On May 17, 2022 Poseida Therapeutics, Inc. (Nasdaq: PSTX), a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure, reported that it will present preclinical data at the American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 2022 Annual Meeting highlighting the use of anti-c-kit CAR-T cells as a preconditioning agent to enable hematopoietic stem cell (HSC) transplants (Press release, Poseida Therapeutics, MAY 17, 2022, View Source [SID1234614755]). The ASGCT (Free ASGCT Whitepaper) Annual Meeting is being held in Washington, D.C. and virtually May 16-19, 2022.
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"We are pleased to present preclinical data from our anti-c-kit CAR-T program demonstrating the broad capabilities of our platform technologies to potentially improve patient outcomes," said Devon Shedlock, Ph.D., Chief Scientific Officer, Cell Therapies at Poseida Therapeutics. "P-ckit-ALLO1 is an allogeneic or ‘off-the-shelf’ adoptive cell therapy comprised of early memory T cells expressing key bone marrow homing markers that enable it to effectively eliminate hematopoietic stem cells (HSC) and robustly inhibit growth of acute myeloid leukemia (AML) cells in animal models. The data presented today show that P-ckit-ALLO1 could be an ideal treatment as both a safer HSC transplantation approach as well as an anti-tumor therapy."
Presentation details:
Poster Presentation: Anti-c-kit CAR-T Cells Enable HSC Engraftment in a Humanized Model of Stem Cell Transplant Conditioning
Session Title: Cell Therapies II
Session Date/Time: Tuesday, May 17, 2022, 5:30 – 6:30 PM ET
Poster Board Number: Tu-239
Location: Walter E. Washington Convention Center, Hall D
Abstract Number: 734
P-ckit-ALLO1 leverages the Company’s proprietary piggyBac Gene Delivery System, Cas-CLOVER Site-specific Gene Editing System, and a proprietary "Booster Molecule" to develop fully allogeneic CAR-T cells targeting human c-kit, which is highly expressed on HSCs as well as on myeloid malignancies such as AML, meaning the treatment can be used for either HSC transplant conditioning or as a treatment for AML. In addition to the CAR gene, the piggyBac transposon includes a selection marker for generation of a pure CAR+ product and a proprietary fast-acting safety switch enabling rapid clearance of the reactive CAR-T cells prior to donor HSC transplant.
Data demonstrated that P-ckit-ALLO1 was able to eliminate 95% of HSCs in bone marrow within four days, which was sufficient to enable HSC transplant in a humanized mouse model with reduced acute myelotoxicity compared to busulfan. In addition, data demonstrated that P-ckit-ALLO1 was able to significantly inhibit growth of AML cells in animal models and significantly prolong survival. These encouraging data support the potential of anti-c-kit CAR-T cells for use as an alternative and less toxic conditioning regimen to facilitate HSC transplantation as well as a potential anti-tumor therapy.