Tiziana Life Sciences to Participate in a Fireside Chat at B. Riley Virtual Oncology Investor Conference: on 21 January 2021 at 3 pm ET/8 pm GMT

On January 20, 2021 Tiziana Life Sciences plc (Nasdaq: TLSA / AIM: TILS) ("Tiziana" or the "Company"), a biotechnology company focused on innovative therapeutics for oncology, inflammation and infectious diseases, reported its CEO and CSO, Dr. Kunwar Shailubhai, will participate in a fireside chat via a video link on Thursday 21 January 2021 at 3 pm ET / 8 pm GMT to provide updates on the Company (Press release, Tiziana Life Sciences, JAN 20, 2021, View Source [SID1234574140]).

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Date: Thursday 21 January 2021
Time: 3 pm U.S. Eastern / 8 pm GMT
Webcast: https://b-riley-oncology-investor-conference.events.issuerdirect.com/signup

Invitae Announces Proposed Public Offering of Common Stock

On January 20, 2021 Invitae Corporation (NYSE: NVTA) reported that it has commenced an underwritten public offering of $400.0 million of shares of its common stock, before deducting underwriting discounts and commissions and other offering expenses (Press release, Invitae, JAN 20, 2021, View Source [SID1234574139]). All of the shares are being offered by Invitae. In addition, Invitae expects to grant the underwriters a 30-day option to purchase up to an additional $60.0 million of shares of its common stock at the public offering price, less underwriting discounts and commissions. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Invitae’s (NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. www.invitae.com (PRNewsFoto/Invitae Corporation)

Invitae currently intends to use the net proceeds from this offering for working capital and other general corporate purposes, including investing in its platform, oncology and reproductive product extensions and international expansion. Invitae may also use a portion of the net proceeds from this offering to acquire or invest in complementary businesses, assets or technologies, although it has no present commitments or agreements to do so.

J.P. Morgan Securities LLC, Morgan Stanley, Cowen and Company, LLC and SVB Leerink LLC are acting as the book-running managers for the proposed offering.

An automatic shelf registration statement relating to the shares was filed with the Securities and Exchange Commission and became effective on March 4, 2019. A copy of the preliminary prospectus supplement and accompanying prospectus relating to the offering, when available, may be obtained from J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (866) 803-9204, or by email at [email protected]; from Morgan Stanley & Co. LLC, 180 Varick Street, 2nd Floor, New York, NY, 10014, Attention: Prospectus Department; from Cowen and Company, LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, Attn: Prospectus Department, by email at [email protected], or by telephone at (833) 297-2926; or from SVB Leerink LLC, One Federal Street, 37th Floor, Boston, MA 02110, Attention: Syndicate Department, by telephone at (800) 808-7535, ext. 6132, or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Neurocrine Biosciences Announces Conference Call and Webcast of Fourth Quarter and Year-End 2020 Financial Results

On January 20, 2021 Neurocrine Biosciences, Inc. (Nasdaq: NBIX) reported that it will report fourth quarter and year-end 2020 financial results after the Nasdaq market closes on Thursday, Feb. 4, 2021 (Press release, Neurocrine Biosciences, JAN 20, 2021, View Source [SID1234574138]). Neurocrine will then host a conference call and webcast to discuss its financial results and provide a company update that day at 1:30 p.m. Pacific Time (4:30 p.m. Eastern Time).

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Participants can access the live conference call by dialing 800-895-3361 (US) or 785-424-1062 (International) using the conference ID: NBIX. The webcast can also be accessed on Neurocrine’s website under Investors at www.neurocrine.com. A replay of the webcast will be available on the website approximately one hour after the conclusion of the event and will be archived for approximately one month.

VECT-HORUS Completes Its €12 Million Fund-raising Operation

On January 20, 2021 VECT-HORUS, a biotech company that designs and develops vectors that enable therapeutic molecules or imaging agents to be delivered to key organs, reported that it has just closed its Series D fund-raising (Press release, Vect-Horus, JAN 20, 2021, View Source [SID1234574137]). The first round, held in September 2020, raised €6.7 million and a second round in December 2020 added €5.3 million from private investors, bringing the total amount raised in these two rounds to €12 million.

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This second funding round strengthens the company’s capital so it can pursue its ambitious programmes, focusing on identifying new vectors, developing theragnostic (therapeutic and diagnostic) agents in a clinical setting and validating its technology for delivering therapeutic antibodies and nucleic acids.

The health crisis has for the first time highlighted the enormous therapeutic potential (in terms of vaccination) of messenger RNAs (mRNAs) encapsulated in lipid nanoparticles. These mRNAs are used to express proteins of interest in the body. In contrast, antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) inhibit the expression of a particular gene and therefore the corresponding protein.
Using the company’s VECTrans platform, nanoparticles of mRNA, as well as ASOs and siRNAs, can be vectorized in order to treat both diseases with a genetic component and cancers.

’Very promising in vivo results have been obtained, for example on skeletal muscle. This means that there is a great potential for our technology to transport nucleic acids and to treat muscular pathologies,’ said Alexandre Tokay, Chairman of VECT-HORUS.

These developments are examples of the agility of the VECT-HORUS teams and its dual economic model, based both on developing proprietary molecules and the availability of its VECTrans technology to pharmaceutical and biotech partners to offer new methods for developing tomorrow’s therapeutic solutions.

FemTech Company MobileODT awarded prestigious National Cancer Institute (NCI) grant

On January 20, 2021 MobileODT, a FemTech company producing the latest digital innovation in cervical screening, reported that it has been awarded a prestigious Small Business Innovation Research Authority grant of $2.3 million (Press release, MobileODT, JAN 20, 2021, https://www.mobileodt.com/press-releases/13493/ [SID1234574136]). This grant is presented by the United States National Cancer Institute (NCI) to leading companies that are technologically and clinically advanced to support the NCI’s goal of reducing suffering and death due to cancer. This grant is a tribute to the groundbreaking advances of MobileODT as an innovative company commercializing a novel cervical cancer screening technology utilizing complex machine learning (ML) and artificial intelligence (AI) algorithms. The company’s technology offers an alternative screening modality to the current standard-of-care with significantly improved accuracy. It allows for a broader range of physicians, to perform cervical cancer screening, while defining the actual status of the patient and reducing loss to follow-up.

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The grant was awarded to MobileODT to perform a large-scale clinical trial validating the efficacy of the company’s EVA VisualCheck (TM) AI technology, as a cervical screening Clinical Decision Support Tool at the Point of Care and providing results in under 60 seconds. The VisualCheck AI technology will be compared to standard of care methods such as Pap smear, and visual inspection of the cervix.

"This award offers MobileODT a great opportunity to independently validate it’s VisualCheck AI technology against the standard of care check with NIH quality" says David Levitz PhD. Principal Investigator of the study. The trial will commence in Q3 2021 and will be conducted in cooperation with the Basic Health International organization (BHI) on a population of 10,000 subjects.

"AI has a lot of potential to revolutionize care for women worldwide. We are excited to test the technology and validate its accuracy and clinical feasibility " says Miriam Cremer MD., MPH, Associate Professor of Obstetrics and Gynecology from Cleveland Clinic, one of the key researchers who will be leading the trial.

"We are honored to receive such a prestigious grant, especially from National Cancer Institute. It’s a recognition of the value that our technology is bringing to women’s health". Says Leon Boston, MobileODT CEO. "The results of the trial are especially important in light of the World Health Organization’s recent global strategic decision to accelerate the elimination of cervical cancer. We see these results bringing our technology to the forefront of women’s health".