On September 10, 2020 Pfizer Inc. (NYSE:PFE) reported that more than 50 abstracts representing data from nine approved and investigational Pfizer medicines, including several biomarker-driven and immuno-therapies, will be presented at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Congress 2020 being held from September 19-21, 2020 (Press release, Pfizer, SEP 10, 2020, View Source [SID1234564968]). Data to be presented include findings from the Phase 3 CROWN study of LORBRENA (lorlatinib)* in first-line ALK-positive non-small cell lung cancer (NSCLC), building on Pfizer’s extensive heritage in precision medicine research.

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In addition to the CROWN study, several biomarker analyses that provide further insights on Pfizer medicines across a range of cancers will be presented, including BAVENCIO (avelumab), BRAFTOVI (encorafenib) + MEKTOVI (binimetinib), and IBRANCE (palbociclib). BAVENCIO is being developed and commercialized in collaboration with Merck KGaA, Darmstadt, Germany.

"Meaningful innovation in cancer care requires building upon our understanding of tumor biology, leveraging cutting-edge research, and applying the knowledge we gain into new treatments that address and prevent resistance," said Chris Boshoff, M.D., Ph.D., Chief Development Officer, Oncology, Pfizer Global Product Development. "We are proud to share the latest insights on our cancer medicines at ESMO (Free ESMO Whitepaper) this year, including data from the CROWN trial examining the first-line use of our third-generation biomarker-driven therapy in ALK-positive non-small cell lung cancer."

Pfizer will also continue its commitment to help non-scientists understand the latest findings with the development of abstract plain language summaries (APLS) for company-sponsored research being presented at ESMO (Free ESMO Whitepaper), which are written in non-technical language. Those interested in learning more can visit www.Pfizer.com/apls to access the summaries starting September 18.

Key presentations featuring Pfizer medicines at ESMO (Free ESMO Whitepaper) include:

Pfizer-Sponsored Studies

Proffered Paper (Presentation LBA2)

Saturday, September 19, 2020

Lorlatinib vs Crizotinib in the First-line Treatment of Patients with Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC): Results of the Phase 3 CROWN Study

Solomon B.

Proffered Paper (Presentation 699O)

Saturday, September 19, 2020

Avelumab First-line (1L) Maintenance + Best Supportive Care (BSC) vs BSC Alone for Advanced Urothelial Carcinoma (UC): Association between Clinical Outcomes and Exploratory Biomarkers

Sridhar S.

Proffered Paper (Presentation 910O)

Saturday, September 19, 2020

Primary Results of the Phase III JAVELIN Head & Neck 100 Trial: Avelumab Plus Chemoradiotherapy (CRT) Followed by Avelumab Maintenance vs CRT in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA SCCHN)

Cohen E.

Mini Oral (Presentation 704MO)

Friday, September 18, 2020

Avelumab First-line (1L) Maintenance + Best Supportive Care (BSC) vs BSC Alone with 1L Chemotherapy (CTx) for Advanced Urothelial Carcinoma (UC): Subgroup Analyses from JAVELIN Bladder 100

Grivas P.

Investigator-Sponsored Studies and Clinical Research Collaborations

Proffered Paper (Presentation LBA12)

Sunday, September 20, 2020

PALLAS: A Randomized Phase III Trial of Adjuvant Palbociclib with Endocrine Therapy Versus Endocrine Therapy Alone for HR+/HER2- Early Breast Cancer

Mayer E.

Proffered Paper (Presentation LBA45)

Saturday, September 19, 2020

First Report of Efficacy and Safety from the Phase II Study SECOMBIT (SEquential COMBo Immuno and Targeted Therapy Study)

Ascierto P.

Mini Oral (Presentation LBA27)

Friday, September 18, 2020

Phase II Multicenter, Randomized Study to Evaluate Efficacy and Safety of Avelumab with Gemcitabine/Carboplatin (CG) vs CG Alone in Patients with Unresectable or Metastatic Urothelial Carcinoma (mUC) Who Are Ineligible to Receive Cisplatin-based Therapy

Pérez Valderrama B.

Presentations will be available to registered attendees during the Congress at www.ESMO.org. A complete list of Pfizer-sponsored abstracts will be available at View Source

Merck KGaA, Darmstadt, Germany and Pfizer have a global strategic alliance to jointly develop and commercialize BAVENCIO.

*LORBRENA (lorlatinib) is available in the European Union under the brand name LORVIQUA.

Prescribing Information for Pfizer Medicines

Please see full US Prescribing Information and Medication Guide for BAVENCIO (avelumab) available at www.Bavencio.com.
Please see full Prescribing Information for BRAFTOVI (encorafenib) + MEKTOVI(binimetinib) available at www.BraftoviMektovi.com.
Please see full Prescribing Information for IBRANCE (palbociclib) at www.Ibrance.com.
Please see full Prescribing Information for LORBRENA (lorlatinib) at www.Lorbrena.com.
Please see full Prescribing Information for XALKORI (crizotinib) at www.Xalkori.com.