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Perrigo To Release Fourth Quarter And Calendar Year 2020 Financial Results On March 1, 2021

On February 16, 2021 Perrigo Company plc (NYSE; TASE: PRGO) reported that it will release its fourth quarter and calendar year 2020 financial results on Monday, March 1, 2021 (Press release, Perrigo Company, FEB 16, 2021, View Source [SID1234575153]). The Company will also host a conference call beginning at 8:00 a.m. (EST).

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The conference call will be available live via webcast to interested parties in the investor relations section of the Perrigo website at View Source or by phone at 888-317-6003, International 412-317-6061, and reference ID # 6715549. A taped replay of the call will be available beginning at approximately 12:00 p.m. (EST) Monday, March 1, until midnight Monday, March 15, 2021. To listen to the replay, dial 877-344-7529, International 412-317-0088, and use access code 10152495.

Menarini Silicon Biosystems announces launch of CellMag™ product line offering affordable Gold Standard Circulating Tumor Cells capture

On February 16, 2021 Menarini Silicon Biosystems, a pioneer of liquid biopsy and single cell technologies, reported the launch of its innovative CellMag product line for the manual enrichment and staining of rare circulating tumor cells (CTCs) (Press release, Menarini, FEB 16, 2021, View Source [SID1234575152]). This new product line, composed of the CellMag CTC Epithelial Cell kit, a magnetic tool and consumables, will allow all liquid biopsy and CTCs Laboratories to have access to a manual system using the same ferrofluid technology offered by the Gold Standard CELLSEARCH system.

This easy to use technology offers researchers who work on translational projects a reliable tool to study the heterogeneous biology of CTCs, whose presence in blood has been associated with poor prognosis in metastatic carcinomas[1].

Despite different available methods to capture CTCs, only the information obtained from CTCs that have been captured by the CELLSEARCH ferrofluid technology have shown a robust clinical value in different settings[1]. Research laboratories will appreciate the convenience, simplicity and affordability of CellMag. Researchers can analyze and characterize enriched CTCs from a molecular perspective with a high level of specificity, gaining valuable insights into how certain tumors progress and disseminate throughout the body. "CellMag is a manual system for the capture and enhancement of CTCs using the established ferrofluid technology. Perfectly tailored to our research needs, it offers a manual version of the reference CELLSEARCH platform," said Dr. Catherine Alix-Panabières, Associate Professor and Director of the Laboratory of Rare Human Circulating Cells (LCCRH) at the University Medical Center of Montpellier, France.

The CellMag CTC Ephitelial Cell kit allows research centers, focusing on liquid biopsies, to conduct highly specific, established and standardized immunomagnetic enrichment and staining of CTCs in peripheral blood. Following the positive selection of enriched cells, performed by capturing cells through ferrofluids labeled with antibodies that target the (EpCAM) antigen, the staining procedure delivers cells that are ready for enumeration, isolation and downstream analysis. The final step of cell sorting can be performed by the DEPArray system or other downstream applications including flow cytometry, fluorescent microscopy or molecular and phenotype analyses.

For Fabio Piazzalunga, President and CEO of Menarini Silicon Biosystems: "Our manual CellMag product line allows all liquid biopsy and CTCs Laboratories to reach high specificity in cell enrichment and staining, leveraging the established CELLSEARCH ferrofluid technology. With this simple and standardized solution we are committed to helping all researchers develop scientific understanding and improve medical knowledge related to human diseases."

The CellMag product line family will be expanded in the coming months to offer a series of additional kits for the enrichment of other rare cell types.

About CELLMAG

CELLMAG is intended for Research Use Only (RUO) – not for use in diagnostic procedures. This product line allows for highly specific and standardized cell enrichment and staining. Cells captured with the CellMag technology are comparable to those captured with the CELLTRACKS AUTOPREP System. The product line is composed of an epithelial CTC kit, for ferrofluid-based EpCAM positive CTC enrichment, a magnetic tool and consumables. The process involves a sample preparation phase, followed by the magnetic separation of CTCs, sample washing, permeabilization and staining.

Medtronic to Announce Financial Results for Its Third Quarter of Fiscal Year 2021

On February 16, 2021 Medtronic plc (NYSE:MDT) reported that it will report financial results for its third quarter of fiscal year 2021 on Tuesday, February 23, 2021 (Press release, Medtronic, FEB 16, 2021, View Source [SID1234575151]). A news release will be issued at approximately 5:45 a.m. Central Standard Time (CST) and will be available at View Source The news release will include summary financial information for the company’s third quarter of fiscal year 2021, which ended on Friday, January 29, 2021.

Medtronic will host a video webcast at 7:00 a.m. CST to discuss financial results for its third quarter of fiscal year 2021. The webcast can be accessed at View Source on February 23, 2021.

Within 24 hours of the broadcast, a replay and transcript of the prepared remarks will be available by clicking on the Investor Events link at View Source.

