On April 17, 2023 Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a clinical stage biotechnology company whose proprietary INTASYL RNAi platform technology is designed to make immune cells more effective in killing tumor cells, reported that in vivo data from a hepatocellular carcinoma model provides insight into the mechanism by which locally administered mouse-targeted PH-762 (mPH-762) exerts systemic anti-tumor efficacy ("abscopal effect") (Press release, Phio Pharmaceuticals, APR 17, 2023, View Source [SID1234630171]).

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In the study, intratumoral administration of mPH-762 stimulated a local anti-tumor immune response and generated systemic tumor-reactive memory T cells, suggesting that the abscopal effects of PH-762 are mediated by the immune system.

"These preclinical study results support intratumoral use of PH-762 in the clinical setting, with deeper understanding of the mechanism of abscopal efficacy," said Dr. Mary Spellman, Phio’s Acting Chief Medical Officer. "In addition, immune-related adverse events noted with systemic PD-1 inhibition may be mitigated by intratumoral administration."

PH-762 is under clinical development in a phase 1b trial for neoadjuvant treatment of advanced resectable melanoma.

Presentation Details:

Poster Title: Intratumoral PH-762, a self-delivering RNAi therapeutic (INTASYL) targeting mouse PD-1, generates systemic tumor-specific memory CD8 T cells, providing a mechanism for abscopal efficacy toward untreated tumors in a murine hepatocarcinoma model.

Session Date and Time: Monday, April 17, 2023 from 9:00 AM – 12:30 PM EST