On March 25, 2021 Portage Biotech Inc. (NASDAQ: PRTG, CSE: PBT.U) ("Portage" or the "Company") a clinical stage immuno-oncology company accelerating research and development to overcome immune resistance, reported that Intensity Therapeutics has executed agreements to conduct a Phase 2 study of INT230-6 (PORT-1) in early stage breast cancer in tandem with the Ottawa Hospital Cancer Centre and The Ontario Institute for Cancer Research (Press release, Portage Biotech, MAR 25, 2021, View Source [SID1234577193]).
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PORT-1 is the first asset from the Intensity platform of intratumoral amphiphilic formulations. PORT-1 delivers potent cancer-killing agents directly into the tumor, immediately reducing cancer burden, breaking down the cytokine wall, and recruiting immune cells to attack residual disease.
The objectives of the INVINCIBLE Trial are to assess proliferative burden and pathological complete response (pCR). This study represents a new cancer treatment paradigm with the potential to kill the cancer and activate an immune response in as little as 4 weeks following administration. Comparatively, typical neoadjuvant chemotherapy treatment often requires administration over 4-6 months prior to surgery. If proven successful, this model could be expanded to other surgical settings without delaying the surgery.
"This approach is indicative of our strategy to provide improved options for different cancer settings by leveraging innovative ways to boost the immune system to fight cancer," said Dr. Ian Walters, chief executive officer of Portage Biotech who conceptualized this study. "This is one of multiple programs that will be yielding clinical data over the next 12-18 months. We expect eight additional phase 2 data reads for PORT-1, being conducted in collaboration with Bristol Myers Squibb and Merck, which will evaluate the asset as both a monotherapy and combination therapy with checkpoint inhibitors in various advanced metastatic settings. Beyond the PORT-1, we also expect data reads from trials of our first-in-class PORT-2 & PORT-3 iNKT agonists in the same timeframe."
To view the full announcement from Intensity Therapeutics, visit their website at: www.intensitytherapeutics.com.