Looking ahead, Medtronic plans to report its fiscal year 2021 fourth quarter results on Thursday, May 27, 2021. For fiscal year 2022, Medtronic plans to report its first, second and third quarter results on Tuesday, August 24, 2021, November 23, 2021, and February 22, 2022, respectively. For these events, confirmation and additional details will be provided closer to the specific event.

Cannabics Pharmaceuticals’ in-vivo Study concludes with a 33% Lower Tumor Volume in Mice Treated with Company’s Proprietary Drug Candidate for Colorectal Cancer

On February 16, 2021 Cannabics Pharmaceuticals Inc. (OTCQB: CNBX), a global leader in the development of cancer related cannabinoid-based medicine, reported the final results of its in-vivo study evaluating the efficacy of the company’s proprietary drug candidate RCC-33 for the treatment of colorectal cancer in nude-mice (Press release, Cannabics Pharmaceuticals, FEB 16, 2021, View Source [SID1234575150]). The final study results demonstrate a significant and robust inhibitory effect on tumor growth, as evidenced by a 33% reduction in tumor volume in mice exposed to RCC-33 in comparison with sham control mice (p ≤ 0.016).

Both the experimental and the control groups were inoculated with human colorectal cancer cells. Daily doses of intraperitoneal (IP) delivery of RCC-33 or sham control were initiated on day 5. Differences in tumor volume between the two groups were first observed after 5 days of treatment (day 10). Previously published interim results showing a 27% reduction in tumor volume were recorded after 12 days of treatment (day 17), with p value ≤ 0.022. The study was concluded after 16 days of treatment (day 21) when a member of the control group reached a predetermined tumor size. Final results recorded a significant and robust 33% reduction in tumor volume in RCC-33 treated mice in comparison with the control group, p value ≤0.016.

Eyal Barad, Cannabics Pharmaceuticals’ Co-founder and CEO said: "The outlook of the oncology market puts this sector’s therapeutics sales forecast at $250 billion by 2024, according to a recent McKinsey report. While this is the market we ultimately have in sight, our initial penetration efforts with RCC-33 are focused on developing a colorectal cancer treatment catering to a $10 billion market with a ‘massive unmet need’, as articulated in the same McKinsey report".

Gabriel Yariv, Cannabics Pharmaceuticals’ President and COO said: "Having successfully completed this in-vivo POC study, the company is now planning to finalize its product dossier preparation for a forthcoming submission to the FDA along with a request for a pre-IND meeting for RCC-33. We are paving the way with a potentially new treatment approach for colorectal cancer patients, one that could possibly have an important positive impact on a large group of patients, and we feel comfortable and look forward to bringing our scientific data before the regulatory authorities for review".

ESSA Pharma Announces Proposed Public Offering of Common Shares

On February 16, 2021 ESSA Pharma Inc. ("ESSA", or the "Company") (Nasdaq: EPIX), a clinical-stage pharmaceutical company focused on developing novel therapies for the treatment of prostate cancer, reported that it has commenced an underwritten public offering of up to $100,000,000 of its common shares (the "Offering") (Press release, ESSA, FEB 16, 2021, View Source [SID1234575149]). ESSA intends to use the net proceeds of the Offering for pre-clinical and clinical activities, chemistry, manufacturing and controls, research and development, as well as working capital and general corporate purposes. In connection with the Offering, ESSA expects to grant the underwriters a 30-day option to purchase up to an additional 15% of the common shares offered in the Offering (the "Option"). All common shares to be sold in the Offering will be offered by ESSA. The Offering is subject to market conditions, and there can be no assurance as to whether or when the Offering may be completed, or the actual size or terms of the Offering.

Jefferies and Piper Sandler are acting as joint book-running managers for the Offering. Oppenheimer & Co. is acting as lead manager for the Offering and Bloom Burton Securities Inc. is acting as co-manager for the Offering.

The securities described above are being offered by ESSA in the United States pursuant to a shelf registration statement on Form S-3 (File No. 333-250971) that was previously filed by ESSA with the Securities and Exchange Commission (the "SEC") and became effective on December 29, 2020 and in Canada pursuant to ESSA’s Canadian short form base shelf prospectus (the "Canadian Base Shelf Prospectus") dated August 24, 2020 that was previously filed with the securities regulatory authorities in each of the provinces of British Columbia, Alberta and Ontario.

A preliminary prospectus supplement and accompanying prospectus relating to the Offering will be filed with the SEC and will be available on the SEC’s website at View Source A preliminary prospectus supplement to ESSA’s Canadian Base Shelf Prospectus will also be filed with the securities regulatory authorities in each of the provinces of British Columbia, Alberta and Ontario and will be available at View Source A copy of the preliminary prospectus supplement and accompanying prospectus can be obtained by contacting Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by e-mail at [email protected] or by telephone at (877) 547-6340; or Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, or by telephone at 800-747-3924 or by email at [email protected].

The Offering is subject to customary closing conditions.

This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.