On November 5, 2024 PharmaJet, a company that strives to improve the performance and outcomes of injectables with its enabling needle-free technology, reported their upcoming poster presentation on November 8, 2024 at the Society of Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) conference (Press release, PharmaJet, NOV 5, 2024, View Source [SID1234647762]). The poster (#741), entitled Modulating Immune Responses to Therapeutic Cancer Vaccines through Precision Delivery Technologies, will be presented by Gregg Wilson, PhD, RN, Director of Medical and Scientific Affairs, PharmaJet. The SITC (Free SITC Whitepaper) conference will be held at the George R. Brown Convention Center in Houston, Texas, bringing together leading cancer immunotherapy researchers, clinicians, scientists and industry leaders in the oncology field.
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Immunotherapeutic strategies for cancer treatment include nucleic acid platforms with antigen presenting cell (APC)-targeting to boost T cell activation and the addition of neo-antigenic epitopes. Combined with checkpoint inhibitors (CPI), therapeutic vaccines significantly enhance anti-tumor and clinical responses. PharmaJet needle-free delivery can improve DNA vaccine delivery and has been successfully adopted into multiple vaccine development programs while demonstrating robust immunogenicity, with favorable clinical outcomes for novel therapeutic vaccines.
The poster presentation will highlight recent partner study results showing immunogenicity improvement when delivered with the PharmaJet Stratis including:
Evaxion: In Phase 1/2 trials the Stratis Needle-free Delivery System was used to administer EVX-02 DNA vaccine in combination with CPI (nivolumab) to patients that had a complete resection of Stage IIIB/IIIC/IIID or Stage IV melanoma and were a high risk of recurrence. The study, comparing Stratis delivery to poloxamer delivery with needle/syringe, showed EVX-02 was immunogenic with an improvement in T cell induction when using Stratis compared to needle/syringe. These patients were relapse-free at their last assessment.2 The 2nd generation EVX-03 vaccine induced a more potent response in a pre-clinical model.
Scancell: The Phase 2 trial with patients that have advanced unresectable melanoma who have received the SCIB1 or ISCIB1+ DNA vaccine with CPI, either with nivolumab and ipilimumab or pembrolizumab is ongoing. Latest data shows SCIB1 administered with Stratis has induced T cell responses in 87% of patients who have been given double CPI and showed a significant increase from baseline T cell counts with full cohort data still to be analyzed.3 According to Lindy Durrant, Scancell CEO, "To date, Stratis is the only technology which has shown effective uptake of the DNA vaccine through intramuscular delivery allowing native cellular machinery to express the target antigen and induce a potent anti-tumor response."4
"PharmaJet Needle-free Systems enable DNA cancer vaccine delivery and can be incorporated into both conventional and novel therapeutic strategies to treat various types of cancer," noted Nathalie Landry, Chief Scientific Officer, PharmaJet. "These study results show that needle-free delivery is safe and well tolerated, induces antigen-specific T cell responses, and leads to favorable clinical outcomes."
For more information visit the PharmaJet booth #533 from November 8-10, 2024, at the SITC (Free SITC Whitepaper) conference, or visit the website at https://pharmajet.com.