first-in-class agent with a new mechanism of action, we plan to see how well people with lymphoma and other cancers tolerate the drug and hope to see some of them benefit," said Dr. Sangha, MD FRCPC, Director, Clinical Trials Unit, Cross Cancer Institute.

Dr. Kuruvilla added "We are excited to be working with other Canadian research teams and Pacylex to study a novel therapy with a unique mechanism of action in patients with lymphoma". Dr. Kuruvilla is Clinician Investigator in the Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre.

Clinical site preparations are underway for the open label, dose escalation, Phase 1 clinical trial, principally to evaluate the safety of PCLX-001. The study will enroll 20-30 patients and the Company anticipates that enrollment will begin in the second quarter of 2021.

Pacylex received a milestone-based Alberta Innovates AICE grant in 2020 to help fund this study, and the No Objection Letter triggered the first milestone payment from this grant. The Alberta Cancer Foundation and the Cure Cancer Foundation both provided support for this research.

PCLX-001

PCLX-001 is a small molecule, first-in-class N-myristoyltransferase (NMT) inhibitor, originally developed by the University of Dundee Drug Discovery Unit as part of a program to treat African sleeping sickness funded by Wellcome Trust. Pacylex is developing PCLX-001, which has excellent oral bioavailabilty, to treat leukemia and lymphoma. PCLX-001 selectively kills cancer cells and completely regresses (eliminates) tumors in animal models of acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL). PCLX-001 has also been shown to inhibit the growth of lung and breast cancer tumors in animal models. In leukemia, lymphoma and breast cancer patients, the level of NMT2 is correlated with survival, suggesting an important biological role in these cancers. In tests using cultured cancer cells in vitro, PCLX-001 is at least ten times as potent as Ibrutinib (Imbruvica) and Dasatinib (Sprycel), two clinically approved drugs currently used to treat hematologic malignancies.

Miravo Healthcare™ to Present at Q1 Virtual Investor Summit

On March 11, 2021 Nuvo Pharmaceuticals Inc. (TSX:MRV; OTCQX:MRVFF) d/b/a Miravo Healthcare (Miravo or the Company), a Canadian focused healthcare company with global reach and a diversified portfolio of commercial products, reported Jesse Ledger, Miravo’s President & Chief Executive Officer and Kelly Demerino, Miravo’s Interim Chief Financial Officer reported that it will be presenting at the Q1 Virtual Investor Summit (Press release, Nuvo Pharmaceuticals, MAR 11, 2021, View Source [SID1234580414]).

DATE: Wednesday, March 24th, 2021

TIME: 3:30 p.m. EST

COMPLIMENTARY
REGISTRATION: View Source

About The Investor Summit

The Investor Summit (formerly MicroCap Conference) is an exclusive, independent conference dedicated to connecting smallcap and microcap companies with qualified investors. The Q1 Investor Summit will take place virtually, featuring 100 companies and over 300 institutional and retail investors.
Please visit the website at www.investorsummitgroup.com