On April 28, 2025 PharmaMar (MSE:PHM), global leader in research, development and commercialization of marine-derived oncology treatments, reported that it is once again participating in the Annual Meeting of the American Association for Cancer Research (AACR) (Free AACR Whitepaper), being held in Chicago from April 25th to 30th, 2025 (Press release, PharmaMar, APR 28, 2025, View Source [SID1234652242]). On this occasion, the Company is presenting eleven new studies with results on the activity of its compounds: lurbinectedin (Zepzelca), ecubectedin, PM54, PM534, and trabectedin (Yondelis).

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This reinforces PharmaMar’s ongoing commitment to innovation and cancer research. "We continue to advance the study of the therapeutic potential of marine-derived molecules, both in well-established compounds and in those in earlier stages of development. Our participation this year in the world’s leading oncology research congress reflects our firm commitment to scientific innovation and the path we are building to provide potential therapeutic alternatives for patients," says Carmen Cuevas, VP of R&D at PharmaMar.

The main conclusions from the presented studies highlight the potential of two novel transcription inhibitors, PM54 and ecubectedin as innovative antitumor agents. Ecubectedin has demonstrated encouraging antitumor efficacy in both gastric and neuroendocrine-prostate cancer models. In collaboration with KU Leuven University (Belgium), data also confirm promising antitumor activity of both ecubectedin and PM54 in representative models of soft tissue sarcomas (STS).

Additionally, data on PM534 are being presented. PM534 is a novel tubulin-targeting agent, that may bypass the most common resistance mechanisms, limiting the effectiveness of standard microtubule-binding drugs.

Finally, the studies also show the antitumor activity of lurbinectedin in NUT carcinoma—a rare type of cancer that forms in the head, neck and lungs. Furthermore, new insights into the mechanism of action of trabectedin will also be shared.

The full list of all presentations supported by PharmaMar or its collaborators at the AACR (Free AACR Whitepaper) 2025 Annual Meeting is as follows:

COMPOUND TITLE LEAD AUTHOR ABSTRACT
Ecubectedin (PM14) Ecubectedin’s role in targeting transcriptional regulators in neuroendocrine prostate cancer. Laura Almalé, PhD Location: Section 22
Board Number: 23
Published Abstract Number: 1771 April 28, 2025
Ecubectedin as a promising therapeutic agent against gastric cancer through Wnt/β-Catenin modulation. Alejandro Losada, PhD Location: Section 21
Board Number: 8
Published Abstract Number: 5630 April 29, 2025
The novel transcriptional inhibitor ecubectedin demonstrates strong antitumor activity in patent-derived xenograft models of soft tissue sarcoma. Daniël Gorgels, PhD Location: Section 21
Board Number: 1
Published Abstract Number: 6857 April 30, 2025
PM534 Overcoming resistance to tubulin-targeting drugs with PM534: an innovative microtubule-targeting compound. Pablo M. Aviles, PharmD, PhD Location: Section 21
Board Number: 8
Published Abstract Number: 6864 April 30, 2025
PM54 PM54, a novel transcription inhibitor with promising broad spectrum antitumor activity. Marcelo Lima Ribeiro, PhD Location: Section 22
Board Number: 25
Published Abstract Number: 1773 April 28, 2025
The next generation transcriptional inhibitor PM54 demonstrates strong antitumor activity in patient-derived xenograft models of soft tissue sarcoma. Daniël Gorgels, PhD Location: Section 21
Board Number: 2
Published Abstract Number: 6858 April 30, 2025
Pan-inhibition of super-enhancer-driven oncogenic transcription by novel synthetic ecteinascidins yields potent anti-cancer activity Julian Obid, PhD Location: Section 21
Board Number: 13
Published Abstract Number: 1738 April 28, 2025
Trabectedin (Yondelis) Redefining the Molecular Target for Trabectedin (ET743) as Stable Covalent Bonding to N2 of Guanine in Duplex Stem-Loops of G-Quadruplexes. Laurence H. Hurley, PhD Location: Section 19
Board Number: 2
Published Abstract Number: 2972 April 28, 2025
Lurbinectedin (Zepzelca) New therapeutic approaches in NUT Carcinoma: an unmet need. María Virgina Sáchéz-Becerra, PhD Location: Section 34
Board Number: 23
Published Abstract Number: 5996 April 29, 2025
Lurbinectedin-Induced Transcriptional Reprogramming: A Pathway to Sensitise SCLC to Immunotherapy J.S. Russo-Cabrera, PhD Location: Section 23
Board Number: 13
Published Abstract Number: 5837 April 29, 2025
Lurbinectedin Irinotecan as a new therapeutic combination for Small Cell Lung Cancer Miguel Ruiz-Torres, PhD Location: Section 34
Board Number: 13
Published Abstract Number: 5986 April 29, 2025